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| 1 | Urogenital schistosomiasis and soiltransmitted helminthiasis(STH)in Cameroon:An epidemiological update at Barombi Mbo and Barombi Kotto crater lakes assessing prospects for intensified control interventions显示文摘Background:The crater lakes of Barombi Mbo and Barombi Kotto are well-known transmission foci of schistosomiasis and soil-transmitted helminthiasis having had several important control initiatives previously.To collect contemporary epidemiological information,a cross-sectional survey was undertaken inclusive of:signs and symptoms of disease,individual treatment histories,local water,sanitation and hygiene(WASH)-related factors and malacological surveillance,with molecular characterisation of specimens.Methods:At each lake,a community cross-sectional survey was undertaken using a combination of stool and urine parasitological sampling,and interview with pro-forma questionnaires.A total of 338 children and adults participated.Material from snail and parasite species were characterised by DNA methods.Results:Egg-patent prevalence of urogenital schistosomiasis was 8.7%at Barombi Mbo(all light-intensity infections)and 40.1%at Barombi Kotto(21.2%heavy-intensity infections).Intestinal schistosomiasis was absent.At Barombi Kotto,significantly more women reported signs and symptoms associated with female genital schistosomiasis.While there had been extensive recent improvement in WASH-related infrastructure at Barombi Mbo,water contact risk scores were higher among schistosomiasis-infected participants(P<0.001)and at Barombi Kotto in general(P<0.001).Across both lakes,mean prevalence of STH was very low(6.3%)evidencing an impressive decrease of 79.0%over the last decade;neither Strongyloides stercoralis nor Ascaris lumbricoides were found.A total of 29 freshwater sampling sites were inspected for snails,13 in Barombi Mbo and 16 in Barombi Kotto;water chemistry differed significantly(P<0.0001)between lakes for both mean pH(7.9 v.9.6)and mean conductivity(64.3μS v.202.1μS)respectively.Only two Bulinus camerunensis found on the central island of Barombi Kotto were observed to shed schistosome cercariae,but schistosome DNA was later detected in Bulinus sampled from both lakes as well as in Indoplanorbis exustus,an invasive species from Asia.Conclusions:STH is currently at very low levels while urogenital schistosomiasis is of greatest concern at Barombi Kotto.This assessment highlights a unique opportunity for further study of the epidemiological dynamics at these crater lakes,to evaluate future intensified interventions both in terms of gaining and sustaining control at Barombi Kotto or in moving towards local interruption of transmission of both diseases at Barombi Mbo. | Suzy J.Campbell J.Russell Stothard Faye O’Halloran Deborah Sankey Timothy Durant Dieudonne Eloundou Ombede Gwladys Djomkam Chuinteu Bonnie LWebster Lucas Cunningham EJames LaCourse Louis-Albert Tchuem-Tchuente | 2017 | Infectious Diseases of Poverty2017，6，1： | 4 |
| 2 | A Risk Model to Predict 90-Day Mortality among Patients Undergoing Hepatic Resection显示文摘 | Omar Hyder Carlo Pulitano Amin Firoozmand Rebecca Dodson Christopher L. Wolfgang Michael A. Choti Luca Aldrighetti Timothy M. Pawlik | 2013 | Journal of the American College of Surgeons2013，，6： | 2 |
| 3 | The surgical treat ment of metastatic disease of the spine显示文摘 | Hatrick N C Lucas J D Timothy A R | 2000 | Radiother Oncol2000，56，3： | 1 |
| 4 | DLL4 Blockade Inhibits Tumor Growth and Reduces Tumor-Initiating Cell Frequency显示文摘 | Timothy Hoey Wan-Ching Yen Fumiko Axelrod Jesspreet Basi Lucas Donigian Scott Dylla Maureen Fitch-Bruhns Sasha Lazetic In-Kyung Park Aaron Sato Sanjeev Satyal Xinhao Wang Michael F. Clarke John Lewicki Austin Gurney | 2009 | Cell Stem Cell2009，，2： | 1 |
| 5 | Enhancing the relevance of Shared Socioeconomic Pathways for climate change impacts, adaptation and vulnerability research显示文摘 | Bas J. Ruijven Marc A. Levy Arun Agrawal Frank Biermann Joern Birkmann Timothy R. Carter Kristie L. Ebi Matthias Garschagen Bryan Jones Roger Jones Eric Kemp-Benedict Marcel Kok Kasper Kok Maria Carmen Lemos Paul L. Lucas Ben Orlove Shonali Pachauri Tom M | 2014 | Climatic Change2014，，3： | 1 |
| 6 | Sequential intra‐arterial therapy and portal vein embolization is feasible and safe in patients with advanced hepatic malignancies显示文摘 | Peter D. Peng Omar Hyder Mark Bloomston Hugo Marques Celia Corona‐Villalobos Elijah Dixon Carlo Pulitano Kenzo Hirose Richard D. Schulick Eduardo Barroso Luca Aldrighetti Michael Choti Feng Shen Ihab Kamel Jean‐Francois H. Geschwind Timothy M. Pawlik | 2012 | HPB2012，，8： | 1 |
| 7 | Effect of donor age and sex on the outcome of liver transplantation显示文摘 | Ignazio Roberto Marino Howard R. Doyle Luca Aldrighetti Cataldo Doria John McMichael Timothy Gayowski John J. Fung Andreas G. Tzakis Thomas E. Starzl | 1995 | Hepatology1995，，6： | 1 |
| 8 | Aggressive behavior, bullying, snoring, and sleepiness in schoolchildren显示文摘 | Louise M. O’Brien Neali H. