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| 1 | Quantitative evaluation of long-term liver repopulation and the reconstitution of bile ductules after hepatocellular transplantation显示文摘AIM: The treatment of liver disease is severely limited by a shortage of donor livers. In trying to address this growing problem, hepatocellular transplantation (HTx) has received much attention as an alternative to whole organ transplant.However, the expansion of transplanted cells is at low level,and the reconstitution of functional liver tissue is limited by this cellular property. We set up an animal model to better understand cell dose effect and the kinetics of liver repopulation following HTx.METHODS: Dipeptidyl peptidase Ⅳ (DPPIV)-deficient rats treated with retrorsine and subjected to partial hepatectomy were infused with DPPIV-positive hepatocytes. Rats were injected with varying numbers of donor hepatocytes down to 100 cells low, and liver repopulation was examined at different time points up to 20 mo long. Repopulation was assessed by computer-aided quantitative detection.RESULTS: Transplanted hepatocytes underwent multiple rounds of proliferation and stably repopulated the injured livers after 20 mo and at all cell doses. Transplanted cells divided 14 times within the 3-mo time period following infusion, and the liver repopulation reached a plateau between 3 and 20 mo. Approximately 90% replacement occurred. Donor-derived cells also reconstituted the bile ductules of the recipients.CONCLUSION: The ability of transplanted hepatocytes to fully reconstitute injured livers strongly supports further investigation into the clinical potential of HTx. Additionally,the observation that transplanted hepatocytes also form components of the biliary system suggests that these cells may have bi-potential property of the stem cells. | Yun-Wen Zheng Nobuhiro Ohkohchi Hideki Taniguchi | 2005 | World Journal of Gastroenterology2005，11，39： | 9 |
| 2 | Cellular reprogramming and hepatocellular carcinoma development显示文摘Hepatocellular carcinoma(HCC)is one of the most common cancers,and is also the leading cause of death worldwide.Studies have shown that cellular reprogramming contributes to chemotherapy and/or radiotherapy resistance and the recurrence of cancers.In this article,we summarize and discuss the latest findings in the area of cellular reprogramming in HCC.The aberrant expression of transcription factors OCT4,KLF4,SOX2,c-MYC,NANOG,and LIN28 have been also observed,and the expression of these transcription factors is associated with unfavorable clinical outcomes in HCC.Studies indicate that cellular reprogramming may play a critical role in the occurrence and recurrence of HCC.Recent reports have shown that DNA methylation,miRNAs,tumor microenvironment,and signaling pathways can induce the expression of stemness transcription factors,which leads to cellular reprogramming in HCC.Furthermore,studies indicate that therapies based on cellular reprogramming could revolutionize HCC treatment.Finally,a novel therapeutic concept is discussed:reprogramming control therapy.A potential reprogramming control therapy method could be developed based on the reprogramming demonstrated in HCC studies and applied at two opposing levels:differentiation and reprogramming.Our increasing understanding and control of cellular programming should facilitate the exploitation of this novel therapeutic concept and its application in clinical HCC treatment,which may represent a promising strategy in the future that is not restricted to liver cancer. | Yun-Wen Zheng Yun-Zhong Nie Hideki Taniguchi | 2013 | World Journal of Gastroenterology2013，19，47： | 5 |
| 3 | Multicenter phase II study of weekly paclitaxel plus S-1 combination chemotherapy in patients with advanced gastric cancer显示文摘 | Yuji Ueda Hisakazu Yamagishi Daisuke Ichikawa Kazuma Okamoto Eigo Otsuji Jun Morii Kinya Koizumi Naoki Kakihara Masataka Shimotsuma Tetsuro Yamashita Fumihiro Taniguchi Hideki Aragane Hiroshi Nishi Yoshiki Itokawa Satoshi Morita Junichi Sakamoto | 2010 | Gastric Cancer2010，，3： | 2 |
| 4 | Perioperative Management of Hepatic Resection Toward Zero Mortality and Morbidity: Analysis of 793 Consecutive Cases in a Single Institution显示文摘 | Toshiya Kamiyama Kazuaki Nakanishi Hideki Yokoo Hirofumi Kamachi Munenori Tahara Kenichiro Yamashita Masahiko Taniguchi Tsuyoshi Shimamura Michiaki Matsushita Satoru Todo | 2010 | Journal of the American College of Surgeons2010，，4： | 2 |
