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| 1 | Clinical features and outcomes of diffuse large B-cell lymphoma based on nodal or extranodal primary sites of origin:Analysis of 1,085 WHO classified cases in a single institution in China显示文摘Objective: To explore the clinicobiologic features and outcomes of diffuse large B-cell lymphoma(DLBCL)patients in China according to the primary site.Methods: A total of 1,085 patients diagnosed with DLBCL in National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College during a 6-year period were enrolled. Their clinical characteristics and outcomes were analyzed according to the primary site.Results: In the 1,085 patients, 679(62.6%) cases were nodal DLBCL(N-DLBCL) and 406 cases(37.4%) were extranodal DLBCL(EN-DLBCL). The most common sites of N-DLBCL were lymphonodus(64.8%), Waldeyer's ring(19.7%), mediastinum(12.8%) and spleen(2.7%), while in EN-DLBCL, stomach(22.4%), intestine(16.0%),nose and sinuses(8.9%), testis(8.4%), skin(7.9%), thyroid(6.9%), central nervous system(CNS)(6.4%), breast(5.7%), bone(3.4%), and salivary gland(2.7%) were most common. N-DLBCL patients tend to present B symptoms, bulky disease, and elevated LDH more often, while age >60 years, extranodal sites >1, Ann Arbor stage I or II, bone marrow involvement, and Ki-67 index >90% were usually seen in EN-DLBCL. The 5-year overall survival(OS) rate and progression-free survival(PFS) rate for all patients were 62.5% and 54.2%. The 5-year OS rate for patients with N-DLBCL and EN-DLBCL were 65.5% and 56.9%(P=0.008), and the 5-year PFS were57.0% and 49.0%(P=0.020). Waldeyer's ring originated DLBCL possessed the highest 5-year OS rate(83.6%) and PFS rate(76.9%) in N-DLBCL. The top five EN-DLBCL subtypes with favorable prognosis were stomach,breast, nose and sinuses, lung, salivary gland, with 5-year OS rate: 70.3%, 69.6%, 69.4%, 66.7% and 63.6%,respectively. While CNS, testis, oral cavity and kidney originated EN-DLBCL faced miserable prognosis, with 5-year OS rate of 26.9%, 38.2%, and 42.9%.Conclusions: In our study, primary sites were associated with clinical characteristics and outcomes. Compared with EN-DLBCL, N-DLBCL had better prognosis. | Yuankai Shi Ying Han Jianliang Yang Peng Liu Xiaohui He Changgong Zhang Shengyu Zhou Liqiang Zhou Yan Qin Yongwen Song Yueping Liu Shulian Wang Jing Jin Lin Gui Yan Sun | 2019 | Chinese Journal of Cancer Research2019，31，1： | 19 |
| 2 | The Kiloton Class Jiaojia Gold Deposit in Eastern Shandong Province and Its Genesis显示文摘当以前建议了,在东方山东省的 Jiaojia 区域的最近的深勘探结果显示 Jiaojia 矿石域几单个金沉积物创作了实际上是极端大的金沉积物。这沉积物盖住 ∼40 km 2, 的一个区域并且由 Jiaojia 差错和它的第二等的差错显示出结构的控制。金 orebodies 通常沿着一样的矿化作用改变带,和主要 orebodies 发生与对方一起交叉或展出平行或重叠的分布。这沉积物的储备被估计是 1,黄金的 200t,是超过 1000t 黄金的第一金沉积物在中国保留。没有。在页岩深的 Sizhuang 矿石块的 I-1 orebody 使金储备保持比 350 t 大,否则 29% 总数保留列在后面由没有。我在有超过 150t 黄金的 Matang-Jiaojia 矿石块的 orebody 保留。这存款主要在 Jiaojia 差错的矿脉基卒下盘发生,并且在矿化作用,改变和结构介绍 zoned 模式。强烈使矿物化的地区强烈同意改变了并且构造地断裂了地区。这些 orebodies 显示象 strataform 一样, veinlike 或透镜的形状,并且通常显示出外面拧并且重现的特征,分叉并且收敛,膨胀并且缩小。orebodies 通常与剧降变化从沿着差错罢工变化的职务并且在轻轻的地点发生对陡峭轻轻。主要 orebodies 与控制矿石的差错的主要飞机平行,并且趋于从表面轻轻到深。orebodies 主要跳入到西南,与跳入 45 °-60° 的角度。控制矿石的差错的主要飞机附近的 Orebodies 比那些有更多的金资源离开主要差错地区。orebodies 的观点深度通常比沿着它的罢工方向的长度大;orebodies 变得厚,金等级从浅区域变得低到深区域。形成矿石的液体是 H 2O 公司 2-NaCl±CH4 类型与对低咸度中等温度、中等。