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| 1 | Cold-chain food contamination as the possible origin of COVID-19 resurgence in Beijing显示文摘COVID-19,caused by SARS-CoV-2[1,2],has been contained in China through stringent non-pharmaceutical interventions.Border control and quarantine have effectively prevented the virus from being spread by infected travellers,but the risk of resurgence caused by other routes of introduction and transmission remains unclear,and current strategies to prevent resurgence could be flawed.Since July,SARS-CoV-2 RNA contaminations in frozen food imported from countries with ongoing epidemics have been reported in nine provinces in China[3,4].However,there is no robust evidence of COVID-19 outbreaks initiated by environmentto-human transmission.Here we add to evidence of such transmission by investigating the recent COVID-19 resurgence in Beijing. | Xinghuo Pang Lili Ren Shuangsheng Wu Wentai Ma Jian Yang Lin Di Jie Li Yan Xiao Lu Kang Shichang Du Jing Du Jing Wang Gang Li Shuguang Zhai Lijuan Chen Wenxiong Zhou Shengjie Lai Lei Gao Yang Pan Quanyi Wang Mingkun Li Jianbin Wang Yanyi Huang Jianwei Wang COVID-19 Field Response Group COVID-19 Laboratory Testing Group | 2020 | National Science Review2020，7，12： | 51 |
| 2 | The Hardy Rubber Tree Genome Provides Insights into the Evolution of Polyisoprene Biosynthesis显示文摘Eucommia ulmoides,也叫的强壮的橡胶树,是一棵经济地重要的树;然而,它的染色体顺序的缺乏 ?限制基本生物研究和这植物种的应用研究。这里,我们在场它的 1.2-Gb 染色体的一个高质量的集会(支架 N50 ?=? 1.88 Mb ) 与至少 26 ? 为 E 的 723 预言的基因。ulmoides,顺序 Garryales 的首先定序的染色体,它用联合定序的 Illumina 的综合策略被获得,定序的 PacBio,和印射的 BioNano。作为到 lamiids 和 campanulids 的姐妹 taxon, E。ulmoides 经历了三倍由核心 eudicots 而是没有进一步整个染色体的复制分享了的一个古老的染色体 ? 在最后 1.25 亿年里。E。ulmoides 为涉及压力回答和第二等的代谢物的生合成的多重基因展出高表达式层次或基因数字扩大,它可以说明它的可观的环境适应性。与橡胶树(Hevea brasiliensis ) 相对照,它生产 cis 聚异式戊二我烯, E。ulmoides 演变综合经由 farnesyl diphosphate synthases (FPS ) 的长链的 trans 聚异式戊二我烯。而且, FPS 和橡胶延伸 factor/small 橡胶粒子蛋白质基因家庭从 H 独立地被扩展。brasiliensis 系。这些结果提供新卓见进 E. 的生物学 ? ulmoides 和聚异式戊二我烯生合成的起源。 | Ta-na Wuyun Lin Wang Huimin Liu Xuewen Wang Liangsheng Zhang Jeffrey L. Bennetzen Tiezhu Li Lirong Yang Panfeng Liu Lanying Du Lu Wang Mengzhen Huang Jun Qing Iili Zhu Wenquan Bao Hongguo Li Qingxin Du Jingle Zhu Hong Yang Shuguang Yang Hui Liu Hui Yue Jiang Hu Suoliang Yu Yu Tian Fan Liang Jingjing Hu Depeng Wang Ruiwen Gao Dejun Li Hongyan Du | 2018 | Molecular Plant2018，11，3： | 24 |
| 3 | ^(40)Ar/^(39)Ar isochron ages of lawsonite blueschists from Jiuquan in the northern Qilian Mountain,NW China,and their tectonic implications显示文摘Using laser 40Ar/39Ar dating method,we have gotten the metamorphic ages of lawsonite blueschist and epidote blueschist from Jiuquan,northern Qilian Mountain,NW China.The high quality laser 40Ar/39Ar dating of glaucophane from lawsonite blueschist gives an isochron age of 413±5 Ma.The isochron age obtained from phengite in epidote blueschist is 415±7 Ma.These data,combining with peak metamorphic P-T conditions and regional geological setting,allow us to infer that the lower limit of the ages of the prograde subduction metamorphism from lawsonite blueschist facies to epidote blueschist facies occurred at ca.413-415 Ma,which also suggests that the formation of lawsonite blueschist in the northern Qilian Mountain maybe resulted from the corner flow in the cold subduction zone.This study shows that the final closing time of the northern Qilian remnant oceanic basin is about 413-415 Ma,which also represents the convergent age between the North China Craton and the Qaidam block. | LIN YiHui ZHANG LiFei JI JianQing WANG QianJie SONG ShuGuang | 2010 | Chinese Science Bulletin2010，55，19： | 15 |
| 4 | Tolerance of VA Mycorrhizal Fungi to Soil Acidity显示文摘A 45-day greenhouse experiment was carried out to determine effect of vesicular-arbuscular (VA) mycorrhizal fungi on colonization rate, plant height, plant growth, hyphae length, total Al in the plants, exchangeable Al in the soil and soil pH by comparison at soil pH 3.5, 4.5 and 6.0. Plant mung bean (Phaseolus radiatus L.) and crotalaria (Crotalaria mucronata Desv.) were grown with and without VA mycorrhizal fungi in pots with red soil. Ten VA mycorrhizal fungi strains were tested, including Glomus epigaeum (No. 90001), Glomus caledonium (No. 90036), Glomus mosseae (No. 90107), Acaulospora