|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Prevalence and trends of aminoglycoside resistance in Shigella worldwide, 1999-2010显示文摘Shigellosis causes diarrheal disease in humans in both developed and developing countries, and multi-drug resistance in Shigella is an emerging problem. Understanding changing resistance patterns is important in determining appropriate antibiotic treatments. This meta-analysis systematically evaluated aminoglycoside resist-ance in Shigella. A systematic review was constructed based on MEDLINE and EMBASE databases. Randomeffect models or fixed-effect models were used based on P value considering the possibility of heterogeneity between studies for meta-analysis. Data manipulation and statistical analyses were performed using software STATA 11.0. By means of meta-analysis, we found a lower resistance to three kinds of aminoglycosides in the Europe-America areas during the 12 year study period than that of the Asia-Africa areas. Kanamycin resistance was observed to be the most common drug resistance among Shigella isolates with a prevalence of 6.88% (95%CI: 6.36%-7.43%). Comparison of data from Europe-America and Asia-Africa areas revealed that Shigella flexneri resistance was greater than the resistance calculated for Shigella sonnei. Importantly,Shigella sonnei has played a significant role in aminoglycoside-resistance in recent years. Similarly, data showed that resistance to these drugs in children was higher than the corresponding data of adults. In conclusion, aminoglycoside-resistant Shigella is not an unusual phenomenon worldwide. Distribution in Shigella resistance differs sharply based on geographic areas, periods of time and subtypes. The results from the present study highlight the need for continuous surveillance of resistance and control of antibiotic usage. | Bing Gu Xing Ke Shiyang Pan Yan Cao Ling Zhuang Rongbin Yu Huimin Qian Genyan Liu Mingqing Tong | 2013 | The Journal of Biomedical Research2013，27，2： | 3 |
| 2 | Integration of high-performance spin-orbit torque MRAM devices by 200-mm-wafer manufacturing platform显示文摘We demonstrate in-plane field-free-switching spin-orbit torque(SOT)magnetic tunnel junction(MTJ)devices that are capable of low switching current density,fast speed,high reliability,and,most importantly,manufactured uniformly by the 200-mm-wafer platform.The performance of the devices is systematically studied,including their magnetic properties,switch-ing behaviors,endurance and data retention.The successful integration of SOT devices within the 200-mm-wafer manufactur-ing platform provides a feasible way to industrialize SOT MRAMs.It is expected to obtain excellent performance of the devices by further optimizing the MTJ film stacks and the corresponding fabrication processes in the future. | Hongchao Zhang Xiangyue Ma Chuanpeng Jiang Jialiang Yin Shuqin Lyu Shiyang Lu Xiantao Shang Bowen Man Cong Zhang Dandan Li Shuhui Li Wenjing Chen Hongxi Liu Gefei Wang Kaihua Cao Zhaohao Wang Weisheng Zhao | 2022 | Journal of Semiconductors2022，43，10： | 2 |
| 3 | Activation of calcium-sensing receptors is associated with apoptosis in a model of simulated cardiomyocytes ischemia/reperfusion显示文摘Objective:Calcium-sensing receptors(CaSRs)are G-protein coupled receptors which maintain systemic calcium homeostasis and participate in hormone secretion,activation of ion channels,cell apoptosis,proliferation,and differentiation.Previous studies have shown that CaSRs induce apoptosis in isolated adult rat heart and in normal neonatal rat cardiomyocytes by G-protein-PLC-IP 3 signaling transduction.However,little knowledge is presently available concerning the role of CaSRs in the apoptosis induced by ischemia and reperfusion in neonatal cardiomyocytes.Methods:Primary neonatal rat ventricular cardiomyocytes were incubated in ischemiamimetic solution for 2 h,and then re-incubated in normal culture medium for 24 h to establish a model of simu- lated ischemia/reperfusion(I/R).Cardiomyocyte apoptosis was detected by terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling(TUNEL).The expression of CaSRs mRNA