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| 1 | Prevalence of Autism Spectrum Disorder in China:A Nationwide Multi-center Population-based Study Among Children Aged 6 to 12 Years显示文摘This study aimed to obtain the first national estimate of the prevalence of autism spectrum disorder(ASD) in Chinese children.We targeted the population of 6 to 12-year-old children for this prevalence study by multistage convenient cluster sampling.The Modified Chinese Autism Spectrum Rating Scale was used for the screening process.Of the target population of 142,086 children,88.5%(n=125,806) participated in the study.A total of 363 children were confirmed as having ASD.The observed ASD prevalence rate was 0.29%(95% CI:0.26%-0.32%) for the overall population.After adjustment for response rates,the estimated number of ASD cases was867 in the target population sample,thereby achieving an estimated prevalence of 0.70%(95% CI:0.64%-0.74%).The prevalence was significantly higher in boys than in girls(0.95%;95% CI:0.87%-1.02% versus 0.30%;95%CI:0.26%-0.34%;P <0.001).Of the 363 confirmed ASD cases,43.3% were newly diagnosed,and most of those(90.4%) were attending regular schools,and 68.8% of the children with ASD had at least one neuropsychiatric comorbidity.Our findings provide reliable data on the estimated ASD prevalence and comorbidities in Chinese children. | Hao Zhou Xiu Xu Weili Yan Xiaobing Zou Lijie Wu Xuerong Luo Tingyu Li Yi Huang Hongyan Guan Xiang Chen Meng Mao Kun Xia Lan Zhang Erzhen Li Xiaoling Ge Lili Zhang Chunpei Li Xudong Zhang Yuanfeng Zhou Ding Ding Andy Shih Eric Fombonne Yi Zheng Jisheng Han Zhongsheng Sun Yong-hui Jiang Yi Wang LATENT-NHC Study Team | 2020 | Neuroscience Bulletin2020，36，9： | 158 |
| 2 | Single-Cell Sequencing Technologies: Current and Future显示文摘Intensively developed in the last few years, single-cell sequencing technologies now present numerous advantages over traditional sequencing methods for solving the problems of biological heterogeneity and low quantities of available biological materials. The application of single-cell sequencing technologies has profoundly changed our understanding of a series of biological phenomena,including gene transcription, embryo development, and carcinogenesis. However, before single-cell sequencing technologies can be used extensively, researchers face the serious challenge of overcoming inherent issues of high amplification bias, low accuracy and reproducibility. Here, we simply summarize the techniques used for single-cell isolation, and review the current technologies used in single-cell genomic, transcriptomic, and epigenomic sequencing. We discuss the merits, defects, and scope of application of single-cell sequencing technologies and then speculate on the direction of future developments. | Jialong Liang Wanshi Cai Zhongsheng Sun | 2014 | Journal of Genetics and Genomics2014，41，10： | 20 |
| 3 | PGC-1α induces apoptosis in human epithelial ovarian cancer cells through a PPARy-dependent pathway显示文摘Peroxisome 激活 proliferator 的受体鲸鱼群妈(PPAR γ) coactivator-1 高山哈(PGC-1 α) coactivates 多重抄写因素并且调整几个代谢过程。Thecurrent 学习在人的上皮的卵巢的癌症房间在 apoptosis 的正式就职调查了 PGC-1 α的角色。在人的卵巢和人的卵巢的上皮的肿瘤之间的 PGC-1 α信使 rna 水平被量的 RT-PCR 检验。更少的 PGC-1 α表示与正常卵巢相比在恶意的肿瘤的表面上皮被发现。在人的上皮的卵巢的癌症房间线 Ho-8910 的 PGC-1 α的 Overexpression 通过 Bcl-2 和 Bax 表示的协调规定导致了房间 apoptosis。Microarray 分析证实 PGC-1 α戏剧性地在 Ho-8910 房间影响了 apoptosis 相关的基因。 Mitochondrial 功能的试金证明 apoptosis 的正式就职通过由细胞色素 c.Furthermore 的版本的终端阶段,导致的 apoptosis 部分是,然而并非完全,由 PPAR γa ntagonist ( GW9662 )堵住了的 PGC-1 α-,并且由 siRNA 的 PPAR γ 表示的抑制也在 Ho-8910 房间禁止了 PGC-1 α- inducedapoptosis 。这些数据建议 PGC-1 α通过 aPPAR γ - 依赖者小径施加了它的效果。我们的调查结果显示 PGC-1 α涉及 apoptotic signaltransduction 小径, PGC-1 α的 down 规定可以是在支持上皮的卵巢的癌症生长和前进的一个关键点。 | Yan Zhang Yi Ba Chang Liu Guoxun Sun Li Ding Songyuan Gao Jihui Hao Zhentao Yu Junfeng Zhang Ke Zen Zhongsheng Tong Yang Xiang Chen-Yu Zhang | 2007 | Cell Research2007，17，4： | 14 |