spp. (No. 34), Scutellospora heterogama (No. 36), Scutellospora calospora (No. 37), Glomus manihotis (No. 38), Gigaspora spp. (No. 47), Glomus manihotis (No. 49), and Acaulospora spp. (No. 53). Being the most tolerant to acidity, strain 34 and strain 38 showed quicker and higher-rated colonization without lagging, three to four times more in number of nodules, two to four times more in plant dry weight, 30% to 60% more in hyphae length, lower soil exchangeable Al, and higher soil pH than without VA mycorrhizal fungi (CK). Other strains also could improve plant growth and enhance plant tolerance to acidity, but their effects were not marked. This indicated that VA mycorrhizal fungi differed in the tolerance to soil acidity and so did their inoculation effects. In the experiment, acidic soil could be remedied by inoculation of promising VA mycorrhizal fungi tolerant of acidity. | LIN XIANGUI, WANG SHUGUANG and SHI YAQIN Institute of Soil Science, the Chinese Academy of Soil Sciences, Nanjing 210008 (China) | 2001 | Pedosphere2001，11，2： | 10 |
| 5 | Predictive factors associated with gefitinib response in patients with advanced non-small-cell lung cancer(NSCLC)显示文摘Purpose: A number of different clinical characteristics have been reported to singly correlate with therapeutic activity of epidermal growth factor receptor(EGFR) tyrosine kinase inhibitors(TKIs) in advanced non-small-cell lung cancer(NSCLC). This study aimed to identify predictive factors associated with prognostic benefits of gefitinib.Patients and methods: EGFR gene typing in 33 advanced NSCLC patients received gefitinib(250 mg/day) were analyzed with mutant-enriched PCR assay. Gefitinib response was evaluated with potential predictive factors retrospectively.Results: The overall objective response rate(ORR) and median progression-free survival(PFS) in the 33 patients treated by gefitinib were 45.5% and 3.0(2.0-4.0) months. The ORR and median PFS in EGFR gene mutation patients were significantly higher/longer than those in EGFR gene wild-type patients(P<0.01). Similarly, the ORR and median PFS in non-smoker patients were significantly higher/longer than those in smoker patients(P<0.05, P<0.01, respectively). However, no difference for ORR and median PFS occurred between male and female patients. Logistic multivariate analysis showed that only EGFR mutated gene was significantly associated with the ORR(P<0.01). Both EGFR mutated gene and non-smoker were the major factors that contributed to PFS(P<0.05). Conclusions: EGFR mutated gene and non-smoker status are potential predictors for gefitinib response in NSCLC patients. | Lian Chen Rui Chen Zhe Zhu Yichen Zhang Zhengwei Wen Yun Li Xiaoming Li Yuwen Luo Liyu Ma Shuguang Lin Xin Chen | 2014 | Chinese Journal of Cancer Research2014，26，4： | 7 |
| 6 | Electronic-property dependent interactions between tetracycline and graphene nanomaterials in aqueous solution显示文摘Understanding the interactions between graphene nanomaterials(GNMs) and antibiotics in aqueous solution is critical to both the engineering applications of GNMs and the assessment of their potential impact on the fate and transport of antibiotics in the aquatic environment. In this study, adsorption of one common antibiotic, tetracycline, by graphene oxide(GO) and reduced graphene oxide(RGO) was examined with multi-walled carbon nanotubes(MWCNTs) and graphite as comparison. The results showed that the tetracycline adsorption capacity by the four selected carbonaceous materials on the unit mass basis followed an order of GO > RGO > MWCNTs > graphite. Upon normalization by surface area,graphite, RGO and MWCNTs had almost the same high tetracycline adsorption affinity while GO exhibited the lowest. We proposed π-electron-property dependent interaction mechanisms to explain the observed different adsorption behaviors. Density functional theory(DFT) calculations suggested that the oxygen-containing functional groups on GO surface reduced its π-electron-donating ability, and thus decreased the π-based interactions between tetracycline and GO surface. Comparison of adsorption efficiency at different p H indicated that electrostatic interaction also played an important role in tetracycline-GO interactions. Site energy analysis confirmed a highly heterogeneous distribution of the binding sites and strong tetracycline binding affinity of GO surface. | Lin He Fei-fei Liu Mengyao Zhao Zhen Qi Xuefei Sun Muhammad Zaheer Afzal Xiaomin Sun Yanhui Li Jingcheng Hao Shuguang Wang | 2018 | Journal of Environmental Sciences2018，30，4： | 4 |
| 7 | Anti-diabetic and anti-hyperlipidemic effects of sea cucumber(Cucumaria frondosa) gonad hydrolysates in type Ⅱ diabetic rats显示文摘The present study investigated the anti-diabetic activity and potential mechanisms of sea cucumber gonad hydrolysates(SCGH)in a rat model of type II diabetes induced by streptozotocin(STZ)combined with high-fat diet(HFD).Results showed that SCGH significantly reduced water intake,fasting blood glucose level and glycated hemoglobin level.Moreover,the oral glucose tolerance,insulin resistance and plasma lipid level in diabetic rats were also alleviated.Furthermore,histological analysis showed that SCGH effectively protected the tissue structure of liver.In addition,mechanism studies showed that SCGH improved glucose metabolism via activating the IRS/Akt signaling pathway,and promoted lipid metabolism via activating the AMPK signaling pathway.In summary,these findings suggested that SCGH have potential anti-diabetic effects by improving insulin resistance and lipid metabolism disorders. | Tingting Wang Lin Zheng Shuguang Wang Mouming Zhao Xiaoling Liu | 2022 | Food Science and Human Wellness2022，11，6： | 3 |
| 8 | Review on corrosion and corrosion scale formation upon unlined cast iron pipes in drinking water distribution systems显示文摘The qualified finished water from water treatment plants(WTPs) may become discolored and deteriorated during transportation in drinking water distribution systems(DWDSs), which affected tap water quality seriously. This water stability problem often occurs due to pipe corrosion and the destabilization of corrosion scales. This paper provides a comprehensive review of pipe corrosion in DWDSs, including corrosion process, corrosion scale formation, influencing factors and monitoring technologies utilized in DWDSs. In terms of corrosion process, corrosion occurrence, development mechanisms, currently applied assays, and indices used to determine the corrosion possibility are summarized, as well as the chemical and bacterial influences. In terms of scale formation, explanations for the nature of corrosion and scale formation mechanisms are discussed and its typical multilayered structure is illustrated. Furthermore, the influences of water quality and microbial activity on scale transformation are comprehensively discussed. Corrosion-related bacteria at the genus level and their associated corrosion mechanism are also summarized. This review helps deepen the current understanding of pipe corrosion and scale formation in DWDSs, providing guidance for water supply utilities to ensure effective measures to maintain water quality stability and guarantee drinking water safety. | Haiya Zhang Dibo Liu Lvtong Zhao Jun Wang Shuguang Xie Shuming Liu Pengfei Lin Xiaojian Zhang Chao Chen | 2022 | Journal of Environmental Sciences2022，34，7： | 2 |
| 9 | Anatomical characteristics of fusoid cells and vascular bundles in Fargesia yunnanensis leaves显示文摘As of today, the functions of fusoid cell, and the transport and loading pathways of photoassimilate in bamboo leaves are still not clear. In this paper, the leaves of Fargesia yunnanensis from a greenhouse and the wild were respectively used as samples to analyze the anatomical characteristics of fusoid cells and vascular bundles.The results showed that the bamboo leaves from greenhouse got shorter and thinner with fewer layers of palisade parenchyma cells than those from the wild. The volumes of fusoid cells were also increased. Fusoid cells originated from a huge parenchyma cell as testified by the observed nuclei. Several fusoid cells usually formed one cell complex close to the midrib. Crystals were detected in fusoid cells but no pits or plasmodesmata on their walls, suggesting that fusoid cells had the function of regulating water. The presence of fusoid cells determined the major difference between a leaf blade and sheath. There were prominent chloroplasts with simple stroma lamellae in the parenchymatous bundle sheath cells and starch grains were also observed in these chloroplast. Photoassimilates could be transported across vascular bundle sheath via symplasmic pathways for an abundant of plasmodesmata in sheath cell walls, and transported into phloem tube by apoplastic pathway as there were no pits in the walls of companion cells and phloem tubes. | Shuguang Wang Hui Zhang Shuyan Lin Chungyun Hse Yulong Ding | 2016 | Journal of Forestry Research2016，27，6： | 2 |
