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| 1 | Comparative effect of electroacupuncture and moxibustion on the expression of substance P and vasoactive intestinal peptide in patients with irritable bowel syndrome显示文摘OBJECTIVE: To compare the impacts of electroacupuncture(EA) and moxibustion(Mox) on the primary gastrointestinal symptoms and the expressions of colonic mucosa-associated neuropeptide substance P(SP) and vasoactive intestinal peptide(VIP)in patients with either diarrhea-predominant or constipation-predominant irritable bowel syndrome(IBS-D and IBS-C,respectively).METHODS: Eighty-five IBS patients were randomly allocated to the EA and Mox groups. Zusanli(ST 36)and Shangjuxu(ST 37) were selected as acupoints for electroacupuncture or warm moxibustion treatment once a day for 14 consecutive days. Before and after the treatment sessions,a Visual Analog Pain Scale and the Bristol Stool Form Scale were used to evaluate gastrointestinal symptoms. There were four dropout cases,leaving 81 participants(41 with IBS-D and 40 with IBS-C) who volunteered to undergo colonoscopy before and after the treatment sessions. During colonoscopy,sigmoid mucosa were collected to detect SP and VIP expression using immunohistochemistry assay.RESULTS: Both EA and Mox treatments were effective at relieving abdominal pain in IBS-D and IBS-C patients. However,Mox was more effective at reducing diarrhea in IBS-D patients,whereas EA was more effective at improving constipation in IBS-C patients. EA and Mox treatments both down-regulated the abnormally increased SP and VIP expression in the colonic mucosa,with no significant difference shown between the two treatments.CONCLUSION: Both EA and Mox treatments are effective at ameliorating gastrointestinal symptoms by reducing SP and VIP expression in the colonic mucosa of IBS patients. | Lu Zhenzhong Yin Xiaojun Teng Weijun Chen Yuehua Sun Jie Zhao Jimeng Wang Anqi Bao Chunhui Shi Yin | 2015 | Journal of Traditional Chinese Medicine2015，35，4： | 24 |
| 2 | Substance P-modified human serum albumin nanoparticles loaded with paclitaxel for targeted therapy of glioma显示文摘The blood–brain barrier(BBB) and the poor ability of many drugs to cross that barrier greatly limits the efficacy of chemotherapies for glioblastoma multiforme(GBM). The present study exploits albumin as drug delivery vehicle to promote the chemotherapeutic efficacy of paclitaxel(PTX) by improving the stability and targeting efficiency of PTX/albumin nanoparticles(NPs). Here we characterize PTX-loaded human serum albumin(HSA) NPs stabilized with intramolecular disulfide bonds and modified with substance P(SP) peptide as the targeting ligand. The fabricated SP-HSA-PTX NPs exhibited satisfactory drug-loading content(7.89%) and entrapment efficiency(85.7%) with a spherical structure(about 150 nm) and zeta potential of -12.0 mV. The in vitro drug release from SP-HSA-PTX NPs occurred in a redox-responsive manner. Due to the targeting effect of the SP peptide, cellular uptake of SP-HSA-PTX NPs into brain capillary endothelial cells(BCECs) and U87 cells was greatly improved.The low IC_(50), prolonged survival period and the obvious pro-apoptotic effect shown by TUNEL analysis all demonstrated that the fabricated SP-HSA-PTX NPs showed a satisfactory anti-tumor effect and could serve as a novel strategy for GBM treatment. | Chunhui Ruan Lisha Liu Yifei Lu Yu Zhang Xi He Xinli Chen Yujie Zhang Qinjun Chen Qin Guo Tao Sun Chen Jiang | 2018 | Acta Pharmaceutica Sinica B2018，8，1： | 19 |
| 3 | Effects of melatonin implantation on cashmere yield,fibre characteristics,duration of cashmere growth as well as growth and reproductive performance of Inner Mongolian cashmere goats显示文摘Background:Exogenous melatonin could induce cashmere growth.However,induced growth of cashmere fleece by melatonin implants cannot be combined with the typical growth,resulting in earlier shedding followed by another cycle of cashmere growth.To address this issue,we examine the effects on the cashmere yield,fibre characteristics,and the growth and reproductive performance of cashmere goats of planned administration of melatonin.Methods:Eighteen half-sib,female goats were assigned