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| 1 | Enhanced secondary pollution offset reduction of primary emissions during COVID-19 lockdown in China显示文摘To control the spread of the 2019 novel coronavirus(COVID-19),China imposed nationwide restrictions on the movement of its population(lockdown)after the Chinese New Year of 2020,leading to large reductions in economic activities and associated emissions.Despite such large decreases in primary pollution,there were nonetheless several periods of heavy haze pollution in eastern China,raising questions about the well-established relationship between human activities and air quality.Here,using comprehensive measurements and modeling,we show that the haze during the COVID lockdown was driven by enhancements of secondary pollution.In particular,large decreases in NOx emissions from transportation increased ozone and nighttime NO_(3)radical formation,and these increases in atmospheric oxidizing capacity in turn facilitated the formation of secondary particulate matter.Our results,afforded by the tragic natural experiment of the COVID-19 pandemic,indicate that haze mitigation depends upon a coordinated and balanced strategy for controlling multiple pollutants. | Xin Huang Aijun Ding Jian Gao Bo Zheng Derong Zhou Ximeng Qi Rong Tang Jiaping Wang Chuanhua Ren Wei Nie Xuguang Chi Zheng Xu Liangduo Chen Yuanyuan Li Fei Che Nini Pang Haikun Wang Dan Tong Wei Qin Wei Cheng Weijing Liu Qingyan Fu Baoxian Liu Fahe Chai Steven JDavis Qiang Zhang Kebin He | 2021 | National Science Review2021，8，2： | 47 |
| 2 | Eastern Asian endemic seed plant genera and their paleogeographic history throughout the Northern Hemisphere显示文摘We review the fossil history of seed plant genera that are now endemic to eastern Asia. Although the majority of eastern Asian endemic genera have no known fossil record at all, 54 genera, or about 9%, are reliably known from the fossil record. Most of these are woody (with two exceptions), and most are today either broadly East Asian, or more specifically confined to Sino-Japanese subcategory rather than being endemic to the Sino-Himalayan area. Of the 'eastern Asian endemic' genera so far known from the fossil record, the majority formerly occurred in Europe and/or North America, indicating that eastern Asia served as a late Tertiary or Quaternary refugium for taxa. Hence, many of these genera may have originated in other parts of the Northern Hemisphere and expanded their ranges across continents and former sea barriers when tectonic and climatic conditions al- lowed, leading to their arrival in eastern Asia. Although clear evidence for paleoendemism is provided by the gymnosperms Amentotaxus, Cathaya, Cephalotaxus, Cunninghamia, Cryptomeria, Glyptostrobus, Ginkgo, Ketel-eeria, Metasequoia, Nothotsuga, Pseudolarix, Sciadopitys, and Taiwania, and the angiosperms Cercidiphyllum, Choerospondias, Corylopsis, Craigia, Cyclocarya, Davidia, Dipelta, Decaisnea, Diplopanax, Dipteronia, Em-menopterys, Eucommia, Euscaphis, Hemiptelea, Hovenia, Koelreuteria, Paulownia, Phellodendron, Platycarya, Pteroceltis, Rehderodendron, Sargentodoxa, Schizophragma, Sinomenium, Tapiscia, Tetracentron, Toricellia, Trapella, and Trochodendron, we cannot rule out the possibility that neoendemism plays an important role especially for herbaceous taxa in the present-day flora of Asia, particularly in the Sino-Himalayan region. In addition to reviewing paleobotanical occurrences from the literature, we document newly recognized fossil occurrences that expand the geographic and stratigraphic ranges previously known for Dipelta, Pteroceltis, and Toricellia. | Steven R. MANCHESTER Zhi-Duan CHEN An-Ming LU Kazuhiko UEMURA | 2009 | Journal of Systematics and Evolution2009，47，1： | 40 |