硫同位素的价值(δ34 S 为金矿石的 CDT ) 在 11.08 ‰ 之间变化并且 12.58 ‰ ,显示混合了硫来源;氢同位素的价值(δD 从 -83.68‰ 的 V 降雪 ) 范围到 -116.95‰并且氧同位素的价值(δ18 O 在 12.04 ‰ 之间的 V 降雪 ) 范围并且 16.28 ‰ 。氢和氧同位素建议形成矿石的液体从主要岩浆发源,并且在迟了的阶段期间与大量大气的水混合。东方山东省金存款与让 mantle-crust-mixed 采购原料的 magmatic 活动被联系,并且也与热水的黄金扔的 orgenic 和 epithermal 分享一些类似。因为东方山东省黄金与与另外的金牌不同的唯一的 metallogenic 特征和形成背景扔,沉积物录入世界,我们把它称为 Jiaojia 类型金存款。千吨班 Jiaojia 金存款与液体活动,延期和分队有关源于岩浆的热 upwelling。在到在东方山东省的早白垩纪的迟了的舞台的中间的强壮的 magmatic 活动为金 depsoits 导致活跃液体,和提供的丰富的形成矿石的材料。而且,源于外壳的扩展的许多 extensional 结构为放的 orebody 提供了赞成空间。 | SONG Mingchun DENG Jun YI Pihou YANG Liqiang CUI Shuxue XU Junxiang ZHOU Mingling HUANG Tailing SONG Guozheng SONG Yingxin | 2014 | Acta Geologica Sinica(English Edition)2014，88，3： | 14 |
| 3 | Gold immunochromatographic sensor for the rapid detection of twenty-six sulfonamides in foods显示文摘一个金 immunochromatographic 传感器(GICS ) 在蜂蜜样品为 26 硫安类药剂的快速的察觉被开发。传感器基于能认出所有 26 硫安类药剂的组特定的 monoclonal 抗体(mAb ) 。三 haptens (1 与 thiazole 包围的 hapten, 2 与苯包围的 hapten,和 3 与直碳锁住的 hapten ) 被用于抗原准备。与 hybridoma 技术,组特定的 mAb 与 50% 最大的禁止的集中被屏蔽(对 sulfathizole (STZ ) 和从 0.08 ~ 90.18 ng/mL 的另外的 25 类似物的 IC 50) 。单音分散金 nanoparticles 与 mAb 被结合开发侧面的 immunochromatographic 长带。0.1 g/mL 的标记的抗体集中和在测试线的 0.2 g/mL 的涂层抗原集中为长带准备被选择。在优化条件,为 STZ 的集中的察觉( vLOD )的视觉限制, sulfamethoxazole , sulfamethizole ,磺胺嘧啶, sulfamerazine , sulfadimethoxine , sulfamonomethoxine , sulfameter , sulfamethoxypyridazine ,和 sulfachloropyridazine 下面是 5 , 0.25 , 0.25 , 10 , 5 , 10 , 25 , 2.5 , 5 , 0.25 ,和 10 g/kg 分别地。在蜂蜜样品的扫描仪分析为 26 硫安类药剂的察觉揭示了好性能。商业蜂蜜样品与传感器被测试,积极结果与高效的液体层析被证实。建议脱衣传感器在爱人样品为硫安类药剂污染物质的快速、可靠的决心提供一个方便方法。 | Yanni Chen Liqiang Liu Liguang Xu Shanshan Song Hua Kuang Gang Cui Chuanlai Xu | 2017 | Nano Research2017，10，8： | 11 |
| 4 | Gold nanoparticle-based paper sensor for ultrasensitive and multiple detection of 32 (fluoro)quinolones by one monoclonal antibody显示文摘为快速、同时的察觉(fluoro ) quinolones,认出 32 的广泛地特定的 monoclonal 抗体(mAb )(fluoro ) quinolone 抗菌素作为 hapten 用 norfloxacin 衍生物和 sarfloxacin 衍生物的混合物被准备。基于黄金, nanoparticles (AuNPs ) 当时是的 immunochromatographic 脱衣与山羊反老鼠抗体和抗原(联合到 ovalbumin 的 sarfloxacin ) 集合了,过去常分别地形成 C 线和 T 线。这抗原与竞争(fluoro ) 在与 mAbs 孵化的一件样品的 quinolones 用 AuNPs 标记。长带能检测 32 ( fluoro ) quinolones 包括 oxolinic 酸, nalidixic 酸, miloxacin , pipemidic 酸, piromidic 酸, rosoxacin , cinoxacin , norfloxacin , pefloxacin , lomfloxacin , enofloxacin , fleroxacin , ciprofloxacin , enrofloxacin , dafloxacin , orbifloxacin , sparfloxacin , gemifloxacin , besifloxacin , balofloxacin , gatifloxacin ,在在 10 mi 以内的牛奶的 moxifloxacin , nadifloxacin , ofloxacin , marbofloxacin , flumequine , pazufloxacin , prulifloxacin , sarafloxacin , difloxacin , trovafloxacin ,和 tosufloxacin 从 1 ~ 100 ng/mL 和察觉的限制的长带范围的截止价值是 0.1-10 ng/mL。长带不包括四圜素, sulfamethazine,氨比西林,抗生素的一种,黄麴毒素 B1,或 gentamicin 与抗菌素做跨 react。简言之,这 immunochromatographic 脱衣是为主要屏蔽的一个很有用的工具(fluoro ) 在牛奶的 quinolones。 | Juan Peng Liqiang Liu Liguang Xu Shanshan Song Hua Kuang Gang Cui Chuanlai Xu | 2017 | Nano Research2017，10，1： | 9 |