| 4 | Studies of the Genotoxicity of Glycidyl Methacrylate (GMA)显示文摘The following experiments were conducted to evaluate the genotoxic effects of GMA (glycidyl methacrylale) on mammalian and human cells.(1) Using the absorption spectrum shift method in vitro, we observed that the maximums of calf thymus DNA and GMA were shifted toward longer wavelengths (a change of more than 15nm) and the absorbance decreased after incubation at room temperature for 15min or more.The result indicates that binding of DNA and GMA had occurred.The binding force is strong, not affected by the addition of concentrated sodium chloride solution, and only slightly decreased by the addition of 8 M urea solution.Therefore the bond between DNA and GMA might be covalent.(2) In cell cultures, unscheduled DNA synthesis (UDS) in human and/or rat lymphocyte was induced and DNA semiconserva-tive replication was inhibited by GMA at concentrations of less than 5.2 mM.(3) Sperm abnormality tests and assays of UDS in germ cells of male mice were conducted to study the in vivo genotoxicity of GMA.The results revealed that GMA could damage DNA, increase sperm abnormality frequency, and reduce the number of sperm cells, 1990 Academic Press.Inc. | DAYING XIE, WEI ZHANG, LAIFU CAO, WENQING SUN, ZHONGSHENG LI, QING GAO, YILI WU, HUILAN GAO, HUIFANG YANG, JIM ZUO,~* AND FUDE FANG~* Institute oF Occupational Medicine. Chinese Academy ol Preventive Medicine. Beijing 100050. and *Institute of Basic Medical Sciences, Chinese Academy ol Medical Sciences. Beijing 100730, China | 1990 | Biomedical and Environmental Sciences1990，3，3： | 7 |
| 5 | Experimental Research of Force Feedback Dataglove Based on Pneumatic Artificial Muscle显示文摘Force feedback dataglove is an important interface of human-machine interaction between manipulator and virtual assembly system,which is in charge of the bidirectional transmission of movement and force information between computer and operator. The exoskeleton force feedback dataglove is designed taking the pneumatic artificial muscle as actuator,meanwhile,its structure and work principle are introduced,and the force control problem is analyzed and researched by experiment. The mathematic model of grasping rigid object for finger is established. Considering the friction of tendon-sheath system and finger deformation,the closed-loop force control for a single joint,a single finger and multi-fingers are studied respectively by the feedforward proportional-integral(PI) control method with variable arguments. On the premise of the force smoothness,the control error of the force exerted on the finger joint is in the range of ±0.25 N,which meets the requirement of force feedback. By experimental analysis,the reason of force fluctuation is that the finger joint has a small amplitude quiver,and the consistent change tendency of the force between proximal interphalangeal(PIP) joint and distal interphalangeal(DIP) joint results from their angle coupling relationship. | SUN Zhongsheng BAO Gang LI Xiaoning | 2009 | Chinese Journal of Mechanical Engineering2009，22，4： | 4 |
