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| 1 | Forming age and tectono-petrogenises of the Jiugequan ophiolite in the North Qilian Mountain,NW China显示文摘The Jiugequan ophiolite is one of the representative ophiolite fragments in the Early Paleozoic orogenic belt of the North Qilian Mountain.It has been drawn much attention and extensively studied in recent years.In this study,ion microprobe(SHRIMP) U-Pb dating was carried out for zircons from isotropic gabbro from the Jiugequan ophiolite.Eighteen analyses yield a relatively consistent apparent 206Pb/238U ages from 480 to 508 Ma with a weighted mean age of 490±5 Ma(MSWD=1.06),which is believed to be the crystallization age of the gabbro and thus the forming age of the Jiugequan ophiolite.Major and trace element geochemical study indicates that the diabase-basalts from the Jiugequan ophiolite have N-MORB and E-MORB characteristics with some subduction-related signatures.The petrological,geochemical and chronological data enable us to conclude that the Jiugequan ophiolite is most likely to be formed at a spreading center of back-arc basin during the early Ordovician,while the ancient Qilian oceanic plate subducted northwards.The acquisition of forming age and determination of tectonic setting for Jiugequan ophiolite provide significant constraints on the evolution of intra-oceanic subduction system in the North Qilian orogenic belt during the Early Paleozoic era. | XIA XiaoHong SONG ShuGuang | 2010 | Chinese Science Bulletin2010，55，18： | 33 |
| 2 | Electromechanical coupling driving control for single-shaft parallel hybrid powertrain显示文摘The single-shaft parallel hybrid powertrain with the automatic mechanical transmission(AMT)is an efficient hybrid driving system in the hybrid electric bus(HEB),while the electromechanical coupling driving control becomes a complicated question to find a transient optimal control method to distribute the power between the engine and the electric machine(EM).This paper proposes an innovative control method to deal with the complicated transient coupling driving process of the electromechanical coupling driving system,considering the accelerating condition and the cruising condition mostly in the city driving cycle of HEB.The EM might be operated at driving mode or generating mode to assist the diesel engine to work in its high-efficiency area.Therefore,the adaptive torque tracking controller has been brought forward to ensure that the EM implements the demand torque as well as compensate the torque fluctuation of diesel engine.The d?q axis mathematical model and back stepping method are employed to deduce the adaptive controller and its adaptive laws.Simulation results demonstrate that the proposed control scheme can make the output torque of two power sources respond rapidly to the demand torque from the powertrain in the given driving condition.The proposed method could be adopted in the real control of HEB to improve the efficiency of the hybrid driving system. | YANG Chao JIAO XiaoHong LI Liang ZHANG YaHui ZHANG LiPeng SONG Jian | 2014 | Science China(Technological Sciences)2014，57，3： | 17 |
| 3 | Petrogenesis of Aoyougou high-silica adakite in the North Qilian orogen,NW China:Evidence for decompression melting of oceanic slab显示文摘A trondhjemitic body occurs in the Aoyougou area,the western part of the North Qilian orogen.It is geochemically characterized by high SiO 2,Na 2 O (high Na/K),elevated Sr/Y and (La/Yb) N,positive Sr anomaly,relatively enriched large ion lithophile elements (LILEs) and light rare earth elements (LREEs),and depleted Nb,Ta,Ti,resembling the high-silica adakite.Zircon U-Pb SHRIMP dating yields a weighted mean age of 438±3 Ma.This age is significantly younger than eclogitization ages of 460-490 Ma in the North Qilian orogen,suggesting that formation of the adakite postdates the subduction of oceanic crust in association with closure of the ancient Qilian Ocean.Whole-rock Sr and Nd isotopic analyses give initial ratios of I Sr =0.7044 0.7047 and Nd (t)=3.0 4.1,indicating that they are derived from partial melting of the juvenile oceanic crust.In view of the tectonic evolution of the North Qilian orogen,the high-silica adakite was probably derived from decompression melting of the exhumed eclogite at the depth of ~60 km. | YuXiao Chen XiaoHong Xia ShuGuang Song | 2012 | Chinese Science Bulletin2012，57，18： | 16 |