| 10 | Evolution of Neolithic site distribution(9.0–4.0 ka BP) in Anhui,East China显示文摘Based on archaeological surveys of Neolithic cultural development and GIS spatial analysis,this study reproduced the main characteristics of temporal distribution and settlement selection of the sites from the Neolithic Age in Anhui and identified a relationship between environmental evolution and human activity.The results show that altitude,slope direction,and slope gradient were consistent among the settlements at different stages of the Neolithic Age in Anhui,and the sites were mostly distributed in hilly and plain areas on southeast-or south-facing slopes of low gradients close to rivers.We determined that early Neolithic Age(9.0–7.0 ka BP) sites were scattered in small numbers and likely had little cultural exchange with communities of other provinces.The environmental characteristics of various regions in Anhui indicated that the climate was warm and humid with extensive water distribution.The sites of the mid Neolithic Age(7.0–5.0 ka BP) increased rapidly with wide distribution.They were mainly distributed in the plain area north of the Huaihe River and the southwestern areas of Anhui.In the mid Neolithic Age,the warm and humid climate gradually dried,and our ancestors slowly developed cultural exchanges.The largest number of sites existed during the late Neolithic Age(5.0–4.0 ka BP),and were distributed throughout the province.During this period,the overall climate was relatively dry,but humans could still obtain water and other resources through migration.The relatively benign climate facilitated cultural interaction and exchange,which increased during this time,and the Wanjiang culture matured.We also determined that as early civilization evolved,cultures in different regions responded differently to environmental changes.In humid subtropical regions,especially in low-lying plains and areas beside lakes,rivers,and coastal areas,the relatively dry climate in the late period of the middle Holocene,prefaced by a period of high humidity,was conducive to the development of human culture.The evidence from the Neolithic settlements in Anhui therefore reflects this subtropical man-land relationship between cultural development and environmental conditions. | WU Li SUN Xiaoling SUN Wei ZHU Cheng ZHU Tongxin LU Shuguang ZHOU Hui GUO Qingchun GUAN Houchun XIE Wei KE Rui LIN Guiping | 2020 | Journal of Geographical Sciences2020，30，9： | 2 |
| 11 | Isolation and Identification of Serotype O101 Bovine Pathogenic Escherichia coli with Multidrug Resistance显示文摘[Objective]The paper was to isolate and identify a multidrug-resistance bovine pathogenic Escherichia coli. [Method]The dead cases of calf diarrhea were collected from a large-scale beef cattle farm,and the isolated pathogen was conducted molecular identification,serological identification,drug sensitivity test,and mice pathogenicity test,respectively. Targeted therapy was undertaken thereafter to herds. [Result] One strain of bovine pathogenic E. coli,serotype O101 with strong multidrug resistance and high pathogenicity to mice,was successfully isolated. It was used to develop sensitive drug for timely treating follow-up diarrhea calves,and successfully controlled calf diarrhea in the farm. [Conclusion]The results provide a basis for effective prevention and control of bovine colibacillosis. | Li Shuguang Liu Xiaoyun Wang Yumao Li Feng Lin Chuwen Shen Zhiqiang Li Jinlin | 2017 | Animal Husbandry and Feed Science2017，9，5： | 1 |
| 12 | Removal of 1,1,1-trichloroethane from aqueous solution by a sono-activated persulfate process显示文摘 | Bingzhi Li Lin Li Kuangfei Lin Wei Zhang Shuguang Lu Qishi Luo | 2012 | Ultrasonics - Sonochemistry2012，，： | 1 |
| 13 | Role of P-glycoprotein in the intesti-nal absorption of tanshinoneⅡA,a major active ingredient inthe root of Salvia miltiorrhiza Bunge显示文摘 | Yu Xiyong Lin Shuguang | 2007 | Current Drug Metab2007，8，4： | 1 |