| 5 | Comparative genomic and transcriptomic analyses uncover the molecular basis of high nitrogen-use efficiency in the wheat cultivar Kenong 9204显示文摘Studying the regulatory mechanisms that drive nitrogen-use efficiency(NUE)in crops is important for sustainable agriculture and environmental protection.In this study,we generated a high-quality genome assembly for the high-NUE wheat cultivar Kenong 9204 and systematically analyzed genes related to nitrogen uptake and metabolism.By comparative analyses,we found that the high-affinity nitrate transporter gene family had expanded in Triticeae.Further studies showed that subsequent functional differentiation endowed the expanded family members with saline inducibility,providing a genetic basis for improving the adaptability of wheat to nitrogen deficiency in various habitats.To explore the genetic and molecular mechanisms of high NUE,we compared genomic and transcriptomic data from the high-NUE cultivar Kenong 9204(KN9204)and the low-NUE cultivar Jing 411 and quantified their nitrogen accumulation under high-and low-nitrogen conditions.Compared with Jing 411,KN9204 absorbed significantly more nitrogen at the reproductive stage after shooting and accumulated it in the shoots and seeds.Transcriptome data analysis revealed that nitrogen deficiency clearly suppressed the expression of genes related to cell division in the young spike of Jing 411,whereas this suppression of gene expression was much lower in KN9204.In addition,KN9204 maintained relatively high expression of NPF genes for a longer time than Jing 411 during seed maturity.Physiological and transcriptome data revealed that KN9204 was more tolerant of nitrogen deficiency than Jing 411,especially at the reproductive stage.The high NUE of KN9204 is an integrated effect controlled at different levels.Taken together,our data provide new insights into the molecular mechanisms of NUE and important gene resources for improving wheat cultivars with a higher NUE trait. | Xiaoli Shi Fa Cui Xinyin Han Yilin He Long Zhao Na Zhang Hao Zhang Haidong Zhu Zhexin Liu Bin Ma Shusong Zheng Wei Zhang Jiajia Liu Xiaoli Fan Yaoqi Si Shuiquan Tian Jianqing Niu Huilan Wu Xuemei Liu Zhuo Chen Deyuan Meng Xiaoyan Wang Liqiang Song Lijing Sun Jie Han Hui Zhao Jun Ji Zhiguo Wang Xiaoyu He Ruilin Li Xuebin Chi Chengzhi Liang Beifang Niu Jun Xiao Junming Li Hong-Qing Ling | 2022 | Molecular Plant2022，15，9： | 6 |
| 6 | Upgrading of Yi'an gas coal by low temperature pyrolysis under different atmospheres显示文摘The quality of Yi'an gas coal before and after low temperature upgrading under either a N 2 or H 2 atmosphere was examined by thermogravimetric and infrared analyses. The effect of upgrading on the prepared coke quality was analyzed. The results show that the carboxyl and phenolic hydroxyls in the coal molecular structure are removed after upgrading by low temperature pyrolysis under either N 2 or H 2 atmospheres. This improves coal caking properties to a certain extent. The upgrading effect under a H 2 atmosphere is remarkably better than the effect observed after upgrading under N 2 . Compared to coke obtained from raw coal, the compressiveand micro-strength of the cokes obtained from upgraded coal are greatly improved. The effect on coke reactivity with CO 2 is not significant. The best upgrading temperature for Yi'an gas coal under either a Nor H atmosphere is 250 or 275 °C respectively. | Wei Xiaomei Zhou Min Zhang Chun Lei Jiali Song Liqiang | 2011 | Mining Science and Technology2011，21，3： | 4 |
