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| 1 | Marginal optimization method to improve the inconsistent comparison matrix in the analytic hierarchy process显示文摘To improve the inconsistency in the analytic hierarchy process(AHP), a new method based on marginal optimization theory is proposed. During the improving process, this paper regards the reduction of consistency ratio(CR) as benefit, and the maximum modification compared to the original pairwise comparison matrix(PCM) as cost, then the improvement of consistency is transformed to a benefit/cost analysis problem. According to the maximal marginal effect principle, the elements of PCM are modified by a fixed increment(or decrement) step by step till the consistency ratio becomes acceptable, which can ensure minimum adjustment to the original PCM so that the decision makers' judgment is preserved as much as possible. The correctness of the proposed method is proved mathematically by theorem. Firstly, the marginal benefit/cost ratio is calculated for each single element of the PCM when it has been modified by a fixed increment(or decrement).Then, modification to the element with the maximum marginal benefit/cost ratio is accepted. Next, the marginal benefit/cost ratio is calculated again upon the revised matrix, and followed by choosing the modification to the element with the maximum marginal benefit/cost ratio. The process of calculating marginal effect and choosing the best modified element is repeated for each revised matrix till acceptable consistency is reached, i.e., CR<0.1. Finally,illustrative examples show the proposed method is more effective and better in preserving the original comparison information than existing methods. | Shihui Wu Jiang Xie Xiaodong Liu Bo He Minxiang Yang Zhengxin Li | 2017 | Journal of Systems Engineering and Electronics2017，28，6： | 11 |
| 2 | CD147-spike protein is a novel route for SARS-CoV-2 infection to host cells显示文摘In face of the everlasting battle toward COVID-19 and the rapid evolution of SARS-CoV-2,no specific and effective drugs for treating this disease have been reported until today.Angiotensin-converting enzyme 2(ACE2),a receptor of SARS-CoV-2,mediates the virus infection by binding to spike protein.Although ACE2 is expressed in the lung,kidney,and intestine,its expressing levels are rather low,especially in the lung.Considering the great infectivity of COVID-19,we speculate that SARS-CoV-2 may depend on other routes to facilitate its infection.Here,we first discover an interaction between host cell receptor CD147 and SARS-CoV-2 spike protein.The loss of CD147 or blocking CD147 in Vero E6 and BEAS-2B cell lines by anti-CD147 antibody,Meplazumab,inhibits SARSCoV-2 amplification.Expression of human CD147 allows virus entry into non-susceptible BHK-21 cells,which can be neutralized by CD147 extracellular fragment.Viral loads are detectable in the lungs of human CD147(hCD147)mice infected with SARS-CoV-2,but not in those of virus-infected wild type mice.Interestingly,virions are observed in lymphocytes of lung tissue from a COVID-19 patient.Human T cells with a property of ACE2 natural deficiency can be infected with SARS-CoV-2 pseudovirus in a dosedependent manner,which is specifically inhibited by Meplazumab.Furthermore,CD147 mediates virus entering host cells by endocytosis.Together,our study reveals a novel virus entry route,CD147-spike protein,which provides an important target for developing specific and effective drug against COVID-19. | Ke Wang Wei Chen Zheng Zhang Yongqiang Deng Jian-Qi Lian Peng Du Ding Wei Yang Zhang Xiu-Xuan Sun Li Gong Xu Yang Lei He Lei Zhang Zhiwei Yang Jie-Jie Geng Ruo Chen Hai Zhang Bin Wang Yu-Meng Zhu Gang Nan Jian-Li Jiang Ling Li Jiao Wu Peng Lin Wan Huang Liangzhi Xie Zhao-Hui Zheng Kui Zhang Jin-Lin Miao Hong-Yong Cui Min Huang Jun Zhang Ling Fu Xiang-Min Yang Zhongpeng Zhao Shihui Sun Hongjing Gu Zhe Wang Chun-Fu Wang Yacheng Lu Ying-Ying Liu Qing-Yi Wang Huijie Bian Ping Zhu Zhi-Nan Chen | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 9 |
| 3 | Experimental Study on Preparation of Natural Gas Hydrate by Crystallization显示文摘In this paper, the saturated solution crystallization method is proposed to promote the formation of hydrate by means of the known similarities between the hydrate formation process and the crystallization process. In this method,adding the second phase crystals was used to replace the spontaneous formation of hydrate crystal nuclei to form hydrate.The effects of saturated Na_2SO_4, MgSO_4, NH_4HCO_3 and CuSO_4 solutions on the formation rates of natural gas hydrate and gas storage capacity were investigated. The results showed that the saturated solution had an influence on the hydrate formation process. Under the given experimental conditions, the saturated Na_2SO_4 solution showed a highest increase in the hydrate formation rate, and the average hydrate formation rate in its presence was 11.8 times higher than that obtained in the deionized water. Moreover, the largest formation rate of gas hydrates observed in the saturated Na_2SO_4 solution was 386 times bigger than that in the deionized water, and the gas storage capacity increased by 10 times. In addition, the average hydrate formation rate in the saturated Mg SO_4 solution was faster than that in water by 20 times. The largest formation rate of gas hydrates in the saturated MgSO_4 solution was 165 times faster than that obtained in the deionized water, and the gas storage capacity increased by 6.2 times. The saturated NH_4HCO_3 and saturated CuSO_4 solutions also influenced the formation process of hydrate. Therefore, the crystallization method of saturated solution can be used to achieve a highefficiency preparation of natural gas hydrates, which provides theoretical guidance for the storage of natural gas in the form of hydrate. | Ma Shihui Pan Zhen Li Ping Wu Yuguo Li Bingfan Kang Jinke Zhang Zhien | 2017 | China Petroleum Processing & Petrochemical Technology2017，19，1： | 7 |
| 4 | One-step approach for full-thickness skin defect reconstruction in rats using minced split-thickness skin grafts with Pelnac overlay显示文摘Background:Split-thickness skin grafting is the current gold standard for the treatment of traumatic skin loss.However,for patients with extensive burns,split-thickness skin grafting is limited by donor skin availability.Grafting split-thickness skin minced into micrografts increases the expansion ratio but may reduce wound repair quality.Dermal substitutes such as Pelnac can enhance the healing of full-thickness skin wounds,but their application currently requires two surgeries.The present study investigated whether it is possible to repair full-thickness skin defects and improve wound healing quality in a single surgery using Pelnac as an overlay of minced split-thickness skin grafts in a rat model.Methods:A full-thickness skin defect model was established using male Sprague-Dawley rats of 10 weeks old.The animals were randomly divided into control and experimental groups in which Vaseline gauze and Pelnac,respectively,were overlaid on minced split-thickness skin grafts to repair the defects.Wound healing rate and quality were compared between the two groups.For better illustration of the quality of wound healing,some results were compared with those obtained for normal skin of rats.Results:We found that using Pelnac as an overlay for minced split-thickness skin grafts accelerated wound closure and stimulated cell proliferation and tissue angiogenesis.In addition,this approach enhanced collagen synthesis and increased the formation of basement membrane and dermis as well as the expression of growth factors related to wound healing while reducing scar formation.Conclusions:Using minced split-thickness skin grafts overlaid with Pelnac enables the reconstruction of fullthickness skin defects in a single step and can increase the healing rate while improving the quality of wound healing. | Tong Liu Chao Qiu Chi Ben Haihang Li Shihui Zhu | 2019 | Burns & Trauma2019，7，1： | 7 |
| 5 | Recombinant vaccine containing an RBD-Fc fusion induced protection against SARS-CoV-2 in nonhuman primates and mice显示文摘The novel coronavirus SARS-CoV-2 has infected more than 104 million individuals and resulted in more than 2.2 million deaths worldwide as of February 7,2021(http://gffzze7c39cdc9e894ca6s05nfkqwobucf6v90.ffgz.tsg.suse.edu.cn).The COVID-19 pandemic highlights the need for safe and effective vaccines against SARS-CoV-2 infection. | Shihui Sun Lei He Zhongpeng Zhao Hongjing Gu Xin Fang Tiecheng Wang Xiaolan Yang Shaolong Chen Yongqiang Deng Jiangfan Li Jian Zhao Liang Li Xinwang Li Peng He Ge Li Hao Li Yuee Zhao Chunrun Gao Xiaoling Lang Xin Wang Guoqiang Fei Yan Li Shusheng Geng Yuwei Gao Wenjin Wei Zhongyu Hu Gencheng Han Yansong Sun | 2021 | Cellular & Molecular Immunology2021，18，4： | 5 |