| 3 | PM_(2.5)-bound polycyclic aromatic hydrocarbons(PAHs) in Beijing:Seasonal variations,sources,and risk assessment显示文摘Polycyclic aromatic hydrocarbons(PAHs) have been of health concern due to its carcinogenesis and mutagenesis. In this study, we aimed to assess the variations, sources, and lifetime excessive cancer risk(ECR) attributable to PAHs bound to ambient particulate matters with aerodynamic diameter less than 2.5 μm(PM_(2.5)) in metropolitan Beijing, China. We collected24-hour integrated PM_(2.5) samples on daily basis between November 2014 and June 2015 across both central heating(cold months) and non-heating(warm months) seasons, and further analyzed the PAH components in these daily PM_(2.5) samples. Our results showed that total concentrations of PM_(2.5)-bound PAHs varied between(88.6 ± 75.4) ng/m^3 in the cold months and(11.0 ± 5.9) ng/m^3 in the warm months. Benzo[a]pyrene(Ba P), the carcinogenic marker of PAHs,averaged at 5.7 and 0.4 ng/m^3 in the cold and warm months, respectively. Source apportionment analyses illustrated that gasoline, biomass burning, diesel, coal combustion and cooking were the major contributors, accounting for 12.9%, 17.8%, 24.7%, 24.3% and 6.4% of PM_(2.5)-bound PAHs, respectively. The BaP equivalent lifetime ECR from inhalation of PM_(2.5)-bound PAHs was 16.2 cases per million habitants. Our results suggested that ambient particulate reduction from energy reconstruction and adaption of clean fuels would result in reductions PM_(2.5)-bound PAHs and its associated cancer risks. However, as only particulate phased PAHs was analyzed in the present study, the concentration of ambient PAHs could be underestimated. | Baihuan Feng Lijuan Li Hongbing Xu Tong Wang Rongshan Wu Jie Chen Yi Zhang Shuo Liu Steven Sai Hang Ho Junji Cao Wei Huang | 2019 | Journal of Environmental Sciences2019，31，3： | 17 |
| 4 | Dual Phosphorylation of Suppressor of Fused (Sufu) by PKA and GSK3 beta Regulates Its Stability and Localization in the Primary Cilium显示文摘 | Chen, Yon Yue, Shen Xie, Lu Pu, Xiao-hong Jin, Tion Cheng, Steven Y. | 2011 | 南京医科大学学报(自然科学版)2011，31，6： | 15 |
| 5 | 2-Year GLOBE Trial Results: Telbivudine Is Superior to Lamivudine in Patients With Chronic Hepatitis B显示文摘 | Yun–Fan Liaw Edward Gane Nancy Leung Stefan Zeuzem Yuming Wang Ching Lung Lai E. Jenny Heathcote Michael Manns Natalie Bzowej Junqi Niu Steven–Huy Han Seong Gyu Hwang Yilmaz Cakaloglu Myron J. Tong George Papatheodoridis Yagang Chen Nathaniel A. Brown Efs | 2009 | Gastroenterology2009，，2： | 13 |
| 6 | MicroRNA regulation of innate immune responses in epithelial cells显示文摘Mucosal surface epithelial cells are equipped with several defense mechanisms that guard against pathogens.Recent studies indicate that microRNAs(miRNAs)mediate post-transcriptional gene suppression and may be a critical component of the complex regulatory networks in epithelial immune responses.Transcription of miRNA genes in epithelial cells can be elaborately controlled through pathogen recognition receptors,such as Toll-like receptors(TLRs),and associated nuclear factor kappaB(NF-kB)and mitogen-activated protein kinase(MAPK)pathways,and ultimately nuclear transcription factor associated-transactivation and transrepression.Activation of these intracellular signaling pathways may also modulate the process of miRNA maturation.Functionally,miRNAs may modulate epithelial immune responses at every step of the innate immune network,including production and release of cytokines/chemokines,expression of adhesion and costimulatory molecules,shuttling of miRNAs through release of exosomes and feedback regulation of immune homeostasis.Therefore,miRNAs act as critical regulators to the fine-tuning of epithelial immune responses. | Rui Zhou Steven P O’Hara Xian-Ming Chen | 2011 | Cellular & Molecular Immunology2011，8，5： | 13 |
