|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Chemical compound cinobufotalin potently induces FOXO1-stimulated cisplatin sensitivity by antagonizing its binding partner MYH9显示文摘In this study,we present novel molecular mechanisms by which FOXO1 functions as a tumor suppressor to prevent the pathogenesis of nasopharyngeal carcinoma(NPC).First,we observed that FOXO1 not only controlled tumor stemness and metastasis,but also sensitized NPC cells to cisplatin(DDP)in vitro and in vivo.Mechanistic studies demonstrated that FOXO1-induced miR-200b expression through the GSK3β/β-catenin/TCF4 network-mediated stimulation of ZEB1,which reduced tumor stemness and the epithelial–mesenchymal transition(EMT)signal.Furthermore,we observed FOXO1 interaction with MYH9 and suppression of MYH9 expression by modulating the PI3K/AKT/c-Myc/P53/miR-133a-3p pathway.Decreased MYH9 expression not only reduced its interactions with GSK3β,but also attenuated TRAF6 expression,which then decreased the ubiquitin-mediated degradation of GSK3βprotein.Increased GSK3βexpression stimulated theβ-catenin/TCF4/ZEB1/miR-200b network,which increased the downstream tumor stemness and EMT signals.Subsequently,we observed that chemically synthesized cinobufotalin(CB)strongly increased FOXO1-induced DDP chemosensitivity by reducing MYH9 expression,and the reduction in MYH9 modulated GSK3β/β-catenin and its downstream tumor stemness and EMT signal in NPC.In clinical samples,the combination of low FOXO1 expression and high MYH9 expression indicated the worst overall survival rates.Our studies demonstrated that CB potently induced FOXO1-mediated DDP sensitivity by antagonizing its binding partner MYH9 to modulate tumor stemness in NPC. | YongHao Li Xiong Liu Xian Lin Menyang Zhao Yanyi Xiao Chen Liu Zixi Liang Zelong Lin Renhui Yi Zibo Tang Jiahao Liu Xin Li Qingping Jiang Libo Li Yinyin Xie Zhen Liu Weiyi Fang | 2019 | Signal Transduction and Targeted Therapy2019，4，1： | 6 |
| 2 | Super enhancer inhibitors suppress MYC driven transcriptional amplification and tumor progression in osteosarcoma显示文摘Osteosarcoma is the most common primary bone sarcoma that mostly occurs in young adults. The causes of osteosarcoma are heterogeneous and still not fully understood. Identification of novel, important oncogenic factors in osteosarcoma and development of better, effective therapeutic approaches are in urgent need for better treatment of osteosarcoma patients. In this study, we uncovered that the oncogene MYC is significantly upregulated in metastastic osteosarcoma samples. In addition, high MYC expression is associated with poor survival of osteosarcoma patients. Analysis of MYC targets in osteosarcoma revealed that most of the osteosarcoma super enhancer genes are bound by MYC. Treatment of osteosarcoma cells with super enhancer inhibitors THZ1 and JQ1 effectively suppresses the proliferation, migration, and invasion of osteosarcoma cells. Mechanistically,THZ1 treatment suppresses a large group of super enhancer containing MYC target genes including CDK6 and TGFB2. These findings revealed that the MYC-driven super enhancer signaling is crucial for the osteosarcoma tumorigenesis and targeting the MYC/super enhancer axis represents as a promising therapeutic strategy for treatment of osteosarcoma patients. | Demeng Chen Zhiqiang Zhao Zixin Huang Du-Chu Chen Xin-Xing Zhu Yi-Ze Wang Ya-Wei Yan Shaojun Tang Subha Madhavan Weiyi Ni Zhan-peng Huang Wen Li Weidong Ji Huangxuan Shen Shuibin Lin Yi-Zhou Jiang | 2018 | Bone Research2018，6，2： | 5 |
| 3 | Wafer-scale arrayed p-n junctions based on few-layer epitaxial GaTe显示文摘二维(2D ) 材料吸引了实质的注意在电子并且有灵活、透明、高度悦耳的优异优点的 optoelectronic 应用。当时,无差距的 graphene 展出极端宽带、快的 photoresponse 半导体的瞬间 2 和门高展出的 2D 敏感和悦耳的 responsivity 到可见的光。然而,设备收益和重覆性打电话让进一步的改进完成大规模一致性。这里,我们与 28.4 厘米 2/(V0 的高洞活动性报导晶片规模门的 layer-by-layer | Xiang Yuan Lei Tang Peng Wang Zhigang Chen Yichao Zou Xiaofeng Su Cheng Zhang Yanwen Liu Weiyi Wang Cong Liu Fansheng Chen Jin Zou Peng Zhou Weida Hu Faxian Xiu | 2015 | Nano Research2015，8，10： | 4 |