| 4 | A phase I study of different doses and frequencies of pegylated recombinant human granulocyte-colony stimulating factor(PEG rhG-CSF) in patients with standard-dose chemotherapy-induced neutropenia显示文摘Objective: The recommended dose of prophylactic pegylated recombinant human granulocyte-colony stimulating factor(PEG rhG-CSF) is 100 μg/kg once per cycle for patients receiving intense-dose chemotherapy.However, few data are available on the proper dose for patients receiving less-intense chemotherapy. The aim of this phase I study is to explore the proper dose and administration schedule of PEG rhG-CSF for patients receiving standard-dose chemotherapy.Methods:Eligible patients received 3-cycle chemotherapy every 3 weeks.No PEG rhG-CSF was given in the first cycle.Patients experienced grade 3 or 4 neutropenia would then enter the cycle 2 and 3.In cycle 2,patients received a single subcutaneous injection of prophylactic PEG rhG-CSF on d 3,and received half-dose subcutaneous injection in cycle 3 on d 3 and d 5,respectively.Escalating doses(30,60,100 and 200μg/kg)of PEG rhG-CSF were investigated.Results:A total of 26 patients were enrolled and received chemotherapy,in which 24 and 18 patients entered cycle 2 and cycle 3 treatment,respectively.In cycle 2,the incidence of grade 3 or 4 neutropenia for patients receiving single-dose PEG rhG-CSF of 30,60,100 and 200 μg/kg was 66.67%,33.33%,22.22% and 0,respectively,with a median duration less than 1(0–2)d.No grade 3 or higher neutropenia was noted in cycle 3 in all dose cohorts.Conclusions:The pharmacokinetic and pharmacodynamic profiles of PEG rhG-CSF used in cancer patients were similar to those reported,as well as the safety.Double half dose administration model showed better efficacy result than a single dose model in terms of grade 3 neutropenia and above.The single dose of 60 μg/kg,100 μg/kg and double half dose of 30 μg/kg were recommended to the phase Ⅱ study,hoping to find a preferable method for neutropenia treatment. | Yan Qin Xiaohong Han Lin Wang Ping Du Jiarui Yao Di Wu Yuanyuan Song Shuxiang Zhang Le Tang Yuankai Shi | 2017 | Chinese Journal of Cancer Research2017，29，5： | 11 |
| 5 | Concurrent chemoradiotherapy comparison of taxanes and platinum versus 5-fluorouracil and platinum in nasopharyngeal carcinoma treatment显示文摘 | Chen Xichuang Hong Yuan Feng Jinhua Ye Jianlin Zheng Panpan Guan Xiyin You Xiaohong Song Huizhu | 2014 | Chinese Medical Journal2014，，1： | 8 |
| 6 | Identification of unconditional and conditional QTL for oil, protein and starch content in maize显示文摘Oil, protein and starch are key chemical components of maize kernels. A population of 245 recombinant inbred lines(RILs) derived from a cross between a high-oil inbred line, By804, and a regular inbred line, B73, was used to dissect the genetic interrelationships among oil, starch and protein content at the individual QTL level by unconditional and conditional QTL mapping. Combined phenotypic data over two years with a genetic linkage map constructed using 236 markers, nine, five and eight unconditional QTL were detected for oil, protein and starch content, respectively. Some QTL for oil, protein and starch content were clustered in the same genomic regions and the direction of their effects was consistent with the sign of their correlation. In conditional QTL mapping, 37(29/8) unconditional QTL were not detected or showed reduced effects, four QTL demonstrated similar effects under unconditional and conditional QTL mapping, and 17 additional QTL were identified by conditional QTL mapping. These results imply that there is a strong genetic relationship among oil, protein and starch content in maize kernels. The information generated in the present investigation could be helpful in marker-assisted breeding for maize varieties with desirable kernel quality traits. | Yuqiu Guo Xiaohong Yang Subhash Chander Jianbing Yan Jun Zhang Tongming Song Jiansheng Li | 2013 | The Crop Journal2013，1，1： | 7 |