to two treatments(n = 9) including a control and a treatment where melatonin(2 mg/kg BW) was implanted at the end of April and end of June.Cashmere growth and shedding were observed for approximately 1 year following implantation.Fibre samples were collected monthly to determine cumulative cashmere length.Initiation and cessation dates for cashmere growth as well as the rate of cashmere growth were calculated.Cashmere yield,weight gain of dam,kidding date,litter size,and birth weight were also recorded.Results:Melatonin implantation increased cashmere yield by 34.5%(control 553.7 g vs.melatonin 745.0 g;P< 0.01),cashmere length by 21.3%(control 95.2 mm vs.melatonin 115.4 mm;P < 0.01),and decreased fibre diameter by 4.4%(control 14.6 μm vs.melatonin 14.0 μm;P < 0.03).In melatonin-treated goats,the average initiation date was earlier than in control goats(May 18,2013 vs.July 2,2013;P< 0.01) but there was a similar cessation date(March 22,2014 vs.March 27,2014).Consequently,the duration of cashmere growth was longer in melatonin-treated goats than in control goats(307 vs.270 days;P< 0.01).The final BW,average daily gain,kidding date,litter size,and birth weight were not influenced by melatonin implantation.Conclusions:These data indicate that melatonin implantation(2 mg/kg BW) on two occasions(late April and June)increased cashmere yield by combining the induced growth of cashmere fleece with the typical growth and decreased the fibre diameter without changing dam growth rate or reproductive performance. | Chunhui Duan Jianhai Xu Changmian Sun Zhihai Jia Wei Zhang | 2015 | Journal of Animal Science and Biotechnology2015，6，4： | 18 |
| 4 | Progress of the key materials for organic solar cells显示文摘Organic solar cells have attracted academic and industrial interests due to the advantages like lightweight,flexibility and roll-to-roll fabrication.Nowadays,18%power conversion efficiency has been achieved in the state-of-the-art organic solar cells.The recent rapid progress in organic solar cells relies on the continuously emerging new materials and device fabrication technologies,and the deep understanding on film morphology,molecular packing and device physics.Donor and acceptor materials are the key materials for organic solar cells since they determine the device performance.The past 25 years have witnessed an odyssey in developing high-performance donors and acceptors.In this review,we focus on those star materials and milestone work,and introduce the molecular structure evolution of key materials.These key materials include homopolymer donors,D-A copolymer donors,A-D-A small molecular donors,fullerene acceptors and nonfullerene acceptors.At last,we outlook the challenges and very important directions in key materials development. | Yang Tong Zuo Xiao Xiaoyan Du Chuantian Zuo Yuelong Li Menglan Lv Yongbo Yuan Chenyi Yi Feng Hao Yong Hua Ting Lei Qianqian Lin Kuan Sun Dewei Zhao Chunhui Duan Xiangfeng Shao Wei Li Hin-Lap Yip Zhengguo Xiaol Bin Zhang Qingzhen Bian Yuanhang Cheng Shengjian Liu Ming Cheng Zhiwen Jin Shangfeng Yang Liming Ding | 2020 | Science China Chemistry2020，63，6： | 15 |
| 5 | A Bayesian method for comprehensive water quality evaluation of the Danjiangkou Reservoir water source area, for the middle route of the South-to-North Water Diversion Project in China显示文摘Danjiangkou 水库是为在中国的 South-to-North 水转向工程的中间的线路的水来源。因此,它的水质量地位担心大。五水质量指示物(溶解的氧,高锰酸盐索引,氨氮,全部的氮,和全部的磷),在三点被测量监视地点( Danjiangkou 水库水坝, Hejiawan 和 Jiangbei 桥),调查变化趋势,并且在到2012年5月的从2006年1月的 Danjiangkou 水库区域的水质量的空间与时间的特征。我们然后使用了一个贝叶斯的统计方法包括地评估水质量。正常分发采样方法被用来计算可能性的,并且熵重量方法被用来为对的兴趣的变量决定指示物重量到学习。结果显示所有五指示物的集中在最后六年期间增加了。另外,在水库的水质量在湿季节期间是更坏的(从 5 月到 10 月) ,比在旱季期间(从 11 月到下一年的 4 月) 。总的来说,水的概率根据为在中国的表面水的环境优秀标准,属于类型 II 的优秀范畴是 27.7%-33.7% ,比它属于另外的四种水质量类型的大。营养素的增加的集中能导致 Danjiangkou 水库的超营养作用。这个方法减少了通常与决定指示物重量和人工的分类被联系的主观,完成更可靠的结果。这些结果显示 interbasin 水转向工程在 Danjiangkou 水库区域实现综合的水质量管理是重要的[出版摘要] | Fangbing MA Chunhui LI Xuan WANG Zhifeng YANG Chengchun SUN Peiyu LIANG | 2014 | Frontiers of Earth Science2014，8，2： | 14 |
