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| 1 | Ability of Rabeprazole to Prevent Gastric Mucosal Damage From Clopidogrel and Low Doses of Aspirin Depends on CYP2C19 Genotype显示文摘 | Takahiro Uotani Mitsushige Sugimoto Masafumi Nishino Chise Kodaira Mihoko Yamade Shu Sahara Takanori Yamada Satoshi Osawa Ken Sugimoto Tatsuo Tanaka Kazuo Umemura Hiroshi Watanabe Hiroaki Miyajima Takahisa Furuta | 2012 | Clinical Gastroenterology and Hepatology2012，，8： | 2 |
| 2 | Photonic engineering of superbroadband near-infrared emission in nanoglass composites containing hybrid metal and dielectric nanocrystals显示文摘Photonic media containing hybrid noble metal-dielectric nanocrystals(NCs)represent a wonderland of nanophotonics,with a myriad of uncharted optical functions yet to be explored.Capitalizing on the unique phase separation and spontaneous formation of Au-metal NCs in a gallosilicate glass,we fabricated Ni^2+-doped transparent nanoglass composites(GCs)containing Au-metal/γ-Ga2O3-dielectric NCs.Compared with GCs free of Au-metal NCs,the super broadband near-infrared emission of Ni^2+with a full width at half-maximum over280 nm is enhanced twice in the Au-metal/γ-Ga2O3 dual-phase GCs.A comparison is given as to the spontaneous emission(SPE)properties of Ni^2+in the dual-phase GCs when pumped resonantly and off-resonantly with the localized surface plasmon resonance band of the Au-metal NCs.The important role of the Au-metal NCs in the SPE enhancement is revealed by theoretical simulation based on the finite-element method.Combining the photonic engineering effect of hybrid Au-metal/γ-Ga2O3 NCs and the sensitization effect of Yb^3+on Ni^2+,a record-high enhancement factor of over 10 of the Ni^2+NIR emission is achieved,and optical gain is demonstrated in the GCs at the fiber communication wavelength. | ZHIGANG GAO HAIBO ZHU BOCHAO SUN YINGKE JI XIAOSONG LU HAO TIAN JING REN SHU GUO JIANZHONG ZHANG JUN YANG XIANGENG MENG KATSUHISA TANAKA | 2020 | Photonics Research2020，8，5： | 2 |
| 3 | Role of double-balloon endoscopy in the diagnosis of small-bowel tumors: the first Japanese multicenter study显示文摘 | Keigo Mitsui Shu Tanaka Hironori Yamamoto Tsuyoshi Kobayashi Akihito Ehara Tomonori Yano Hidemi Goto Hiroshi Nakase Shinji Tanaka Toshiyuki Matsui Mitsuo Iida Kentaro Sugano Choitsu Sakamoto | 2009 | Gastrointestinal Endoscopy2009，，3： | 1 |
| 4 | Association between body mass index and cardiovascular disease mortality in east Asians and south Asians: pooled analysis of prospective data from the Asia Cohort Consortium显示文摘 | Yu Chen Wade K Copeland Rajesh Vedanthan Eric Grant Jung Eun Lee Dongfeng Gu Prakash C Gupta Kunnambath Ramadas Manami Inoue Shoichiro Tsugane Akiko Tamakoshi Yu-Tang Gao Jian-Min Yuan Xiao-Ou Shu Kotaro Ozasa Ichiro Tsuji Masako Kakizaki Hideo Tanaka Yos | 2013 | 2013 (oct0)2013，，0： | 1 |
| 5 | Late‐evening snack with branched‐chain amino acids improves liver function after radiofrequency ablation for hepatocellular carcinoma显示文摘 | Daisuke Morihara Kaoru Iwata Takayuki Hanano Hideo Kunimoto Shizuka Kuno Atsushi Fukunaga Kaoru Yotsumoto Kazuhide Takata Takashi Tanaka Kunitoshi Sakurai Hideyuki Iwashita Shu‐ichi Ueda Genryu Hirano Keiji Yokoyama Hidetoshi Nakane Shinya Nishizawa Makot | 2012 | Hepatology Research2012，，7： | 1 |