| 14 | Research on active heave compensation for offshore rig显示文摘 | WANG Lin LIU Shuguang | 2012 | Proceedings of 2012 Interna- tional Conference on Mechanic Automation and Control Engineering2012，，： | 1 |
| 15 | Insulin-like growth factor 1 enhances the migratory capacity of mesenchymal stem cells显示文摘 | Yangxin Li XiYong Yu ShuGuang Lin XiaoHong Li Saidan Zhang Yao-Hua Song | 2007 | Biochemical and Biophysical Research Communications2007，，3： | 1 |
| 16 | The neuroprotective effect of walnut-derived peptides against glutamate-induced damage in PC12 cells: mechanism and bioavailability显示文摘In our previous study, defatted walnut meal hydrolysate(DWMH) could attenuate D-galactose-induced acute memory deficits in vivo, and six potent active peptides including WSREEQ, WSREEQE, WSREEQEREE, ADIYTE, ADIYTEEAG and ADIYTEEAGR were identified. The aim of this study was to investigate the possible mechanism underlying their neuroprotective effects on glutamate-induced apoptosis in PC12 cells and their digestive stability. Results showed that all these peptides could attenuate the reduction of cell viability caused by glutamate in PC12 cells, especially WSREEQEREE and ADIYTEEAGR. The addition of Arg residue in WSREEQEREE and ADIYTEEAGR might be the potential reason for their stronger protective effects. Additionally, these two peptides possibly protected PC12 cells against glutamate-induced apoptosis via activating intracellular antioxidant defence(superoxide dismutase(SOD) and glutathione peroxidase(GSH-Px)) through Kelch-like ECH-associated protein 1(Keap1) inhibition, inhibiting ROS production, Ca;influx and mitochondrial membrane potential(MMP) collapse as well as regulating the expression of apoptosis-related proteins(Bax and Bcl-2). This might be due to the presence of Trp, Tyr and Arg in these two peptides. However, encapsulation of WSREEQEREE and ADIYTEEAGR should be considered based on their digestive sensibility during in vitro gastrointestinal digestion. | Shuguang Wang Lin Zheng Tiantian Zhao Qi Zhang Guowan Su Mouming Zhao | 2022 | Food Science and Human Wellness2022，11，4： | 1 |
| 17 | Insulin-like growth factor 1 enhances the migratory capacity of mesenchymal stem cells 显示文摘 | Li Yangxin Yu Xiyong Lin Shuguang | 2007 | Biochem Biophys Res Commun2007，356，： | 1 |
| 18 | Shoot proliferation and callus regeneration from nodular buds of Drepanostachyum luodianense显示文摘This research reports on an efficient shoot proliferation and callus regeneration system for bamboo.Young, semi-lignified branches with one lateral bud from Drepanostachyum luodianense(Yi et R. S. Wang) Keng f.were used as explants. Disinfection with 0.1% HgCl2 for 8 min was the optimum treatment and the best medium for bud initiation was Murashige and Skoog(MS) medium containing 3.0 mg L-16-benzyladenine(BA). Multiple shoots were induced from nodal shoot segments on MS medium containing 5.0 mg L-1 BA, 0.5 mg L-1 kinetin(Kin), and 1.0 mg L-1 naphthaleneacetic acid(NAA). The highest frequency of callus formation(65.6%) was on MS medium containing 4.0 mg L-12,4-dichlorophenoxyacetic acid(2, 4-D), 0.5 mg L-1 NAA, and 0.1 mg L-1 thidiazuron(TDZ). The optimum medium for callus proliferation was MS medium with 4 mg L-12,4-D, 0.5 mg L-1 TDZ and 0.5 mg L-1 NAA, and the optimum hormone combination was 4 mg L-1 BA ? 0.5 mg L-1 NAA for callus redifferentiation(up to 85.6%). A 100% rooting was achieved on MS medium supplemented with 2.0 mg L-1 NAA and 0.5 mg L-13-indole butyric acid(IBA). Rooted plantlets were acclimatized in a greenhouse in humus soil ? perlite(1:1) substrate. These micropropagated callus induction and regeneration systems for bamboo will be useful for genetic engineering and multiplication. | Shuyan Lin Guohua Liu Tingting Guo Li Zhang Shuguang Wang Yulong Ding | 2019 | Journal of Forestry Research2019，30，6： | 1 |
| 19 | Pathological and computed tomography findings of lymphoepithelioma?likegastric carcinoma with epithelioid granulomas: A case report显示文摘 | Shuguang Liu Long Jin Xiaoyan Xu Ni Lin Bin Lei Hong Shen | 2013 | Oncology Letters2013，，2： | 1 |
| 20 | EMD analysis of solar insolation显示文摘 | Lin Zhenshan Wang Shuguang | | 0，，： | 1 |
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