| 7 | A Peer-to-Peer Resource Sharing Scheme Using Trusted Computing Technology显示文摘Facing the increasing security issues in P2P networks,a scheme for resource sharing using trusted computing technolo-gies is proposed in this paper. We advance a RS-UCON model with decision continuity and attribute mutability to control the usage process and an architecture to illustrate how TC technolo-gies support policy enforcement with bidirectional attestation. The properties required for attestation should include not only integrity measurement value of platform and related application,but also reputation of users and access history,in order to avoid the limita-tion of the existing approaches. To make a permission,it is re-quired to evaluate both the authorization and conditions of the subject and the object in resource usage to ensure trustable re-sources to be transferred to trusted users and platform. | CHEN Lu ZHANG Huanguo ZHANG Liqiang LI Song CAI Liang | 2008 | Wuhan University Journal of Natural Sciences2008，13，5： | 2 |
| 8 | 铜绿假单胞菌中基于CRISPR/Cas9系统的基因组编辑与假单胞菌中胞苷脱氨酶介导的碱基编辑技术显示文摘文章简介假单胞菌在自然界分布广泛,种类繁多,在工业生产、生物医学、生态保护等领域具有重要的应用价值。然而假单胞菌的基因组编辑工作操作复杂、步骤繁琐,严重制约了假单胞菌的开发研究工作。 | 陈未中 Ya Zhang Yifei Zhang Yishuang Pi Tongnian Gu Liqiang Song Yu Wang 季泉江 | 2019 | 科学新闻2019，0，2： | 2 |
| 9 | Evaluation of Influence of Motorized Wheels on Contact Force and Comfort for Electric Vehicle显示文摘 | Liqiang Jin Chuanxue Song Qingnian Wang | 2011 | Journal of Computers2011，，3： | 1 |
| 10 | Effects of the co-addition of Zn2 + and sodium dodecylbenzenesulfonate on photocatalytic activity and wetting performance of anatase TiO2 nanoparticle films 显示文摘 | Yichun Qu Shu Song Liqiang Jing | 2010 | Thin Solid Films2010，518，12： | 1 |
| 11 | A combination of Chinese herbs, Astragalus membranaceus var. mongholicus and Angelica sinensis , improved renal microvascular insufficiency in 5/6 nephrectomized rats显示文摘 | Jinye Song Liqiang Meng Shen Li Lei Qu Xiaomei Li | 2009 | Vascular Pharmacology2009，，5： | 1 |
| 12 | Superhydrophilic anatase TiO2 film with the micro - and nanometer - scale hierarchical surface structure 显示文摘 | Song Shu Jing Liqiang Li Shudan | 2008 | Materials Letters2008，62，20： | 1 |
| 13 | Air-stable ambipolar field-effect transistors based on copper phthalocyanine and tetracyanoquinodimethane显示文摘 | Liqiang Li Hongxiang Li Yabin Song Wei Xu Wenping Hu Daoben Zhu | 2008 | Research on Chemical Intermediates2008，，2： | 1 |
| 14 | Study on the com- posite ABS control of vehicles with four electric wheels 显示文摘 | Song Chuanxue Wang Ji Jin Liqiang | 2011 | Journal of Computers2011，6，3： | 1 |
| 15 | Evaluation of Influence of Motorized Wheels on Contact Force and Comfort for Electric Vehicle 显示文摘 | JIN LIQIANG SONG CHUANXUE WANG QINGNIAN | 2011 | Journal of Computers2011，6，3： | 1 |
| 16 | GIScience and remote sensing in natural resource and environmental research:Status quo and future perspectives显示文摘Geographic information science(GIScience)and remote sensing have long provided essential data and method-ological support for natural resource challenges and environmental problems research.With increasing advances in information technology,natural resource and environmental science research faces the dual challenges of data and computational intensiveness.Therefore,the role of remote sensing and GIScience in the fields of natural resources and environmental science in this new