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| 1 | Heart-type fatty acid binding protein (H-FABP) as a biomarker for acute myocardial injury and long-term post-ischemic prognosis显示文摘尖锐心肌的梗塞(AMI ) 是一个威胁生活的事件。甚至与及时处理,尖锐 ischemic 心肌的损害和随后的局部缺血灌注损害(IRI ) 能仍然是困难的问题处理。除了放射学并且另外的辅助考试,适用的心脏的 biomarkers 的实验室测试为这混乱监视的早诊断和结束也是必要的。心类型丰满的酸绑定蛋白质(H-FABP ) 主要在 cardiomyocytes 内存在,最近为心肌的损害作为潜在地有希望的 biomarker 出现了。在这评论,我们在对心肌的损害和 IRI 的评价讨论 H-FABP 的敏感和特性,特别在早阶段,和它与另外的通常使用的心脏的 biomarkers 比较的长期的预示的价值,包括肌球素( Mb ),心脏的 troponin 我( cTnI ),肌酸 kinase MB ( CK-MB ),C反应的蛋白质( CRP ),肝糖 phosphorylase isoenzyme BB ( GPBB ),和高敏感的心脏的 troponin T ( hs-cTnT )。有另外的 biomarkers 的 H-FABP 的联合申请的潜力和值也被讨论。最后, H-FABP 的前景被总结;几个技术问题被讨论在临床的实践便于 H-FABP 的更宽的申请。 | Xiao-dong YE Yi HE Sheng WANG Gordon T WONG Michael G IRWIN Zhengyuan XIA | 2018 | Acta Pharmacologica Sinica2018，39，7： | 72 |
| 2 | STAT5 programs a distinct subset of GM-CSF-producing T helper cells that is essential for autoimmune neuroinflammation显示文摘 | Wanqiang Sheng Fan Yang Yi Zhou Henry Yang Pey Yng Low David Michael Kemeny Patrick Tan Akira Moh Mark H Kaplan Yongliang Zhang Xin-Yuan Fu | 2014 | Cell Research2014，24，12： | 7 |
| 3 | Hsa-miR-1246, hsa-miR-320a and hsa-miR-196b-5p inhibitors can reduce the cytotoxicity of Ebola virus glycoprotein in vitro显示文摘Ebola virus(EBOV)causes a highly lethal hemorrhagic fever syndrome in humans and has been associated with mortality rates of up to 91%in Zaire,the most lethal strain.Though the viral envelope glycoprotein(GP)mediates widespread inflammation and cellular damage,these changes have mainly focused on alterations at the protein level,the role of microRNAs(miRNAs)in the molecular pathogenesis underlying this lethal disease is not fully understood.Here,we report that the miRNAs hsa-miR-1246,hsa-miR-320a and hsa-miR-196b-5p were induced in human umbilical vein endothelial cells(HUVECs)following expression of EBOV GP.Among the proteins encoded by predicted targets of these miRNAs,the adhesion-related molecules tissue factor pathway inhibitor(TFPI),dystroglycan1(DAG1)and the caspase 8 and FADD-like apoptosis regulator(CFLAR)were significantly downregulated in EBOV GP-expressing HUVECs.Moreover,inhibition of hsa-miR-1246,hsa-miR-320a and hsa-miR-196b-5p,or overexpression of TFPI,DAG1 and CFLAR rescued the cell viability that was induced by EBOV GP.Our results provide a novel molecular basis for EBOV pathogenesis and may contribute to the development of strategies to protect against future EBOV pandemics. | SHENG MiaoMiao ZHONG Ying CHEN Yang DU JianChao JU XiangWu ZHAO Chen ZHANG GuiGen ZHANG LiFang LIU KangTai YANG Ning XIE Peng LI DangSheng ZHANG Michael Q. JIANG ChengYu | 2014 | Science China(Life Sciences)2014，57，10： | 7 |
| 4 | A history of high-power laser research and development in the United Kingdom显示文摘The first demonstration of laser action in ruby was made in 1960 by T.H.Maiman of Hughes Research Laboratories,USA.Many laboratories worldwide began the search for lasers using different materials,operating at different wavelengths.In the UK,academia,industry and the central laboratories took up the challenge from the earliest days to develop these systems for a broad range of applications.This historical review looks at the contribution the UK has made to the advancement of the technology,the development of systems and components and their