| 6 | Rational development of a human antibody cocktail that deploys multiple functions to confer Pan-SARS-CoVs protection显示文摘Structural principles underlying the composition and synergistic mechanisms of protective monoclonal antibody cocktails are poorly defined.Here,we exploited antibody cooperativity to develop a therapeutic antibody cocktail against SARS-CoV-2.On the basis of our previously identified humanized cross-neutralizing antibody H014,we systematically an a lyzed a fully human n aive antibody library and rationally identified a potent neutralizing antibody partner,P17,which confers effective protection in animal model.Cryo-EM studies dissected the nature of the P17 epitope,which is SARS-CoV-2 specific and distinctly different from that of HOI4.High-resolution structure of the SARS-CoV-2 spike in complex with HOM and P17,together with functional investigations revealed that in a two-antibody cocktail,synergistic neutralization was achieved by S1 shielding and conformational locking,thereby blocking receptor attachment and viral membrane fusion,conferring high potency as well as robustness against viral mutation escape.Furthermore,cluster analysis identified a hypothetical 3rd antibody partner for further reinforcing the cocktail as pan-SARS-CoVs therapeutics. | Hangping Yao Yao Sun Yong-Qiang Deng Nan Wang Yongcong Tan Na-Na Zhang Xiao-Feng Li Chao Kong Yan-Peng Xuc Qi Chen Tian-Shu Cao Hui Zhao Xintian Yan Lei Cao Zhe Lv Dandan Zhu Rui Feng Nanping Wu Wenhai Zhang Yuhao Hu Keda Chen Rong-Rong Zhang Qingyu Lv Shihui Sun Yunhua Zhou Run Yan Guan Yang Xinglu Chanjuan Liu Xiangyun Lu Linfang Cheng Hongying Qiu Xing-Yao Huang Tianhao Weng Danrong Shi Weidong Jiang Junbin Shao Lei Wang Jie Zhang Tao Jiang Guojun Lang Cheng-Feng Qinc Lanjuan Li Xiangxi Wang | 2021 | Cell Research2021，31，1： | 5 |
| 7 | Evaluation of seed production in a first-generation seed orchard of Chinese pine (Pinus tabuliformis)显示文摘We evaluated seed production in a first-generation orchard of Chinese pine(Pinus tabuliformis) during the crucial transition period from first generation to advanced generations.Clones varied significantly in all traits related to seed production.Repeatability of these traits ranged from 0 to 0.96.Seed production per ramet(SPPR),seed producing index(SPI),the number of relative female strobili(RFS),the number of scales,and the number of ineffective scales had comparatively high repeatability at 0.86,0.87,0.89,0.96,and 0.91,respectively.Correlation analysis showed that SPPR was greatly influenced by RFS and by the number of full seeds per cone.Finally,we showed that SPI was the best predictor of the seed-producing ability of clones.Our findings will assist seed orchard managers in effectively predicting and improving seed production of Chinese pine seed orchards. | Huwei Yuan Shihui Niu Xianqing Zhou Qingping Du Yue Li Wei Li | 2016 | Journal of Forestry Research2016，27，5： | 4 |
| 8 | Carbon performance evaluation model from the perspective of circular economy~The case of Chinese thermal power enterprise显示文摘Carbon emission reduction is the only way to alleviate environmental problems,such as global warming.Effective evaluation of carbon performance can help enterprises to carry out energy saving and emission reduction activities to a certain extent and promote sustainable development.This paper constructs a carbon performance evaluation index system that includes the four dimensions of carbon resource(energy)input,cycle,output,and carbon management by incorporating the principles of circular economy and the theory of resource value circulation from the perspective of the flow trajectory of carbon-containing resources in the circulation of enterprises combined with the production characteristics of thermoelectric enterprises.Subsequently,combined with the case study,this paper discusses the scientific and practical nature of the system and provides another way of thinking for carbon performance evaluation of micro-enterprises in other industries.This paper expands the application boundary of matter-element model and supplements the literature of carbon performance,which has certain theoretical and practical significance. | Zhifang ZHOU Jinhao LIU Huixiang ZENG Mengmeng XU Shihui LI | 2022 | Frontiers of Engineering Management2022，9，2： | 4 |
| 9 | Limiting profile of blow-up solutions for the Gross-Pitaevskii equation显示文摘This paper is concerned with the blow-up solutions of the Gross-Pitaevskii equation. Using the concentration compact principle and the variational characterization of the corresponding ground state, we obtain the limiting profile of blow-up solutions with critical mass in the corresponding weighted energy space. Moreover, we extend this result to small super-critical mass case by the variational methods and scaling technique. | ZHU ShiHui ZHANG Jian LI XiaoGuang | 2009 | Science China Mathematics2009，52，5： | 4 |
