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| 1 | Self-Assembly and Photocatalysis of Mesoporous TiO2 Nanocrystal Clusters显示文摘有大表面区域和提高的 photocatalytic 活动的锐钛矿 TiO2 的 Mesoporous nanocrystal 簇成功地被综合了。合成包含进亚微米簇,有硅石层的这些簇的涂层,移开器官的 ligands 并且改进簇的 crystallinity 的热处理,和暴露 mesoporous 催化剂的最后搬迁的硅石的恐水病的 TiO2 nanocrystals 自己组装。在硅石涂层的帮助下,簇不仅维持他们的小谷物尺寸而且在高温度在锻烧以后保留他们的 mesoporous 结构(与象 277 m2/g 一样高的赌注表面区域) 。蚀刻 SiO2 也导致在水里有高 dispersity 的簇。我们能识别最佳的锻烧温度生产拥有高 crystallinity 和大表面区域的 TiO2 nanocrystal 簇,因此由紫外光在照明下面在器官的分子的分解显示出优秀催化效率。与氮的方便的做在可见的光和自然日光把这些 nanocrystal 簇变换成活跃光催化剂。用 nanocrystals 形成明确的 mesoporous 簇的策略为与提高的活动和稳定性设计光催化剂答应一个万用、有用的方法。 | Qiao Zhang Ji-Bong Joo Zhenda Lu Michael Dahl Diana Q. L. Oliveira Miaomiao Ye Yadong Yin | 2011 | Nano Research2011，4，1： | 17 |
| 2 | Hsa-miR-1246, hsa-miR-320a and hsa-miR-196b-5p inhibitors can reduce the cytotoxicity of Ebola virus glycoprotein in vitro显示文摘Ebola virus(EBOV)causes a highly lethal hemorrhagic fever syndrome in humans and has been associated with mortality rates of up to 91%in Zaire,the most lethal strain.Though the viral envelope glycoprotein(GP)mediates widespread inflammation and cellular damage,these changes have mainly focused on alterations at the protein level,the role of microRNAs(miRNAs)in the molecular pathogenesis underlying this lethal disease is not fully understood.Here,we report that the miRNAs hsa-miR-1246,hsa-miR-320a and hsa-miR-196b-5p were induced in human umbilical vein endothelial cells(HUVECs)following expression of EBOV GP.Among the proteins encoded by predicted targets of these miRNAs,the adhesion-related molecules tissue factor pathway inhibitor(TFPI),dystroglycan1(DAG1)and the caspase 8 and FADD-like apoptosis regulator(CFLAR)were significantly downregulated in EBOV GP-expressing HUVECs.Moreover,inhibition of hsa-miR-1246,hsa-miR-320a and hsa-miR-196b-5p,or overexpression of TFPI,DAG1 and CFLAR rescued the cell viability that was induced by EBOV GP.Our results provide a novel molecular basis for EBOV pathogenesis and may contribute to the development of strategies to protect against future EBOV pandemics. | SHENG MiaoMiao ZHONG Ying CHEN Yang DU JianChao JU XiangWu ZHAO Chen ZHANG GuiGen ZHANG LiFang LIU KangTai YANG Ning XIE Peng LI DangSheng ZHANG Michael Q. JIANG ChengYu | 2014 | Science China(Life Sciences)2014，57，10： | 7 |
| 3 | Population dynamics of cancer cells with cell state conversions显示文摘 | Da Zhou Dingming Wu Zhe Li Minping Qian Michael Q. Zhang | 2013 | Frontiers of Electrical and Electronic Engineering in China2013，8，3： | 6 |
| 4 | HiC-3DViewer: a new tool to visualize Hi-C data in 3D space显示文摘 | Mohamed Nadhir Djekidel Mengjie Wang Michael Q. Zhang Juntao Gao | 2017 | Frontiers of Electrical and Electronic Engineering in China2017，5，2： | 3 |
| 5 | Cell-Type-Based Analysis of MicroRNA Profiles in the Mouse Brain显示文摘 | Miao He Yu Liu Xiaowo Wang Michael Q. Zhang Gregory J. Hannon Z. Josh Huang | 2012 | Neuron2012，，1： | 2 |
