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| 1 | Broadband diffusion of terahertz waves by multi-bit coding metasurfaces显示文摘The terahertz region is a special region of the electromagnetic spectrum that incorporates the advantages of both microwaves and infrared light waves.In the past decade,metamaterials with effective medium parameters or gradient phases have been studied to control terahertz waves and realize functional devices.Here,we present a new approach to manipulate terahertz waves by using coding metasurfaces that are composed of digital coding elements.We propose a general coding unit based on a Minkowski closed-loop particle that is capable of generating 1-bit coding(with two phase states of 0 and 180°),2-bit coding(with four phase states of 0,90°,180°,and 270°),and multi-bit coding elements in the terahertz frequencies by using different geometric scales.We show that multi-bit coding metasurfaces have strong abilities to control terahertz waves by designing-specific coding sequences.As an application,we demonstrate a new scattering strategy of terahertz waves—broadband and wide-angle diffusion—using a 2-bit coding metasurface with a special coding design and verify it by both numerical simulations and experiments.The presented method opens a new route to reducing the scattering of terahertz waves. | Li-Hua Gao Qiang Cheng Jing Yang Shao-Jie Ma Jie Zhao Shuo Liu Hai-Bing Chen Qiong He Wei-Xiang Jiang Hui-Feng Ma Qi-Ye Wen Lan-Ju Liang Biao-Bing Jin Wei-Wei Liu Lei Zhou Jian-Quan Yao Pei-Heng Wu Tie-Jun Cui | 2015 | Light(Science & Applications)2015，4，1： | 31 |
| 2 | Phylogeny and Classifcation of Prunus sensu lato (Rosaceae)显示文摘The classifcation of the economically important genus Prunus L.sensu lato(s.l.)is controversial due to the high levels of convergent or the parallel evolution of morphological characters.In the present study,phylogenetic analyses of ffteen main segregates of Prunus s.l.represented by eighty-four species were conducted with maximum parsimony and Bayesian approaches using twelve chloroplast regions(atpB-rbcL,matK,ndhF,psbA-trnH,rbcL,rpL16,rpoC1,rps16,trnS-G,trnL,trnL-F and ycf1)and three nuclear genes(ITS,s6pdh and SbeI)to explore their infrageneric relationships.The results of these analyses were used to develop a new,phylogeny-based classifcation of Prunus s.l.Our phylogenetic reconstructions resolved three main clades of Prunus s.l.with strong supports.We adopted a broad-sensed genus,Prunus,and recognised three subgenera corresponding to the three main clades:subgenus Padus,subgenus Cerasus and subgenus Prunus.Seven sections of subgenus Prunus were recognised.The dwarf cherries,which were previously assigned to subgenus Cerasus,were included in this subgenus Prunus.One new section name,Prunus L.subgenus Prunus section Persicae(T.T.Yü&L.T.Lu)S.L.Zhou and one new species name,Prunus tianshanica(Pojarkov)S.Shi,were proposed. | Shuo Shi Jinlu Li Jiahui Sun Jing Yu Shiliang Zhou | 2013 | Journal of Integrative Plant Biology2013，55，11： | 18 |
| 3 | The X-linked mental retardation gene PHF8 is a histone demethylase involved in neuronal differentiation显示文摘最近的研究在 PHF8 识别了变化,编码 JmjC 的 X 连接基因包含域的蛋白质,为 X 连接智力迟钝(XLMR ) 的一个原因的因素并且劈开 lip/cleft 腭。然而,内在的机制是未知的。这里,我们证明 PHF8 为 retinoic 酸受体(RAR ) 是 histone demethylase 和激活剂。尽管为 H3K4me3/2/1 和 H3K9me2/1 demethylation 的活动在细胞底的试金被检测, recombinant PHF8 在 vitro 展出了仅仅 H3K9me2/1 demethylase 活动,建议 PHF8 是其特性可以在 vivo 被调制的 H3K9me2/1 demethylase。重要地,在 XLMR 病人识别的变异的 PHF8 (在到丝氨酸的位置 279 点的本氨基丙酸) 在酶的活动是有缺点的,显示 histone demethylase 活动的损失有原因地与疾病的发作被连接。另外,我们证明 PHF8 经由一个 N 终端哲学博士手指领域明确地绑在 H3K4me3/2 肽。与为在 neuronal 区别的 PHF8 的一个角色一致,在鼠标的 PHF8 击倒胚胎的癌 P19 房间损害导致 RA 的 neuronal 区别,而 overexpression 野类型然而并非向 neuronal 区别的 F279S 变异的 PHF8 驱动器 P19 房间。而且,我们证明 PHF8 为 RAR 伪作为激活剂与 RAR 伪和功能交往。一起拿,我们的结果建议 PHF8 调制的 histone methylation 在 neuronal 区别起一个关键作用。 | Jihui Qiu Guang Shi Yuanhui Jia Jing Li Meng Wu Jiwen Li Shuo Dong Jiemin Wong | 2010 | Cell Research2010，20，8： | 16 |