exploitation over the last 60 years. | Colin N.Danson Malcolm White John R.M.Barr Thomas Bett Peter Blyth David Bowley Ceri Brenner Robert J.Collins Neal Croxford A.E.Bucker Dangor Laurence Devereux Peter E.Dyer Anthony Dymoke-Bradshaw Christopher B.Edwards Paul Ewart Allister I.Ferguson John M.Girkin Denis R.Hall David C.Hanna Wayne Harris David I.Hillier Christopher J.Hooker Simon M.Hooker Nicholas Hopps Janet Hull David Hunt Dino A.Jaroszynski Mark Kempenaars Helmut Kessler Sir Peter L.Knight Steve Knight Adrian Knowles Ciaran L.S.Lewis Ken S.Lipton Abby Littlechild John Littlechild Peter Maggs Graeme P.A.Malcolm OBE Stuart P.D.Mangles William Martin Paul McKenna Richard O.Moore Clive Morrison Zulfikar Najmudin David Neely Geoff H.C.New Michael J.Norman Ted Paine Anthony W.Parker Rory R.Penman Geoff J.Pert Chris Pietraszewski Andrew Randewich Nadeem H.Rizvi Nigel Seddon MBE Zheng-Ming Sheng David Slater Roland A.Smith Christopher Spindloe Roy Taylor Gary Thomas John W.G.Tisch Justin S.Wark Colin Webb S.Mark Wiggins Dave Willford Trevor Winstone | 2021 | High Power Laser Science and Engineering2021，9，2： | 5 |
| 5 | Superior anti-corrosion and self-healing bi-functional polymer composite coatings with polydopamine modified mesoporous silica/graphene oxide显示文摘In this article,graphene oxide(GO)and benzotriazole-loaded mesoporous silica nanoparticles(BTA/MSNs)are combined on micro scale through the in situ polymerization of polydopamine(PDA),preparing a selfhealing bi-functional GO(fGO)used as nano-fillers for anti-corrosion enhancement of waterborne epoxy(WEP)coatings.Scanning electronic microscopy(SEM)images show that the BTA/MSNs are uniformly distributed on the surface of high aspect ratio GO nanosheets to endow GO nanocontainer characteristics.UV-vis profiles demonstrate that fGO has p H-controlled release function.Modulus at lowest frequency is generally used for comparing the corrosion resistance of organic coatings.Modulus at lowest frequency(1.42×10^(5)Ωcm^(2))after 30 days immersion in 3.5 wt.%Na Cl solution revealed 2 orders of magnitude higher that of blank WEP(1.17×10^(7)Ωcm^(2)).With artificial cracks on its coatings,fGO/WEP had no obvious rust compared with blank WEP after 240 h of immersion.We anticipate that self-healing and physical barrier bi-functional nanocontainers improve the traditional anticorrosion coating efficiency with better,longer-lasting performance for shipping,oil drilling or bridge maintenance. | Yanqi Ma Haowei Huang Hongda Zhou Michael Graham James Smith Xinxin Sheng Ying Chen Li Zhang Xinya Zhang Elena Shchukina Dmitry Shchukin | 2021 | Journal of Materials Science & Technology2021，，36： | 4 |
| 6 | Primer containing dimethylaminododecyl methacrylate kills bacteria impregnated in human dentin blocks显示文摘Antibacterial dimethylaminododecyl methacrylate(DMADDM) was recently synthesized. The objectives of this study were to:(1)investigate antibacterial activity of DMADDM-containing primer on Streptococcus mutans impregnated into dentin blocks for the first time, and(2) compare the antibacterial efficacy of DMADDM with a previous quaternary ammonium dimethacrylate(QADM).Scotchbond Multi-Purpose(SBMP) bonding agent was used. DMADDM and QADM were mixed into SBMP primer. Six primers were tested: SBMP control primer P, P+2.5% DMADDM, P+5% DMADDM, P+7.5% DMADDM, P+10% DMADDM, and