| 6 | Fungal diversity notes 253-366:taxonomic and phylogenetic contributions to fungal taxa显示文摘Notes on 113 fungal taxa are compiled in this paper,including 11 new genera,89 new species,one new subspecies,three new combinations and seven reference specimens.Awide geographic and taxonomic range of fungal taxa are detailed.In the Ascomycota the new genera Angustospora(Testudinaceae),Camporesia(Xylariaceae),Clematidis,Crassiparies(Pleosporales genera incertae sedis),Farasanispora,Longiostiolum(Pleosporales genera incertae sedis),Multilocularia(Parabambusicolaceae),Neophaeocryptopus(Dothideaceae),Parameliola(Pleosporales genera incertae sedis),and Towyspora(Lentitheciaceae)are introduced.Newly introduced species are Angustospora nilensis,Aniptodera aquibella,Annulohypoxylon albidiscum,Astrocystis thailandica,Camporesia sambuci,Clematidis italica,Colletotrichum menispermi,C.quinquefoliae,Comoclathris pimpinellae,Crassiparies quadrisporus,Cytospora salicicola,Diatrype thailandica,Dothiorella rhamni,Durotheca macrostroma,Farasanispora avicenniae,Halorosellinia rhizophorae,Humicola koreana,Hypoxylon lilloi,Kirschsteiniothelia tectonae,Lindgomyces okinawaensis,Longiostiolum tectonae,Lophiostoma pseudoarmatisporum,Moelleriella phukhiaoensis,M.pongdueatensis,Mucoharknessia anthoxanthi,Multilocularia bambusae,Multiseptospora thysanolaenae,Neophaeocryptopus cytisi,Ocellularia arachchigei,O.ratnapurensis,Ochronectria thailandica,Ophiocordyceps karstii,Parameliola acaciae,P.dimocarpi,Parastagonospora cumpignensis,Pseudodidymosphaeria phlei,Polyplosphaeria thailandica,Pseudolachnella brevifusiformis,Psiloglonium macrosporum,Rhabdodiscus albodenticulatus,Rosellinia chiangmaiensis,Saccothecium rubi,Seimatosporium pseudocornii,S.pseudorosae,Sigarispora ononidis and Towyspora aestuari.New combinations are provided for Eutiarosporella dactylidis(sexual morph described and illus trated)and Pseudocamarosporium pini.Descriptions,illustrations and/or reference specimens are designated for Aposphaeria corallinolutea,Cryptovalsa ampelina,Dothiorella vidmadera,Ophiocordyceps formosana,Petrakia echinata,Phragmoporthe conformis and Pseudocamarosporium pini.The new species of Basidiomycota are Agaricus coccyginus,A.luteofibrillosus,Amanita atrobrunnea,A.digitosa,A.gleocystidiosa,A.pyriformis,A.strobilipes,Bondarzewia tibetica,Cortinarius albosericeus,C.badioflavidus,C.dentigratus,C.duboisensis,C.fragrantissimus,C.roseobasilis,C.vinaceobrunneus,C.vinaceogrisescens,C.wahkiacus,Cyanoboletus hymenoglutinosus,Fomitiporia atlantica,F.subtilissima,Ganoderma wuzhishanensis,Inonotus shoreicola,Lactifluus armeniacus,L.ramipilosus,Leccinum indoaurantiacum,Musumecia alpina,M.sardoa,Russula amethystina subp.tengii and R.wangii are introduced.Descriptions,illustrations,notes and/or reference specimens are designated for Clarkeinda trachodes,Dentocorticium ussuricum,Galzinia longibasidia,Lentinus stuppeus and Leptocorticium tenellum.The other new genera,species new combinations are Anaeromyces robustus,Neocallimastix californiae and Piromyces finnis from Neocallimastigomycota,Phytophthora estuarina,P.rhizophorae,Salispina,S.intermedia,S.lobata and S.spinosa from Oomycota,and Absidia stercoraria,Gongronella orasabula,Mortierella calciphila,Mucor caatinguensis,M.koreanus,M.merdicola and Rhizopus koreanus in Zygomycota. | Guo Jie Li Kevin D.Hyde Rui Lin Zhao Sinang Hongsanan Faten Awad Abdel-Aziz Mohamed A.Abdel-Wahab Pablo Alvarado Genivaldo Alves-Silva Joseph F.Ammirati Hiran A.Ariyawansa Abhishek Baghela Ali Hassan Bahkali Michael Beug D.Jayarama