| 7 | Mapping the magnetic field in the solar corona through magnetoseismology显示文摘Magnetoseismology,a technique of magnetic field diagnostics based on observations of magnetohydrodynamic(MHD)waves,has been widely used to estimate the field strengths of oscillating structures in the solar corona.However,previously magnetoseismology was mostly applied to occasionally occurring oscillation events,providing an estimate of only the average field strength or one-dimensional distribution of field strength along an oscillating structure.This restriction could be eliminated if we apply magnetoseismology to the pervasive propagating transverse MHD waves discovered with the Coronal Multi-channel Polarimeter(CoMP).Using several CoMP observations of the Fe xiii 1074.7 nm and 1079.8 nm spectral lines,we obtained maps of the plasma density and wave phase speed in the corona,which allow us to map both the strength and direction of the coronal magnetic field in the plane of sky.We also examined distributions of the electron density and magnetic field strength,and compared their variations with height in the quiet Sun and active regions.Such measurements could provide critical information to advance our understanding of the Sun's magnetism and the magnetic coupling of the whole solar atmosphere. | YANG ZiHao TIAN Hui TOMCZYK Steven MORTON Richard BAI XianYong SAMANTA Tanmoy CHEN YaJie | 2020 | Science China(Technological Sciences)2020，63，11： | 8 |
| 8 | 人为气溶胶排放导致最近80年东亚夏季风在过去四个世纪以来空前减弱显示文摘亚洲夏季风(Asian Summer Monsoon,ASM)对亚洲数十亿人口的生存、亚洲生态系统和生物多样性的分布、以及农业生产(粮食安全)和工业活动影响严重。因此了解ASM过去时空变化及其动力学过程对陆地生态系统、水资源、森林和景观研究至关重要。近几十年,器测记录显示以降水量为代表的ASM强度一直在减弱,但这一减弱趋势的起始时间和动力学过程尚不清楚。为此,第一次集成了ASM西部-中部边缘带10个对降水敏感的树木年轮宽度年表,重建了公元1566年以来反映ASM强度变化的降水序列。重建结果不仅捕捉到了ASM过去4个世纪以来强弱变化历史,也反映出历史上蝗灾与弱季风的关联。特别是发现了最近80年具有过去448年中前所未有的、最为强烈的、显著且持续时间最长的ASM强度减弱趋势。这一减弱趋势与在温室效应影响下ASM本该增强的预期大相庭径。耦合气候模型实验表明,北半球人为硫酸盐气溶胶排放的逐渐增加,对ASM减弱起了决定性作用。 | 刘禹 蔡文炬 孙长峰 宋慧明 Kim MCobb 李建平 Steven WLeavitt 吴立新 蔡秋芳 刘若时 Benjamin Ng Paolo Cherubini Ulf Büntgen 宋怡 王国建 雷莺 晏利斌 李强 马永永 方丛羲 孙军艳 李旭祥 Deliang Chen Hans WLinderholm | 2019 | 地球环境学报2019，10，6： | 7 |
| 9 | Global methane and nitrous oxide emissions from terrestrial ecosystems due to multiple environmental changes显示文摘Greenhouse gas(GHG)-induced climate change is among the most pressing sustainability challenges facing humanity today,posing serious risks for ecosystem health.Methane(CH_(4))and nitrous oxide(N_(2)O)are the two most important GHGs after carbon dioxide(CO_(2)),but their regional and global budgets are not well known.In this study,we applied a process-based coupled biogeochemical model to concurrently estimate the magnitude and spatial and temporal patterns of CH_(4)and N_(2)O fluxes as driven by multiple environmental changes,including climate variability,rising atmospheric CO_(2),increasing nitrogen deposition,tropospheric ozone pollution,land use change,and nitrogen fertilizer use.The estimated CH_(4)and N_(2)O emissions from global land ecosystems during 1981-2010 were 144.39±12.90 Tg C/yr(mean 62 SE;1 Tg=1012 g)and 12.52±0.74 Tg N/yr,respectively.Our simulations indicated a significant(P,0.01)annually increasing