was detected by real-time reverse transcription polymerase chain reaction(RT-PCR).In addition,the expressions of caspase-3 and Bcl-2 were analyzed by western blot.Results:The simulated I/R enhanced the expression of CaSRs and cardiomyocyte apopto- sis.GdCl 3 ,a specific activator of CaSRs,further increased the expression of CaSRs and cardiomyocyte apoptosis, along with up-regulation of caspase-3 and down-regulation of Bcl-2.Conclusion:CaSRs are associated with I/R injury and apoptosis in neonatal rat ventricular cardiomyocytes via suppressing Bcl-2 and promoting caspase-3 expression. | Ling Yan Tlebing Zhu Tingting Sun Liansheng Wang Shiyang Pan Zhengxlan Tao Zhijian Yang Kejiang Cao | 2010 | The Journal of Biomedical Research2010，24，4： | 2 |
| 4 | Transcriptomic Response to Yersinia pestis:RIG-I Like Receptor Signaling Response Is Detrimental to the Host against Plague显示文摘Bacterial pathogens have evolved various mechanisms to modulate host immune responses for successful infection.In this study,RNAsequencing technology was used to analyze the responses of human monocytes THP1 to Yersinia pestis infection.Over 6000 genes were differentially expressed over the 12 h infection.Kinetic responses of pathogen recognition receptor signaling pathways,apoptosis,antigen processing,and presentation pathway and coagulation system were analyzed in detail.Among them,RIG-I-like receptor(RLR) signaling pathway,which was established for antiviral defense,was significantly affected.Mice lacking MAVS,the adaptor of the RLR signahng pathway,were less sensitive to infection and exhibited lower IFN-P production,higher Thl-type cytokines IFN-y and IL-12 production,and lower Th2-type cytokines EL-4 and IL-13 production in the serum compared with wild-type mice.Moreover,infection of pathogenic bacteria other than Y.pestis also altered the expression of the RLR pathway,suggesting that the response of RLR pathway to bacterial infection is a universal mechanism. | Zongmin Du Huiying Yang Yafang Tan Guang Tian Qingwen Zhang Yujun Cui Yanfeng Yan Xiaohong Wu Zuyun Chen Shiyang Cao Yujing Bi Yanping Han Xiaoyi Wang Yajun Song Ruifu Yan | 2014 | Journal of Genetics and Genomics2014，41，7： | 2 |
| 5 | Deciphering pitting behavior of lithium metal anodes in lithium sulfur batteries显示文摘Unambiguous understanding in lithium anode failure mechanism calls for a comprehensive methodology to investigate the coupled morphological,electrochemical and mechanical behaviors during the stripping process.In this work,a mechanistic investigation of the pitting behavior of lithium metal in an electrolyte containing lithium polysulfides in lithium sulfur batteries was developed.It is found that lithium polysulfides could aggravate the nonuniform stripping of lithium electrodes. | Fanyang Huang Shuai Wang Yulin Jie Evan Hansen Shiyang Wang Zhanwu Lei Jian Liu Ruiguo Cao Genqiang Zhang Shuhong Jiao | 2020 | Journal of Energy Chemistry2020，29，10： | 1 |
| 6 | Y ersinia protein kinase A phosphorylates vasodilator‐stimulated phosphoprotein to modify the host cytoskeleton显示文摘 | Yuehua Ke Yafang Tan Na Wei Fen Yang Huiying Yang Shiyang Cao Xiaohui Wang Jian Wang Yanping Han Yujing Bi Yujun Cui Yanfeng Yan Yajun Song Xiaoming Yang Zongmin Du Ruifu Yang | 2015 | Cell Microbiol2015，，： | 1 |
| 7 | Deregulated expression of miR-21, miR-143 and miR-181a in non small cell lung cancer is related to clinicopathologic characteristics or patient prognosis显示文摘 | Wen Gao Yue Yu Hailong Cao Hua Shen Xiaodong Li Shiyang Pan Yongqian Shu | 2010 | Biomedicine & Pharmacotherapy2010，，6： | 1 |
| 8 | Deregulated expression of miR-21, miR-143 and miR-181a in non small cell lung cancer is related to clinicopathologic characteristics or patient prognosis显示文摘 | Wen Gao Yue Yu Hailong Cao Hua Shen Xiaodong Li Shiyang Pan Yongqian Shu | 2010 | Biomedicine & Pharmacotherapy2010，，6： | 1 |