| 6 | FORCE FEEDBACK DATAGLOVE BASED ON PNEUMATIC ARTIFICIAL MUSCLES显示文摘一只皮骨骼力量反馈数据手套被开发,它使用灵魂人工的肌肉作为致动器。根据简化的手模型,运动方程根据 Denavit-Hartenberg 的理论被推出。目标在手指上施加的相等的接触力量的模型被建议。由虚拟工作的原则,手指的静态的平衡被建立。手指的力量 Jacobian 矩阵被计算,然后手指的联合转矩掌握什么时候反对,被获得。力量反馈 datagolve 的理论和结构被介绍。基于四酒吧的连接的运动稳定的理论,关节的屈曲角度被测量。灵魂的产量力量引起人工的肌肉的手指关节上的转矩是计算的。输出灵魂强迫人工的肌肉,其值被它的内部压力控制,当掌握对象时,能被手指的联合转矩计算。力量,开车转矩和灵魂肌肉的需要的产量力量的手臂为食指的每个关节被计算。灵魂肌肉的产量力量的标准被给。 | BAO Gang SUN Zhongsheng WANG Zuwen | 2006 | Chinese Journal of Mechanical Engineering2006，19，4： | 4 |
| 7 | Entinostat,a classⅠselective histone deacetylase inhibitor,plus exemestane for Chinese patients with hormone receptor-positive advanced breast cancer:A multicenter,randomized,double-blind,placebo-controlled,phase 3 trial显示文摘Entinostat plus exemestane in hormone receptor-positive(HR+)advanced breast cancer(ABC)previously showed encouraging outcomes.This multicenter phase 3 trial evaluated the efficacy and safety of entinostat plus exemestane in Chinese patients with HR+ABC that relapsed/progressed after≥1 endocrine therapy.Patients were randomized(2:1)to oral exemestane 25 mg/day plus entinostat(n=235)or placebo(n=119)5 mg/week in 28-day cycles.The primary endpoint was the independent radiographic committee(IRC)-assessed progression-free survival(PFS).The median age was 52(range,28—75)years and 222(62.7%)patients were postmenopausal.CDK4/6 inhibitors and fulvestrant were previously used in 23(6.5%)and 92(26.0%)patients,respectively.The baseline characteristics were comparable between the entinostat and placebo groups.The median PFS was 6.32(95%CI,5.30—9.11)and 3.72(95%CI,1.91—5.49)months in the entinostat and placebo groups(HR,0.76;95%CI,0.58—0.98;P=0.046),respectively.Grade≥3 adverse events(AEs)occurred in 154(65.5%)patients in the entinostat group versus 23(19.3%)in the placebo group,and the most common grade≥3 treatment-related AEs were neutropenia[103(43.8%)],thrombocytopenia[20(8.5%)],and leucopenia[15(6.4%)].Entinostat plus exemestane significantly improved PFS compared with exemestane,with generally manageable toxicities in HR+ABC(ClinicalTrials.gov#NCT03538171). | Binghe Xu Qingyuan Zhang Xichun Hu Qing Li Tao Sun Wei Li Quchang Ouyang Jingfen Wang Zhongsheng Tong Min Yan Huiping Li Xiaohua Zeng Changping Shan Xian Wang Xi Yan Jian Zhang Yue Zhang Jiani Wang Liang Zhang Ying Lin Jifeng Feng Qianjun Chen Jian Huang Lu Zhang Lisong Yang Ying Tian Hongyan Shang | 2023 | Acta Pharmaceutica Sinica B2023，13，5： | 3 |
| 8 | Mechanism of lithium insertion into NiSi_2 anode material for lithium ion batteries显示文摘As a promising high capacity anode material for lithium ion batteries, the lithium insertion performance and possible insertion mechanism of binary alloy of NiSi2 were discussed. The initial lithium insertion of crystal NiSi2 can reach up to 600 mAh·g-1, but large irreversible capacity occurrs simultaneously for serious structure transformation and the irreversible phase forms. XRD and XPS were employed to detect the crystal structure and composition changes produced by lithium insertion. The lithium insertion-extraction behavior of NiSi2 electrode is similar to that of silicon after the first discharge. The structure stability seems related to the non-stoichimometric Ni-Si compound formed by lithium insertion into NiSi2. | WEN Zhongsheng JI Shijun SUN Juncai TIAN Feng TIAN Rujin XIE Jingying | 2006 | Rare Metals2006，25，z1： | 2 |
