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| 1 | Survival of geriatric patients after percutaneous endoscopic gastrostomy in Japan显示文摘AIM: To examine the long term survival of geriatric patients treated with percutaneous endoscopic gastrostomy (PEG) in Japan. METHODS: We retrospectively included 46 Japanese community and tertiary hospitals to investigate 931 consecutive geriatric patients (≥ 65 years old) with swallowing difficulty and newly performed PEG between Jan 1st 2005 and Dec 31st 2008. We set death as an outcome and explored the associations among patient’s characteristics at PEG using log-rank tests and Cox proportional hazard models. RESULTS: Nine hundred and thirty one patients were followed up for a median of 468 d. A total of 502 deaths were observed (mortality 53%). However, 99%, 95%, 88%, 75% and 66% of 931 patients survived more than 7, 30, 60 d, a half year and one year, respectively. In addition, 50% and 25% of the patients survived 753 and 1647 d, respectively. Eight deaths were considered as PEG-related, and were associated with lower serum albumin levels (P = 0.002). On the other hand, among 28 surviving patients (6.5%), PEG was removed. In a multivariate hazard model, older age [hazard ratio (HR), 1.02; 95% confidence interval (CI), 1.00-1.03; P = 0.009], higher C-reactive protein (HR, 1.04; 95% CI: 1.01-1.07; P = 0.005), and higher blood urea nitrogen (HR, 1.01; 95% CI: 1.00-1.02; P = 0.003) were significant poor prognostic factors, whereas higher albumin (HR, 0.67; 95% CI: 0.52-0.85; P = 0.001), female gender (HR, 0.60; 95% CI: 0.48-0.75; P < 0.001) and no previous history of ischemic heart disease (HR, 0.69; 95% CI: 0.54-0.88, P = 0.003) were markedly better prognostic factors. CONCLUSION: These results suggest that more than half of geriatric patients with PEG may survive longer than 2 years. The analysis elucidated prognostic factors. | Yutaka Suzuki Seryna Tamez Akihiko Murakami Akihiko Taira Akihiro Mizuhara Akira Horiuchi Chie Mihara Eiji Ako Hirohito Muramatsu Hitoshi Okano Hitoshi Suenaga Kazuaki Jomoto Junya Kobayashi Katsunari Takifuji Kazuhiro Akiyama Koh Tahara Koji Onishi Makoto Shimazaki Masami Matsumoto Masashi Ijima Masato Murakami Masato Nakahori Michiaki Kudo Michio Maruyama Mikako Takahashi Naohiro Washizawa Shigeru Onozawa Satoshi Goshi Satoyoshi Yamashita Shigeki Ono Shin Imazato Shinji Nishiwaki Shuichirou Kitahara Takao Endo Takao Iiri Takeshi Nagahama Takuto Hikichi Tatsuya Mikami Tetsuo Yamamoto Tetsushi Ogawa Tomoko Ogawa Tomoyuki Ohta Toshifumi Matsumoto Toshiroh Kura Tsutomu Kikuchi Tsuyoshi Iwase Tsuyotoshi Tsuji Yukio Nishiguchi Mitsuyoshi Urashima | 2010 | World Journal of Gastroenterology2010，16，40： | 4 |
| 2 | Decreased Expression of the RAS-GTPase Activating Protein RASAL1 Is Associated With Colorectal Tumor Progression显示文摘 | Miki Ohta Motoko Seto Hideaki Ijichi Koji Miyabayashi Yotaro Kudo Dai Mohri Yoshinari Asaoka Motohisa Tada Yasuo Tanaka Tsuneo Ikenoue Fumihiko Kanai Takao Kawabe Masao Omata | 2009 | Gastroenterology2009，，1： | 2 |