| 7 | Internalization of the TGF-β type I receptor into caveolin-1 and EEA1 double-positive early endosomes显示文摘 | Kangmin He Xiaohua Yan Nan Li Song Dang Li Xu Bing Zhao Zijian Li Zhizhen Lv Xiaohong Fang Youyi Zhang Ye-Guang Chen | 2015 | Cell Research2015，25，6： | 7 |
| 8 | Trehalose-6-phosphate phosphatase E modulates ABA-controlled root growth and stomatal movement in Arabidopsis显示文摘Trehalose plays important roles in plant growth and stress responses and is synthesized from trehalose-6-phosphate by trehalose-6-phosphate phosphatase(TPP).Here,we show that trehalose and abscisic acid(ABA)have synergistic effects on root growth and stomatal closure.The Arabidopsis thaliana genome contains ten genes encoding TPPs and the expression level of one,TPPE,and trehalose contents increased in response to ABA.In the pres-ence of ABA,the ABA-responsive transcription factor ABA RESPONSE ELEMENT BINDING FACTOR2(ABF2)directly binds to the TPPE promoter to activate its expression.Genetic analysis revealed that TPPE acts downstream of ABF2,which is supported by the findings that TPPE expression and trehalose content are reduced in the abf2 mutant and that a mutation in TPPE abolished the ABA-sensitive root elongation phenotype of 35S:ABF2 plants.Reactive oxygen spe-cies(ROS)accumulation in response to ABA failed to occur in tppe mutant plants,suggesting that TPPE is involved in ABA-controlled root elongation and sto-matal movement by inducing ROS accumulation.This study uncovers a new branch of the ABA signaling pathway and provides a molecular basis for the role of trehalose in plant responses to abiotic stress. | Wenjing Wang Qingbin Chen Shouming Xu Wen-Cheng Liu Xiaohong Zhu Chun-Peng Song | 2020 | Journal of Integrative Plant Biology2020，62，10： | 6 |
| 9 | Evaluation of oxygen transfer parameters of fine-bubble aeration system in plug flow aeration tank of wastewater treatment plant显示文摘Knowledge of the oxygen mass transfer of aerators under operational conditions in a full-scale wastewater treatment plant (WWTP) is meaningful for the optimization of WWTP, however, scarce to best of our knowledge. Through analyzing a plug flow aeration tank in the Lucun WWTP, in Wuxi, China, the oxygenation capacity of fine-bubble aerators under process conditions have been measured in- situ using the off-gas method and the non-steady-state method. The off-gas method demonstrated that the aerators in different corridors in the aeration tank of WWTP had significantly different oxygen transfer performance; furthermore, the aerators in the same corridor shared almost equal oxygen transfer performance over the course of a day. Results measured by the two methods showed that the oxygen transfer performance of fine-bubble aerators in the aeration tank decreased dramatically compared with that in the clean water. The loss of oxygen transfer coefficient was over 50% under low-aeration conditions (aeration amount < 0.67 Nm 3 /hr). However, as the aeration amount reached 0.96 Nm 3 /hr, the discrepancy of oxygen transfer between the process condition and clean water was negligible. The analysis also indicated that the non-steady-state and off-gas methods resulted in comparable estimates of oxygen transfer parameters for the aerators under process conditions. | Xiaohong Zhou Yuanyuan Wu Hanchang Shi Yanqing Song | 2013 | Journal of Environmental Sciences2013，25，2： | 6 |
