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| 1 | 2D MOF Nanoflake-Assembled Spherical Microstructures for Enhanced Supercapacitor and Electrocatalysis Performances显示文摘Metal–organic frameworks(MOFs) are of great interest as potential electrochemically active materials.However, few studies have been conducted into understanding whether control of the shape and components of MOFs can optimize their electrochemical performances due to the rational realization of their shapes. Component control of MOFs remains a significant challenge. Herein, we demonstrate a solvothermal method to realize nanostructure engineering of 2D nanoflake MOFs. The hollow structures withNi/Co-and Ni-MOF(denoted as Ni/Co-MOF nanoflakes and Ni-MOF nanoflakes) were assembled for their electrochemical performance optimizations in supercapacitors and in the oxygen reduction reaction(ORR). As a result, the Ni/CoMOF nanoflakes exhibited remarkably enhanced performance with a specific capacitance of 530.4 F g^(-1)at 0.5 A g^(-1)in1 M LiO H aqueous solution, much higher than that of NiMOF(306.8 F g^(-1)) and ZIF-67(168.3 F g^(-1)), a good rate capability, and a robust cycling performance with no capacity fading after 2000 cycles. Ni/Co-MOF nanoflakes also showed improved electrocatalytic performance for the ORR compared to Ni-MOF and ZIF-67. The present work highlights the significant role of tuning 2D nanoflake ensembles of Ni/Co-MOF in accelerating electron and charge transportation for optimizing energy storage and conversion devices. | Huicong Xia Jianan Zhang Zhao Yang Shiyu Guo Shihui Guo Qun Xu | 2017 | Nano-Micro Letters2017，9，4： | 14 |
| 2 | Marginal optimization method to improve the inconsistent comparison matrix in the analytic hierarchy process显示文摘To improve the inconsistency in the analytic hierarchy process(AHP), a new method based on marginal optimization theory is proposed. During the improving process, this paper regards the reduction of consistency ratio(CR) as benefit, and the maximum modification compared to the original pairwise comparison matrix(PCM) as cost, then the improvement of consistency is transformed to a benefit/cost analysis problem. According to the maximal marginal effect principle, the elements of PCM are modified by a fixed increment(or decrement) step by step till the consistency ratio becomes acceptable, which can ensure minimum adjustment to the original PCM so that the decision makers' judgment is preserved as much as possible. The correctness of the proposed method is proved mathematically by theorem. Firstly, the marginal benefit/cost ratio is calculated for each single element of the PCM when it has been modified by a fixed increment(or decrement).Then, modification to the element with the maximum marginal benefit/cost ratio is accepted. Next, the marginal benefit/cost ratio is calculated again upon the revised matrix, and followed by choosing the modification to the element with the maximum marginal benefit/cost ratio. The process of calculating marginal effect and choosing the best modified element is repeated for each revised matrix till acceptable consistency is reached, i.e., CR<0.1. Finally,illustrative examples show the proposed method is more effective and better in preserving the original comparison information than existing methods. | Shihui Wu Jiang Xie Xiaodong Liu Bo He Minxiang Yang Zhengxin Li | 2017 | Journal of Systems Engineering and Electronics2017，28，6： | 11 |