| 9 | Peering into the Milky Way by FAST:Ⅳ.Identification of two new Galactic supernova remnants G203.1+6.6and G206.7+5.9显示文摘A 5°×7°sky area containing two large radio structures of G203.1+6.6 and G206.7+5.9 with a size of about 2.°5 and 3.°5 respectively is scanned by using the L-band 19-beam receiver of the Five-hundred-meter Aperture Spherical radio Telescope(FAST).The FAST L-band receiver covers a frequency range of 1.0-1.5 GHz.Commissioning of the receiving system,including the measurements of the half-power beam width,gain,and main-beam efficiency is made by observing the calibrators.The multi-channel spectroscopy backend mounted to the receiver allows an in-band spectral-index determination.The brightness-temperature spectral indices of both objects are measured to beβ~-2.6 to-2.7.Polarized emission is detected from the archival Effelsbergλ11 cm data for all the shell structures of G203.1+6.6 and G206.7+5.9.These results clearly indicate a non-thermal synchrotron emitting nature,confirming that G203.1+6.6 and G206.7+5.9 are large shell-type supernova remnants(SNRs).Based on morphological correlation between the radio continuum emission of G206.7+5.9 and the H i structures,the kinematic distance to this new SNR is estimated to be about 440 pc,placing it in the Local Arm. | XuYang Gao Wolfgang Reich XiaoHui Sun He Zhao Tao Hong ZhongSheng Yuan Patricia Reich JinLin Han | 2022 | Science China(Physics,Mechanics & Astronomy)2022，65，12： | 1 |
| 10 | Reducing the Prob-ability of Bankruptcy Through Supply Chain Coordination 显示文摘 | Xu Xiaoyan Sun Yanhong Hua Zhongsheng | 2010 | JEEE Transactions On Systems Man and Cybernetics-Part C:Applications and Reviews2010，40，2： | 1 |
| 11 | Mapping of de novo mutations in primary biliary cholangitis to a disease-specific co-expression network underlying homeostasis and metabolism显示文摘Primary biliary cholangitis(PBC) is an autoimmune disease involving dysregulation of a broad array of homeostatic and metabolic processes. Although considerable single-nucleotide polymorphisms have been unveiled, a large fraction of risk factors remains enigmatic. Candidate genes with rare mutations that tend to confer more deleterious effects need to be identified. To help pinpoint cellular and developmental mechanisms beyond common noncoding variants, we integrate whole exome sequencing with integrative network analysis to investigate genes harboring de novo mutations. Prominent convergence has been revealed on a network of disease-specific co-expression comprised of 55 genes associated with homeostasis and metabolism. The transcription factor gene MEF2 D and the DNA repair gene PARP2 are highlighted as hub genes and identified to be up-and down-regulated, respectively, in peripheral blood data set. Enrichment analysis demonstrates that altered expression of MEF2 D and PARP2 may trigger a series of molecular and cellular processes with pivotal roles in PBC pathophysiology. Our study identifies genes with de novo mutations in PBC and suggests that a subset of genes in homeostasis and metabolism tend to act in synergy through converging on co-expression network, providing novel insights into the etiology of PBC and expanding the pool of molecular candidates for discovering clinically actionable biomarkers. | Lu Wang Jinchen Li Chan Wang Ruqi Tang Jialong Liang Yuhua Gong Yaping Dai Ningling Ding Jian Wu Na Dai Lei Liu Yi Zhao Youlin Shao Weifeng Zhao Peng Jiang Xingjuan Shi Weichang Chen Ye Tian Xiangdong Liu Xiong Ma Zhongsheng Sun | 2022 | Journal of Genetics and Genomics2022，49，2： | 1 |
| 12 | Operational causes of bankruptcy propagation in supply chain显示文摘 | Hua Zhongsheng Sun Yanhong Xu Xiaoyan | | 0，，03： | 1 |
| 13 | Composite silicon film with connected silicon nanowires for lithium ion batteries显示文摘 | Zhongsheng Wen Meikang Cheng Juncai Sun Liang Wang | 2010 | Electrochimica Acta2010，，1： | 1 |