| 10 | Effects of acid,acid-ZVI/PMS,Fe(Ⅱ)/PMS and ZVI/PMS conditioning on the wastewater activated sludge(WAS)dewaterability and extracellular polymeric substances(EPS)显示文摘The effects of four conditioning approaches:Acid,Acid-zero-valent iron(ZVI)/peroxydisulfate(PMS),Fe(Ⅱ)/PMS and ZVI/PMS,on wastewater activated sludge(WAS)dewatering and organics distribution in supernatant and extracellular polymeric substances(EPS)layers were investigated.The highest reduction in bound water and the most WAS destruction was achieved by Acid-ZVI/PMS,and the optimum conditions were pH 3,ZVI dosage 0.15 g/g dry solid(DS),oxone dosage 0.07 g/g DS and reaction time 10.6 min with the reductions in capillary suction time(CST)and water content(Wc)as 19.67%and 8.49%,respectively.Four conditioning approaches could result in TOC increase in EPS layers and supernatant,and protein(PN)content in tightly bound EPS(TB-EPS).After conditioning,organics in EPS layers could migrate to supernatant.Polysaccharide(PS)was easier to migrate to supernatant than PN.In addition,Acid,Acid-ZVI/PMS or Fe(Ⅱ)/PMS conditioning promoted the release of some polysaccharides containing ring vibrations v P=O,v C-O-C,v C-O-P functional groups from TB-EPS.ESR spectra proved that both radicals of SO4-·and·OH contributed to dewatering and organics transformation and migration.CST value of WAS positively correlated with the ratios of PN/PS in LB-EPS and total EPS,while it negatively correlated with TOC,PN content and PS content in TB-EPS,as well as PS content in supernatant and LB-EPS.BWC negatively correlated to zeta potential and TOC value,PN content,and HA content in supernatant. | Xiaoyang Fan Yili Wang Daxin Zhang Yajie Guo Shihui Gao Enrui Li Huaili Zheng | 2020 | Journal of Environmental Sciences2020，32，5： | 4 |
| 11 | Single-cell transcriptomic landscape of human blood cells显示文摘High throughput single-cell RNA-seq has been successfully implemented to dissect the cellular and molecular features underlying hematopoiesis.However,an elaborate and comprehensive transcriptome reference of the whole blood system is lacking.Here,we profiled the transcriptomes of 7551 human blood cells representing 32 immunophenotypic cell types,including hematopoietic stem cells,progenitors and mature blood cells derived from 21 healthy donors.With high sequencing depth and coverage,we constructed a single-cell transcriptional atlas of blood cells(ABC) on the basis of both protein-coding genes and long noncoding RNAs(lncRNAs),and showed a high consistence between them.Notably,putative lncRNAs and transcription factors regulating hematopoietic cell differentiation were identified.While common transcription factor regulatory networks were activated in neutrophils and monocytes,lymphoid cells dramatically changed their regulatory networks during differentiation.Furthermore,we showed a subset of nucleated erythrocytes actively expressing immune signals,suggesting the existence of erythroid precursors with immune functions.Finally,a web portal offering transcriptome browsing and blood cell type prediction has been established.Thus,our work provides a transcriptional map of human blood cells at single-cell resolution,thereby offering a comprehensive reference for the exploration of physiological and pathological hematopoiesis. | Xiaowei Xie Mengyao Liu Yawen Zhang Bingrui Wang Caiying Zhu Chenchen Wang Qing Li Yingying Huo Jiaojiao Guo Changlu Xu Linping Hu Aiming Pang Shihui Ma Una Wang Wenbin Cao Shulian Chen Qiuling Li Sudong Zhang Xueying Zhao Wen Zhou Hongbo Luo Guoguang Zheng Erlie Jiang Sizhou Feng Lixiang Chen Lihong Shi Hui Cheng Sha Hao Ping Zhu Tao Cheng | 2021 | National Science Review2021，8，3： | 3 |