| 3 | CD147-spike protein is a novel route for SARS-CoV-2 infection to host cells显示文摘In face of the everlasting battle toward COVID-19 and the rapid evolution of SARS-CoV-2,no specific and effective drugs for treating this disease have been reported until today.Angiotensin-converting enzyme 2(ACE2),a receptor of SARS-CoV-2,mediates the virus infection by binding to spike protein.Although ACE2 is expressed in the lung,kidney,and intestine,its expressing levels are rather low,especially in the lung.Considering the great infectivity of COVID-19,we speculate that SARS-CoV-2 may depend on other routes to facilitate its infection.Here,we first discover an interaction between host cell receptor CD147 and SARS-CoV-2 spike protein.The loss of CD147 or blocking CD147 in Vero E6 and BEAS-2B cell lines by anti-CD147 antibody,Meplazumab,inhibits SARSCoV-2 amplification.Expression of human CD147 allows virus entry into non-susceptible BHK-21 cells,which can be neutralized by CD147 extracellular fragment.Viral loads are detectable in the lungs of human CD147(hCD147)mice infected with SARS-CoV-2,but not in those of virus-infected wild type mice.Interestingly,virions are observed in lymphocytes of lung tissue from a COVID-19 patient.Human T cells with a property of ACE2 natural deficiency can be infected with SARS-CoV-2 pseudovirus in a dosedependent manner,which is specifically inhibited by Meplazumab.Furthermore,CD147 mediates virus entering host cells by endocytosis.Together,our study reveals a novel virus entry route,CD147-spike protein,which provides an important target for developing specific and effective drug against COVID-19. | Ke Wang Wei Chen Zheng Zhang Yongqiang Deng Jian-Qi Lian Peng Du Ding Wei Yang Zhang Xiu-Xuan Sun Li Gong Xu Yang Lei He Lei Zhang Zhiwei Yang Jie-Jie Geng Ruo Chen Hai Zhang Bin Wang Yu-Meng Zhu Gang Nan Jian-Li Jiang Ling Li Jiao Wu Peng Lin Wan Huang Liangzhi Xie Zhao-Hui Zheng Kui Zhang Jin-Lin Miao Hong-Yong Cui Min Huang Jun Zhang Ling Fu Xiang-Min Yang Zhongpeng Zhao Shihui Sun Hongjing Gu Zhe Wang Chun-Fu Wang Yacheng Lu Ying-Ying Liu Qing-Yi Wang Huijie Bian Ping Zhu Zhi-Nan Chen | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 9 |
| 4 | Recombinant vaccine containing an RBD-Fc fusion induced protection against SARS-CoV-2 in nonhuman primates and mice显示文摘The novel coronavirus SARS-CoV-2 has infected more than 104 million individuals and resulted in more than 2.2 million deaths worldwide as of February 7,2021(http://gffzze7c39cdc9e894ca6s099cpn56q9c669qk.ffgz.tsg.suse.edu.cn).The COVID-19 pandemic highlights the need for safe and effective vaccines against SARS-CoV-2 infection. | Shihui Sun Lei He Zhongpeng Zhao Hongjing Gu Xin Fang Tiecheng Wang Xiaolan Yang Shaolong Chen Yongqiang Deng Jiangfan Li Jian Zhao Liang Li Xinwang Li Peng He Ge Li Hao Li Yuee Zhao Chunrun Gao Xiaoling Lang Xin Wang Guoqiang Fei Yan Li Shusheng Geng Yuwei Gao Wenjin Wei Zhongyu Hu Gencheng Han Yansong Sun | 2021 | Cellular & Molecular Immunology2021，18，4： | 5 |
| 5 | Rational development of a human antibody cocktail that deploys multiple functions to confer Pan-SARS-CoVs protection显示文摘Structural principles underlying the composition and synergistic mechanisms of protective monoclonal antibody cocktails are poorly defined.Here,we exploited antibody cooperativity to develop a therapeutic antibody cocktail against SARS-CoV-2.On the basis of our previously identified humanized cross-neutralizing antibody H014,we systematically an a lyzed a fully human n aive antibody library and rationally identified a potent neutralizing antibody partner,P17,which confers effective protection in animal model.Cryo-EM studies dissected the nature of the P17 epitope,which is SARS-CoV-2 specific and distinctly different from that of HOI4.High-resolution structure of the SARS-CoV-2 spike in complex with HOM and P17,together with functional investigations revealed that in a two-antibody cocktail,synergistic neutralization was achieved by S1 shielding and conformational locking,thereby blocking receptor attachment and viral membrane fusion,conferring high potency as well as robustness against viral mutation escape.Furthermore,cluster analysis identified a hypothetical 3rd antibody partner for further reinforcing the cocktail as pan-SARS-CoVs therapeutics. | Hangping Yao Yao Sun Yong-Qiang Deng Nan Wang Yongcong Tan Na-Na Zhang Xiao-Feng Li Chao Kong Yan-Peng Xuc Qi Chen Tian-Shu Cao Hui Zhao Xintian Yan Lei Cao Zhe Lv Dandan Zhu Rui Feng Nanping Wu Wenhai Zhang Yuhao Hu Keda Chen Rong-Rong Zhang Qingyu Lv Shihui Sun Yunhua Zhou Run Yan Guan Yang Xinglu Chanjuan Liu Xiangyun Lu Linfang Cheng Hongying Qiu Xing-Yao Huang Tianhao Weng Danrong Shi Weidong Jiang Junbin Shao Lei Wang Jie Zhang Tao Jiang Guojun Lang Cheng-Feng Qinc Lanjuan Li Xiangxi Wang | 2021 | Cell Research2021，31，1： | 5 |
