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| 1 | Pseudomembranous colitis presenting as acute colonic obstruction without diarrhea in a patient with gastric Burkitt lymphoma显示文摘Pseudomembranous colitis (PMC) usually manifests asfever and diarrhea in hospitalized patients treated withsystemic antibiotics. We described a case of PMC withintestinal obstruction but without diarrhea. A 60-yearold man was hospitalized for chemotherapy for the treatment of Burkitt lymphoma of the stomach. The patient became febrile and complained of crampy abdominal pain during the post-chemotherapy nadir. Plain abdominal radiography showed some intestinal gas and niveau. Because stool cytotoxin assay for clostridium difficile was positive and colon fiberscopic examination showed a pseudomembrane at the left side of the colon,and a diagnosis of PMC was made. Treatment with intracolonic vancomycin administration by colonoscopy and nasoileus tube was successful. Physicians should take into account the possibility of bowel obstruction due to PMC occurring in patients undergoing chemotherapy and perform emergency colonoscopy examination of suspected cases. | Kenichi Nomura Kohei Fukumoto Daisuke Shimizu Takashi Okuda Naohisa Yoshida Yuri Kamitsuji Yosuke Matsumoto Hideyuki Konishi Yuji Ueda Shigeo Horiike Takeshi Okanoue Masafumi Taniwaki | 2005 | World Journal of Gastroenterology2005，11，17： | 5 |
| 2 | Partially hydrolyzed guar gum attenuates non-alcoholic fatty liver disease in mice through the gut-liver axis显示文摘BACKGROUND The gut-liver axis has attracted much interest in the context of chronic liver disease pathogenesis.Prebiotics such as dietary fibers were shown to attenuate non-alcoholic fatty liver disease(NAFLD)by modulating gut microbiota.Partially hydrolyzed guar gum(PHGG),a water-soluble dietary fiber,has been reported to alleviate the symptoms of various intestinal diseases and metabolic syndromes.However,its effects on NAFLD remain to be fully elucidated.To determine whether treatment with PHGG attenuates NAFLD development in mice through the gut-liver axis.METHODS Seven-week-old male C57BL/6J mice with increased intestinal permeability were fed a control or atherogenic(Ath)diet(a mouse model of NAFLD)for 8 wk,with or without 5%PHGG.Increased intestinal permeability was induced through chronic intermittent administration of low-dose dextran sulfate sodium.Body weight,liver weight,macroscopic findings in the liver,blood biochemistry[aspartate aminotransferase(AST)and alanine aminotransferase(ALT),total cholesterol,triglyceride,free fatty acids,and glucose levels],liver histology,myeloperoxidase activity in liver tissue,mRNA expression in the liver and intestine,serum endotoxin levels in the portal vein,intestinal permeability,and microbiota and short-chain fatty acid(SCFA)profiles in the cecal samples were investigated.RESULTS Mice with increased intestinal permeability subjected to the Ath diet showed significantly increased serum AST and ALT levels,liver fat accumulation,liver inflammatory(tumor necrosis factor-αand monocyte chemotactic protein-1)and fibrogenic(collagen 1a1 andαsmooth muscle actin)marker levels,and liver myeloperoxidase activity,which were significantly attenuated by PHGG treatment.Furthermore,the Ath diet combined with increased intestinal