P+10% QADM.S. mutans were impregnated into human dentin blocks, and each primer was applied to dentin to test its ability to kill bacteria in dentinal tubules. Bacteria in dentin were collected via a sonication method, and the colony-forming units(CFU) and inhibition zones were measured. The bacterial inhibition zone of P+10% DMADDM was 10 times that of control primer(Po0.05). CFU in dentin with P+10% DMADDM was reduced by three orders of magnitude, compared with control. DMADDM had a much stronger antibacterial effect than QADM, and antibacterial efficacy increased with increasing DMADDM concentration. Dentin shear bond strengths were similar among all groups(P40.1). In conclusion, antibacterial DMADDM-containing primer was validated to kill bacteria inside dentin blocks, possessing a much stronger antibacterial potency than the previous QADM. DMADDM-containing bonding agent was effective in eradicating bacteria in dentin, and its efficacy was directly proportional to DMADDM mass fraction. Therefore, DMADDM may be promising for use in bonding agents as well as in other restorative and preventive materials to inhibit bacteria. | Chen Chen Lei Cheng Michael D Weir Nancy J Lin Sheng Lin-Gibson Xue-Dong Zhou Hockin HK Xu | 2016 | International Journal of Oral Science2016，8，4： | 4 |
| 7 | Effect of closure of live poultry markets on poultry-to-person transmission of avian influenza A H7N9 virus: an ecological study显示文摘 | Hongjie Yu Joseph T Wu Benjamin J Cowling Qiaohong Liao Vicky J Fang Sheng Zhou Peng Wu Hang Zhou Eric H Y Lau Danhuai Guo Michael Y Ni Zhibin Peng Luzhao Feng Hui Jiang Huiming Luo Qun Li Zijian Feng Yu Wang Weizhong Yang Gabriel M Leung | 2013 | The Lancet2013，，： | 2 |
| 8 | 19.34 cm2 large-area quaternary organic photovoltaic module with 12.36% certified efficiency显示文摘In this study, a quaternary blending strategy was applied in the fabrication of organic photovoltaic devices and large-area modules. As a result, the ultimate quaternary organic solar cells(OSCs) deliver 16.71% efficiency for small-area devices and 13.25% for large-area(19.34 cm2) modules(certified as 12.36%), which is one of the highest efficiencies for organic solar modules to date. Our results have proved the synergistic effects of multiple components in OSCs, providing an effective strategy for achieving high-performance organic photovoltaic devices and modules. | Ziyan Jia Zeng Chen Xu Chen Jizhong Yao Buyi Yan Rui Sheng Haiming Zhu Yang(Michael)Yang | 2021 | Photonics Research2021，9，3： | 2 |
| 9 | Myeloid mineralocorticoid receptor controls macrophage polarization and cardiovascular hypertrophy and remodeling in mice显示文摘 | Usher Michael G Duan Sheng Zhong Ivaschenko Christine Y Frieler Ryan A Berger Stefan Schütz Günther Lumeng Carey N Mortensen Richard M | 2010 | Journal of Clinical Investigation2010，，9： | 1 |
| 10 | Peroxisome proliferator-activated receptor-γ-mediated effects in the vasculature显示文摘 | Sheng ZD Michael GU Richard MM | 2008 | Circ Res2008，102，3： | 1 |
| 11 | Intraocular Pressure Monitoring Post Intravitreal Steroids: A Systematic Review显示文摘 | Weerawat Kiddee Graham E. Trope Lisa Sheng Laura Beltran-Agullo Michael Smith M. Hermina Strungaru Jasrajbir Baath Yvonne M. Buys | 2013 | Survey of Ophthalmology2013，，4： | 1 |
