|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Arbitrary polarization conversion dichroism metasurfaces for all-in-one full Poincare sphere polarizers显示文摘The control of polarization,an essential property of light,is of broad scientific and technological interest.Polarizers are indispensable optical elements for direct polarization generation.However,arbitrary polarization generation,except that of common linear and circular polarization,relies heavily on bulky optical components such as cascading linear polarizers and waveplates.Here,we present an effective strategy for designing all-in-one full Poincare sphere polarizers based on perfect arbitrary polarization conversion dichroism and implement it in a monolayer all-dielectric metasurface.This strategy allows preferential transmission and conversion of one polarization state located at an arbitrary position on the Poincare sphere to its handedness-flipped state while completely blocking its orthogonal state.In contrast to previous methods that were limited to only linear or circular polarization,our method manifests perfect dichroism of nearly 100%in theory and greater than 90%experimentally for arbitrary polarization states.By leveraging this attractive dichroism,our demonstration of the generation of polarization beams located at an arbitrary position on a Poincare sphere directly from unpolarized light can substantially extend the scope of meta-optics and dramatically promote state-of-the-art nanophotonic devices. | Shuai Wang Zi-Lan Deng Yujie Wang Qingbin Zhou Xiaolei Wang Yaoyu Cao Bai-Ou Guan Shumin Xiao Xiangping Li | 2021 | Light(Science & Applications)2021，10，2： | 6 |
| 2 | Mesenchymal stem cell treatment improves outcome of COVID-19 patients via multiple immunomodulatory mechanisms显示文摘The infusion of coronavirus disease 2019(COVID-19)patients with mesenchymal stem cells(MSCs)potentially improves clinical symptoms,but the underlying mechanism remains unclear.We conducted a randomized,single-blind,placebo-controlled(29 patients/group)phase II clinical trial to validate previous findings and explore the potential mechanisms.Patients treated with umbilical cord-derived MSCs exhibited a shorter hospital stay(P=0.0198)and less time required for symptoms remission(P=0.0194)than those who received placebo.Based on chest images,both severe and critical patients treated with MSCs showed improvement by day 7(P=0.0099)and day 21(P=0.0084).MSC-treated patients had fewer adverse events.MSC infusion reduced the levels of C-reactive protein,proinflammatory cytokines,and neutrophil extracellular traps(NETs)and promoted the maintenance of SARS-CoV-2-specific antibodies.To explore how MSCs modulate the immune system,we employed single-cell RNA sequencing analysis on peripheral blood.Our analysis identified a novel subpopulation of VNN2+hematopoietic stem/progenitorlike(HSPC-like)cells expressing CSF3R and PTPRE that were mobilized following MSC infusion.Genes encoding chemotaxis factors—CX3CR1 and L-selectin—were upregulated in various immune cells.MSC treatment also regulated B cell subsets and increased the expression of costimulatory CD28 in T cells in vivo and in vitro.In addition,an in vivo mouse study confirmed that MSCs suppressed NET release and reduced venous thrombosis by upregulating kindlin-3 signaling.Together,our results underscore the role of MSCs in improving COVID-19 patient outcomes via maintenance of immune homeostasis. | Rongjia Zhu Tingdong Yan Yingmei Feng Yan Liu Hongcui Cao Gongxin Peng Yanlei Yang Zhen Xu Jingqi Liu Wei Hou Xiaoyue Wang Zhe Li Luchan Deng Shihua Wang Jing Li Qin Han Hongling Li Guangliang Shan Yinghao Cao Xingyan An Jianshe Yan Zhonghui Zhang Huafei Li Xuebin Qu Jiaqi Zhu Shumin Zhou Jiao Wang Fengchun Zhang Jinming Gao Ronghua Jin Dayong Xu Yan-Qing Ma Tao Huang Shuang Peng Zhi Zheng Ilia Stambler Eric Gilson Lee Wei Lim Alexey Moskalev Antonio Cano Sasanka Chakrabarti Brun Ulfhake Huanxing Su Haoying Xu Sihuan Xu Feng Wei Holly MBrown-Borg Kyung-Jin Min Georgina Ellison-Hughes Calogero Caruso Kunlin Jin Robert Chunhua Zhao | 2021 | Cell Research2021，31，12： | 5 |
| 3 | Phyllotaxis-inspired nanosieves with multiplexed orbital angular momentum显示文摘Nanophotonic platforms such as metasurfaces,achieving arbitrary phase profiles within ultrathin thickness,emerge as miniaturized,ultracompact and kaleidoscopic optical vortex generators.However,it is often required to segment or interleave independent sub-array metasurfaces to multiplex optical vortices in a single nano-device,which in turn affects the device’s compactness and channel capacity.Here,inspired by phyllotaxis patterns in pine cones and sunflowers,we theoretically prove and experimentally report that multiple optical vortices can be produced in a single compact phyllotaxis nanosieve,both in free space and on a chip,where one meta-atom may contribute to many vortices simultaneously.The time-resolved dynamics of on-chip interference wavefronts between multiple plasmonic vortices was revealed by ultrafast time-resolved photoemission electron microscopy.Our nature-inspired optical vortex generator would facilitate various vortex-related optical applications,including structured wavefront shaping,free-space and plasmonic vortices,and high-capacity information metaphotonics. | Zhongwei Jin David Janoschka Junhong Deng Lin Ge Pascal Dreher Bettina Frank Guangwei Hu Jincheng Ni Yuanjie Yang Jing Li Changyuan Yu Dangyuan Lei Guixin Li Shumin Xiao Shengtao Mei Harald Giessen Frank Meyer zu Heringdorf Cheng-Wei Qiu | 2021 | eLight2021，1，1： | 3 |
| 4 | Association of PDE4D and IL-1 gene polymorphism with ischemic stroke in a Han Chinese population显示文摘 | Nan Li Zhiyi He Jialiang Xu Fang Liu Shumin Deng Hui Zhang | 2009 | Brain Research Bulletin2009，，1： | 1 |
| 5 | Neural symbolic reasoning with knowledge graphs:Knowledge extraction,relational reasoning,and inconsistency checking显示文摘Knowledge graphs(KGs)express relationships between entity pairs,and many real-life problems can be formulated as knowledge graph reasoning(KGR).Conventional approaches to KGR have achieved promising performance but still have some drawbacks.On the one hand,most KGR methods focus only on one phase of the KG lifecycle,such as KG completion or refinement,while ignoring reasoning over other stages,such as KG extraction.On the other hand,traditional KGR methods,broadly categorized as symbolic and neural,are unable to balance both scalability and interpretability.To resolve these two problems,we take a more comprehensive perspective of KGR with regard to the whole KG lifecycle,including KG extraction,completion,and refinement,which correspond to three subtasks:knowledge extraction,relational reasoning,and inconsistency checking.In addition,we propose the implementation of KGR using a novel neural symbolic framework,with regard to both scalability and interpretability.Experimental results demonstrate that our proposed methods outperform traditional neural symbolic models. | Huajun Chen Shumin Deng Wen Zhang Zezhong Xu Juan Li Evgeny Kharlamov | 2021 | Fundamental Research2021，1，5： | 1 |
| 6 | Au Nanoparticles Loaded on Hollow TiO2 Microspheres with (001) Exposed Facets: a Strategy for Promoting Photocatalytic Performance显示文摘 | WANG Shumin YAN Xiaoxia ZHU Yan DENG Dongmei HE Haibo LUO Liqiang | 2018 | Chemical Research in Chinese Universities2018，34，5： | 1 |
| 7 | Discovery of small molecule Gαq/11 protein inhibitors against uveal melanoma显示文摘Constitutively activated G proteins caused by specific mutations mediate the development of multiple malignancies. The mutated Gaq/11 are perceived as oncogenic drivers in the vast majority of uveal melanoma(UM) cases, making directly targeting Gaq/11 to be a promising strategy for combating UM. Herein, we report the optimization of imidazopiperazine derivatives as Gaq/11 inhibitors, and identified GQ262 with improved Gaq/11 inhibitory activity and drug-like properties. GQ262 efficiently blocked UM cell proliferation and migration in vitro. Analysis of the apoptosis-related proteins, extracellular signal-regulated kinase(ERK), and yes-associated protein(YAP) demonstrated that GQ262 distinctly induced UM cells apoptosis and disrupted the downstream effectors by targeting Gaq/11directly. Significantly, GQ262 showed outstanding antitumor efficacy in vivo with good safety at the testing dose. Collectively, our findings along with the favorable pharmacokinetics of GQ262 revealed that directly targeting Gaq/11 may be an efficient strategy against uveal melanoma. | Yang Ge Jun-Jie Deng Jianzheng Zhu Lu Liu Shumin Ouyang Zhendong Song Xiaolei Zhang Xiao-Feng Xiong | 2022 | Acta Pharmaceutica Sinica B2022，12，8： | 1 |
| 8 | Hugan Qingzhi medication ameliorates hepatic steatosis by activating AMPK and PPARα pathways in L02 cells and HepG2 cells显示文摘 | JinJin Yin YanQin Luo HouLiang Deng ShuMin Qin WaiJiao Tang Lu Zeng BenJie Zhou | 2014 | Journal of Ethnopharmacology2014，，1： | 1 |
| 9 | Suggestion on further strengthening ultra-low emission standards for PM emission from coal-fired power plants in China显示文摘China has established the largest clean coal-fired power generation system in the world by accomplishing the technological transformation of coal-fired power plants(CFPPs)to achieve ultra-low emission.The potential for further particulate matter(PM)emission reduction to achieve near-zero emission for CFPPs has become a hotspot issue.In this study,PM emission from some ultra-low emission CFPPs adopting advanced air pollutant control technologies in China was reviewed.The results revealed that the average filterable particulate matter(FPM)concentration,measured as the total particulate matter(TPM)according to the current national monitoring standard,was(1.67±0.86)mg/m^(3),which could fully achieve the ultra-low emission standard for key regions(5 mg/m^(3)),but that achieving the near-zero emission standard was difficult(1 mg/m^(3)).However,the condensable particulate matter(CPM),with an average concentration of(1.06±1.28)mg/m^(3),was generally ignored during monitoring,which led to about 38.7%underestimation of the TPM.Even considering both FPM and CPM,the TPM emission from current CFPPs would contribute to less than 5%of atmospheric PM_(2.5) concentrations in the key cities and regions in China.Therefore,further reduction in FPM emission proposed by the near-zero emission plan of CFPPs may have less environmental benefit than emission control of other anthropogenic sources.However,it is suggested that the management of CPM emission should be strengthened,and a national standard for CPM emission monitoring based on the indirect dilution method should be established for CFPPs.Those measurements are helpful for optimal operation of air pollutant control devices and continuously promoting further emission reduction. | Jianguo Deng Shumin Wang Jiawei Zhang Yi Zhang Jingkun Jiang Yongzheng Gu Tao Han Lei Feng Jian Gao Lei Duan | 2023 | Journal of Environmental Sciences2023，，1： | 1 |
| 10 | Lanthanide-doped nanocrystals in high-Q microtoroids for stable on-chip white-light lasers显示文摘The plentiful energy states of lanthanide(Ln^(3+))-doped nanomaterials make them very promising for on-chip integrated white-light lasers.Despite the rapid progresses,the Ln^(3+)-based white upconversion emissions are strongly restricted by their low upconversion quantum efficiency and the color stability.Herein,we combine the CaF_(2):Yb_(35)Tm_(1.5)Er_(0.5)nanocrystals and the high-Q microtoroids,and experimentally demonstrate the chip-integrated stable white-light laser.By optimizing the sizes,density,and distributions of Ln^(3+)-doped nanocrystals,the Q factors of Ln^(3+)-doped microtoroids are maintained as high as 5×10^(5).The strong light matter interaction in high-Q microtoroids greatly enhances the upconversion emission and dramatically reduces the laser thresholds at 652 nm,545 nm,and 475 nm to similarly low values(1.89-2.10 m J cm^(-2)).Consequently,robust white-light microlaser has been experimentally achieved from a single microtoroid.This research has paved a solid step toward the chip-scale integrated broadband microlasers. | LIMIN JIN ZHUO LIU YUQI ZHANG YUNKAI WU YILIN LIU HUACHUN DENG QINGHAI SONG SHUMIN XIAO | 2022 | Photonics Research2022，10，7： | 1 |
| 11 | A Methodology Framework for Regional Land-use Change Studies based on Landsat TM images: A Case Study in Northeast China显示文摘Land-use change is an important aspect of global environment change. It is, in a sense, the direct result of human activities influencing our physical environment. This paper analyzed the land-use change in Northeast China during 1985-2000 based on Landsat TM images. It divides Northeast China into five land-use zones based on the dynamic degree model of land-use: woodland/grassland-arable land conversion zone, dry land-paddy field conversion zone; urban expansion zone, interlocked zone of farming and pasturing and reclamation and abandon zone. The findings include the obvious increase of cropland area, paddy field and dry land increased by 75 and 276 thousand hm2 respectively; urban areas expanded rapidly, areas of town and rural residence increased by 76.8 thousand hm2; areas of forests and grassland decreased sharply with the amounts of 1399 and 1521 thousand hm2 respectively; areas of water body and unused land increased by 148 and 514 thousand hm2 respectively. This paper also discusses the | Deng Xiangzheng , Huang Shumin , Zhan Jinyan & Zhao Tao Center for Chinese Agricultural Policy, Chinese Academy of Sciences, Beijing 100101 Institute of Geographical Sciences and Natural Resources Research, Chinese Academy of Sciences, Beijing 100101 Anthropology Department, Iowa State University, Ames, Iowa 50010-1050, USA, | 2004 | Chinese Journal of Population,Resources and Environment2004，2，4： | 0 |
| 12 | Primary Studies on Biological Effects of SMMC-7721 Irradiated with 25 MeV/u ^(40)Ar^(14+)显示文摘Primary Studies on Biological Effects of SMMC-7721 Irradiated with 25 MeV/u ^(40)Ar^(14+)PrimaryStudiesonBiologicalEffectsofSM... | Zhou Guangming Chen Weiqiang Wei Zengquan Li Wenjian Xie Hongmei Deng Bingrong Li Qiang Han Guangwu Zhang Shumin Jiang Xinzhou Huang Tao Gao Qingaiang and Yang Hanmin | 1995 | IMP & HIRFL Annual Report1995，，0： | 0 |
| 13 | Clear cell renal cell carcinoma located in sinus renalis confused with renal pelvis mass in image显示文摘58-year-old Chinese woman presented with a mass in right renal pelvis incidentally detected by ultrasonography(Fig.1A).No positive signs were found by physical examination,and urinalysis was also normal.Enhanced computed tomography(CT)of abdomen displayed a polycystic mass of 2.3 cm2.1 cm1.6 cm in right sinus renalis(Fig.1B and C)with ample blood perfusion in arterial phase(Fig.1B)and less perfusion in venous phase(Fig.1C). | Pengjie Wu Dong Wei Liqing Zhang Shumin Deng Gang Zhu Jianye Wang | 2015 | Asian Journal of Urology2015，2，3： | 0 |
| 14 | Neuroprotective effect of Eleutheroside B on 1-methyl-4-phenylpyridinium ion-induced apoptosis in PC12 cells显示文摘Apoptosis and viability of PC12 cells following 1-methyl-4-phenylpyridinium ion (MPP+)-induced injury were monitored by flow cytometry, following Annexin V-propidium iodide double labeling, and 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay, respectively. The release of lactate dehydrogenase, superoxide dismutase activity and levels of malondialdehyde were determined by UV spectrophotometry. The changes in mitochondrial membrane potential and the intracellular concentration of calcium were determined by flow cytometry, and the activity of caspase-3 was monitored by western blot. According to cell viability and apoptosis studies, MPP+-induced apoptosis in PC12 cells was inhibited in the presence of 10 μg/mL of Eleutheroside B. Our results indicate that the neuroprotective effect of Eleutheroside B, following MPP+-induced apoptosis in PC12 cells, involves increasing the anti-oxidative stress capacity of cells, maintaining the high-energy state of mitochondrial membrane potential, reducing intracellular calcium concentration and inhibiting caspase-3 activity. | Fang Lu Yang Dong Laijun Deng Shumin Liu Shihui Zhou Lifeng An Bo Tang | 2011 | Neural Regeneration Research2011，6，18： | 0 |
| 15 | Diversity,community structure,and quantity of eukaryotic phytoplankton revealed using 18S rRNA and plastid 16S rRNA genes and pigment markers:a case study of the Pearl River Estuary显示文摘Understanding consistencies and discrepancies in characterizing diversity and quantity of phytoplankton is essential for better modeling ecosystem change.In this study,eukaryotic phytoplankton in the Pearl River Estuary,South China Sea were investigated using nuclear 18S rRNA and plastid 16S or 23S rRNA genes and pigment analysis.It was found that 18S abundance poorly explained the variations in total chlorophyll a(Chl-a).However,the ratios of log-transformed 18S abundance to Chl-a in the major phytoplankton groups were generally environment dependent,suggesting that the ratio has potential as an indicator of the physiological state of phytoplankton.The richness of 18S-based operational taxonomic units was positively correlated with the richness of 16S-based amplicon sequence variants of the whole phytoplankton community,but insignifcant or weak for individual phytoplankton groups.Overall,the 18S based,rather than the 16S based,community structure had a greater similarity to pigment-based estimations.Relative to the pigment data,the proportion of haptophytes in the 18S dataset,and diatoms and cryptophytes in the 16S dataset,were underestimated.This study highlights that 18S metabarcoding tends to refect biomass-based community organization of eukaryotic phytoplankton.Because there were lower copy numbers of plastid 16S than 18S per genome,metabarcoding of 16S probably approximates cell abundance-based community organization.Changes in biomass organization of the pigment-based community were sensitive to environmental changes.Taken together,multiple methodologies are recommended to be applied to more accurately profle the diversity and community composition of phytoplankton in natural ecosystems. | Shumin Xu Guihao Li Cui He Yi Huang Dan Yu Huiwen Deng Zhuyin Tong Yichong Wang Christine Dupuy Bangqin Huang Zhuo Shen Jie Xu Jun Gong | 2023 | Marine Life Science & Technology2023，5，3： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员