| 10 | The RppC-AvrRppC NLR-effector interaction mediates the resistance to southern corn rust in maize显示文摘Southern corn rust(SCR),caused by the fungal pathogen Puccinia polysora,is a major threat to maize pro-duction worldwide.Efficient breeding and deployment of resistant hybrids are key to achieving durable control of SCR.Here,we report the molecular cloning and characterization of RppC,which encodes an NLR-type immune receptor and is responsible for a major SCR resistance quantitative trait locus.Further-more,we identified the corresponding avirulence effector,AvrRppC,which is secreted by P.polysora and triggers RppC-mediated resistance.Allelic variation of AvrRppC directly determines the effectiveness of RppC-mediated resistance,indicating that monitoring of AvrRppC variants in the field can guide the rational deployment of RppC-containing hybrids in maize production.Currently,RppC is the most frequently deployed SCR resistance gene in China,and a better understanding of its mode of action is crit-ical for extending its durability. | Ce Deng April Leonard James Cahill Meng Lv Yurong Li Shawn Thatcher Xueying Li Xiaodi Zhao Wenjie Du Zheng Li Huimin Li Victor Llaca Kevin Fengler Lisa Marshall Charlotte Harris Girma Tabor Zhimin Li Zhiqiang Tian Qinghua Yang Yanhui Chen Jihua Tang Xintao Wang Junjie Hao Jianbing Yan Zhibing Lai Xiaohong Fei Weibin Song Jinsheng Lai Xuecai Zhang Guoping Shu Yibo Wang Yuxiao Chang Weiling Zhu Wei Xiong Juan Sun Bailin Li Junqiang Ding | 2022 | Molecular Plant2022，15，5： | 6 |
| 11 | Modulation of Guard Cell Turgor and Drought Folerance by a Peroxisomal Acetate-Malate Shunt显示文摘 | Huan Dong Ling Bai Yu Zhang Guozeng Zhang Yanqing Mao Lulu Min Fuyou Xiang Dongdong Qian Xiaohong Zhu Chun-Peng Song | 2018 | Molecular Plant2018，11，10： | 6 |
| 12 | Advances in COVID-19 mRNA vaccine development显示文摘To date,the coronavirus disease 2019(COVID-19)caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)has determined 399,600,607 cases and 5,757,562 deaths worldwide.COVID-19 is a serious threat to human health globally.The World Health Organization(WHO)has declared COVID-19 pandemic a major public health emergency.Vaccination is the most effective and economical intervention for controlling the spread of epidemics,and consequently saving lives and protecting the health of the population.Various techniques have been employed in the development of COVID-19 vaccines.Among these,the COVID-19 messenger RNA(mRNA)vaccine has been drawing increasing attention owing to its great application prospects and advantages,which include short development cycle,easy industrialization,simple production process,flexibility to respond to new variants,and the capacity to induce better immune response.This review summarizes current knowledge on the structural characteristics,antigen design strategies,delivery systems,industrialization potential,quality control,latest clinical trials and real-world data of COVID-19 mRNA vaccines as well as mRNA technology.Current challenges and future directions in the development of preventive mRNA vaccines for major infectious diseases are also discussed. | Enyue Fang Xiaohui Liu Miao Li Zelun Zhang Lifang Song Baiyu Zhu Xiaohong Wu Jingjing Liu Danhua Zhao Yuhua Li | 2022 | Signal Transduction and Targeted Therapy2022，7，4： | 5 |
| 13 | Phase I study of chimeric anti-CD20 monoclonal antibody in Chinese patients with CD20-positive non-Hodgkin's lymphoma显示文摘Objective: This study was designed to determine the safety, pharmacokinetics and biologic effects of a humanmouse chimeric anti-CD20 monoclonal antibody(SCT400) in Chinese patients with CD20-positive B-cell nonHodgkin's lymphoma(CD20+ B-cell NHL). SCT400 has an identical amino acid sequence as rituximab, with the exception of one amino acid in the CH1 domain of the heavy chain, which is common in Asians.Methods: Fifteen patients with CD20+ B-cell NHL received dose-escalating SCT400 infusions(250 mg/m^2: n=3; 375 mg/m^2: n=9; 500 mg/m^2: n=3) once weekly for 4 consecutive weeks with a 24-week follow-up period. The data of all patients were collected for pharmacokinetics and pharmacodynamics analyses.Results: No dose-limiting toxicities were observed. Most drug-related adverse events were grade 1 or 2. Two patients had grade 3 or 4 neutropenia. Under premedication, the drug-related infusion reaction was mild. A rapid, profound and durable depletion of circulating B cells was