| 5 | Perioperative Management of Hepatic Resection Toward Zero Mortality and Morbidity: Analysis of 793 Consecutive Cases in a Single Institution显示文摘 | Toshiya Kamiyama Kazuaki Nakanishi Hideki Yokoo Hirofumi Kamachi Munenori Tahara Kenichiro Yamashita Masahiko Taniguchi Tsuyoshi Shimamura Michiaki Matsushita Satoru Todo | 2010 | Journal of the American College of Surgeons2010，，4： | 2 |
| 6 | Multi-institutional study of risk factors of liver metastasis from colorectal cancer: correlation with CD10 expression显示文摘 | Shin Fujita Hirokazu Taniguchi Takashi Yao Tadakazu Shimoda Hideki Ueno Takashi Hirai Masayuki Ohue | 2010 | International Journal of Colorectal Disease2010，，6： | 1 |
| 7 | Enhanced Self-Renewal Capability in Hepatic Stem/Progenitor Cells Drives Cancer Initiation显示文摘 | Tetsuhiro Chiba Yun-Wen Zheng Kaoru Kita Osamu Yokosuka Hiromitsu Saisho Masafumi Onodera Hiroyuki Miyoshi Masayuki Nakano Yoh Zen Yasuni Nakanuma Hiromitsu Nakauchi Atsushi Iwama Hideki Taniguchi | 2007 | Gastroenterology2007，，3： | 1 |
| 8 | Usefulness of enhanced recovery after surgery protocol as compared with conventional perioperative care in gastric surgery显示文摘 | Takanobu Yamada Tsutomu Hayashi Haruhiko Cho Takaki Yoshikawa Hideki Taniguchi Ryoji Fukushima Akira Tsuburaya | 2012 | Gastric Cancer2012，，1： | 1 |
| 9 | Genotype of bovine sterol regulatory element binding protein-1 (SREBP-1) is associated with fatty acid composition in Japanese Black cattle显示文摘 | Shogo Hoashi Nobuhisa Ashida Hideki Ohsaki Takeshi Utsugi Shinji Sasazaki Masaaki Taniguchi Kenji Oyama Fumio Mukai Hideyuki Mannen | 2007 | Mammalian Genome2007，，12： | 1 |
| 10 | Off-axial HMD optical system consisting of aspherical surfaces without rotational symmetry 显示文摘 | Hiroaki Hoshi Naosato Taniguchi Hideki Morishima | 1996 | Proceedings of SPIE1996，3653，： | 1 |
| 11 | Pillaring and photocatalytic property of partially substituted layered titanates, Na2Ti3-xMxO7 and K2Ti4-xMxO9 (M=Mn, Fe, Co, Ni, Cu) 显示文摘 | Machida Masato Ma Xu Wei Taniguchi Hideki | 2000 | Journal of Molecular Catalysis A: Chemical2000，，155： | 1 |
| 12 | A New Flow Control Technique Using Diluted Epinephrine in the N-butyl-2-cyanoacrylate Embolization of Visceral Artery Pseudoaneurysms Secondary to Chronic Pancreatitis显示文摘 | Hiroyuki Morishita Takuji Yamagami Yoshito Takeuchi Tomohiro Matsumoto Shunsuke Asai Koji Masui Hideki Sato Fumihiro Taniguchi Osamu Sato Tsunehiko Nishimura | 2012 | CardioVascular and Interventional Radiology2012，，4： | 1 |
| 13 | Pillaring and photocalatytic property of partially substituted layered titanates,Na2Ti3-xMxO7 and K2Ti4-xMxO9 (M=Mn,Fe,Co,Ni,Cu) 显示文摘 | MASATO MACHIDA XU WEI MA HIDEKI TANIGUCHI | 2000 | JMolecular Cata A:Chemical2000，155，： | 1 |
| 14 | Prospective Isolation of Muhipotent Pancreatic Progenitors Using Flow-Cytometric Cell Sorting显示文摘 | Atsushi Suzuki Hiromitsu Nakauchi Hideki Taniguchi | 2004 | Diabetes2004，53，2： | 1 |
| 15 | Quantitative molecular diagnosis of peritoneal lavage fluid for predictionof peritoneal recurrence in gastric cancer显示文摘 | Yurika Sugita Yoshiyuki Fujiwara Hirokazu Taniguchi Takuji Mori Takaaki Ishii Hideki Niwa Yoshihiro Okada Shuji Takiguchi Takushi Yasuda Masahiko Yano Morito Monden | 2003 | International Journal of Oncology2003，，： | 1 |
| 16 | Multicenter phase II study of weekly paclitaxel plus S-1 combination chemotherapy in patients with advanced gastric cancer显示文摘 | Yuji Ueda Hisakazu Yamagishi Daisuke Ichikawa Kazuma Okamoto Eigo Otsuji Jun Morii Kinya Koizumi Naoki Kakihara Masataka Shimotsuma Tetsuro Yamashita Fumihiro Taniguchi Hideki Aragane Hiroshi Nishi Yoshiki Itokawa Satoshi Morita Junichi Sakamoto | 2010 | Gastric Cancer2010，，3： | 1 |
| 17 | Prolonged hepatic warm ischemia in non-heart-beating donors: Protective effects of FK506 and a platelet activating factor antagonist in porcine liver transplantation显示文摘 | Yasutsugu Takada Hideki Taniguchi Kiyoshi Fukunaga Kenji Yuzawa Masaaki Otsuka Takeshi Todoroki Tatsuo Iijima Katashi Fukao | 1998 | Surgery1998，，6： | 1 |