| 4 | Synthesis of fluorinated hyperbranched polymers capable as highly hydrophobic and oleophobic coating materials 显示文摘 | Tang Weiyi Huang Yangen Meng Weidong | 2010 | European Polymer Journal2010，46，： | 1 |
| 5 | Interference-aware topology control and QoS routing in multi-channel wireless mesh networks显示文摘 | Tang Jian Xue Guoliang Zhang Weiyi | 2005 | MobiHoc ''05 Proceedings of the 6th ACM international symposium on Mobile ad hoc networking and computing2005，，： | 1 |
| 6 | Cross-layer optimization for end-to-end rate allocation in multi-radio wireless mesh networks显示文摘 | Jian Tang Guoliang Xue Weiyi Zhang | 2009 | Wireless Networks2009，，1： | 1 |
| 7 | Utrasonic wind velocity measurement based on DSP显示文摘 | TANG Huiqiang HUANG Weiyi LI Ping | 2005 | J Southeast University2005，，1： | 1 |
| 8 | Manganese and chromium doping in atomically thin MoS2显示文摘Recently,two-dimensional materials have been attracting increasing attention because of their novel properties and promising applications.However,the impurity doping remains a significant challenge owing to the lack of the doping strategy in the atomically thin layers.Here we report on the chromium(Cr) and manganese(Mn)doping in atomically-thin MoS_2 crystals grown by chemical vapor deposition.The Cr/Mn doped MoS_2 samples are characterized by a peak at 1.76 and 1.79 eV in photoluminescence spectra,respectively,compared with the undoped one at 1.85 eV.The field-effect transistor(FET) devices based on the Mn doping show a higher threshold voltage than that of the pure MoS_2 while the Cr doping exhibits the opposite behavior.Importantly,the carrier concentration in these samples displays a remarkable difference arising from the doping effect,consistent with the evolution of the FET performance.The temperature-dependent conductivity measurements further demonstrate a large variation in activation energy.The successful incorporation of the Mn and Cr impurities into the monolayer MoS_2 paves the way towards the high Curie temperature two-dimensional dilute magnetic semiconductors. | Ce Huang Yibo Jin Weiyi Wang Lei Tang Chaoyu Song Faxian Xiu | 2017 | Journal of Semiconductors2017，38，3： | 1 |
| 9 | The Laplacian on the level 3 Sierpinski gasket via the method of averages显示文摘 | Tang Donglei Su Weiyi | | 0，，： | 1 |
| 10 | Thermaldegradation and flame retardance of biobased polylactidecomposites based on aluminum hypophosphite 显示文摘 | Gang Tang Xin Wang Weiyi Xing | 2012 | In-dustrial & Engineering Chemistry Research2012，51，12： | 1 |
| 11 | Nitric oxide-mediated immunosuppressive effect of Human amniotic membrane-derived mesenchymal stem cells on the viability and migration of microglia显示文摘 | Ke Yan Run Zhang Lei Chen Fanfan Chen Yi Liu Lingmei Peng Haitao Sun Weiyi Huang Chengmei Sun Bingke Lv Feng Li Yingqian Cai Yanping Tang Yuxi Zou Mouxuan Du Lingsha Qin Hengzhu Zhang Xiaodan Jiang | 2014 | Brain Research2014，，： | 1 |
| 12 | Cross-layer optimization for end-to-end rate allocation in multi-radio wireless mesh networks显示文摘 | Tang Jian Xue Guoliang Zhang Weiyi | 2009 | Wireless Networks2009，15，1： | 1 |
| 13 | Thermal degradation and flame retardance of biobased polylactide composites based on aluminum hypophosphite显示文摘 | Tang Gang Wang Xin Xing Weiyi | 2012 | Industrial & Engineering Chemistry Research2012，51，12： | 1 |
| 14 | Cross-layer optimization for end-to-end rate allocation in multi-radio wireless mesh networks显示文摘 | Jian Tang Guoliang Xue Weiyi Zhang | 2009 | Wireless Networks2009，，1： | 1 |
| 15 | Synthesis and char- acterization of fluorinated polyaerylate graft copolymers capable as water and oil repellent finishing agents显示文摘 | Weiyi Tang Yangen Huang Feng Ling Qing | 2011 | Journal of Applied Polymer Science2011，117，1： | 1 |