| 4 | MR DIFFUSION WEIGHTED IMAGING FOR EVALUATION OF RADIOTHERAPEUTIC EFFECTS ON RABBIT VX2 TUMOR MODEL显示文摘Objective To investigate the feasibility of magnetic resonance (MR) diffusion weighted imaging (DWI) for evaluation of radiotherapeutic effects on rabbit VX2 tumor model. Methods Sixteen New Zealand white rabbits received a subcutaneous implantation of VX2 tumor cell suspension 0.5 mL (4×107 cells/mL) in their right thighs to set up tumor model. And 2 weeks later they were randomly divided into therapy group (Group T, n = 10) and control group (Group C, n = 6). Group T received radiotherapy at a single dose of 10 Gy. MR imaging (MRI) scan including short TI inversion recovery echo-planar imaging DWI, T1-weighted imaging (T1WI) and T2-weighted imaging (T2WI) sequences were performed 1 day prior to as well as 1 day, 2 days, 3 days and 7 days after radiotherapy. Group C received only MRI scan at the same time points without any treatment. MRI appearance on T2WI, T1WI, and DWI images was compared and tumor volume was calculated. Apparent diffusion coefficient (ADC) values of the tumor were evaluated in all cases. HE staining was used for pathological study. Results Necrosis (n = 8) and hemorrhage (n = 2) were seen gradually on T2WI and T1WI images of Group T after time point of day 2 after irradiation. In Group C, no obvious necrosis was found until day 7. There was no significant difference in tumor volume between the two groups before radiotherapy. After radiotherapy, tumors in Group T showed a gradual growth but not as obvious as Group C. There was a significant difference in tumor volume between the two groups from day 2 on (P < 0.05). ADC value changed dramatically right from the 1st day after radio- therapy in Group T [(0.99 ± 0.15) ×10-3 mm2/s for 1 day before radiotherapy, (1.23 ± 0.08) ×10-3, (1.45 ± 0.07) ×10-3, (1.63 ± 0.06) ×10-3, and (2.02 ± 0.18) ×10-3 mm2/s for day 1, 2, 3, and 7]; and ADC value had no significant changes after radiotherapy in Group C except day 7 [(1.07 ± 0.08) ×10-3 mm2/s for 1 day before radiotherapy, (1.03 ± 0.04) × 10-3, (1.05 ± 0.02) ×10-3, (1.05 ± 0.05) ×10-3, and (0.95 ± 0.07) ×10-3 mm2/s for day 1, 2, 3, and 7]. There was significant difference in ADC value between the two groups for each time point after radiotherapy (P < 0.01). Pathological study showed that the number of viable tumor cells in Group T decreased 1 day after radiotherapy, and the inflammatory cell infiltration was marked and almost all viable tumor cells disappeared by day 7 after radiotherapy. Conclusions DWI is a new promising technique for monitoring radiotherapy outcomes. ADC value may give a prior clue on physiological changes of radiotherapy before routine MRI could tell. | Shuo Li Hua-dan Xue Xin-hai Wang Fei Sun Bo Jiang Dong Liu Jing Lei Zheng-yu Jin | 2008 | Chinese Medical Sciences Journal2008，23，3： | 15 |
| 5 | MiR-27a Promotes Hepatocellular Carcinoma Cell Proliferation Through Suppression of its Target Gene Peroxisome Proliferator-activated Receptor γ显示文摘 | Shuo Li Jing Li Bing-Yuan Fei Dan Shao Yue Pan Zhan-Hao MO Bao-Zhen Sun Dan Zhang Xiao Zheng Ming Zhang Xue-Wen Zhang Li Chen | 2015 | Chinese Medical Journal2015，，7： | 15 |
| 6 | Humoral immune response to circulating SARS-CoV-2 variants elicited by inactivated and RBD-subunit vaccines显示文摘SARS-CoV-2 variants could induce immune escape by mutations on the receptor-binding domain(RBD)and N-terminal domain(NTD).Here we report the humoral immune response to circulating SARS-CoV-2 variants,such as 501Y.V2(B.1.351),of the plasma and neutralizing antibodies(NAbs)elicited by CoronaVac(inactivated vaccine),ZF2001(RBD-subunit vaccine)and natural infection.Among 86 potent NAbs identified by high-throughput single-cell VDJ sequencing of peripheral blood mononuclear cells from vaccinees and convalescents,near half anti-RBD NAbs showed major neutralization reductions against the K417N/E484K/N501Y mutation combination,with E484K being the dominant cause.VH3-53/VH3-66 recurrent antibodies respond differently to RBD variants,and K417N compromises the majority of neutralizing activity through reduced polar contacts with complementarity determining regions.In contrast,the 242–244 deletion(242–244Δ)would abolish most neutralization activity of anti-NTD NAbs by