| 18 | Synchronous coexistence of liver metastases from cecal leiomyosarcoma and rectal adenocarcinoma: A case report显示文摘Multiple liver tumors represent a challenging condition for abdominal surgeons both in the selection of technique and the rarity of diagnosis. There are no case reports on co-existence of liver metastases from both intestinal leiomyosarcoma and adenocarcinoma. The patient described in this report successfully underwent resection of both primary lesions and liver metastases in combination with chemotherapy. As for the leiomyosarcoma, the primary cecal lesion was revealed more than three years after the patient's first visit. Peritoneal, lymph-node, and lung recurrences were observed afterward, and thus surgeries on those regions were performed. Pathologically, the peritoneal and lung recurrences comprised leiomyosarcoma and the lymphnode recurrence was diagnosed as adenocarcinoma. Despite newly discovered multiple lung recurrences and regional lymph-node metastases, the patient lived a normal life for 73 mo after the initial operation based on multidisciplinary therapy. He ultimately died of liver failure due to invasive lymph-node recurrence from the rectal adenocarcinoma, in addition to multiple lung recurrences from the leiomyosarcoma. Hepatic recurrence did not occur in this patient's case, which appears to be one reason for his long-term survival. | Hideki Aoki Takashi Arata Masashi Utsumi Yutaka Mushiake Tomoyoshi Kunitomo Isao Yasuhara Fumitaka Taniguchi Koh Katsuda Kohji Tanakaya Hitoshi Takeuchi Rie Yamasaki | 2017 | World Journal of Gastroenterology2017，23，9： | 0 |
| 19 | Development of the nervous system in mouse liver显示文摘BACKGROUND The role of the hepatic nervous system in liver development remains unclear.We previously created functional human micro-hepatic tissue in mice by co-culturing human hepatic endodermal cells with endothelial and mesenchymal cells.However,they lacked Glisson’s sheath[the portal tract(PT)].The PT consists of branches of the hepatic artery(HA),portal vein,and intrahepatic bile duct(IHBD),collectively called the portal triad,together with autonomic nerves.AIM To evaluate the development of the mouse hepatic nervous network in the PT using immunohistochemistry.METHODS Liver samples from C57BL/6J mice were harvested at different developmental time periods,from embryonic day(E)10.5 to postnatal day(P)56.Thin sections of the surface cut through the hepatic hilus were examined using protein gene product 9.5(PGP9.5)and cytokeratin 19(CK19)antibodies,markers of nerve fibers(NFs),and biliary epithelial cells(BECs),respectively.The numbers of NFs and IHBDs were separately counted in a PT around the hepatic hilus(center)and the peripheral area(periphery)of the liver,comparing the average values between the center and the periphery at each developmental stage.NF-IHBD and NF-HA contacts in a PT were counted,and their relationship was quantified.SRYrelated high mobility group-box gene 9(SOX9),another BEC marker;hepatocyte nuclear factor 4α(HNF4α),a marker of hepatocytes;and Jagged-1,a Notch ligand,were also immunostained to observe the PT development.RESULTS HNF4αwas expressed in the nucleus,and Jagged-1 was diffusely positive in the primitive liver at E10.5;however,the PGP9.5 and CK19 were negative in the fetal liver.SOX9-positive cells were scattered in the periportal area in the liver at E12.5.The Jagged-1 was mainly expressed in the periportal tissue,and the number of SOX9-positive cells increased at E16.5.SOX9-positive cells constructed the ductal plate and primitive IHBDs mainly at the center,and SOX-9-positive IHBDs partly acquired CK19 positivity at the same period.PGP9.5-positive bodies were first found at E16.5 and HAs were first found at P0 in the periportal tissue of the center.Therefore,primitive PT structures were first constructed at P0 in the center.Along with remodeling of the periportal tissue,the number of CK19-positive IHBDs and PGP9.5-positive NFs gradually increased,and PTs were also formed in the periphery until P5.The numbers of NFs and IHBDs were significantly higher in the center than in the periphery from E16.5 to P5.The numbers of NFs and IHBDs reached the adult level at P28,with decreased differences between the center and periphery.NFs associated more frequently with HAs than IHBDs in PTs at the early phase after birth,after which the number of NF-IHBD contacts gradually increased.CONCLUSION Mouse hepatic NFs first emerge at the center just before birth and extend toward the periphery.The interaction between NFs and IHBDs or HAs plays important roles in the morphogenesis of PT structure. | Naoto Koike Tomomi Tadokoro Yasuharu Ueno Satoshi Okamoto Tatsuya Kobayashi Soichiro Murata Hideki Taniguchi | 2022 | World Journal of Hepatology2022，14，2： | 0 |
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