| 16 | Associations of prediabetes with all-cause and cardiovascular mortality: A meta-analysis显示文摘 | Yi Huang Xiaoyan Cai Peisong Chen Weiyi Mai Hongfeng Tang Yuli Huang Yunzhao Hu | 2014 | Annals of Medicine2014，，8： | 1 |
| 17 | Utrasonic wind velocity measurement based on DSP显示文摘 | TANG Huiqiang HUANG Weiyi LI Ping | 2005 | J Southeast University2005，，1： | 1 |
| 18 | Energy-efficient collaborative sensing with mobile phones 显示文摘 | Sheng Xiang Tang Jian Zhang Weiyi | 2012 | Proceed-ings-IEEE INFOCOM2012，131，5： | 1 |
| 19 | Theoretical perspective on synthetic man-made life:Learning from the origin of life显示文摘Creating a man-made life in the laboratory is one of life science's most intriguing yet challenging problems.Advances in synthetic biology and related theories,particularly those related to the origin of life,have laid the groundwork for further exploration and understanding in this field of artificial life or man-made life.But there remains a wealth of quantitative mathematical models and tools that have yet to be applied to this area.In this paper,we review the two main approaches often employed in the field of man-made life:the top-down approach that reduces the complexity of extant and existing living systems and the bottom-up approach that integrates welldefined components,by introducing the theoretical basis,recent advances,and their limitations.We then argue for another possible approach,namely'bottom-up from the origin of life':Starting with the establishment of autocatalytic chemical reaction networks that employ physical boundaries as the initial compartments,then designing directed evolutionary systems,with the expectation that independent compartments will eventually emerge so that the system becomes free-living.This approach is actually analogous to the process of how life originated.With this paper,we aim to stimulate the interest of synthetic biologists and experimentalists to consider a more theoretical perspective,and to promote the communication between the origin of life community and the synthetic man-made life community. | Lu Peng Zecheng Zhang Xianyi Wang Weiyi Qiu Liqian Zhou Hui Xiao Chunxiuzi Liu Shaohua Tang Zhiwei Qin Jiakun Jiang Zengru Di Yu Liu | 2023 | Quantitative Biology2023，11，4： | 0 |
| 20 | Prediction of protected band edge states and dielectric tunable quasiparticle and excitonic properties of monolayer MoSi_(2)N_(4)显示文摘The electronic structure of two-dimensional(2D)materials are inherently prone to environmental perturbations,which may pose significant challenges to their applications in electronic or optoelectronic devices.A 2D material couples with its environment through two mechanisms:local chemical coupling and nonlocal dielectric screening effects.The local chemical coupling is often difficult to predict or control experimentally.Nonlocal dielectric screening,on the other hand,can be tuned by choosing the substrates or layer thickness in a controllable manner.Therefore,a compelling 2D electronic material should offer band edge states that are robust against local chemical coupling effects.Here it is demonstrated that the recently synthesized MoSi_(2)N_(4)is an ideal 2D semiconductor with robust band edge states protected from capricious environmental chemical coupling effects.Detailed many-body perturbation theory calculations are carried out to illustrate how the band edge states of MoSi_(2)N_(4)are shielded from the direct chemical coupling effects,but its quasiparticle and excitonic properties can be modulated through the nonlocal dielectric screening effects.This unique property,together with the moderate band gap and the thermodynamic and mechanical stability of this material,paves the way for a range of applications of MoSi_(2)N_(4)in areas including energy,2D electronics,and optoelectronics. | Yabei Wu Zhao Tang Weiyi Xia Weiwei Gao Fanhao Jia Yubo Zhang Wenguang Zhu Wenqing Zhang Peihong Zhang | 2022 | npj Computational Materials2022，，1： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员