observed in all dose groups without significant effects on T cell count, natural killer(NK) cell count or immunoglobulin levels. No patient developed antiSCT400 antibodies during the course of the study. SCT400 serum half-life(T1/2), maximum concentration(Cmax) and area under the curve(AUC) generally increased between the first and fourth infusions(P<0.05). At the 375 mg/m^2 dose, the T1/2 was 122.5±46.7 h vs. 197.0±75.0 h, respectively, and the Cmax was 200.6±20.2 μg/m L vs. 339.1±71.0 μg/m L, respectively. From 250 mg/m^2 to 500 mg/m^2, the Cmax and AUC increased significantly in a dose-dependent manner(P<0.05). Patients with a high tumor burden had markedly lower serum SCT400 concentrations compared with those without or with a low tumor burden. Of the 9 assessable patients, 1 achieved complete response and 2 achieved partial responses.Conclusions: SCT400 is well-tolerated and has encouraging preliminary efficacy in Chinese patients with CD20+ B-cell NHL. | Lin Gui Xiaohong Han Xiaohui He Yuanyuan Song Jiarui Yao Jianliang Yang Peng Liu Yan Qin Shuxiang Zhang Weijing Zhang Wenlin Gai Liangzhi Xie Yuankai Shi | 2016 | Chinese Journal of Cancer Research2016，28，2： | 5 |
| 14 | ZnFe2O4 deposited on BiOCl with exposed (001) and (010) facets for photocatalytic reduction of C02 in cyclohexanol显示文摘 | Guixian Song Xionggang Wu Feng Xin Xiaohong Yin | 2017 | Frontiers of Chemical Science and Engineering2017，11，2： | 5 |
| 15 | DeST 3.0:A new-generation building performance simulation platform显示文摘Buildings contribute to almost 30%of total energy consumption worldwide.Developing building energy modeling programs is of great significance for lifecycle building performance assessment and optimization.Advances in novel building technologies,the requirements of high-performance computation,and the demands for multi-objective models have brought new challenges for building energy modeling software and platforms.To meet the increasing simulation demands,DeST 3.0,a new-generation building performance simulation platform,was developed and released.The structure of DeST 3.0 incorporates four simulation engines,including building analysis and simulation(BAS)engine,HVAC system engine,combined plant simulation(CPS)engine,and energy system(ES)engine,connected by air loop and water loop balancing iterations.DeST 3.0 offers numerous new simulation features,such as advanced simulation modules for building envelopes,occupant behavior and energy systems,cross-platform and compatible simulation kernel,FMI/FMU-based co-simulation functionalities,and high-performance parallel simulation architecture.DeST 3.0 has been thoroughly evaluated and validated using code verification,inter-program comparison,and case-study calibration.DeST 3.0 has been applied in various aspects throughout the building lifecycle,supporting building design,operation,retrofit analysis,code appliance,technology adaptability evaluation as well as research and education.The new generation building simulation platform DeST 3.0 provides an efficient tool and comprehensive simulation platform for lifecycle building performance analysis and optimization. | Da Yan Xin Zhou Jingjing An Xuyuan Kang Fan Bu Youming Chen Yiqun Pan Yan Gao Qunli Zhang Hui Zhou Kuining Qiu Jing Liu Yan Liu Honglian Li Lei Zhang Hong Dong Lixin Sun Song Pan Xiang Zhou Zhe Tian Wenjie Zhang Ruhong Wu Hongsan Sun Yu Huang Xiaohong Su Yongwei Zhang Rui Shen Diankun Chen Guangyuan Wei Yixing Chen Jinqing Peng | 2022 | Building Simulation2022，15，11： | 5 |