| 14 | A new candidate as the cathode material for intermediate and low temperature SOFCs显示文摘In order to develop the new cathode materials suitable for intermediate and low temperature solid oxide fuel cells (IT/LTSOFCs), LaNi1-xFexO3 (x=0.4-0.8) (LNF) materials were synthesized using coprecipitation method. Their structures and morphologies were investigated by XRD and SEM, and their electronic conductivities at different temperatures were measured by dc four terminal method. Fuel cells were fabricated to evaluate the electrochemical properties of the LNF materials as cathodes at different temperatures. The performance of 450-497 mW·cm-2 was obtained in the temperature region of 580-650 ℃ for the LaNi0.2Fe0.8O3 cathode, and of 209-227 mW·cm-2 at 400-500 ℃ for the LaNi0.4Fe0.6O3. The excellent fuel cell performances indicate that the LNF materials are good cathodes for IT/LTSOFCs. | LI Song SUN Xueli WEN Zhongsheng SUN Juncai | 2006 | Rare Metals2006，25，z1： | 1 |
| 15 | Altered expressions of memory genes in food-entrained circadian rhythm显示文摘 | Yue Mei Jianghong Zhang Zhigang Li Huajing Teng Yan Wang Zhongsheng Sun | 2018 | Acta Biochimica et Biophysica Sinica2018，50，10： | 1 |
| 16 | Multiple walking human recognition based on radar micro-Doppler signatures显示文摘The recognition of human movements based on radar m-D(micro-Doppler) signatures attracts great interest in the field of radar research on automatic target recognition. Because there are multiple frequency components overlapping seriously in the radar echoes from walking humans, it is a very difficult work to recognize walking humans based on radar echoes. In this paper, a recognition method of walking humans based on radar m-D signatures is proposed. In this method, the m-D spectrum is generated by generalized S transform first,and then the entropy segmentation is used to segment the interesting region from the original spectrum. Next,the m-D features are extracted from the m-D region. Lastly, the support vector machine is used to recognize different walking human targets. The simulation experiments considering two factors of height and velocity are also conducted to test the performance of this proposed method. | SUN ZhongSheng WANG Jun ZHANG YaoTian SUN JinPing YUAN ChangShun BI YanXian | 2015 | Science China Chemistry2015，58，12： | 1 |
| 17 | Operational causes of bankruptcy propagation in supply chain显示文摘 | Hua Zhongsheng Sun Yanghong Xu Xiaoyan | 2011 | Decision Support Systems2011，51，3： | 1 |
| 18 | Reducing the probability of bankruptcy through supply chain coordination显示文摘 | Xu Xiaoyan Sun Yanhong Hua Zhongsheng | 2010 | IEEE Transactions on Systems Man and Cybernetic Part C:Applications and Reviews2010，40，2： | 1 |
| 19 | Mitigating bankruptcy propagation through contractual incentive schemes显示文摘 | Sun Yanhong Xu Xiaoyan Hua Zhongsheng | 2012 | Decision Support Systems2012，53，： | 1 |
| 20 | Crystal and Molecular Structure of Mo_2[(μ_2-S)SCNEt_2]_2(S_2CNEt_2)_2显示文摘Crystal structure of the title complex was determined by X-ray diffraction method. It crystallizes in space group P21/n with cell dimensions:α=10. 041(5) , b=10. 719(4) , c= 1. 5671(6) nm, β=104. 36(3)°. The structure was solved by Patterson method. The final residual factor is R=0. 050. | Sun Chunting, Huang Qijun, Li Shuqin and Wang Tiegang(Department of Chemistry, Jilin University, Changchun)Zhang Guangren, Qu Xiangbang, Tang Zhongkun, He Guoqiang and Shen Yankui (Logistics Engineering Institute, Chongqing) Jin Zhongsheng and Wei Gecheng (Changchun Institute of Applied Chemistry, Changchun) | 1991 | Chemical Research in Chinese Universities1991，7，2： | 0 |
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