| 6 | CDKN2A/p16 Inactivation Mechanisms and Their Relationship to Smoke Exposure and Molecular Features in Non–Small-Cell Lung Cancer显示文摘 | Kit W. Tam Wei Zhang Junichi Soh Victor Stastny Min Chen Han Sun Kelsie Thu Jonathan J. Rios Chenchen Yang Crystal N. Marconett Suhaida. A. Selamat Ite A. Laird-Offringa Ayumu Taguchi Samir Hanash David Shames Xiaotu Ma Michael Q. Zhang Wan L. Lam Adi Gaz | 2013 | Journal of Thoracic Oncology2013，，11： | 1 |
| 7 | A novel method to identify topological domains using Hi-C data显示文摘 | YangWang Yanjian Li Juntao Gao Michael Q. Zhang | 2015 | Frontiers of Electrical and Electronic Engineering in China2015，10，2： | 1 |
| 8 | CRISPR Inversion of CTCF Sites Alters Genome Topology and Enhancer/Promoter Function显示文摘 | Ya Guo Quan Xu Daniele Canzio Jia Shou Jinhuan Li David U. Gorkin Inkyung Jung Haiyang Wu Yanan Zhai Yuanxiao Tang Yichao Lu Yonghu Wu Zhilian Jia Wei Li Michael Q. Zhang Bing Ren Adrian R. Krainer Tom Maniatis Qiang Wu | 2015 | Cell2015，，： | 1 |
| 9 | Functional Mutation of SMAC / DIABLO , Encoding a Mitochondrial Proapoptotic Protein, Causes Human Progressive Hearing Loss DFNA64显示文摘 | Jing Cheng Yuhua Zhu Sudan He Yanping Lu Jing Chen Bing Han Marco Petrillo Kazimierz O. Wrzeszczynski Shiming Yang Pu Dai Suoqiang Zhai Dongyi Han Michael Q. Zhang Wei Li Xuezhong Liu Huawei Li Zheng-Yi Chen Huijun Yuan | 2011 | The American Journal of Human Genetics2011，，1： | 1 |
| 10 | Advances in computational ChlA-PET data analysis显示文摘 | Chao He Guipeng Li Diekidel M. Nadhir Yang Chen Xiaowo Wang Michael Q. Zhang | 2016 | Frontiers of Electrical and Electronic Engineering in China2016，4，3： | 0 |
| 11 | QB: A new inter- and multi-disciplinary forum for modeling, engineering and understanding life显示文摘 | Michael Q. Zhang Chao Tang | 2013 | Frontiers of Electrical and Electronic Engineering in China2013，8，1： | 0 |
| 12 | Computational Identification of Active Enhancers in Model Organisms显示文摘As a class of cis-regulatory elements, enhancers were first identified as the genomic regions that are able to markedly increase the transcription of genes nearly 30 years ago. Enhancers can regulate gene expression in a cell-type specific and developmental stage specific manner.Although experimental technologies have been developed to identify enhancers genome-wide, the design principle of the regulatory elements and the way they rewire the transcriptional regulatory network tempo-spatially are far from clear. At present, developing predictive methods for enhancers, particularly for the cell-type specific activity of enhancers, is central to computational biology.In this review, we survey the current computational approaches for active enhancer prediction and discuss future directions. | Chengqi Wang Michael Q. Zhang Zhihua Zhang | 2013 | Genomics, Proteomics & Bioinformatics2013，11，3： | 0 |
| 13 | )eveloping biolmaging and quantitative methods to study 3D genome显示文摘 | Juntao Gao Xusan Yang Mohamed Nadhir Djekide Yang Wang Peng Xi Michael Q. Zhang | 2016 | Frontiers of Electrical and Electronic Engineering in China2016，4，2： | 0 |
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