| 9 | Mo-based perpendicularly magnetized thin films with low damping for fast and low-power consumption magnetic memory显示文摘Perpendicular magnetic anisotropy-based magnetic tunnel junctions(p-MTJs) with low Gilbert damping constant(α) are of particular interest for fast and low-power consumption magnetic random-access memory(MRAM). However, obtaining a faster switching speed and lower power consumption is still a big challenge. Herein, we report a Mo-based perpendicular double free layer structure with a low Gilbert damping constant of 0.02 relative to W-based films, as measured by time-resolved magnetooptical Kerr effect equipment. To show the influence of different film structures on the Gilbert damping constant, we measured the Mo-based single free layer. Thereafter, we deposited the full stacks with the Mo-based double free layer and obtained a high tunneling magnetoresistance of 136.3% and high thermal stability. The results of high-resolution transmission electron microscopy(HR-TEM) and energy-dispersive X-ray spectroscopy(EDS) showed that the Mo-based films had better crystallinity,sharper interfaces, and weaker diffusion than the W-based films and thus produced a weaker external contribution of the Gilbert damping constant. As a result of the weak spin-orbit coupling in the Mo-based structure, the intrinsic contribution of the Gilbert damping constant was also weak, thereby leading to the small Gilbert damping constant of the Mo-based stacks. In addition, the macro-spin simulation results demonstrated that the magnetization switching by the spin transfer torque of the Mo-based MTJs was faster than that of the W-based MTJs. These findings help to understand the mechanism behind the good performance of Mo-based p-MTJ films and show the great promise of these structures in low-power consumption MRAM or other spintronic devices. | Houyi Cheng Boyu Zhang Yong Xu Shiyang Lu Yuxuan Yao Rui Xiao Kaihua Cao Yongshan Liu Zilu Wang Renyou Xu Danrong Xiong Yan Wang Helin Ma Sylvain Eimer Chao Zhao Weisheng Zhao | 2022 | Science China(Physics,Mechanics & Astronomy)2022，65，8： | 0 |
| 10 | Single-cell transcriptomics of immune cells in lymph nodes reveals their composition and alterations in functional dynamics during the early stages of bubonic plague显示文摘Bubonic plague caused by Yersinia pestis is highly infectious and often fatal.Characterization of the host immune response and its subsequent suppression by Y.pestis is critical to understanding the pathogenesis of Y.pestis.Here,we utilized single-cell RNA sequencing to systematically profile the transcriptomes of immune cells in draining lymph nodes(d LNs)during the early stage of Y.pestis infection.Dendritic cells responded to Y.pestis within 2 h post-infection(hpi),followed by the activation of macrophages/monocytes(Mφs/Mons)and recruitment of polymorphonuclear neutrophils(PMNs)to d LNs at 24 hpi.Analysis of cell-to-cell communication suggests that PMNs may be recruited to lymph nodes following the secretion of CCL9 by Mφs/Mons stimulated through CCR1-CCL9 interaction.Significant functional suppression of all the three innate immune cell types occurred during the early stage of infection.In summary,we present a dynamic immune landscape,at single-cell resolution,of murine d LNs involved in the response to Y.pestis infection,which may facilitate the understanding of the plague pathogenesis of during the early stage of infection. | Yifan Zhao Tong Wang Ziyang Liu Yuehua Ke Ruoyan Li Hongyan Chen Yang You Gengshan Wu Shiyang Cao Zongmin Du Fan Bai Ruifu Yang | 2023 | Science China(Life Sciences)2023，66，1： | 0 |
| 11 | Spin-orbit torque efficiency enhancement to tungsten-based SOT-MTJs by interface modification with an ultrathin MgO显示文摘Spin-orbital torque (SOT) based three-terminal magnetic tunnel junctions (MTJs) have attracted much interest as the next generation magnetic random-access memory (MRAM)key device both in the academy and the industry.This is because SOT-MTJs feature high endurance and fast switching speed,benefiting tremendously from the separation of read/write current paths and less incubation time during the write in contrast to the spin-transfer torque (STT) MTJs [1]. | Shiyang LU Xiaobai NING Hongchao ZHANG Sixi ZHEN Xiaofei FAN Danrong XIONG Dapeng ZHU Gefei WANG Hong-Xi LIU Kaihua CAO Weisheng ZHAO | 2024 | Science China(Information Sciences)2024，67，1： | 0 |