| 6 | Soil biofilms:microbial interactions,challenges,and advanced techniques for ex-situ characterization显示文摘Soil is inhabited by a myriad of microorganisms,many of which can form supracellular structures,called biofilms,comprised of surface-associated microbial cells embedded in hydrated extracellular polymeric substance that facilitates adhesion and survival.Biofilms enable intensive inter-and intra-species interactions that can increase the degradation efficiency of soil organic matter and materials commonly regarded as toxins.Here,we first discuss organization,dynamics and properties of soil biofilms in the context of traditional approaches to probe the soil microbiome.Social interactions among bacteria,such as cooperation and competition,are discussed.We also summarize different biofilm cultivation devices in combination with optics and fluorescence microscopes as well as sequencing techniques for the study of soil biofilms.Microfluidic platforms,which can be applied to mimic the complex soil environment and study microbial behaviors at the microscale with highthroughput screening and novel measurements,are also highlighted.This review aims to highlight soil biofilm research in order to expand the current limited knowledge about soil microbiomes which until now has mostly ignored biofilms as a dominant growth form. | Peng Cai Xiaojie Sun Yichao Wu Chunhui Gao Monika Mortimer Patricia A.Holden Marc Redmile-Gordon Qiaoyun Huang | 2019 | Soil Ecology Letters2019，1，3： | 4 |
| 7 | Analysis of the efficacy of transcatheter arterial infusion chemotherapy in the treatment of pancreatic carcinoma显示文摘Objective:To evaluate the clinical efficacy of infusion of gemcitabine(GEM) and fluorouracil(5-FU)through the celiac artery and superior mesenteric artery in the treatment of pancreatic carcinoma(PC).Methods:We analyzed 20 patients diagnosed clinically or pathologically with PC,without metastases,who had an estimated survival duration of>3 months in our department from May 2009 to December 2014.Nine patients were treated directly without surgical resection of the tumor,while the other 11 patients were treated after surgery.In all patients,the femoral artery was punctured using the Seldinger technique,and a catheter was placed in the opening of the celiac artery or the superior mesenteric artery.We administered 500 mg/m2 GEM and 500 mg/m2 5-FU.Observational data included data on clinical efficacy and survival rates during the follow-up period of 3-72 months.Results:Twenty patients were treated 85 times with transcatheter arterial infusion chemotherapy(TAI).The survival rates were 80%,40%,35%,20%,10%,and 5% at 3,6,12,24,and 72 months,respectively.Conclusion: TAI chemotherapy with GEM and 5-FU may be a therapeutic option for the treatment of PC. | Chunhui Nie Yuelin Zhang Guanhui Zhou Tanyang Zhou Tongyin Zhu Baoquan Wang Shengqun Chen Hongliang Wang Ziniu Yu Li Jing Junhui Sun | 2021 | Journal of Interventional Medicine2021，4，1： | 4 |
| 8 | Solution processed inorganic V20x as interfacial function materials for inverted planar-heterojunction perovskite solar cells with enhanced efficiency显示文摘 | Haitao Peng Weihai Sun Yunlong Li Senyun Ye Haixia Rao Weibo Yan Huanping Zhou Zuqiang Bian Chunhui Huang | 2016 | Nano Research2016，9，10： | 4 |
| 9 | Optimal control on special Euclidean group via natural gradient algorithm显示文摘Considering the optimal control problem about the control system of the special Euclidean group whose output only depends on its input is meaningful in practical applications. The optimal control considered here is described as the output matrix is as close as possible to the target matrix by adjusting the system input.The geodesic distance is adopted as the measure of the difference between the output matrix and the target matrix, and the trajectory of the control input obtained in the process is achieved. Furthermore, some numerical simulations are shown to illustrate our outcomes based on the natural gradient descent algorithm for optimizing the control system of the special Euclidean group. | Chunhui LI Erchuan ZHANG Lin JIU Huafei SUN | 2016 | Science China(Information Sciences)2016，59，11： | 4 |