| 3 | Cancer-derived VEGF plays no role in malignant ascites formation in the mouse显示文摘AIM: Vascular endothelial growth factor (VEGF) is a potent mediator of peritoneal fluid accumulation following tumor progression. This study investigated the role of VEGF secreted by cancerous cells in the formation of malignant ascites.METHODS: VEGF expression was eliminated byknockdown in the pancreas cancer cell-line PancO2 using vector-based short-hairpin type RNA interference (RNAi).Malignant ascites formation in the mouse was analyzed by intraperitoneal injection of PancO2 cells expressing VEGF or with expression knockdown.RESULTS: The VEGF knockdown PancO2 cell was successfully established. Knockdown of VEGF did not affect cancer cell proliferation in vitro or in vivo. The volume of ascites following peritoneal expansion of the tumor in VEGF knockdown cells and control cells did not differ statistically in this in vivo study. Moreover, the VEGF concentration in the ascites did not differ statistically.CONCLUSION: Malignant ascites formation might be mediated by VEGF production in noncancerous tissues,such as stromal compartments. An anti-VEGF strategy against malignant ascites could be applied to various tumors regardless of whether they secrete VEGF. | Bayasi Guleng Keisuke Tateishi Fumihiko Kanai Amarsanaa Jazag Miki Ohta Yoshinari Asaoka Hideaki Ijichi Yasuo Tanaka Jun Imamura Tsuneo Ikenoue Yasushi Fukushima Keita-Morikane Makoto Miyagishi Kazunari Taira Takao Kawabe Masao Omata | 2005 | World Journal of Gastroenterology2005，11，35： | 2 |
| 4 | Assessment of the Risk Factors for Colonic Diverticular Hemorrhage显示文摘 | Atsuo Yamada Takafumi Sugimoto Shintaro Kondo Miki Ohta Hirotsugu Watabe Shin Maeda Goichi Togo Yutaka Yamaji Keiji Ogura Makoto Okamoto Haruhiko Yoshida Takao Kawabe Tateo Kawase Masao Omata | 2008 | Diseases of the Colon & Rectum2008，，1： | 2 |
| 5 | Gene expression profiles predicting the response to IFN-β and a combinationof temozolomide and IFN-β in malignant gliomas显示文摘 | Atsuo Yoshino Shinya Tashiro Akiyoshi Ogino Kazunari Yachi Takashi Ohta Takao Fukushima Takao Watanabe Yoichi Katayama Yutaka Okamoto Emiko Sano Kouhei Tsumoto | 2011 | International Journal of Oncology2011，，3： | 1 |
| 6 | Metabolic syndrome is a risk factor for acute cerebral infarction in a younger elderly Kurashiki population 显示文摘 | Ohta Y Takao Y Harada K | 2012 | J Stroke Cerebrovasc Dis2012，21，3： | 1 |
| 7 | Metabolic syn- drome is a risk factor for acute cerebral infarction in a younger elderly kurashiki population 显示文摘 | Ohta Y Takao Y Harada K | 2012 | Journal of Stroke and Cerebrovascular Diseases2012，21，3： | 1 |
| 8 | Significance ofHelicobacter pylori infection as a risk factor in gastric cancer: Serological and histological studies显示文摘 | R. Barreto-Zu?iga Masakazu Maruyama Yo Kato Kenji Aizu Hirotoshi Ohta Takao Takekoshi Sahagun F. Bernal | 1997 | Journal of Gastroenterology1997，，3： | 1 |
| 9 | Assessment of the Risk Factors for Colonic Diverticular Hemorrhage显示文摘 | Atsuo Yamada M.D. Takafumi Sugimoto M.D. Shintaro Kondo M.D. Miki Ohta M.D. Hirotsugu Watabe M.D. Shin Maeda M.D. Goichi Togo M.D. Yutaka Yamaji M.D. Keiji Ogura M.D. Makoto Okamoto M.D. Haruhiko Yoshida M.D. Takao Kawabe M.D. Tateo Kawase M.D. Masao Omat | 2008 | Diseases of the Colon & Rectum2008，，1： | 1 |