| 12 | Demonstration of a manufacturable SOT-MRAM multiplexer array towards industrial applications显示文摘We have successfully demonstrated a 1 Kb spin-orbit torque(SOT)magnetic random-access memory(MRAM)multiplexer(MUX)array with remarkable performance.The 1 Kb MUX array exhibits an in-die function yield of over 99.6%.Additionally,it provides a sufficient readout window,with a TMR/RP_sigma%value of 21.4.Moreover,the SOT magnetic tunnel junctions(MTJs)in the array show write error rates as low as 10^(-6)without any ballooning effects or back-hopping behaviors,ensuring the write stability and reliability.This array achieves write operations in 20 ns and 1.2 V for an industrial-level temperature range from-40 to 125℃.Overall,the demonstrated array shows competitive specifications compared to the state-of-the-art works.Our work paves the way for the industrial-scale production of SOT-MRAM,moving this technology beyond R&D and towards widespread adoption. | Chuanpeng Jiang Jinhao Li Hongchao Zhang Shiyang Lu Pengbin Li Chao Wang Zhongkui Zhang Zhengyi Hou Xu Liu Jiagao Feng He Zhang Hui Jin Gefei Wang Hongxi Liu Kaihua Cao Zhaohao Wang Weisheng Zhao | 2023 | Journal of Semiconductors2023，44，12： | 0 |
| 13 | The effects of incident light wavelength difference on the collective stimulated Brillouin scattering in plasmas显示文摘The first laser–plasma interaction experiment using lasers of eight beams grouped into one octad has been conducted on the Shenguang Octopus facility.Although each beam intensity is below its individual threshold for stimulated Brillouin backscattering(SBS),collective behaviors are excited to enhance the octad SBS.In particular,when two-color/cone lasers with wavelength separation 0.3 nm are used,the backward SBS reflectivities show novel behavior in which beams of longer wavelength achieve higher SBS gain.This property of SBS can be attributed to the rotation of the wave vectors of common ion acoustic waves due to the competition of detunings between geometrical angle and wavelength separation.This mechanism is confirmed using massively parallel supercomputer simulations with the three-dimensional laser–plasma interaction code LAP3D. | Qiang Wang Zhichao Li Zhanjun Liu Tao Gong Wenshuai Zhang Tao Xu Bin Li Ping Li Xin Li Chunyang Zheng Lihua Cao Xincheng Liu Kaiqiang Pan Hang Zhao Yonggang Liu Bo Deng Lifei Hou Yingjie Li Xiangming Liu Yulong Li Xiaoshi Peng Zanyang Guan Qiangqiang Wang Xingsen Che Sanwei Li Qiang Yin Wei Zhang Liqiong Xia Peng Wang Xiaohua Jiang Liang Guo Qi Li Minqing He Liang Hao Hongbo Cai Wudi Zheng Shiyang Zou Dong Yang Feng Wang Jiamin Yang Baohan Zhang Yongkun Ding Xiantu He | 2023 | Matter and Radiation at Extremes2023，8，5： | 0 |
| 14 | Pomegranate-like C_(60)@cobalt/nitrogen-codoped porous carbon for high-performance oxygen reduction reaction and lithium-sulfur battery显示文摘Porous carbon materials play essential roles in electrocatalysis and electrochemical energy storage.It is of significant importance to rationally design and tune their porous structure and active sites for achieving high electrochemical activity and stability.Herein,we develop a novel approach to tune the morphology of porous carbon materials(PCM)by embedding fullerene C_(60),achieving improved performance of oxygen reduction reaction(ORR)and lithium-sulfur(Li-S)battery.Owing to the strong interaction between C_(60)and imidazole moieties,pomegranate-like hybrid of Ow-embedded zeolitic imidazolate framework(ZIF-67)precursor is synthesized,which is further pyrolyzed to form C_(60)-embedded cobalt/nitrogen-codoped porous carbon materials(abbreviated as C_(60)@Co-N-PCM).Remarkably,the unique structure of C_(60)@Co-N-PCM offers excellent ORR electrocatalytic activity and stability in alkaline solutions,outperforming the commercial Pt/C(20 wt.%)catalyst.Besides,C_(60)@Co-N-PCM as a novel cathode delivers a high specific capacity of-900 mAh·g^(-1) at 0.2 C rate in Li-S batteries,which is superior to the pristine ZIF-67-derived PCM without embedding C_(60). | Jianhua Wu Shiyang Wang Zhanwu Lei Runnan Guan Muqing Chen Pingwu Du Yalin Lu Ruiguo Cao Shangfeng Yang | 2021 | Nano Research2021，14，8： | 0 |