| 10 | An efficient and recyclable iron(III)-containing imidazolium salt catalyst for cross-coupling of aryl Grignard reagents with alkyl halides显示文摘1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride, [DIPrim]Cl, was used to produce a novel iron(III)-containing imidazolium salt [DIPrim][FeCl 4 ], which included a N,N-diarylimidazolium cation (R = 2,6-diisopropylphenyl), [DIPrim] + , and tetrachloroferrate(III) anion, [FeCl 4 ]. This compound was an effective and easy-to-use catalyst for the cross-coupling of aryl Grignard reagents with primary and secondary alkyl halides bearing -hydrogens. After simply decanting the cross-coupling product in the ether layer, [DIPrim][FeCl 4 ] could be reused in at least four successive runs without significant loss of catalytic activity. | YAN ChunHui WANG LinLin GAO HuanHuan SUN HongMei SHEN Qi | 2012 | Chinese Science Bulletin2012，57，16： | 4 |
| 11 | Safrole oxide induced neuronal differentiation of rat bone-marrow mesenchymal stem cells by elevating Hsp70显示文摘 | YanChun Zhao Jie Xin ChunHui Sun BaoXiang Zhao Jing Zhao Le Su | 2012 | Gene2012，，1： | 2 |
| 12 | The deep structure of the Duanqiao hydrothermal field at the Southwest Indian Ridge显示文摘Polymetalic sulfide is the main product of sea-floor hydrothermal venting, and has become an important sea-floor mineral resources for its rich in many kinds of precious metal elements. Since 2007, a number of investigations have been carried out by the China Ocean Mineral Resources Research and Development Association(COMRA)cruises(CCCs) along the Southwest Indian Ridge(SWIR). In 2011, the COMRA signed an exploration contract of sea-floor polymetallic sulfides of 10 000 km2 on the SWIR with the International Seabed Authority. Based on the multibeam data and shipborne gravity data obtained in 2010 by the R/V Dayang Yihao during the leg 6 of CCCs21, together with the global satellite surveys, the characteristics of gravity anomalies are analyzed in the Duanqiao hydrothermal field(37°39′S, 50°24′E). The 'subarea calibration' terrain-correcting method is employed to calculate the Bouguer gravity anomaly, and the ocean bottom seismometer(OBS) profile is used to constrain the two-dimensional gravity anomaly simulation. The absent Moho in a previous seismic model is also calculated.The results show that the crustal thickness varies between 3 and 10 km along the profile, and the maximum crustal thickness reaches up to 10 km in the Duanqiao hydrothermal field with an average of 7.5 km. It is by far the most thicker crust discovered along the SWIR. The calculated crust thickness at the Longqi hydrothermal field is approximately 3 km, 1 km less than that indicated by seismic models, possibly due to the outcome of an oceanic core complex(OCC). | SUN Chaofeng WU Zhaocai TAO Chunhui RUAN Aiguo ZHANG Guoyin GUO Zhikui HUANG Enxian | 2018 | Acta Oceanologica Sinica2018，37，3： | 2 |
| 13 | Contribution of Global Warming and Atmospheric Circulation to the Hottest Spring in Eastern China in 2018显示文摘The spring of 2018 was the hottest on record since 1951 over eastern China based on station observations,being 2.5°C higher than the 1961−90 mean and with more than 900 stations reaching the record spring mean temperature.This event exerted serious impacts in the region on agriculture,plant phenology,electricity transmission systems,and human health.In this paper,the contributions of human-induced climate change and anomalous anticyclonic circulation to this event are investigated using the newly homogenized observations and updated Met Office Hadley Centre system for attribution of extreme events,as well as CanESM2(Second Generation Canadian Earth System Model)simulations.Results indicate that both anthropogenic influences and anomalous anticyclonic circulation played significant roles in increasing the probability of the 2018 hottest spring.Quantitative estimates of the probability ratio show that anthropogenic forcing may have increased the chance of this event by ten-fold,while the anomalous circulation increased it by approximately two-fold.The persistent anomalous anticyclonic circulation located on the north side of China blocked the air with lower temperature from high latitudes into eastern China.Without anthropogenic forcing or without the anomalous circulation in northern China,the occurrence probability of the extreme warm spring is significantly reduced. | Chunhui LU Ying SUN Nikolaos CHRISTIDIS Peter ASTOTT | 2020 | Advances in Atmospheric Sciences2020，37，11： | 2 |