| 12 | Late Mesozoic rifting and its deep dynamic mechanisms in the central Sulu orogenic belt: Records from Lingshan Island显示文摘The Lingshan Island scientific drill confirms that two episodes(Laiyang period and Qingshan period) of rifting developed in the central Sulu orogenic belt(SOB) in Late Mesozoic. With a set of methods including fieldwork, drilling, core logging, zircon U-Pb dating and whole rock geochemistry applied, the age, the depositional sequence and the deep dynamic mechanisms of rift evolution were unraveled. The stratigraphic sequence of the Laiyang-Qingshan Groups on Lingshan Island was composed of two different rifting sequences:(1) Laiyang Group(147–125 Ma), which consists of deep-water gravity flow deposits with interlayers of intermediate volcanic rocks;and(2) Lower Qingshan Group(125–119 Ma), which unconformably overlies the former sequence and contains subaerial volcanic deposits and terrestrial deposits. The tectonic environment changed during the evolution of these two episodes of rifting: the rift was in a NNW-SSE extensional environment in the Laiyang period and showed the typical passive rifting character that “lithospheric extension and rifting preceded volcanism”. The passive rifting period was ended by a short WNW-ESE compression at about 125 Ma. After that, the tectonic environment transferred to a strong NW-SE extensional environment and the rifting evolved into a volcanic arc basin in the Qingshan period. The igneous rocks are shoshonitic to high-K calc-alkaline trachyandesites to trachytes with a few intercalated lamprophyres and a rhyolite.The geochemical characteristics of the igneous rocks indicate that they are mantle-derived melts with a metasomatized mantle source and/or crustal contamination. In addition, an increased thinning of the lithosphere happened during the rifting episodes.The low-angle subduction of the Paleo-Pacific plate in the Jurassic weakened the thickened SOB lithospheric mantle. The rollback of the subducting plate started in late Jurassic to early Cretaceous, and the SOB lithospheric mantle was delaminated synchronously because of the gravity collapse. Thus, this caused passive rifting in the Laiyang period. Thereafter, the rollback and trench retreat of the high-angle subducting Paleo-Pacific plate would have achieved its climax, resulting in the strong regional extension. Passive rifting was ended by the crustal uplift caused by asthenospheric upwelling beneath the rift. The lower crust was heated by the upwelling asthenosphere and partially melted to form felsic melts, which were emplaced upwards and erupted explosively. The rift evolved into a volcanic arc basin in the Qingshan period and showed some characteristics of active rifting. Above all, a passive rifting in the Laiyang period and a volcanic arc basin in the Qingshan period developed successively in the Lingshan Island area(the central SOB). This records the transfer of the study area from the Paleo-Tethys tectonic domain to the circum-Pacific tectonic domain. The delamination of SOB lithospheric mantle and the upwelling of asthenospheric material were the deep dynamic mechanisms driving the development and evolution of two rift episodes. Additionally, the rift development was controlled remotely by the subduction of the Paleo-Pacific plate. | Tengfei ZHOU Yaoqi ZHOU Nina SФAGER Paul Martin HOLM Zhenkai ZHANG Jun WANG Zhao LIANG Hongyu MU Yanjun CHENG Feifei LIU Miao WANG Yue ZHANG Hui ZHANG Yangjian GU Shihui DONG Hanjie ZHAO Manjie LI Yang CHEN Yanzi LIU | 2022 | Science China Earth Sciences2022，65，9： | 3 |
| 13 | Experimental investigation on vibration characteristics of the medium-low-speed maglev vehicle-turnout coupled system显示文摘The steel turnout is one of the key components in the medium–low-speed maglev line system.However,the vehicle under active control is prone to vehicle–turnout coupled vibration,and thus,it is necessary to identify the vibration characteristics of this coupled system through field tests.To this end,dynamic performance tests were conducted on a vehicle–turnout coupled system in a medium–low-speed maglev test line.Firstly,the dynamic response data of the coupled system under various operating conditions were obtained.Then,the natural vibration characteristics of the turnout were analysed using the free attenuation method and the finite element method,indicating a good agreement between the simulation results and the measured results;the acceleration response characteristics of the coupled system were analysed in detail,and the ride quality of the vehicle was assessed by Sperling index.Finally,the frequency distribution characteristics of the coupled system were discussed.All these test results could provide references for model validation and optimized design of medium–low-speed maglev transport systems. | Miao Li Dinggang Gao Tie Li Shihui Luo Weihua Ma Xiaohao Chen | 2022 | Railway Engineering Science2022，30，2： | 3 |