| 15 | Synthesis and Electrochemical Investigation of O3-Type High-nickel NCM Cathodes for Sodium-ion Batteries显示文摘Sodium ion batteries(SIBs)are promising energy storage devices for smart grid applications due to their low cost and the high abundance of sodium,but few cathode materials of SIBs with high energy density are available for practical applications.Herein,a series of NaNCM ternary materials(NCM=nickel-cobalt-manganese)is obtained by solid-phase reaction with well-regulated temperature and other reaction conditions.XRD results show that impure NiO phase is more likely to occur under high nickel content.The cross-section SEM indicates that the primary particles in the electrode materials are radially distributed along the radial direction,and the internal porous structure is conducive to the infiltration of electrolyte.The initial specific capacities of Na[Ni0.68Co0.10Mn0.22]O2(NaNCM712),Na[Ni0.6Co0.2Mn0.2]O2(NaNCM622)and Na[Ni0.4Co0.3Mn0.3]O2(NaNCM433)at 0.2 C are 165.5,153.1 and 146.8 mA·h/g,and the corresponding capacity retention rates are 63.2%,78.5%and 71.7%after 100 cycles.NaNCM712 possesses the highest initial specific capacity,and NaNCM433 delivers the best rate capability.The rate capabilities of high-nickel and low-cobalt NaNCM cathodes need to be further improved.Moreover,ex-situ XRD pattern reveals the structure evolution(from O3 type to P2 type)during a long cycling charge and discharge process. | CHEN Yawei WANG Shiyang JIE Yulin LEI Zhanwu CAO Ruiguo JIAO Shuhong | 2021 | Chemical Research in Chinese Universities2021，37，2： | 0 |
| 16 | Collective stimulated Brillouin scattering modes of two crossing laser beams with shared scattered wave显示文摘In inertial confinement fusion(ICF),overlapping of laser beams is common.Owing to the effective high laser intensity of the overlapped beams,the collective mode of stimulated Brillouin scattering(SBS)with a shared scattered light wave is potentially important.In this work,an exact analytic solution for the convective gain coefficient of the collective SBS modes with shared scattered wave is presented for two overlapped beams based on a linear kineticmodel.The effects of the crossing angle,polarization states,and finite beamoverlapping volume of the two laser beams on the shared light modes are analyzed for cases with zero and nonzero wavelength difference between the two beams.It is found that all these factors have a significant influence on the shared lightmodes of SBS.Furthermore,the out-of-plane modes,in which the wavevectors of daughter waves lie in different planes from the two overlapped beams,are found to be important for certain polarization states and especially for obtuse crossing angles.In particular,adjusting the polarization directions of the two beams to be orthogonal to each other or tuning the wavelength difference to a sufficiently large value(of the order of nanometers)are found to be effective methods to suppress the shared light modes of SBS.This work will be helpful for comprehending and suppressing collective SBS with shared scattered waves in ICF experiments. | Jie Qiu Liang Hao Lihua Cao Shiyang Zou | 2021 | Matter and Radiation at Extremes2021，6，6： | 0 |
| 17 | Conductive metal-organic frameworks promoting polysulfides transformation in lithium-sulfur batteries显示文摘Metal organic frameworks(MOFs) have been extensively investigated in Li-S batteries owing to high surface area, adjustable structures and abundant catalytic sites. Nevertheless, the insulating nature of traditional MOFs render retarded kinetics of polysulfides conversion, leading to insufficient utilization of sulfur. In comparison, conductive MOFs(c-MOFs) show great potential for promoting polysulfides transformation due to superb electronic conductivity. In this work, a nickel-catecholates based c-MOF, NiHHTP(HHTP = 2,3,6,7,10,11-hexahydroxytriphenylene), is designed to regulate surface chemistry of self-supported carbon paper for advanced Li-S batteries. Taking advantage of the porous structure and high conductivity, the as-prepared Ni-HHTP is conducive to synergising strengthening the chemisorption of polysulfides and accelerating the reaction kinetics in Li-S batteries, significantly mitigating the polysulfides diffusion from the non-encapsulated sulfur cathode, therefore promoting polysulfides transformation in Li-S batteries. This work points out a promising modification strategy for developing advanced sulfur cathode in Li-S batteries. | Shuai Wang Fanyang Huang Zhengfeng Zhang Wenbin Cai Yulin Jie Shiyang Wang Pengfei Yan Shuhong Jiao Ruiguo Cao | 2021 | Journal of Energy Chemistry2021，30，12： | 0 |