interrupting the conformation of NTD antigenic supersite,indicating a much less diversity of anti-NTD NAbs than anti-RBD NAbs.Plasma of convalescents and CoronaVac vaccinees displayed comparable neutralization reductions against pseudo-and authentic 501Y.V2 variants,mainly caused by E484K/N501Y and 242–244Δ,with the effects being additive.Importantly,RBD-subunit vaccinees exhibit markedly higher tolerance to 501Y.V2 than convalescents,since the elicited anti-RBD NAbs display a high diversity and are unaffected by NTD mutations.Moreover,an extended gap between the third and second doses of ZF2001 leads to better neutralizing activity and tolerance to 501Y.V2 than the standard three-dose administration.Together,these results suggest that the deployment of RBD-vaccines,through a third-dose boost,may be ideal for combating SARS-CoV-2 variants when necessary,especially for those carrying mutations that disrupt the NTD supersite. | Yunlong Cao Ayijiang Yisimayi Yali Bai Weijin Huang Xiaofeng Li Zhiying Zhang Tianjiao Yuan Ran An Jing Wang Tianhe Xiao Shuo Du Wenping Ma Liyang Song Yongzheng Li Xiang Li Weiliang Song Jiajing Wu Shuo Liu Xuemei Li Yonghong Zhang Bin Su Xianghua Guo Yangyang Wei Chuanping Gao Nana Zhang Yifei Zhang Yang Dou Xiaoyu Xu Rui Shi Bai Lu Ronghua Jin Yingmin Ma Chengfeng Qin Youchun Wang Yingmei Feng Junyu Xiao Xiaoliang Sunney Xie | 2021 | Cell Research2021，31，7： | 12 |
| 7 | Genome Characteristics and Evolution of Pseudorabies Virus Strains in Eastern China from 2017 to 2019显示文摘Since late 2011,outbreaks of pseudorabies virus(PRV)have occurred in southern China causing major economic losses to the pig industry.We previously reported that variant PRV forms and recombination in China could be the source of continued epidemics.Here,we analyzed samples from intensive pig farms in eastern China between 2017 and 2019,and sequenced the main glycoproteins(gB,gC,gD,and gE)to study the evolution characteristics of PRV.Based on the gC gene,we found that PRV variants belong to clade 2 and detected a founder effect during by the PRV epidemic.In addition,we detected inter-and intra-clade recombination;in particular,inter-clade recombination in the gB genes of strains FJ-ZXF and FJ-W2,which were recombinant with clade 1 strains.We also found specific amino-acid changes and positively selected sites,possibly associated with functional changes.This analysis of the emergence of PRV in China illustrates the need for continuous monitoring and the development of vaccines against specific variants of PRV. | Xiaofeng Zhai Wen Zhao Kemang Li Cheng Zhang Congcong Wang Shuo Su Jiyong Zhou Jing Lei Gang Xing Haifeng Sun Zhiyu Shi Jinyan Gu | 2019 | Virologica Sinica2019，34，6： | 12 |
| 8 | Acanthopanax senticosus polysaccharides-induced intestinal tight junction injury alleviation via inhibition of NF-κB/MLCK pathway in a mouse endotoxemia model显示文摘AIM To examine the effects of Acanthopanax senticosus polysaccharides(ASPS) on intestinal tight junction(TJ) disruption and nuclear factor-kappa B(NF-κB)/myosin light chain kinase(MLCK) activation in endotoxemia.METHODS BALB/C mice(6-8-weeks-old) received continuous intragastric gavage of ASPS for 7 d before injection of lipopolysaccharide(LPS), or received ASPS once after LPS injection. Blood and intestinal mucosal samples were collected 6 h after LPS challenge. Clinical symptoms, histological injury, intestinal permeability,TJ ultrastructure, and TJ protein expression were determined.RESULTS Compared with mice in the LPS group, pretreatment with ASPS improved clinical and histological scores by 390.9%(P < 0.05) and 57.89%(P < 0.05), respectively, and gut permeability change in endotoxemic mice was shown by a 61.93% reduction in reduced leakage of fluorescein isothiocyanate-dextran 6 h after LPS injection(P < 0.05). ASPS pretreatment also prevented LPS-induced TJ ultrastructure breakdown supported by increased electron dense materials between adjoining cells, sustained redistribution and expression of occludin(0.597 ± 0.027 vs 0.103 ± 0.009, P < 0.05) and zonula occludens-1(0.507 ± 0.032 vs 0.125 ± 0.019, P < 0.05), and suppressed activation of the NF-κB/MLCK pathway indicated by reduced expression of NF-κB, phospho-inhibitor kappa B-alpha, MLCK and phospho-myosin light-chain-2 by 16.06%(P < 0.05), 54.31%(P < 0.05), 66.10%(P < 0.05) and 64.82%(P < 0.05), respectively. CONCLUSION ASPS pretreatment may be associated with inhibition of the NF-κB/MLCK pathway and concomitant amelioration of LPS-induced TJ dysfunction of intestinal epithelium in endotoxemia. | Jie Han Ji-Hong Li Guang Bai Guo-Shun Shen Jing Chen Jia-Nan Liu Shuo Wang Xian-Jun Liu | 2017 | World Journal of Gastroenterology2017，23，12： | 11 |