| 6 | Asymmetric neurocognitive representation of ethnic in-group/out-group faces显示文摘To investigate asymmetric neurocognitive representation of ethnic in-group and out-group members, we recorded event-related potentials (ERPs) to faces in a perceptual task after the faces had been primed with positive or negative affective links. The affective link priming did not influence the ERPs to ethnic out-group faces. However, relative to the positive affective link priming, the negative affective link priming increased the amplitudes of an early frontal negativity (N100) and a following central negativity but decreased the amplitude of a late positive potential elicited by ethnic in-group faces. Moreover, the N100 amplitude correlated with the degree of negative attitudes towards ethnic in-group faces. The findings suggest that multiple-level neural mechanisms are involved in individuation of heterogeneous ethnic in-group faces. | MA YiNa GE JianQiao XU XiaoJing FAN Yan YANG ShengMin HAN ShiHui | 2009 | Chinese Science Bulletin2009，54，12： | 3 |
| 7 | Late Mesozoic rifting and its deep dynamic mechanisms in the central Sulu orogenic belt: Records from Lingshan Island显示文摘The Lingshan Island scientific drill confirms that two episodes(Laiyang period and Qingshan period) of rifting developed in the central Sulu orogenic belt(SOB) in Late Mesozoic. With a set of methods including fieldwork, drilling, core logging, zircon U-Pb dating and whole rock geochemistry applied, the age, the depositional sequence and the deep dynamic mechanisms of rift evolution were unraveled. The stratigraphic sequence of the Laiyang-Qingshan Groups on Lingshan Island was composed of two different rifting sequences:(1) Laiyang Group(147–125 Ma), which consists of deep-water gravity flow deposits with interlayers of intermediate volcanic rocks;and(2) Lower Qingshan Group(125–119 Ma), which unconformably overlies the former sequence and contains subaerial volcanic deposits and terrestrial deposits. The tectonic environment changed during the evolution of these two episodes of rifting: the rift was in a NNW-SSE extensional environment in the Laiyang period and showed the typical passive rifting character that “lithospheric extension and rifting preceded volcanism”. The passive rifting period was ended by a short WNW-ESE compression at about 125 Ma. After that, the tectonic environment transferred to a strong NW-SE extensional environment and the rifting evolved into a volcanic arc basin in the Qingshan period. The igneous rocks are shoshonitic to high-K calc-alkaline trachyandesites to trachytes with a few intercalated lamprophyres and a rhyolite.The geochemical characteristics of the igneous rocks indicate that they are mantle-derived melts with a metasomatized mantle source and/or crustal contamination. In addition, an increased thinning of the lithosphere happened during the rifting episodes.The low-angle subduction of the Paleo-Pacific plate in the Jurassic weakened the thickened SOB lithospheric mantle. The rollback of the subducting plate started in late Jurassic to early Cretaceous, and the SOB lithospheric mantle was delaminated synchronously because of the gravity collapse. Thus, this caused passive rifting in the Laiyang period. Thereafter, the rollback and trench retreat of the high-angle subducting Paleo-Pacific plate would have achieved its climax, resulting in the strong regional extension. Passive rifting was ended by the crustal uplift caused by asthenospheric upwelling beneath the rift. The lower crust was heated by the upwelling asthenosphere and partially melted to form felsic melts, which were emplaced upwards and erupted explosively. The rift evolved