| 18 | Magnetic coupling governed pinning directions in magnetic tunnel junctions under magnetic field annealing with zero magnetic field cooling显示文摘With the rapid development of emerging concepts,such as the Internet of things and big data,the use of various magnetoresistance(MR)sensors,especially tunneling MR(TMR)in magnetic tunnel junctions(MTJs),for information perception is considered the critical first step.A typical topic in this field is the construction of a Wheatstone bridge structure to restrain the temperature drift and amplify the magnetic response signal. | Weibin CHEN Shaohua YAN Zhiqiang CAO Shiyang LU Xiaonan ZHAO Runrun HAO Zitong ZHOU Zhi LI Kun ZHANG Shishen YAN Qunwen LENG | 2023 | Science China(Information Sciences)2023，66，4： | 0 |
| 19 | Determination of laser entrance hole size for ignition-scale octahedral spherical hohlraums显示文摘A recently proposed octahedral spherical hohlraum with six laser entrance holes(LEHs)is an attractive concept for an upgraded laser facility aiming at a predictable and reproducible fusion gain with a simple target design.However,with the laser energies available at present,LEH size can be a critical issue.Owing to the uncertainties in simulation results,the LEH size should be determined on the basis of experimental evidence.However,determination of LEH size of an ignition target at a small-scale laser facility poses difficulties.In this paper,we propose to use the prepulse of an ignition pulse to determine the LEH size for ignition-scale hohlraums via LEH closure behavior,and we present convincing evidence from multiple diagnostics at the SGIII facility with ignition-scale hohlraum,laser prepulse,and laser beam size.The LEH closure observed in our experiment is in agreement with data from the National Ignition Facility.The total LEH area of the octahedral hohlraum is found to be very close to that of a cylindrical hohlraum,thus successfully demonstrating the feasibility of the octahedral hohlraum in terms of laser energy,which is crucially important for sizing an ignition-scale octahedrally configured laser system.This work provides a novel way to determine the LEH size of an ignition target at a small-scale laser facility,and it can be applied to other hohlraum configurations for the indirect drive approach. | Yao-Hua Chen Zhichao Li Hui Cao Kaiqiang Pan Sanwei Li Xufei Xie Bo Deng Qiangqiang Wang Zhurong Cao Lifei Hou Xingsen Che Pin Yang Yingjie Li Xiaoan He Tao Xu Yonggang Liu Yulong Li Xiangming Liu Haijun Zhang Wei Zhang Baibin Jiang Jun Xie Wei Zhou Xiaoxia Huang Wen Yi Huo Guoli Ren Kai Li Xudeng Hang Shu Li Chuanlei Zhai Jie Liu Shiyang Zou Yongkun Ding Ke Lan | 2022 | Matter and Radiation at Extremes2022，7，6： | 0 |
| 20 | Regulating surface chemistry of separator with LiF for advanced Li-S batteries显示文摘Lithium-sulfur(Li-S)batteries have attracted intensive attention owing to their ultrahigh theoretical energy density.Nevertheless,the practical application of Li-S batteries is prevented by uncontrollable shuttle effect and retarded reaction kinetics.To address the above issues,lithium fluoride(LiF)was employed to regulate the surface chemistry of routine separator.The functional separator demonstrates a great ability to suppress active S loss and protect lithium anode.This work provides a facile strategy for the development of advanced Li-S batteries. | Shuai WANG Fanyang HUANG Shuhong JIAO Yulin JIE Yawei CHEN Shiyang WANG Ruiguo CAO | 2022 | Frontiers in Energy2022，16，4： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员