trend for CH_(4)(0.43±0.06 Tg C/yr)and N_(2)O(0.14±0.02 Tg N/yr)in the study period.CH_(4)and N_(2)O emissions increased significantly in most climatic zones and continents,especially in the tropical regions and Asia.The most rapid increase in CH_(4)emission was found in natural wetlands and rice fields due to increased rice cultivation area and climate warming.N_(2)O emission increased substantially in all the biome types and the largest increase occurred in upland crops due to increasing air temperature and nitrogen fertilizer use.Clearly,the three major GHGs(CH_(4),N_(2)O,and CO_(2))should be simultaneously considered when evaluating if a policy is effective to mitigate climate change. | Hanqin Tian Guangsheng Chen Chaoqun Lu Xiaofeng Xu Wei Ren Bowen Zhang Kamaljit Banger Bo Tao Shufen Pan Mingliang Liu Chi Zhang Lori Bruhwiler Steven Wofsy | 2015 | Ecosystem Health and Sustainability2015，1，1： | 7 |
| 10 | A new phylogenetic tribal classification of the grape family (Vitaceae)显示文摘Vitaceae (葡萄家庭) 由 16 个类和 ca 组成。首先在热带区域散布的 950 种类。家庭为葡萄的经济重要性是著名的,并且作为热带、适度的森林里的主导的登山者与许多种类也是生态地重要的。最近种系发生并且从所有三个染色体的顺序数据的 phylogenomic 分析在 Vitaceae 以内支持了五主要 clades:(i) 白蔹属, Nekemias, Rhoicissus,和 Clematicissus 的 clade;(ii ) Cissus clade;(iii ) Cayratia, Causonis, Cyphostemma, Pseudocayratia, Tetrastigma,和 undescribed 类 Afrocayratia 的 clade;(iv ) Parthenocissus 和 Yua 的 clade;并且(v) 葡萄类 Vitis 和它的近热带的亲戚 Ampelocissus, Pterisanthes 和 Nothocissus,与在 Ampelocissus 以内嵌套的 Nothocissus 和 Pterisanthes。基于种系发生、词法(主要开花期,花并且种子人物) 证据,新分类把 950 种类和 16 个类放进五个部落:(i) 部落 Ampelopsideae J.Wen 与 Z.L.Nie, trib。nov。(在四个类的 47 种类;白蔹属, Nekemias, Rhoicissus 和 Clematicissus ) ;(ii ) 部落 Cisseae Rchb。(在一个类的 300 种类;Cissus ) ;(iii ) 部落 Cayratieae J.Wen 与 L.M.Lu, trib。nov。(在七个类的 370 种类;Cayratia, Causonis, Afrocayratia, Pseudocayratia, Acareosperma, Cyphostemma 和 Tetrastigma ) ;(iv ) 部落 Parthenocisseae J.Wen 与 Z.D.Chen, trib。nov。( ca。16 spp。在二个类;Parthenocissus 和 Yua ) ;并且(v) 部落 Viteae Dumort。( ca。在二个类的 190 种类;Ampelocissus 和 Vitis ) 。 | JunWen Li-Min Lu Ze-Long Nie Xiu-Qun Liu Ning Zhang Stefanie Ickert-Bond Jean Gerrath Steven R. Manchester John Boggan Zhi-Duan Chen | 2018 | Journal of Systematics and Evolution2018，56，4： | 6 |
| 11 | A constipation scoring system to simplify evaluation and management of constipated patients显示文摘 | Dr. Feran Agachan M.D. Teng Chen M.D. Johann Pfeifer M.D. Petachia Reissman M.D. Steven D. Wexner M.D | 1996 | Diseases of the Colon & Rectum1996，，6： | 4 |
| 12 | Preparation and Surfactant Properties of Amino Acid-based Surfactants显示文摘1-O-aminoacyl-3-O-alkyl acyl glycerols were synthesized by lipases in good yields andtheir surfactant properties were explored. | Qian CHEN Steven F. CHEN Zu Yi LI(1 Shanghai Institute of Organic Chemistry. Chinese Academy of Sciences. 354 Fenglin Lu.Shanghai 2000322 Depaftment of Botany. The University of Hong Kong) | 1999 | Chinese Chemical Letters1999，10，9： | 4 |
| 13 | Tailored PEDOT:PSS hole transport layer for higher performance in perovskite solar cells: Enhancement of electrical and optical properties with improved morphology显示文摘Precise control over the charge carrier dynamics throughout the device can result in outstanding performance of perovskite solar cells(PSCs).Poly(3,4-ethylenedioxythiophene):poly(styrene sulfonate)(PEDOT:PSS)is the most actively studied hole transport material in p-i-n structured PSCs.However,charge transport in the PEDOT:PSS is limited and inefficient because of its low conductivity with the presence of the weak ionic conductor PSS.In addition,morphology of the underlying PEDOT:PSS layer in