| 9 | Cancer incidence in Beijing, 2014显示文摘Objective: To analyze cancer incidence data in Beijing in 2014 and temporal trends for selected common cancers during 2005 and 2014.Methods: A total of 144 secondary and tertiary hospitals reported newly diagnosed cancer cases to Beijing Cancer Registry, which covers 13 million residents in Beijing. The cancer incidence rate was calculated in strata by cancer type, sex, age group and area. The population composition of China in 1982 and Segi's population structure were used to calculate age-standardized rates. Extensive procedures were used to assure the quality of the data.Results: The overall data quality indicators of the percentage of morphology verification(MV)(%), the percentage of death certificate-only(DCO)(%) and the mortality to incidence ratio(M/I) were 72.15%, 0.94% and0.54 respectively. A total of 45,300 new cancer cases were diagnosed in Beijing in 2014. The incidence rate was341.92/100,000(343.50/100,000 in males, 340.33/100,000 in females), and the age-standardized incidence rates by Chinese standard population(ASIRC) and by world standard population(ASIRW) were 143.48/100,000 and182.99/100,000, respectively. The cumulative incidence rate for cancer before 75 years was 20.61%. Cancers of lung, colorectum, liver, stomach and prostate were the top five common cancer types for males, while cancers of breast, lung, thyroid, colorectum and uterus were the top five common cancer types for females. The different patterns were also observed between rural and urban areas. Regarding temporal trends, the incidence of thyroid cancer has the fastest growth between 2005 and 2014. The incidence of liver cancer decreased, and stomach and esophageal cancer also decreased significantly for males in the last decade. Incidence rate for lung cancer was relatively stable during that period of time.Conclusions: With more than 45,000 new cases in Beijing in 2014, cancer remains an important public health problem. Actions should be taken to diminish total cancer incidence in Beijing. | Shuo Liu Lei Yang Yannan Yuan Huichao Li Jing Tian Sijia Lu Ning Wang Jiafu Ji | 2018 | Chinese Journal of Cancer Research2018，30，1： | 11 |
| 10 | Imaging through unknown scattering media based on physics-informed learning显示文摘Imaging through scattering media is one of the hotspots in the optical field, and impressive results have been demonstrated via deep learning(DL). However, most of the DL approaches are solely data-driven methods and lack the related physics prior, which results in a limited generalization capability. In this paper, through the effective combination of the speckle-correlation theory and the DL method, we demonstrate a physics-informed learning method in scalable imaging through an unknown thin scattering media, which can achieve high reconstruction fidelity for the sparse objects by training with only one diffuser. The method can solve the inverse problem with more general applicability, which promotes that the objects with different complexity and sparsity can be reconstructed accurately through unknown scattering media, even if the diffusers have different statistical properties. This approach can also extend the field of view(FOV) of traditional speckle-correlation methods. This method gives impetus to the development of scattering imaging in practical scenes and provides an enlightening reference for using DL methods to solve optical problems. | SHUO ZHU ENLAI GUO JIE GU LIANFA BAI JING HAN | 2021 | Photonics Research2021，9，5： | 10 |
| 11 | Transdifferentiation of tumor infiltrating innate lymphoid cells during progression of colorectal cancer显示文摘Innate lymphoid cells(ILCs)reside in mucosal surfaces to potentiate immune responses,sustain mucosal integrity and maintain tissue homeostasis.However,how tumor infiltrating ILCs modulate tumor development and progression is unclear.Here we profiled tumor infiltrating ILCs during colorectal cancer(CRC)progression by single-cell RNA sequencing.We identified six clusters of tumor infiltrating ILCs with unique features.ILC1s expressed inhibitory receptors and underwent inhibitory functional conversion at the late stage of CRC.ILC2s were classified into three subsets(called ILC2-A,-B,-C),of which ILC2-C subset could facilitate tumor progression.HS3ST1 and PD1 were highly expressed in ILC2s of late stage CRC tumors and deficiency of HS3ST1 or PD1 in ILC2s suppressed tumor growth.Moreover,ILC3s transdifferentiated into ILCregs during CRC progression and ILCregs promoted tumor growth.Of note,TGF-βsignaling initiated the conversion of ILC3s to ILCregs and blockade of TGF-βsignaling could disrupt the ILCreg transdifferentiation and inhibited tumor growth.Thus,intervention of ILC conversions might be a potential strategy for CRC immunotherapy. | Shuo Wang Yuan Qu Pengyan Xia Yi Chen Xiaoxiao Zhu Jing Zhang Guan Wang Yong Tian Jianming Ying Zusen Fan | 2020 | Cell Research2020，30，7： | 9 |
| 12 | Contribution of Mass Elevation Effect to the Altitudinal Distribution of Global Treelines显示文摘Alpine treeline, as a prominent ecological boundary between forested mountain slopes and alpine meadow/shrub, is highly complex in altitudinal distribution and sensitive to warming climate. Great efforts have been made to explore their distribution patterns and ecological mechanisms that determine these patterns for more than 100 years, and quite a number of geographical and ecophysiological models have been developed to correlate treeline altitude with latitude or a latitude related temperature. However,on a global scale, all of these models have great difficulties to accurately predict treeline elevation due to the extreme diversity of treeline site conditions.One of the major reasons is that 'mass elevation effect'(MEE) has not been quantified globally and related with global treeline elevations although it has been observed and its effect on treeline elevations in the Eurasian continent and Northern Hemisphere recognized. In this study, we collected and compiled a total of 594 treeline sites all over the world from literatures, and explored how MEE affects globaltreeline elevation by developing a ternary linear regression model with intra-mountain base elevation(IMBE, as a proxy of MEE), latitude and continentality as independent variables. The results indicated that IMBE, latitude and continentality together could explain 92% of global treeline elevation variability, and that IMBE contributes the most(52.2%), latitude the second(40%) and continentality the least(7.8%) to the altitudinal distribution of global treelines. In the Northern Hemisphere, the three factors' contributions amount to 50.4%, 45.9% and 3.7% respectively; in the south hemisphere, their contributions are 38.3%, 53%, and 8.7%, respectively. This indicates that MEE, virtually the heating effect of macro-landforms, is actually the most significant factor for the altitudinal distribution of treelines across the globe, and that latitude is relatively more significant for treeline elevation in the Southern Hemisphere probably due to fewer macro-landforms there. | ZHAO Fang ZHANG Bai-ping ZHANG Shuo QI Wen-wen HE Wen-hui WANG Jing YAO Yong-hui | 2015 | Journal of Mountain Science2015，12，2： | 9 |
| 13 | Long-term follow-up of auditory performance and speech perception and effects of age on cochlear implantation in children with pre-lingual deafness显示文摘Background: The development of auditory and speech perception ability of children with hearing loss is affected by many factors after they undergo cochlear implantation (CI). Age at CI (CI age) appears to play an important role among these factors. This study aimed to evaluate the development of auditory and speech perception ability and explore the impact of CI age on children with pre-lingual deafness present before 3 years of age. Methods: Two hundred and seventy-eight children with pre-lingual deafness (176 boys and 102 girls) were included in this study, and the CI age ranged from 6 to 36 months (mean age, 19 months). Categorical auditory performance (CAP) was assessed to evaluate auditory ability, and the speech intelligibility rating was used to evaluate speech intelligibility. The evaluations were performed before CI and 1, 3, 6, 12, 18, 24, 36, 48, and 60 months after CI. Results: The auditory ability of the pre-lingually hearing-impaired children showed the fastest development within 6 months after CI (k = 0.524, t = 30.992, P < 0.05);then, the progress started to decelerate (k = 0.14, t = 3.704, P < 0.05) and entered a plateau at the 24th month (k = 0.03, t = 1.908, P < 0.05). Speech intelligibility showed the fastest improvement between the 12th and 24th months after CI (k = 0.138, t = 5.365, P < 0.05);then, the progress started to decelerate (k = 0.026, t = 1.465, P < 0.05) and entered a plateau at the 48th month (k = 0.012, t = 1.542, P < 0.05). The CI age had no statistical significant effect on the auditory and speech abilities starting at 2 years after CI (P > 0.05). The optimal cutoff age for CI was 15 months. Conclusions: Within 5 years after CI, the auditory and speech ability of young hearing-impaired children continuously improved, although speech development lagged behind that of hearing. An earlier CI age is recommended;the optimal cutoff age for CI is at 15 months. | Jing Lyu Ying Kong Tian-Qiu Xu Rui-Juan Dong Bei-Er Qi Shuo Wang Yong-Xin Li Hai-Hong Liu Xue-Qing Chen | 2019 | Chinese Medical Journal2019，，16： | 9 |
| 14 | The characteristic and evolution of coal-forming swamp in Hanshuiquan district,Santanghu Coalfield, Xinjiang,NW China,during the Middle Jurassic: evidence from coal petrography,coal facies and sporopollen显示文摘Santanghu Coalfield is the largest integrated coalfield exploration area in China. The major coal seams developing in Xishanyao Formation (Middle Jurassic) are the high-quality steam coals characterized by large thickness, favorable horizontal continuity and high coal quality. In this paper, twenty-two samples were collected from the three typical boreholes in Hanshuiquan disirict, representing the 11 coal seam sequences (7#,8#,9#,13#, 14#,15#,17#,18#,19#,20#,22#), respectively. The petrographic characteristics of the coal-bearing sequence in Xishanyao Formation were firstly summarized systematicly, and then the coal-forming swamp characteristics and succession mechanism of the coal seam in Xishanyao Formation were defined by analyzing the samples. The maceral composition, structure, geochemical and geophysical characteristics of coal are in eluded in original genetic criteria of coal-forming swamp an alysis. And the composition of coal petrography, maceral and microlithotype are the most frequently used parameters. Coal is composed of microscopic constituents and inorganic substances. The Xishanyao Formation maceral mainly consists of vitrinite (65.74%-97.01 %), inert i nite (1.93%-34%), and the exinite shows the mode of regular change. The coal-forming swamp in Xishanyao Formation possesses the characteristics of mainly marsh, wet forest swamp facies, and shallow water covered forest swamp facies, and a few of coal seams distribute in the deep water covered forest swamp facies. In addition, the sporopollens in Xishanyao Formation are mainly Pinaceae evergreen broad leaf and needle-leaved plants. Osmundaceae, Cyatheaceae and Lygodiaceae, indicating that the warm and humid tropic-subtropical climate conductive to the persistent growth of coal-forming plants in the Middle Jurassic. The coal-forming swamp shows the characteristics of vertically upward fluctuation through the periodic transition. It indicates a shallow-deep-shallow change process of the water covered depth in the swamp. This is the prin ci pal factor for the formation of the high-quality and continuous coal seam in Hanshuiquan district, Santanghu Coalfield. | Shuo Feng Jing He Jijun Tian Xingyu Lu Bo Yang | 2019 | International Journal of Coal Science & Technology2019，6，1： | 8 |