into a volcanic arc basin in the Qingshan period and showed some characteristics of active rifting. Above all, a passive rifting in the Laiyang period and a volcanic arc basin in the Qingshan period developed successively in the Lingshan Island area(the central SOB). This records the transfer of the study area from the Paleo-Tethys tectonic domain to the circum-Pacific tectonic domain. The delamination of SOB lithospheric mantle and the upwelling of asthenospheric material were the deep dynamic mechanisms driving the development and evolution of two rift episodes. Additionally, the rift development was controlled remotely by the subduction of the Paleo-Pacific plate. | Tengfei ZHOU Yaoqi ZHOU Nina SФAGER Paul Martin HOLM Zhenkai ZHANG Jun WANG Zhao LIANG Hongyu MU Yanjun CHENG Feifei LIU Miao WANG Yue ZHANG Hui ZHANG Yangjian GU Shihui DONG Hanjie ZHAO Manjie LI Yang CHEN Yanzi LIU | 2022 | Science China Earth Sciences2022，65，9： | 3 |
| 8 | IntegrinαEβ7^(+)T cells direct intestinal stem cell fate decisions via adhesion signaling显示文摘Intestinal stem cell(ISC)differentiation is regulated precisely by a niche in the crypt,where lymphocytes may interact with stem and transient amplifying(TA)cells.However,whether and how lymphocyte–stem/TA cell contact affects ISC differentiation is largely unknown.Here,we uncover a novel role of T cell–stem/TA cell contact in ISC fate decisions.We show that intestinal lymphocyte depletion results in skewed ISC differentiation in mice,which can be rescued by T cell transfer.Mechanistically,integrinαEβ7 expressed on T cells binds to E-cadherin on ISCs and TA cells,triggering E-cadherin endocytosis and the consequent Wnt and Notch signaling alterations.BlockingαEβ7−E-cadherin adhesion suppresses Wnt signaling and promotes Notch signaling in ISCs and TA cells,leading to defective ISC differentiation.Thus,αEβ7^(+)T cells regulate ISC differentiation at single-cell level through cell–cell contact-mediatedαEβ7−E-cadherin adhesion signaling,highlighting a critical role of the T cell–stem/TA cell contact in maintaining intestinal homeostasis. | Shiyang Chen Yajuan Zheng Xiaojuan Ran Hui Du Hua Feng Lei Yang Yating Wen Changdong Lin Shihui Wang Mengwen Huang Zhanjun Yan Dianqing Wu Hongyan Wang Gaoxiang Ge An Zeng Yi Arial Zeng Jianfeng Chen | 2021 | Cell Research2021，31，12： | 3 |
| 9 | Coordination Polymerization of Renewable (E)-4,8-Dimethyl-1,3,7-Nonatriene by Rare-Earth Metal Catalysts显示文摘Coordination polymerization of renewable(E)-4,8-dimethyl-1,3,7-nonatriene(DMNT)has been performed using pyridyl-methylene-fluorenyl scandium complex 1,half-sandwich scandium complex 2,diiminophosphinato rare-earth metal complexes 3a—3c and 4a—4b,bis(phosphino)carbazolide yttrium complex 5 andβ-diketiminato yttrium complex 6.Fluorenyl scandium complexes 1 and 2,activated by[Ph3C][B(C6F5)4]and AliBu3,are moderately active and show perfect 1,2-regioselective(1,2>99%).Conversely,asymmetric diiminophophinato complexes 3a—3c promote the DMNT polymerization to produce high trans-1,4 regulated products with the activity trend:Sc | Yang Jiang Zhen Zhang Shihui Li Dongmei Cui | 2022 | Chinese Journal of Chemistry2022，40，16： | 2 |
| 10 | Strength-increase mechanism and microstructural characteristics of a biotreated geomaterial显示文摘Microbially induced calcite precipitation(MICP)is a recently proposed method that is environmentally friendly and has considerable potential applications in artificial biotreated geomaterials.New artificial biotreated geomaterials are produced based on the MICP technology for different parent soils.The purpose of this study is to explore the strength-increase mechanism and microstmctural characteristics of the biotreated geomaterial through a series of experiments.The results show that longer mineralization time results in higher-strength biotreated geomaterial.The strength growth rate rapidly increases in the beginning and remains stable afterwards.The calcium ion content significantly increases with the extended mineralization time.When standard sand was used as a parent soil,the calcium ion content increased to a factor of 39 after 7 days.The bacterial cells with attached calcium ions serve as the nucleus of crystallization and fill the pore space.When fine sand was used as a parent soil,the calcium ion content increased to only a factor of 7 after 7 days of mineralization.The nucleus of crystallization could not normally grow because of the limited pore space.The porosity and variation in porosity are clearly affected by the parent soil.Therefore,the strength of the biotreated geomaterial is affected by the parent soil properties,mineralization time,and granular material pore space.This paper provides a basis for theory and experiments for biotreated geomaterials in future engineering practice. | Chi LI Siriguleng BAI Tuanjie ZHOU Hanlong LIU Xiao QIN Shihui LIU Xiaoying LIU Yang XIAO | 2020 | Frontiers of Structural and Civil Engineering2020，14，3： | 2 |
| 11 | Whole genome engineering by synthesis显示文摘Whole genome engineering is now feasible with the aid of genome editing and synthesis tools. Synthesizing a genome from scratch allows modifications of the genomic structure and function to an extent that was hitherto not possible, which will finally lead to new insights into the basic principles of life and enable valuable applications. With several recent genome synthesis projects as examples, the technical details to synthesize a genome and applications of synthetic genome are addressed in this perspective. A series of ongoing or future synthetic genomics projects, including the different genomes to be synthesized in GPwrite, synthetic minimal genome, massively recoded genome, chimeric genome and synthetic genome with expanded genetic alphabet, are also discussed here with a special focus on theoretical and technical impediments in the design and synthesis process. Synthetic genomics will become a commonplace to engineer pathways and genomes according to arbitrary sets of design principles with the development of high-efficient, low-cost genome synthesis and assembly technologies. | Zhouqing Luo Qing Yang Binan Geng Shuangying Jiang Shihui Yang Xiaozheng Li Yizhi Cai Junbiao Dai | 2018 | Science China(Life Sciences)2018，61，12： | 2 |
| 12 | Assessment of the curving performance of heavy haul trains under braking conditions显示文摘To study the curving performance of trains,ID and 3D dynamic models of trains were built using numerical methods.The ID model was composed of 210 simple wagons,each allowed only longitudinal motion;whereas the 3D model included three complicated wagons for which longitudinal,lateral,and vertical degrees of freedom were considered.Combined with the calculated results from the ID model under braking conditions,the behavior of draft gears and brake shoes were added to the3 D model.The assessment of the curving performance of trains was focused on making comparisons between idling and braking conditions.The results indicated the following:when a train brakes on a curved track,the wheel-rail lateral force and derailment factor are greater than under idling conditions.Because the yawing movement of the wheelset is limited by brake shoes,the zone of wheel contact along the wheel tread is wider than under idling conditions.Furthermore,as the curvature becomes tighter,the traction ratio shows a nonlinear increasing trend,whether under idling or braking conditions.By increasing the brake shoe pressure,train steering becomes more difficult. | Liangliang Yang Yu Kang Shihui Luo Maohai Fu | 2015 | Journal of Modern Transportation2015，23，3： | 2 |
| 13 | Analysis of the combustion of sewage sludge-derived fuel by a thermogravimetric method in China显示文摘 | Jianguo Jiang Xuejuan Du Shihui Yang | 2010 | Waste Management2010，，7： | 1 |
| 14 | On connected 2 - Kn-residual graphs显示文摘 | Liao Jiangdong Yang Shihui Deng Yong | 2012 | Mediterranean Journal of Mathematics2012，，10： | 1 |