information era is a key concern of researchers.This study clarifies the definition and frameworks of these two disciplines and discusses their role in natural resource and environmental research.GIScience is the discipline that studies the abstract and formal expressions of the basic concepts and laws of geography,and its research framework mainly consists of geo-modeling,geo-analysis,and geo-computation.Remote sensing is a comprehensive technology that deals with the mechanisms of human ef-fects on the natural ecological environment system by observing the earth surface system.Its main areas include sensors and platforms,information processing and interpretation,and natural resource and environmental appli-cations.GIScience and remote sensing provide data and methodological support for resource and environmental science research.They play essential roles in promoting the development of resource and environmental science and other related technologies.This paper provides forecasts of ten future directions for GIScience and eight future directions for remote sensing,which aim to solve issues related to natural resources and the environment. | Tao Pei Jun Xu Yu Liu Xin Huang Liqiang Zhang Weihua Dong Chengzhi Qin Ci Song Jianya Gong Chenghu Zhou | 2021 | Geography and Sustainability2021，2，3： | 1 |
| 17 | Evaluation of influence of motorized wheels on contact force and comfort for electric vehicle显示文摘 | JIN Liqiang SONG Chuanxue WANG Qingnian | 2011 | Journal of Computers2011，6，3： | 1 |
| 18 | Superhydrophilic anatase TiO2 film with the micro-and nanometer-scale hierarchical surface structure 显示文摘 | Song Shu Jing Liqiang Li Shudan | 2008 | Materials Letters2008，62，20： | 1 |
| 19 | Immunoaffinity removal and immunoassay for rhodamine B in chilli powder显示文摘 | SONG Shanshan LIN Fei LIU Liqiang | 2010 | Int J Food Sci Technol2010，45，12： | 1 |
| 20 | Monolithic bilayered In_(2)O_(3) as an efficient interfacial material for high-performance perovskite solar cells显示文摘Carrier recombination at the buried SnO_(2)/perovskite interface limits the efficiency and stability of n-i-p-structured perovskite solar cells(PSCs).Herein,we report an In_(2)O_(3)interfacial layer with the distinctive structure of the monolithic compact/nanostructured bilayer.The partial hydrolysis nature of the In^(3+)ion enables the formation of nanorods on top of the compact In_(2)O_(3)layer when spin-coating the In(NO_(3))_(3) aqueous solution.This novel interfacial layer reduces the pinholes of the SnO_(2)film and increases the contact area between the perovskite and electron transport material.Therefore,PSCs with the incorporation of the interfacial layer demonstrate enhanced electron extraction and suppressed carrier recombination.Consequently,the champion device achieves a power conversion efficiency of 23.87%with a high fill factor of 82.14%.The optimized device also shows robust operational stability,retaining over 80%of the initial power conversion efficiency after working at the maximum power point for over 500 h under continuous one-sun illumination. | Wanjia Tian Peiquan Song Yaping Zhao Lina Shen Kaikai Liu Lingfang Zheng Yujie Luo Chengbo Tian Liqiang Xie Zhanhua Wei | 2022 | Interdisciplinary Materials2022，1，4： | 1 |
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