| 14 | A consistency improving method in the analytic hierarchy process based on directed circuit analysis显示文摘Test of consistency is critical for the analytic hierarchy process(AHP) methodology. When a pairwise comparison matrix(PCM) fails the consistency test, the decision maker(DM) needs to make revisions. The state of the art focuses on changing a single entry or creating a new matrix based on the original inconsistent matrix so that the modified matrix can satisfy the consistency requirement. However, we have noticed that the reason that causes inconsistency is not only numerical inconsistency, but also logical inconsistency, which may play a more important role in the whole inconsistency. Therefore, to realize satisfactory consistency, first of all, we should change some entries that form a directed circuit to make the matrix logically consistent, and then adjust other entries within acceptable deviations to make the matrix numerically consistent while preserving most of the original comparison information. In this paper, we firstly present some definitions and theories, based on which two effective methods are provided to identify directed circuits. Four optimization models are proposed to adjust the original inconsistent matrix. Finally, illustrative examples and comparison studies show the effectiveness and feasibility of our method. | WU Shihui LIU Xiaodong LI Zhengxin ZHOU Yu | 2019 | Journal of Systems Engineering and Electronics2019，30，6： | 2 |
| 15 | Coordination Polymerization of Renewable (E)-4,8-Dimethyl-1,3,7-Nonatriene by Rare-Earth Metal Catalysts显示文摘Coordination polymerization of renewable(E)-4,8-dimethyl-1,3,7-nonatriene(DMNT)has been performed using pyridyl-methylene-fluorenyl scandium complex 1,half-sandwich scandium complex 2,diiminophosphinato rare-earth metal complexes 3a—3c and 4a—4b,bis(phosphino)carbazolide yttrium complex 5 andβ-diketiminato yttrium complex 6.Fluorenyl scandium complexes 1 and 2,activated by[Ph3C][B(C6F5)4]and AliBu3,are moderately active and show perfect 1,2-regioselective(1,2>99%).Conversely,asymmetric diiminophophinato complexes 3a—3c promote the DMNT polymerization to produce high trans-1,4 regulated products with the activity trend:Sc | Yang Jiang Zhen Zhang Shihui Li Dongmei Cui | 2022 | Chinese Journal of Chemistry2022，40，16： | 2 |
| 16 | Application of immunosuppressant facilitates the therapy of optic neuritis combined with Sj(o)gren's syndrome显示文摘 | Li Hongyang Liu Zihao Gong Yan Jiang Zhaocai Zhang Yixin Dai Yanli Zhang Yan Wei Shihui | 2014 | Chinese Medical Journal2014，，17： | 2 |
| 17 | Strength-increase mechanism and microstructural characteristics of a biotreated geomaterial显示文摘Microbially induced calcite precipitation(MICP)is a recently proposed method that is environmentally friendly and has considerable potential applications in artificial biotreated geomaterials.New artificial biotreated geomaterials are produced based on the MICP technology for different parent soils.The purpose of this study is to explore the strength-increase mechanism and microstmctural characteristics of the biotreated geomaterial through a series of experiments.The results show that longer mineralization time results in higher-strength biotreated geomaterial.The strength growth rate rapidly increases in the beginning and remains stable afterwards.The calcium ion content significantly increases with the extended mineralization time.When standard sand was used as a parent soil,the calcium ion content increased to a factor of 39 after 7 days.The bacterial cells with attached calcium ions serve as the nucleus of crystallization and fill the pore space.When fine sand was used as a parent soil,the calcium ion content increased to only a factor of 7 after 7 days of mineralization.The nucleus of crystallization could not normally grow because of the limited pore space.The porosity and variation in porosity are clearly affected by the parent soil.Therefore,the strength of the biotreated geomaterial is affected by the parent soil properties,mineralization time,and granular material pore space.This paper provides a basis for theory and experiments for biotreated geomaterials in future engineering practice. | Chi LI Siriguleng BAI Tuanjie ZHOU Hanlong LIU Xiao QIN Shihui LIU Xiaoying LIU Yang XIAO | 2020 | Frontiers of Structural and Civil Engineering2020，14，3： | 2 |