Bhat Dimitar Bojantchev Thitiya Boonpratuang Timur S.Bulgakov Erio Camporesi Marcela CBoro Oldriska Ceska Dyutiparna Chakraborty Jia Jia Chen K.W.Thilini Chethana Putarak Chomnunti Giovanni Consiglio Bao Kai Cui Dong Qin Dai Yu Cheng Dai Dinushani A.Daranagama Kanad Das Monika C.Dayarathne Eske De Crop Rafael J.V.De Oliveira Carlos Alberto Fragoso de Souza JoséIde Souza Bryn T.M.Dentinger Asha J.Dissanayake Mingkwan Doilom E.Ricardo Drechsler-Santos Masoomeh Ghobad-Nejhad Sean P.Gilmore Aristóteles Góes-Neto MichałGorczak Charles H.Haitjema Kalani Kanchana Hapuarachchi Akira Hashimoto Mao Qiang He John K.Henske Kazuyuki Hirayama Maria J.Iribarren Subashini C.Jayasiri Ruvishika S.Jayawardena Sun Jeong Jeon Gustavo H.Jerônimo Ana L.Jesus E.B.Gareth Jones Ji Chuan Kang Samantha C.Karunarathna Paul M.Kirk Sirinapa Konta Eric Kuhnert Ewald Langer Haeng Sub Lee Hyang Burm Lee Wen Jing Li Xing Hong Li Kare Liimatainen Diogo Xavier Lima Chuan Gen Lin Jian Kui Liu Xings Zhong Liu Zuo Yi Liu J.Jennifer Luangsa-ard Robert Lücking H.Thorsten Lumbsch Saisamorn Lumyong Eduardo M.Leaño Agostina V.Marano Misato Matsumura Eric H.C.McKenzie Suchada Mongkolsamrit Peter E.Mortimer Thi Thuong Thuong Nguyen Tuula Niskanen Chada Norphanphoun Michelle A.O’Malley Sittiporn Parnmen Julia Pawłowska Rekhani H.Perera Rungtiwa Phookamsak Chayanard Phukhamsakda Carmen L.A.Pires-Zottarelli Olivier Raspé Mateus A.Reck Sarah C.O.Rocha AndréL.C.M.Ade Santiago Indunil C.Senanayake Ledo Setti Qiu Ju Shang Sanjay K.Singh Esteban B.Sir Kevin V.Solomon Jie Song Prasert Srikitikulchai Marc Stadler Satinee Suetrong Hayato Takahashi Takumasa Takahashi Kazuaki Tanaka Li Ping Tang Kasun M.Thambugala Donnaya Thanakitpipattana Michael K.Theodorou Benjarong Thongbai Tuksaporn Thummarukcharoen Qing Tian Saowaluck Tibpromma Annemieke Verbeken Alfredo Vizzini Josef Vlasák Kerstin Voigt Dhanushka N.Wanasinghe Yong Wang Gothamie Weerakoon Hua An Wen Ting Chi Wen Nalin N.Wijayawardene Sarunyou Wongkanoun Marta Wrzosek Yuan Pin Xiao Jian Chu Xu Ji Ye Yan Jing Yang Shu Da Yang Yu Hu Jin Feng Zhang Jie Zhao Li Wei Zhou Derek Peršoh Alan J.L.Phillips Sajeewa S.N.Maharachchikumbura | 2016 | Fungal Diversity2016，，3： | 1 |
| 7 | Diagnostic yield of double-balloon endoscopy in patients with obscure GI bleeding显示文摘 | Shu Tanaka Keigo Mitsui Yukie Yamada Akihito Ehara Tsuyoshi Kobayashi Tsuguhiko Seo Atsushi Tatsuguchi Shunji Fujimori Katya Gudis Choitsu Sakamoto | 2008 | Gastrointestinal Endoscopy2008，，4： | 1 |
| 8 | Even low-intensity and low-volume exercise training may improve insulin resistance in the elderly 显示文摘 | Kodama S Shu M Saito K Murakami H Tanaka K Kuno S | 2007 | Intern Med2007，46，： | 1 |
| 9 | Surface treatment of titanium dioxide nanopowder using rotary electrode dielectric barrier discharge reactor显示文摘Titanium dioxide(Ti O_(2))nanopowder(P-25;Degussa AG)was treated using dielectric barrier discharge(DBD)in a rotary electrode DBD(RE-DBD)reactor.Its electrical and optical characteristics were investigated during RE-DBD generation.The treated TiO_(2)nanopowder properties and structures were analyzed using x-ray diffraction(XRD)and Fourier-transform infrared spectroscopy(FTIR).After RE-DBD treatment,XRD measurements indicated that the anatase peak theta positions shifted from 25.3°to 25.1°,which can be attributed to the substitution of new functional groups in the TiO_(2)lattice.The FTIR results show that hydroxyl groups(OH)at 3400 cm-1 increased considerably.The mechanism used to modify the TiO_(2)nanopowder surface by air DBD treatment was confirmed from optical emission spectrum measurements.Reactive species,such as OH radical,ozone and atomic oxygen can play key roles in hydroxyl formation on the TiO_(2)nanopowder surface. | Naw Rutha PAW Takuma KIMURA Tatsuo ISHIJIMA Yasunori TANAKA Yusuke NAKANO Yoshihiko UESUGI Shiori SUEYASU Shu WATANABE Keitaro NAKAMURA | 2021 | Plasma Science and Technology2021，23，10： | 1 |