| 12 | Antibacterial amorphous calcium phosphate nanocomposites with a quaternary ammonium dimethacrylate and silver nanoparticles显示文摘 | Lei Cheng Michael D. Weir Hockin H.K. Xu Joseph M. Antonucci Alison M. Kraigsley Nancy J. Lin Sheng Lin-Gibson Xuedong Zhou | 2012 | Dental Materials2012，，5： | 1 |
| 13 | Antibacterial and physical properties of calcium–phosphate and calcium–fluoride nanocomposites with chlorhexidine显示文摘 | Lei Cheng Michael D. Weir Hockin H.K. Xu Alison M. Kraigsley Nancy J. Lin Sheng Lin-Gibson Xuedong Zhou | 2012 | Dental Materials2012，，5： | 1 |
| 14 | Efficient Recovery of Structured Sparse Signals via Approximate Message Passing with Structured Spike and Slab Prior显示文摘Due to limited volume, weight and power consumption, micro-satellite has to reduce data transmission and storage capacity by image compression when performs earth observation missions. However, the quality of images may be unsatisfied. This paper considers the problem of recovering sparse signals by exploiting their unknown sparsity pattern. To model structured sparsity, the prior correlation of the support is encoded by imposing a transformed Gaussian process on the spike and slab probabilities. Then, an efficient approximate message-passing algorithm with structured spike and slab prior is derived for posterior inference, which, combined with a fast direct method, reduces the computational complexity significantly. Further, a unified scheme is developed to learn the hyperparameters using expectation maximization(EM) and Bethe free energy optimization. Simulation results on both synthetic and real data demonstrate the superiority of the proposed algorithm. | Xiangming Meng Sheng Wu Michael Riis ANDersen Jiang Zhu Zuyao Ni | 2018 | China Communications2018，15，6： | 1 |
| 15 | Neuropilin-1 promotes cirrhosis of the rodent and human liver by enhancing PDGF/TGF-[Beta] signaling in hepatic stellate cells显示文摘 | Cao Sheng Yaqoob Usman Das Amitava Shergill Uday Jagavelu Kumaravelu Huebert Robert C Routray Chittaranjan Abdelmoneim Soha Vasdev Meher Leof Edward Charlton Michael Watts Ryan J Mukhopadhyay Debabrata Shah Vijay H | 2010 | Journal of Clinical Investigation2010，，7： | 1 |
| 16 | Mn Ⅱ Is Not a productive substrate for wild-type or recominant lignin peroxidase isozyme H2显示文摘 | Maarten D Sollewijn Gelpke Dawei Sheng Michael HGold | 2000 | Archives of Biochemistry and Biophysics2000，3819，10： | 1 |
| 17 | Rev/ew显示文摘 | Michael Sheng | | 0，，03： | 1 |
| 18 | Self-aligned Cu–Si core–shell nanowire array as a high-performance anode for Li-ion batteries显示文摘 | Jun Qu Huaqing Li John J. Henry Surendra K. Martha Nancy J. Dudney Hanbing Xu Miaofang Chi Michael J. Lance Shannon M. Mahurin Theodore M. Besmann Sheng Dai | 2011 | Journal of Power Sources2011，，： | 1 |
| 19 | Global Resting-State Functional Magnetic Resonance Imaging Analysis Identifies Frontal Cortex, Striatal, and Cerebellar Dysconnectivity in Obsessive-Compulsive Disorder显示文摘 | Alan Anticevic Sien Hu Sheng Zhang Aleksandar Savic Eileen Billingslea Suzanne Wasylink Grega Repovs Michael W. Cole Sarah Bednarski John H. Krystal Michael H. Bloch Chiang-Shan R. Li Christopher Pittenger | 2013 | Biological Psychiatry2013，，： | 1 |
| 20 | FAIR: A Call to Make Published Data More Findable, Accessible, Interoperable, and Reusable显示文摘 | Leonore Reiser Lisa Harper Michael Freeling Bin Han Sheng Luan | 2018 | Molecular Plant2018，11，9： | 1 |
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