| 18 | Current status and trends in forest genomics显示文摘Forests are not only the most predominant of the Earth's terrestrial ecosystems,but are also the core supply for essential products for human use.However,global climate change and ongoing population explosion severely threatens the health of the forest ecosystem and aggravtes the deforestation and forest degradation.Forest genomics has great potential of increasing forest productivity and adaptation to the changing climate.In the last two decades,the field of forest genomics has advanced quickly owing to the advent of multiple high-throughput sequencing technologies,single cell RNA-seq,clustered regularly interspaced short palindromic repeats(CRISPR)-mediated genome editing,and spatial transcriptomes,as well as bioinformatics analysis technologies,which have led to the generation of multidimensional,multilayered,and spatiotemporal gene expression data.These technologies,together with basic technologies routinely used in plant biotechnology,enable us to tackle many important or unique issues in forest biology,and provide a panoramic view and an integrative elucidation of molecular regulatory mechanisms underlying phenotypic changes and variations.In this review,we recapitulated the advancement and current status of 12 research branches of forest genomics,and then provided future research directions and focuses for each area.Evidently,a shift from simple biotechnology-based research to advanced and integrative genomics research,and a setup for investigation and interpretation of many spatiotemporal development and differentiation issues in forest genomics have just begun to emerge. | Dulal Borthakur Victor Busov Xuan Hieu Cao Qingzhang Du Oliver Gailing Fikret Isik Jae-Heung Ko Chenghao Li Quanzi Li Shihui Niu Guanzheng Qu Thi Ha Giang Vu Xiao-Ru Wang Zhigang Wei Lin Zhang Hairong Wei | 2022 | Forestry Research2022，2，1： | 2 |
| 19 | Whole genome engineering by synthesis显示文摘Whole genome engineering is now feasible with the aid of genome editing and synthesis tools. Synthesizing a genome from scratch allows modifications of the genomic structure and function to an extent that was hitherto not possible, which will finally lead to new insights into the basic principles of life and enable valuable applications. With several recent genome synthesis projects as examples, the technical details to synthesize a genome and applications of synthetic genome are addressed in this perspective. A series of ongoing or future synthetic genomics projects, including the different genomes to be synthesized in GPwrite, synthetic minimal genome, massively recoded genome, chimeric genome and synthetic genome with expanded genetic alphabet, are also discussed here with a special focus on theoretical and technical impediments in the design and synthesis process. Synthetic genomics will become a commonplace to engineer pathways and genomes according to arbitrary sets of design principles with the development of high-efficient, low-cost genome synthesis and assembly technologies. | Zhouqing Luo Qing Yang Binan Geng Shuangying Jiang Shihui Yang Xiaozheng Li Yizhi Cai Junbiao Dai | 2018 | Science China(Life Sciences)2018，61，12： | 2 |
| 20 | Effects of different aperture-sized type I collagen/silk fibroin scaffolds on the proliferation and differentiation of human dental pulp cells显示文摘This study aimed at evaluate the effects of different aperture-sized type I collagen/silk fibroin(CSF)scaffolds on the proliferation and differentiation of human dental pulp cells(HDPCs).The CSF scaffolds were designed with 3D mapping software Solidworks.Three different aperture-sized scaffolds(CSF1-CSF3)were prepared by low-temperature deposition 3D printing technology.The morphology was observed by scanning electron microscope(SEM)and optical coherence tomography.The porosity,hydrophilicity and mechanical capacity of the scaffold were detected,respectively.HDPCs(third passage,1105 cells)were seeded into each scaffold and investigated by SEM,CCK-8,alkaline phosphatase(ALP)activity and HE staining.The CSF scaffolds had porous structures with macropores and micropores.The macropore size of CSF1 to CSF3 was 421627 lm,579636 lm and 707643 lm,respectively.The porosity was 69.862.2%,80.162.8%and 86.563.3%,respectively.All these scaffolds enhanced the adhesion and proliferation of HDPCs.The ALP activity in the CSF1 group was higher than that in the CSF3 groups(P<0.01).HE staining showed HDPCs grew in multilayer within the scaffolds.CSF scaffolds significantly improved the adhesion and ALP activity of HDPCs.CSF scaffolds were promising candidates in dentine-pulp complex regeneration. | Shihui Jiang Zhaoxia Yu Lanrui Zhang Guanhua Wang Xiaohua Dai Xiaoli Lian Yan Yan Linpu Zhang Yue Wang Ruixin Li Huiru Zou | 2021 | Regenerative Biomaterials2021，8，4： | 2 |
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