| 16 | Microstructure and magnetic properties of(SmCo+FeCo)/NdFeB multicomponent nanocomposite magnets fabricated by HPTC with change in heating temperature and composition显示文摘We report the fabrication of bulk anisotropic(SmCo+FeCo)/NdFeB multicomponent nanocomposite magnets using high-pressure thermal compression(HPTC).The correlations among microstructure,magnetic properties,heating temperature and composition of the HPTC nanocomposite magnets were studied.The HPTC magnet made under variable temperatures(VT),with 19 wt% of FeCo phase,exhibits a maximum energy product of 32 MGOe,which is much higher than that(14 MGOe) for the HPTC magnet made under a constant temperature(CT).When the FeCo content increases to^23 wt%,the HPTC magnet made under VT still remains a high energy product of about 25 MGOe.With increasing NdFeB content,the(SmCo+FeCo)/NdFeB multicomponent nanocomposite magnets exhibit an enhanced magnetic anisotropy and coercivity.This work is beneficial to fabricating high-performance and low-cost permanent magnets for practical applications. | Guangwei Huang Li Lou Wenpeng Song Ming Li Fuchen Hou Xiaohong Li | 2020 | Journal of Rare Earths2020，38，7： | 4 |
| 17 | Mobility in China,2020:a tale of four phases显示文摘2020 was an unprecedented year;with rapid and drastic changes in human mobility due to the COVID-19 pandemic.To understand the variation in commuting patterns among the Chinese population across stable and unstable periods,we used nationwide mobility data from 318 million mobile phone users in China to examine the extreme fluctuations of population movements in 2020,ranging from the Lunar New Year travel season(chunyun),to the exceptional calm of COVID-19 lockdown,and then to the recovery period.We observed that cross-city movements;which increased substantially in chunyun and then dropped sharply during the lockdown,are primarily dependent on travel distance and the socio-economic development of cities.Following the Lunar New Year holiday,national mobility remained low until mid-February,and COVID-19 interventions delayed more than 72.89 million people returning to large cities.Mobility network analysis revealed clusters of highly connected cities,conforming to the social-economic division of urban agglomerations in China.While the mass migration back to large cities was delayed,smaller cities connected more densely to form new clusters.During the recovery period after travel restrictions were lifted,the netflows of over 55%city pairs reversed in direction compared to before the lockdown.These findings offer the most comprehensive picture of Chinese mobility at fine resolution across various scenarios in China and are of critical importance for decision making regarding future public-health-emergency response,transportation planning and regional economic development,among others. | Suoyi Tan Shengjie Lai Fan Fang Ziqiang Cao Bin Sai Bing Song Bitao Dai Shuhui Guo Chuchu Liu Mengsi Cai Tong Wang Mengning Wang Jiaxu Li Saran Chen Shuo Qin Jessica R.Floyd Zhidong Cao Jing Tan Xin Sun Tao Zhou Wei Zhang Andrew J.Tatem Petter Holme Xiaohong Chen Xin Lu | 2021 | National Science Review2021，8，11： | 3 |
| 18 | Hepatitis B virus evades immune recognition via RNA adenosine deaminase ADAR1-mediated viral RNA editing in hepatocytes显示文摘HBV is considered as a“stealth”virus that does not invoke interferon(IFN)responses;however,the mechanisms by which HBV bypasses innate immune recognition are poorly understood.In this study,we identified adenosine deaminases acting on RNA 1(ADAR1),which is a key factor in HBV evasion from IFN responses in hepatocytes.Mechanically,ADAR1 interacted with HBV RNAs and deaminated adenosine(A)to generate inosine(I),which disrupted host immune recognition and thus promoted HBV replication.Loss of ADAR1 or its deficient deaminase activity promoted IFN responses and inhibited HBV replication in hepatocytes,and blocking the IFN signaling pathways released the inhibition of HBV replication caused by ADAR1 deficiency.Notably,the HBV X protein(HBx)transcriptionally promoted ADAR1 expression to increase the threshold required to trigger intrinsic immune activation,which in turn enhanced HBV escape from immune recognition,leading to persistent infection.Supplementation with 8-azaadenosine,an ADAR1 inhibitor,efficiently enhanced liver immune activation to promote HBV clearance in vivo and in vitro.Taken together,our results delineate a molecular mechanism by which HBx promotes ADAR1-derived HBV immune escape and suggest a targeted therapeutic intervention for HBV infection. | Liyuan Wang Yang Sun Xiaojia Song Zehua Wang Yankun Zhang Ying Zhao Xueqi Peng Xiaodong Zhang Chunyang Li Chengjiang Gao Nailin Li Lifen Gao Xiaohong Liang Zhuanchang Wu Chunhong Ma | 2021 | Cellular & Molecular Immunology2021，18，8： | 2 |