| 10 | Microsomal prostaglandin E synthase protein levels correlate with prognosis in colorectal cancer patients显示文摘 | Tsuguhiko Seo Atsushi Tatsuguchi Seiichi Shinji Masaoki Yonezawa Keigo Mitsui Shu Tanaka Shunji Fujimori Katya Gudis Yuh Fukuda Choitsu Sakamoto | 2009 | Virchows Archiv2009，，6： | 1 |
| 11 | Diagnostic yield of double-balloon endoscopy in patients with obscure GI bleeding显示文摘 | Shu Tanaka Keigo Mitsui Yukie Yamada Akihito Ehara Tsuyoshi Kobayashi Tsuguhiko Seo Atsushi Tatsuguchi Shunji Fujimori Katya Gudis Choitsu Sakamoto | 2008 | Gastrointestinal Endoscopy2008，，4： | 1 |
| 12 | Diagnostic yield of double-balloon endoscopy in patients with obscure GI bleeding显示文摘 | Shu Tanaka Keigo Mitsui Yukie Yamada Akihito Ehara Tsuyoshi Kobayashi Tsuguhiko Seo Atsushi Tatsuguchi Shunji Fujimori Katya Gudis Choitsu Sakamoto | 2008 | Gastrointestinal Endoscopy2008，，4： | 1 |
| 13 | Current status of double balloon endoscopy—indications, insertion route, sedation, complications, technical matters显示文摘 | Shu Tanaka Keigo Mitsui Atsushi Tatsuguchi Tsuyoshi Kobayashi Akihito Ehara Katya Gudis Choitsu Sakamoto | 2007 | Gastrointestinal Endoscopy2007，，3： | 1 |
| 14 | Dimethylarginine Dimethylaminohydrolase 2 Increases Vascular Endothelial Growth Factor Expression Through Spl Transcription Factor in Endothelial Cells 显示文摘 | Kazuhiro Hasegawa Shu Wakino Toru Tanaka | 2006 | Arterioscler Thromb Vasc Biol2006，26，： | 1 |
| 15 | Diagnostic yield of double-balloon endoscopy in patients with obscure GI bleeding显示文摘 | Shu Tanaka Keigo Mitsui Yukie Yamada Akihito Ehara Tsuyoshi Kobayashi Tsuguhiko Seo Atsushi Tatsuguchi Shunji Fujimori Katya Gudis Choitsu Sakamoto | 2008 | Gastrointestinal Endoscopy2008，，4： | 1 |
| 16 | The frequency of 4977 base pair deletion of mitochondrial DNA in various types of liver disease and in normal liver显示文摘 | Shu Fukushima Kazuo Honda Masaaki Awane Eiji Yamamoto Ryouji Takeda Ichiro Kaneko Akira Tanaka Taisuke Morimoto Koichi Tanaka Yoshio Yamaoka | 1995 | Hepatology1995，，6： | 1 |
| 17 | Clinical significance of programmed cell death-ligand expression in small bowel adenocarcinoma is determined by the tumor microenvironment显示文摘BACKGROUND Comprehensive genomic analysis has shown that small bowel adenocarcinoma(SBA)has different genomic profiles from gastric and colorectal cancers.Hence,it is essential to establish chemotherapeutic regimens based on SBA characteristics.The expression of programmed cell death-ligand 1(PD-L1)and programmed cell death-ligand 2(PD-L2)in SBA is not fully understood.Anti-PD-L1/PD-1 therapy uses tumor-infiltrating lymphocytes(TILs);therefore,the status of TILs in the tumor microenvironment(TME)may influence their efficacy.The ratio of FoxP3+to CD8+T cells has been reported to be useful in predicting the prognosis of digestive system cancers.AIM To investigate the clinicopathological significance of PD-L1/2 expression according to