| 15 | Surface tension of liquid metal: role, mechanism and application显示文摘表面紧张在统治各种各样的表面和接口现象起一个核心作用。为有高融化温度的液体金属,表面紧张的行为的深刻理解在象扔那样的工业过程是关键的,焊接,并且团结,等等。最近,房间温度液体金属(RTLM ) 主要基于镓的合金创作了由于它的逐渐地认识到的唯一的优点引起了普遍担心。如此的材料的表面性质在将近应用程序包含了从的所有是相当重要的削收获的冷却、热精力,氢产生,塑造可变软机器,打印电子学到 3D 制造,由于它约 700 mN/m 的相当大的表面紧张的等等。以便支持 RTLM 的表面紧张的研究,这篇论文被奉献在液体金属的表面紧张的角色和机制上给出概述并且在基本知识,理论,影响因素和到目前为止澄清的试验性的测量方法的理解上总结最近的进步。当调整 electrowetting 的 RTLM,基本原则和应用的表面紧张的一种实际技术也被解释。而且,表面紧张发给驾驶自我使活动,各种各样的底层上的修改 wettability 和氧化物的功能例如表面紧张的 RTLM 的唯一的现象被讨论给卓见进表面紧张的代理机制。而且,值得追求的未来方向被指出。 | Xi ZHAO Shuo XU Jing LIU | 2017 | Frontiers in Energy2017，11，4： | 8 |
| 16 | PPC-based Reactive Hot Melt Polyurethane Adhesive(RHMPA)--Efficient Glues for Multiple Types of Substrates显示文摘Tens of billion metric tons of anthropogenic CO_2 discharged from the burning of fossil fuels lead to an enormous environmental and resource burden. It is charming to transform CO_2 to desirable, economical chemicals and materials. Poly(propylene carbonate)(PPC) is an emerging CO_2-based material. Herein, we report the design, synthesis and characterization of the reactive hot melt polyurethane adhesive(RHMPA) based on PPC polyol. The resultant RHMPAs exhibit good adhesion properties to multiple substrates including plastics(PC, PMMA, ABS) and metals(aluminium, steel), which is comparable to or even better than conventional RHMPAs prepared from petro-based polyol. Furthermore, the PPC-based RHMPAs have tunable mechanical properties, and are thermally stable in the typical working range of bonding process(up to 270 °C). The study is expected to expand the applications of PPC and provide a new type of CO_2-based renewable and eco-friendly materials. | Zeng-He Liu Ji-Qing Huang Li-Jie Sun Dong Lei Jing Cao Shuo Chen Wen-Chang Shih Feng-Ling Qing Zheng-Wei You | 2018 | Chinese Journal of Polymer Science2018，36，1： | 7 |
| 17 | A mouse model for SARS-CoV-2 infection by exogenous delivery of hACE2 using alphavirus replicon particles显示文摘Dear Editor,Since the outbreak of a novel coronavirus disease(COVID-19)in late 2019,it has spread rapidly and developed into a global pandemic.As of August 12,2020,more than 215 countries and territories around the world have reported more than 20.5 million confirmed COVID-19 cases with over 745,693 deaths(http://gffzz58cf6dffd44b443csbpc6ofnp6ppn69uu.ffgz.tsg.suse.edu.cn/coronavirus/#countries).Such harsh conditions urged scientists across the world to gear up to develop vaccines and antiviral drugs against COVID-19,which also lead to massive requirement for experimental animals. | Ya-Nan Zhang Xiao-Dan Li Zhe-Rui Zhang Hong-Qing Zhang Na Li Jing Liu Jia-Qi Li Hua-Jun Zhang Ze-Jun Wang Shuo Shen Zheng-Li Shi Hong-Ping Wei Zhi-Ming Yuan Han-Qing Ye Bo Zhang | 2020 | Cell Research2020，30，11： | 7 |
| 18 | Secular trends in incidence of lung cancer by histological type in Beijing, China, 2000-2016显示文摘Objective: The objective of this study was to characterize secular trends in the sex-specific, age-standardized incidence of lung cancer by histological type in Beijing, China, from 2000 to 2016 based on data from a populationbased cancer registry.Methods: Data on the incidence of cancer from 2000 to 2016 were obtained from the Beijing Cancer Registry.We examined trends in the sex-specific, age-standardized incidence of lung cancer by histological type using a Joinpoint regression model.Results: A total of 117,409 cases of lung cancer were diagnosed from 2000 to 2016. Overall, 73,062(62.23%)patients were males. The most common histological type among both sexes was adenocarcinoma; however, the proportion of adenocarcinoma differed significantly between males and females(45.36% vs. 77.14%, respectively,P<0.0001). The age-standardized incidence of total lung cancer increased from 2000 to 2010 with an annual percent change(APC) of 2.2% [95% confidence interval(95% CI), 1.5% to 2.9%] and stabilized thereafter. Among males, the incidence of total lung cancer peaked in 2008 and then decreased slightly, with