| 14 | Novel polybenzimidazole/graphitic carbon nitride nanosheets composite membrane for the application of acid-alkaline amphoteric water electrolysis显示文摘It is a great challenge to develop membrane materials with high performance and long durability for acidalkaline amphoteric water electrolysis.Hence,the graphitic carbon nitride(g-C_(3)N_(4))nanosheets were compounded with the(2,2'-m-phenylene)-5,5'-benzimidazole(m-PBI)matrix for the preparation of m-PBI/g-C_(3)N_(4) composite membranes.The synthesis of g-C_(3)N_(4) nanosheets and m-PBI matrix have been confirmed by X-ray diffraction(XRD),scanning electron microscopy(SEM),transmission electron microscoy(TEM)and ^(1)H nuclear magnetic resonance spectra(^(1)H NMR),respectively.The fourier transform infrared spectroscopy(FT-IR)and SEM of the composite membranes showed the g-C_(3)N_(4) nanosheets were well dispersed in the m-PBI/g-C_(3)N_(4) composite membrane.The mechanical properties test exhibited the good mechanical strength,and the TGA curves of m-PBI showed the high thermal stability of composite membranes.Besides,the m-PBI/g-C_(3)N_(4) composite membrane showed excellent proton and hydroxide ion conductivity,which was higher than pure m-PBI and Nafion 115 membrane.The acid-alkaline amphoteric water electrolysis test showed m-PBI/1%g-C_(3)N_(4) composite membrane has the best performance with a current density of 800 mA cm^(-2) at cell voltage of 1.98 V at 20℃.It showed that m-PBI/g-C_(3)N_(4) composite membrane has a good application prospect for acid-alkaline amphoteric water electrolysis. | Bo Lv Hang Yin Zhigang Shao Zoujie Luan Ziyi Huang Shucheng Sun Yue Teng Chunhui Miu Qiang Gao | 2022 | Journal of Energy Chemistry2022，31，1： | 2 |
| 15 | Rapid and Complete Conversion of CH3NH3PbI3 for Perovskite/C60 Planar-Heterojunction Solar Cells by Two-Step Deposition显示文摘 | Weihai Sun Yunlong Li Weibo Yan Haitao Peng Senyun Ye Haixia Rao Ziran Zhao Zhiwei Liu Zuqiang Bian Chunhui Huang | 2017 | Chinese Journal of Chemistry2017，35，5： | 2 |
| 16 | Synthesis of hexagonal and triangular Fe3O4 nanosheets via seed-mediated solvothermal growth显示文摘 | Chunhui Li Ruixue Wei Yanmin Xu Ailing Sun Liuhe Wei | 2014 | Nano Research2014，7，4： | 2 |
| 17 | Synthesis, structure of iron(Ⅲ)-containing imidazolium salts and their catalytic activity in the alkylation of aryl Grignard reagents显示文摘A series of iron(III)-containing imidazolium salts of the general formula [DRim][FeX 4 ] (R=2,6-diisopropylphenyl, IPr, X=Cl, 1; R=IPr, X=Br, 2; R=tertbutyl, t Bu, X=Cl, 3; R=isopropyl, i Pr, X=Cl, 4; R=benzyl, Bn, X=Cl, 5; R=Bn, X=Br, 6) have been prepared in high yields via reactions of anhydrous ferric halides with equivalent of the corresponding N,N-dihydro- carby-limidazolium halides, where 2-6 are novel ones. All of the complexes were characterized by elemental analysis, Raman spectroscopy, electrospray ionization mass spectroscopy, and X-ray crystallography for 1 and 2. All of them were non-hygroscopic and air-stable, with four of them existing as solids (1-4) and two as liquids (5 and 6) at room temperature. A preliminary catalytic study on the coupling of 4-tolylmagnesium bromide with cyclohexyl bromide revealed that 1 and 3 possessed the highest activity. In comparison, 2, 4 and 5 exhibited moderate activity and the least active complex was 6. | XIA Ying YAN ChunHui LI Zhuang GAO HuanHuan SUN HongMei SHEN Qi ZHANG Yong | 2013 | Chinese Science Bulletin2013，58，4： | 2 |
| 18 | Synthesis and electrochemical properties of MnO 2 nanorods/graphene composites for supercapacitor applications显示文摘 | SiXu Deng Dan Sun ChunHui Wu Hao Wang JingBing Liu YuXiu Sun Hui Yan | 2013 | Electrochimica Acta2013，，： | 1 |
| 19 | A generalized morphological filter based on adaptive weighted average显示文摘 | Zhao Chunhui Sun Shenghe Qiao Jinlu | 1997 | Chinese Journal of Electroniics1997，6，3： | 1 |
| 20 | An Efficient Group Key Agreement Scheme for Mobile Ad-hoc Networks显示文摘 | Yang Yang Hu Yuping Sun Chunhui | 2013 | International Arab Journal of Information Technology2013，10，1： | 1 |
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