PSCs plays a crucial role in determining the optoelectronic quality of the active perovskite absorber layer.This work is focused on realization of a non-wetting conductive surface of hole transport layer suitable for the growth of larger perovskite crystalline domains.This is accomplished by employing a facile solventengineered(ethylene glycol and methanol)approach resulting in removal of the predominant PSS in PEDOT:PSS.The consequence of acquiring larger perovskite crystalline domains was observed in the charge carrier dynamics studies,with the achievement of higher charge carrier lifetime,lower charge transport time and lower transfer impedance in the solvent-engineered PEDOT:PSS-based PSCs.Use of this solventengineered treatment for the fabrication of MAPbI3 PSCs greatly increased the device stability witnessing a power conversion efficiency of 18.18%,which corresponds to^37%improvement compared to the untreated PEDOT:PSS based devices. | Khan Mamun Reza Ashim Gurung Behzad Bahrami Sally Mabrouk Hytham Elbohy Rajesh Pathak Ke Chen Ashraful Haider Chowdhury Md Tawabur Rahman Steven Letourneau Hao-Cheng Yang Gopalan Saianand Jeffrey WElam Seth BDarling Qiquan Qiao | 2020 | Journal of Energy Chemistry2020，29，5： | 4 |
| 14 | Preclinical Profile and Characterization of the Hepatitis C Virus NS3 Protease Inhibitor Asunaprevir (BMS-650032)显示文摘 | Fiona McPhee Amy K. Sheaffer Jacques Friborg Dennis Hernandez Paul Falk Guangzhi Zhai Steven Levine Susan Chaniewski Fei Yu Diana Barry Chaoqun Chen Min S. Lee Kathy Mosure Li-Qiang Sun Michael Sinz Nicholas A. Meanwell Richard J. Colonno Jay Knipe Paul S | 2012 | Antimicrobial Agents and Chemotherapy2012，，10： | 2 |
| 15 | Development of a CLDN18.2-targeting immuno-PET probe for non-invasive imaging in gastrointestinal tumors显示文摘Claudin18.2(CLDN18.2)is a tight junction protein that is overexpressed in a variety of solid tumors such as gastrointestinal cancer and oesophageal cancer.It has been identified as a promising target and a potential biomarker to diagnose tumor,evaluate efficacy,and determine patient prognosis.TST001 is a recombinant humanized CLDN18.2 antibody that selectively binds to the extracellular loop of human Claudin18.2.In this study,we constructed a solid target radionuclide zirconium-^(89)(^(89)Zr)labled-TST001 to detect the expression of in the human stomach cancer BGC823CLDN18.2 cell lines.The[^(89)Zr]Zr-desferrioxamine(DFO)-TST001 showed high radiochemical purity(RCP,>99%)and specific activity(24.15±1.34 GBq/mmol),and was stable in 5%human serum albumin,and phosphate buffer saline(>85%RCP at 96 h).The EC_(50) values of TST001 and DFO-TST001 were as high as 0.413±0.055 and 0.361±0.058 nM(P>0.05),respectively.The radiotracer had a significantly higher average standard uptake values in CLDN18.2-positive tumors than in CLDN18.2-negative tumors(1.11±0.02 vs.0.49±0.03,P=0.0016)2 days post injection(p.i.).BGC823CLDN18.2 mice models showed high tumor/muscle ratios 96 h p.i.with[^(89)Zr]Zr-DFO-TST001 was much higher than those of the other imaging groups.Immunohistochemistry results showed that BGC823CLDN18.2 tumors were highly positive(+++)for CLDN18.2,while those in the BGC823 group did not express CLDN18.2().The results of ex vivo biodistribution studies showed that there was a higher distribution in the BGC823CLDN18.2 tumor bearing mice(2.05±0.16%ID/g)than BGC823 mice(0.69±0.02%ID/g)and blocking group(0.72±0.02%ID/g).A dosimetry estimation study showed that the effective dose of[^(89)Zr]Zr-DFO-TST001 was 0.0705 mSv/MBq,which is within the range of acceptable doses for nuclear medicine research.Taken together,these results suggest that Good Manufacturing Practices produced by this immuno-positron emission tomography probe can detect CLDN18.2-overexpressing tumors. | Yan Chen Xingguo Hou Dapeng Li Jin Ding Jiayue Liu Zilei Wang Fei Teng Hongjun Li Fan Zhang Yi Gu Steven Yu Xueming Qian Zhi Yang Hua Zhu | 2023 | Journal of Pharmaceutical Analysis2023，13，4： | 2 |