an APC of-1.1%(95%CI,-2.1% to-0.1%). Among females, the incidence increased continuously during the study period, with an APC of 1.4%(95% CI, 0.9% to 1.9%). The incidence of squamous cell carcinoma decreased significantly in recent years among both sexes, with APCs of-2.6%(95% CI,-4.5% to-0.6%) from 2007 to 2016 for males and-5.4%(95%CI,-7.2% to-3.6%) from 2004 to 2016 for females. In contrast, the incidence of adenocarcinoma increased continuously throughout the study period, by APCs of 4.0%(95% CI, 2.6% to 5.4%) for males and 6.2%(95% CI,4.8% to 7.6%) for females. The incidence of small cell carcinoma peaked in 2007 and stabilized thereafter among males, whereas it peaked in 2012 and then decreased with an APC of-14.7%(95% CI,-25.3% to-2.6%) among females. The incidence of large cell carcinoma and other specified malignant neoplasm did not change much,whereas the incidence of unspecified type decreased among both sexes during the study period.Conclusions: Although the incidence of squamous cell carcinoma decreased significantly among both sexes in recent years in Beijing, China, adenocarcinoma increased continuously throughout the study period among both sexes. Knowledge of differences in trends is useful for surveillance and control of lung cancer. However, the reason for the increase in adenocarcinoma remains unclear and warrants investigation. | Lei Yang Ning Wang Yannan Yuan Shuo Liu Huichao Li Jing Tian Jiafu Ji Aiguo Ren | 2019 | Chinese Journal of Cancer Research2019，31，2： | 6 |
| 19 | Self-standing oxygen-deficient a-MoO_(3-x)nanoflake arrays as 3D cathode for advanced all-solid-state thin film lithium batteries显示文摘Compared with the planar two-dimensional(2D)all-solid-state thin film batteries(TFBs),threedimensional(3D)all-solid-state TFBs with interdigitated contact between electrode and electrolyte possess great advantage in achieving both high energy and power densities.Herein,we report a facile fabrication of vertically aligned oxygen-deficient a-MoO3-x nanoflake arrays(3D MO_(x))using metal Mo target by direct current(DC)magnetron sputtering.By utilizing the 3D MO_(x)cathode,amorphous lithium phosphorus oxynitride solid electrolyte,and lithium thin film anode,3D solid-state TFBs have been successfully fabricated,exhibiting high specific capacity(266 mAh g^(-1)at 50 mA g^(-1)),good rate performance(110 mAh g^(-1)at 1000mA g^(-1)),and excellent cycle performance(92.7%capacity retention after 1000 cycles)in comparison with the 2D TFBs using the planar MO_(x)thin film as cathode.The superior electrochemical performance of the 3D TFBs can be attributed to the 3D architecture of the cathode,maximizing the cathode/electrolyte interface while retaining the short Lit diffusion length.The charge/discharge measurements of the 3D MO_(x)cathode in liquid electrolyte,however,exhibit fast capacity fading,demonstrating the advantage of using transition metal oxide as cathode in solid-state batteries. | Shuo Sun Qiuying Xia Jizi Liu Jing Xu Feng Zan Jili Yue Serguei V.Savilov Valery V.Lunin Hui Xia | 2019 | Journal of Materiomics2019，5，2： | 6 |
| 20 | FGF/FGFR signaling in health and disease显示文摘Growing evidences suggest that the fibroblast growth factor/FGF receptor(FGF/FGFR)signaling has crucial roles in a multitude of processes during embryonic development and adult homeostasis by regulating cellular lineage commitment,differentiation,proliferation,and apoptosis of various types of cells.In this review,we provide a comprehensive overview of the current understanding of FGF signaling and its roles in organ development,injury repair,and the pathophysiology of spectrum of diseases,which is a consequence of FGF signaling dysregulation,including cancers and chronic kidney disease(CKD).In this context,the agonists and antagonists for FGF-FGFRs might have therapeutic benefits in multiple systems. | Yangli Xie Nan Su Jing Yang Qiaoyan Tan Shuo Huang Min Jin Zhenhong Ni Bin Zhang Dali Zhang Fengtao Luo Hangang Chen Xianding Sun Jian Q.Feng Huabing Qi Lin Chen | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 5 |
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