the status of TILs in SBA tissues.METHODS We performed immunohistochemical analysis for PD-L1,PD-L2,CD8,FoxP3,and DNA mismatch repair(MMR)proteins using formalin-fixed,paraffin-embedded tissues from 50 patients diagnosed with primary SBA.The immunoreactivities of PD-L1 and PD-L2 were determined separately in tumor cells and tumor-infiltrating immune cells throughout the tumor center and invasive margins,and finally evaluated using the combined positive score(CPS).We assessed CD8+and FoxP3+T cells in the intratumoral and tumor-surrounding stroma.Subsequently,we calculated and summed the ratio of FoxP3 to CD8+T cell counts.Immune-related cell densities were graded as low or high.Immunohistochemical results were compared with clinicopathological factors and patient prognosis.The distribution of cancer-specific survival(CSS)was estimated using the Kaplan–Meier method,and the log-rank test was used to test for significant differences in CSS.A Cox proportional hazard model was also used to assess the effect of tumor variables on CSS.RESULTS PD-L1 expression was positive in 34%in tumor cells(T-PD-L1)and 54%in tumor-infiltrating immune cells(I-PDL1)of the cases examined.T-PD-L2 was positive in 34%and I-PD-L2 was positive in 42%of the cases.PD-L1 CPS≥10 and PD-L2 CPS≥10 were observed in 50%and 56%of the cases,respectively.Deficient MMR(dMMR)was 14%of the cases.T-PD-L1,I-PD-L1 and PD-L1 CPS≥10 were all significantly associated with dMMR(P=0.037,P=0.009,and P=0.005,respectively).T-PD-L1,I-PD-L1,and PD-L1 CPS≥10 were all associated with deeper depth of invasion(P=0.001,P=0.024,and P=0.002,respectively).I-PD-L2 expression and PD-L2 CPS≥10 were significantly higher in the differentiated histological type(P=0.015 and P=0.030,respectively).The I-PD-L1 and IPD-L2 levels were significantly associated with better CSS(P=0.037 and P=0.015,respectively).CD8-high was significantly associated with less lymph node metastasis(P=0.047),less distant metastasis(P=0.024),less peritoneal dissemination(P=0.034),and earlier TNM stage(P=0.047).The CD8-high group had better prognosis than the CD8-low group(P=0.018).FoxP3 expression was not associated with any clinicopathological factors or prognosis.We found that patients with PD-L2 CPS≥10 tended to have worse prognosis in the FoxP3/CD8-low group(P=0.088).CONCLUSION The clinicopathological significance of PD-L1/2 expression may differ depending on the TME status.Immune checkpoint inhibitors may improve the prognosis of SBA patients with low FoxP3/CD8 ratio and PD-L2 expression. | Aitoshi Hoshimoto Atsushi Tatsuguchi Ryohei Hamakubo Takayoshi Nishimoto Jun Omori Naohiko Akimoto Shu Tanaka Shunji Fujimori Tsutomu Hatori Akira Shimizu Katsuhiko Iwakiri | 2023 | World Journal of Gastroenterology2023，29，40： | 0 |
| 18 | Risk factors for small intestinal adenocarcinomas that are common in the proximal small intestine显示文摘The frequency of primary small intestinal adenocarcinoma is increasing but is still low.Its frequency is approximately 3%of that of colorectal adenocarcinoma.Considering that the small intestine occupies 90%of the surface area of the gastrointestinal tract,small intestinal adenocarcinoma is very rare.The main site of small intestinal adenocarcinoma is the proximal small intestine.Based on this characteristic,dietary animal proteins/lipids and bile concentrations are implicated and reported to be involved in carcinogenesis.Since most nutrients