| 16 | Sources of organic matter and paleo-environmental implications inferred from carbon isotope compositions of lacustrine sediments at Inexpressible Island, Ross Sea, Antarctica显示文摘The carbon isotopic composition of organic matter(δ^(13)C_(org)) was determined in two sediment cores(IIL1 and IIL9) recovered from Inexpressible Island, Ross Sea, Antarctica, and analyzed to identify the sources of that organic matter. The δ^(13)C_(org) values of sediments of IIL9 were found to vary between-14.6‰ and-11.6‰, with a mean of-13.4‰(n=48). These values were significantly higher than those of IIL1 sediments which varied between-23.2‰ and-20.4‰, with a mean of-21.8‰(n=55). The variation in δ^(13)C_(org) values in these two sediment cores indicate different sources of organic matter. The relatively high δ^(13)C_(org) values in IIL9 are in accordance with a source from algae, while the low δ^(13)C_(org) values in IIL1 evince significant influence from penguin guano with algae as the secondary source. Compared with the reference data from other high-latitude lake sediments and plants, the δ^(13)C_(org) values in IIL9 were extremely high, a result likely related to intense competition for CO_2 assimilation among algal species during the growing season in this relatively shallow pond. These results indicate that sedimentary δ^(13)C_(org) is a reliable proxy for paleo-primary productivity in ponds at Inexpressible Island. | WEI Yangyang JIN Jing NIE Yaguang CHEN Xin WU Libin FU Pingqing LIU Xiaodong Steven D.Emslie | 2016 | Advances in Polar Science2016，27，4： | 2 |
| 17 | Hepatocellular carcinoma screening in patients waiting for liver transplantation: A decision analytic model显示文摘 | Sammy Saab David Ly Jose Nieto Fasiha Kanwal David Lu Steven Raman Rafael Amado Barbara Nuesse Francisco Durazo Steven Han Douglas G. Farmer Rafik M. Ghobrial Hasan Yersiz Pauline Chen Kathy Schwegel Leonard I. Goldstein Myron Tong Ronald W. Busuttil | 2003 | Liver Transplantation2003，，7： | 2 |
| 18 | Economic freedom and IPO underpricing显示文摘这篇论文检验在机构的环境的差别怎么越过国家组成微分 IPO underpricing。用基础在时期 1993-2014 上从 22 个国家和区域为 3728 IPO 的异构的机构的环境,和一件样品作为一个代理经济自由(IEF ) 索引的遗产,我们发现有更高经济的自由的国家显著地有不太严肃的 IPO underpricing 问题。而且,我们发现在 theIEF 盖住的 10 个经济自由因素之中,金融自由联系了因素玩在减少 IPO underpricing 问题的一个更重要的角色。最后,与市场情绪假设一致,我们发现 pre-IPO 市场情绪影响 IPO firstday 归还的充分证据,并且当市场是熊市的时, IPO underpricing 问题是不太严重的。 | Yibiao Chen Steven S.Wang Wilson H.S.Tong Hui Zhu | 2017 | Frontiers of Business Research in China2017，11，4： | 2 |
| 19 | A constipation scoring system to simplify evaluation and management of constipated patients显示文摘 | Feran Agachan Teng Chen Johann Pfeifer Petachia Reissman Steven D. Wexner | 1996 | Diseases of the Colon & Rectum1996，，： | 2 |
| 20 | Analysis of Long-term Outcomes of 3200 Liver Transplantations Over Two Decades: A Single-Center Experience显示文摘 | Ronald W. Busuttil Douglas G. Farmer Hasan Yersiz Jonathan R. Hiatt Sue V. McDiarmid Leonard I. Goldstein Sammy Saab Steven Han Francisco Durazo Michael Weaver Carlos Cao Tony Chen Gerald S. Lipshutz Curtis Holt Sherilyn Gordon Jeffery Gornbein Farin Amer | 2005 | Annals of Surgery2005，，6： | 2 |
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