| 15 | Design and Synthesis of Proteolysis Targeting Chimeras for Inducing BRD4 Protein Degradation显示文摘 | WANG Shihui LI Haiyan WANG Yue GAO Yang YU Shanshan ZHAO Qianqian JIN Xiangqun LU Haibin | 2018 | Chemical Research in Chinese Universities2018，34，2： | 1 |
| 16 | Bilirubin adsorption on nanocrystalline titania films 显示文摘 | Yang Zhengpeng Si Shihui Fung Yingsing | 2007 | Thin Solid Films2007，515，7： | 1 |
| 17 | Coordinated regulation of BACH1 and mitochondrial metabolism through tumor-targeted self-assembled nanoparticles for effective triple negative breast cancer combination therapy显示文摘The poor prognosis of triple negative breast cancer(TNBC)results from a lack of approved targeted therapies coupled with aggressive proliferation and metastasis,which is associated with high recurrence and short overall survival.Here we developed a strategy by employing tumor-targeted selfassembled nanoparticles to coordinately regulate BACH1(BTB domain and CNC homology 1)and mitochondrial metabolism.The BACH1 inhibitor hemin and mitochondria function inhibitor berberine derivative(BD)were used to prepare nanoparticles(BH NPs)followed by the modification of chondroitin sulfate(CS)on the surface of BH NPs to achieve tumor targeting(CS/BH NPs).CS/BH NPs were found to be able to inhibit tumor migration and invasion by significantly decreasing the amounts of tumor cell metabolites,glycolysis and metastasis-associated proteins,which were related to the inhibition of BACH1 function.Meanwhile,decreased mitochondrial membrane potential,activated caspase 3/9 and increased ROS production demonstrated coordinated regulation of BACH1 and mitochondrial metabolism.In a xenograft mice model of breast cancer,CS/BH NPs significantly inhibited tumor growth and metastasis due to the synergetic effect of hemin and BD without showing obvious toxicities for major organs.In sum,the results of efficacy and safety experiments suggest potential clinical significance of the prepared self-assembled CS/BH nanoparticles for the treatment of TNBC. | Xuan Yang Yalong Wang Junke Zhao Hehui Rong Yujun Chen Mengting Xiong Xiaoxing Ye Shihui Yu Haiyan Hu | 2022 | Acta Pharmaceutica Sinica B2022，12，10： | 1 |
| 18 | Intelligent back-analysis of displacements monitored in tunneling 显示文摘 | Li Shihui Yang Jie Hao Weidong | 2006 | Rock Mechanics and Mining Sciences2006，43，2： | 1 |
| 19 | Intelligent back-analysis of displacements monitored in tunneling显示文摘 | LI Shihui YANG Jie HAO Weidong | 2006 | Rock Mechanics and Mining Sciences2006，43，2： | 1 |
| 20 | Soft magnetic properties of (Ni_(50)Fe_(50)) SiO_2 granular thin films for high frequency application显示文摘A series of (Ni50Fe50)x(SiO2)(1-x) films with different volume fraction x was fabricated by magnetron co-sputtering technique. The microstructure, magnetic and electrical properties were investigated systematically by using X-ray diffraction, transmission electronic microscope, vibrating sample magnetometer and the traditional four point measurement method of resistivity. The results show that the samples consist of nano-scaled Ni50Fe50 metallic particles with fcc structure uniformly embedded in amorphous insulating SiO2 matrix, and the particle size decreases with the decrease of x. The rapid change of coercivity with x is observed, and a minimum value 160 A·m-1 of Hc was obtained for the sample of x=0.83 with film thickness of 180 nm, which can be contributed to the exchange coupling between nano-scaled Ni50Fe50 particles. At the frequency lower than 1 GHz, the real part μ′ of complex permeability keeps about 110 and the image part μ″ is less than 15. Besides, this film exhibits high resistivity ρ=263 μΩ·cm, high saturation magnetization 4πMs=1.25 T, high in-plane magnetic anisotropy field Hk=6.37 kA·m-1, and the ferromagnetic resonance (FMR) frequency is estimated to be 2.8 GHz. Therefore, this film can be used in high frequency devices operating over 2 GHz. | YANG Xiaolin GE Shihui RUAN Chengli | 2006 | Rare Metals2006，25，z1： | 1 |
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