permeability resulted in elevated portal endotoxin levels and activated toll-like receptor(TLR)4 and TLR9 expression,confirming that intestinal permeability was significantly elevated,as observed by evaluating the lumen-to-blood clearance of fluorescein isothiocyanate-conjugated dextran.PHGG treatment did not affect fatty acid metabolism in the liver.However,it decreased lipopolysaccharide signaling through the gut-liver axis.In addition,it significantly increased the abundance of cecal Bacteroides and Clostridium subcluster XIVa.Treatment with PHGG markedly increased the levels of SCFAs,particularly,butyric acid,acetic acid,propionic acid,and formic acid,in the cecal samples.CONCLUSION PHGG partially prevented NAFLD development in mice through the gut-liver axis by modulating microbiota and downstream SCFA profiles. | Shun Takayama Kazuhiro Katada Tomohisa Takagi Takaya Iida Tomohiro Ueda Katsura Mizushima Yasuki Higashimura Mayuko Morita Tetsuya Okayama Kazuhiro Kamada Kazuhiko Uchiyama Osamu Handa Takeshi Ishikawa Zenta Yasukawa Tsutomu Okubo Yoshito Itoh Yuji Naito | 2021 | World Journal of Gastroenterology2021，27，18： | 4 |
| 3 | Affinity for α-tocopherol transfer protein as a determinant of the biological activities of vitamin E analogs显示文摘 | Akihiro Hosomi Makoto Arita Yuji Sato Chikako Kiyose Tadahiko Ueda Osamu Igarashi Hiroyuki Arai Keizo Inoue | 1997 | FEBS Letters1997，，1： | 3 |
| 4 | Decrease in alpha-fetoprotein levels predicts reduced incidence of hepatocellular carcinoma in patients with hepatitis C virus infection receiving interferon therapy: a single center study显示文摘 | Yukio Osaki Yoshihide Ueda Hiroyuki Marusawa Jun Nakajima Toru Kimura Ryuichi Kita Hiroki Nishikawa Sumio Saito Shinichiro Henmi Azusa Sakamoto Yuji Eso Tsutomu Chiba | 2012 | Journal of Gastroenterology2012，，4： | 3 |
| 5 | One‐step venous reconstruction for a right lobe graft with multiple venous orifices in living donor liver transplantation显示文摘 | Yuji Soejima Naoyuki Ueda Takasuke Fukuhara Tomoharu Yoshizumi Toru Ikegami Yoichi Yamashita Keishi Sugimachi Akinobu Taketomi Yoshihiko Maehara | 2008 | Liver Transpl2008，，5： | 2 |
| 6 | Multicenter phase II study of weekly paclitaxel plus S-1 combination chemotherapy in patients with advanced gastric cancer显示文摘 | Yuji Ueda Hisakazu Yamagishi Daisuke Ichikawa Kazuma Okamoto Eigo Otsuji Jun Morii Kinya Koizumi Naoki Kakihara Masataka Shimotsuma Tetsuro Yamashita Fumihiro Taniguchi Hideki Aragane Hiroshi Nishi Yoshiki Itokawa Satoshi Morita Junichi Sakamoto | 2010 | Gastric Cancer2010，，3： | 2 |
| 7 | Immunotherapy of solid cancer using dendritic cells pulsed with the HLA-A24-restricted peptide of carcinoembryonic antigen显示文摘 | Tsuyoshi Itoh Yuji Ueda Ichiro Kawashima Ikuei Nukaya Hitoshi Fujiwara Nobuaki Fuji Tetsuro Yamashita Tetsunori Yoshimura Kaori Okugawa Tomoko Iwasaki Mitsuko Ideno Kazutoh Takesako Masakazu Mitsuhashi Kunzo Orita Hisakazu Yamagishi | 2002 | Cancer Immunology,Immunotherapy2002，，2： | 2 |
| 8 | Reduced photoinhibition of a phycocyanin-deficient mutant of Synechocystis PCC 6714显示文摘 | Yuji Nakajima Mikio Tsuzuki Ryohei Ueda | 1998 | Journal of Applied Phycology1998，，5： | 1 |
| 9 | Improvement of photosynthesis in dense microalgal suspension by reduction of light harvesting pigments显示文摘 | Yuji Nakajima Ryohei Ueda | 1997 | Journal of Applied Phycology1997，，6： | 1 |