are absorbed in the proximal small intestine,the effect of absorbable intestinal content is a suitable explanation for why small intestinal adenocarcinoma is more common in the proximal small intestine.The proportion of aerobic bacteria is high in the proximal small intestine,but the absolute number of bacteria is low.In addition,the length and density of villi are greater in the proximal small intestine.However,the involvement of villi is considered to be low because the number of small intestinal adenocarcinomas is much smaller than that of colorectal adenocarcinomas.On the other hand,the reason for the low incidence of small intestinal adenocarcinoma in the distal small intestine may be that immune organs reside there.Genetic and disease factors increase the likelihood of small intestinal adenocarcinoma.In carcinogenesis experiments in which the positions of the small and large intestines were exchanged,tumors still occurred in the large intestinal mucosa more often.In other words,the influence of the intestinal contents is small,and there is a large difference in epithelial properties between the small intestine and the large intestine.In conclusion,small intestinal adenocarcinoma is rare compared to large intestinal adenocarcinoma due to the nature of the epithelium.It is reasonable to assume that diet is a trigger for small intestinal adenocarcinoma. | Shunji Fujimori Ryohei Hamakubo Aitoshi Hoshimoto Takayoshi Nishimoto Jun Omori Naohiko Akimoto Shu Tanaka Atsushi Tatsuguchi Katsuhiko Iwakiri | 2022 | World Journal of Gastroenterology2022，28，39： | 0 |
| 19 | Effectiveness of patient education focusing on circadian pain rhythms:A case report and review of literature显示文摘BACKGROUND Neuropathic pain management should aim at improving quality of life and daily living activities of patients;therefore,emphasis should be placed on pain management including understanding the pain patterns during daily activity.Therefore,lifestyle guidance should be based on a detailed understanding of pain;however,previous studies commonly evaluated pain intensity at a single point in time.We report a case on patient education intervention based on the relationship between pain circadian rhythms and detailed physical activity during the day.CASE SUMMARY A man in his 60s,who suffered a brachial plexus injury in a traffic accident,presented with neuropathic pain.Early assessment of the importance of daily living activities to the patient,pain rhythmicity,and physical activity,was performed.The early assessments showed that the pain intensity was lower on days when more light-intensity physical activity(LIPA)was performed,than on days when less LIPA was performed.Consequently,patient education focused on methods to decrease the pain intensity that tended to worsen in the afternoon,and encouraged behavioral changes by suggesting the patient to take walks,which could be used to maintain LIPA in the afternoon.On reassessment,the afternoon LIPA,which had been the focus of attention,had increased and a change was noted in the circadian rhythm of pain.CONCLUSION Patient education based on a composite assessment elicited positive results in relation to the pain circadian rhythm and physical activity. | Yoichi Tanaka Gosuke Sato Ryota Imai Michihiro Osumi Hayato Shigetoh Ren Fujii Shu Morioka | 2021 | World Journal of Clinical Cases2021，9，17： | 0 |
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