| 10 | On the pressure projection in elasto-hydrostatic lubrication problems-Part 2:FE approximation to observe the pressure projection显示文摘 | Takao Sawada Toru Ohta | 2005 | International Journal of Mechanical Sciences2005，47，： | 1 |
| 11 | Probability of the freak wave appearance in a 3 - dimensional sea condition显示文摘 | Akira Kimura Takao Ohta | 1994 | Japan Society of Civil Engineers ASCE1994，，： | 1 |
| 12 | Metabolic syndrome is a risk factorfor acute cerebral infarction in a younger elderly Kurashiki population显示文摘 | Ohta Y Takao Y Harada k | 2012 | J Stroke Cerebrovasc I)is2012，21，3： | 1 |
| 13 | Neuroprotective Effect of an Antioxidant, Ebselen, in Patients with Delayed Neurological Deficits after Aneurysmal Subarachnoid Hemorrhage显示文摘 | Isamu Saito Takao Asano Keiji Sano Kintomo Takakura Hiroshi Abe Takashi Yoshimoto Haruhiko Kikuchi Tomio Ohta Sadahiko Ishibashi | 1998 | Neurosurgery1998，，2： | 1 |
| 14 | Assessment of the Risk Factors for Colonic Diverticular Hemorrhage显示文摘 | Atsuo Yamada M.D. Takafumi Sugimoto M.D. Shintaro Kondo M.D. Miki Ohta M.D. Hirotsugu Watabe M.D. Shin Maeda M.D. Goichi Togo M.D. Yutaka Yamaji M.D. Keiji Ogura M.D. Makoto Okamoto M.D. Haruhiko Yoshida M.D. Takao Kawabe M.D. Tateo Kawase M.D. Masao Omat | 2008 | Diseases of the Colon & Rectum2008，，1： | 1 |
| 15 | Metabolic syndromeis a risk factor for acute cerebral infarction in ayounger elderly Kurashiki population显示文摘 | Ohta Y Takao Y Harada K | 2012 | J Stroke Cerebrovasc Dis2012，21，3： | 1 |
| 16 | Metabolic syndrome is a risk factor for acute cerebral infarction in a younger elderly Kurashiki population显示文摘 | Ohta Y Takao Y Harada K | 2012 | Journal of stroke and cerebrovascular diseases2012，21，3： | 1 |
| 17 | Different subtypes of intraductal papillary mucinous neoplasm in the pancreas have distinct pathways to pancreatic cancer progression显示文摘 | Dai Mohri Yoshinari Asaoka Hideaki Ijichi Koji Miyabayashi Yotaro Kudo Motoko Seto Miki Ohta Motohisa Tada Yasuo Tanaka Tsuneo Ikenoue Keisuke Tateishi Hiroyuki Isayama Fumihiko Kanai Noriyoshi Fukushima Minoru Tada Takao Kawabe Masao Omata Kazuhiko Koike | 2012 | Journal of Gastroenterology2012，，2： | 1 |
| 18 | Metabolic syndrome is a risk factor for acute cerebral infarction in a younger elderly kurashiki population显示文摘 | Ohta Y Takao Y Harada K | 2010 | Journal of Stroke and Cerebrovascu-lar Diseases2010，7，3： | 1 |
| 19 | A strategy for selective anti-cancer drug concentration increase in rat glioma tissue with Ca2+-channel blocker co-administration: calcium kinetics in intra-glioma arteriolar smooth muscle cells显示文摘 | Kiichiro Zenke Koh Nakagawa Yoshiaki Kumon Shinsuke Ohta Takao Hatakeyama Saburo Sakaki | 1996 | Journal of Neuro - Oncology1996，，1： | 1 |
| 20 | Validation of the Japanese Osteoporosis Quality of Life Questionnaire显示文摘 | Keigo Kumamoto Toshitaka Nakamura Takao Suzuki Itsuo Gorai Osamu Fujinawa Hiroaki Ohta Masataka Shiraki Kosei Yoh Saeko Fujiwara Naoto Endo Toshio Matsumoto | 2010 | Journal of Bone and Mineral Metabolism2010，，1： | 1 |
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