| 10 | Usefulness of Plasma Brain Natriuretic Peptide Concentration for Predicting Subsequent Left Ventricular Remodeling After Coronary Angioplasty in Patients With Acute Myocardial Infarction显示文摘 | Atsushi Hirayama Hideo Kusuoka Hiroyoshi Yamamoto Yasushi Sakata Masanori Asakura Yoshiharu Higuchi Hiroya Mizuno Kazunori Kashiwase Yasunori Ueda Yuji Okuyama Masatsugu Hori Kazuhisa Kodama | 2006 | The American Journal of Cardiology2006，，4： | 1 |
| 11 | Melanotic Schwannoma of the Pancreas: Report of a Case显示文摘 | Takashi Akiyoshi Yuji Ueda Kohsuke Yanai Hiroshi Yamaguchi Masahiko Kawamoto Kiyokazu Toyoda Tohru Hayashi Jiro Ohuchida | 2004 | Surgery Today2004，，6： | 1 |
| 12 | Improvement of microalgal photosynthetic productivity by reducing the content of light harvesting pigment显示文摘 | Yuji Nakajima Ryohei Ueda | 1999 | Journal of Applied Phycology1999，，2： | 1 |
| 13 | Correlation between p14 ARF /p16 INK4A expression and HPV infection in uterine cervical cancer显示文摘 | Hiroyuki Kanao Takayuki Enomoto Yutaka Ueda Masami Fujita Ryuichi Nakashima Yuko Ueno Takashi Miyatake Tatsuo Yoshizaki Gregory S Buzard Toshihiro Kimura Kiyoshi Yoshino Yuji Murata | 2004 | Cancer Letters2004，，1： | 1 |
| 14 | Reduced photoinhibition of a phycocyanin-deficient mutant of Synechocystis PCC 6714显示文摘 | Yuji Nakajima Mikio Tsuzuki Ryohei Ueda | 1998 | Journal of Applied Phycology1998，，5： | 1 |
| 15 | Improvement of photosynthesis in dense microalgal suspension by reduction of light harvesting pigments显示文摘 | Yuji Nakajima Ryohei Ueda | 1997 | Journal of Applied Phycology1997，，6： | 1 |
| 16 | Chloride ions control the G 1 /S cell-cycle checkpoint by regulating the expression of p21 through a p53-independent pathway in human gastric cancer cells显示文摘 | Hiroaki Miyazaki Atsushi Shiozaki Naomi Niisato Rumi Ohsawa Hirosumi Itoi Yuji Ueda Eigo Otsuji Hisakazu Yamagishi Yoshinobu Iwasaki Takashi Nakano Takashi Nakahari Yoshinori Marunaka | 2007 | Biochemical and Biophysical Research Communications2007，，2： | 1 |
| 17 | Pravastatin inhibits advanced glycation end products (AGEs)-induced proximal tubular cell apoptosis and injury by reducing receptor for AGEs (RAGE) level显示文摘 | Yuji Ishibashi Sho-ichi Yamagishi Takanori Matsui Keisuke Ohta Ryuichiro Tanoue Masayoshi Takeuchi Seiji Ueda Kei-ichiro Nakamura Seiya Okuda | 2012 | Metabolism2012，，8： | 1 |
| 18 | Melanotic Schwannoma of the Pancreas: Report of a Case显示文摘 | Takashi Akiyoshi Yuji Ueda Kohsuke Yanai Hiroshi Yamaguchi Masahiko Kawamoto Kiyokazu Toyoda Tohru Hayashi Jiro Ohuchida | 2004 | Surgery Today2004，，6： | 1 |
| 19 | The role of thymidylate synthase and dihydropyrimidine dehydrogenase in resistance to 5-fluorouracil in human lung cancer cells显示文摘 | Tetsuya Oguri Hiroyuki Achiwa Yuji Bessho Hideki Muramatsu Hiroyoshi Maeda Takashi Niimi Shigeki Sato Ryuzo Ueda | 2005 | Lung Cancer2005，，3： | 1 |
| 20 | Early gastric cancer with Krukenberg tumor and review of cases of intramucosal gastric cancers with Krukenberg tumor显示文摘 | Naomi Kakushima Toshiro Kamoshida Shinji Hirai Soichi Hotta Tsuyoshi Hirayama Jun Yamada Kazumitsu Ueda Munekatsu Sato Minoru Okumura Tatsuro Shimokama Yuji Oka | 2003 | Journal of Gastroenterology2003，，12： | 1 |
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