| 19 | Overexpression of LPCAT1 enhances endometrial cancer stemness and metastasis by changing lipid components and activating TGF-β/Smad2/3 signaling pathway显示文摘The incidence of endometrial cancer(EC)increases annually and tends to occur in younger women.A particularly important relationship exists between EC and metabolic disorders.As one of the most important components of lipid metabolism,phospholipids play an indispensable role in metabolic balance.LPCAT1 is a key enzyme regulating phospholipid metabolism.In this study,we perform further investigations to seek mechanistic insight of LPCAT1 in EC.Our results demonstrate that silencing of LPCAT1 inhibits the growth of endometrial cancer,while overexpression of LPCAT1 results in enhanced stemness and metastasis in endometrial cancer cell lines.Meanwhile,the contents of various phospholipids including phosphatidylethanolamine(PE),phosphatidylcholine(PC),and triglyceride(TG)change significantly after overexpression of LPCAT1.In addition,through RNA-sequencing and western blot analysis,we observe that the TGF-β/Smad2/3 signaling pathway is of great importance in the tumor-promoting function of LPCAT1.LPCAT1 promotes the expressions of stem cell-related transcription factors and epithelialmesenchymal transition(EMT)related proteins through the TGF-β/Smad2/3 signaling pathway.Moreover,we find that TSI-01,which can inhibit the activity of LPCAT1,is able to restrain the proliferation of EC cell lines and promote cell apoptosis.Collectively,we demonstrate that LPCAT1 enhances the stemness and metastasis of EC by activating the TGF-β/Smad2/3 signaling pathway and that TSI-01 may have potential use for the treatment of EC. | Tianyi Zhao Rui Sun Xiaohong Ma Lina Wei Yixin Hou Kun Song Jie Jiang | 2022 | Acta Biochimica et Biophysica Sinica2022，54，7： | 2 |
| 20 | Early ABA-stimulated maintenance of Cl^(−) homeostasis by mepiquat chloride priming confers salt tolerance in cotton seeds显示文摘Mepiquat chloride(MC)priming alleviates the effects of salt stress during seed germination in cotton(Gossypium hirsutum L.),but the mechanisms underlying its effects are unknown.We found that MC priming increases salt tolerance,as evidenced by marked increases in seed vigor and germination rates,and alleviated salt toxicity by reducing Cl^(−)accumulation in germinating seeds.Consistently,electrophysiological experiments revealed that the seeds with MC priming displayed superior Cl^(−)exclusion ability in the root apex.These beneficial effects of MC priming were abolished by the abscisic acid(ABA)-synthesis blocker fluridone under salt stress.MC priming induced an early response to acclimatization and stress,as indicated by rapidly increasing ABA content during initial exposure to salt stress.Transcriptome analyses revealed that MC priming induced an array of differentially expressed genes(DEGs)in germinating seeds.The most noticeable changes in germinating seeds were MC priming-induced increases in the expression of DEGs encoding components of ABA biosynthesis,ABA catabolism,and ABA signaling pathways under salt stress.MC priming also increased the expression of some DEGs encoding Cl^(−)ion transporters(e.g.CCC,SLAC1/SLAH1/SLAH3,CLC,and ALMT9)in germinating seeds.These results indicate that MC priming-induced ABA contributes to Cl^(−)homeostasis in tissues and acts as a positive regulator of salt tolerance via regulation of Cl^(−)transporters(particularly CCC and SLAC1/SLAH1/SLAH3).Taken together,these findings shed light on the molecular mechanism underlying MC-mediated tolerance to salt stress during seed germination. | Ning Wang Xiangru Wang Hengheng Zhang Xiaohong Liu Jianbin Shi Qiang Dong Qinghua Xu Huiping Gui Meizhen Song Gentu Yan | 2021 | The Crop Journal2021，9，2： | 2 |
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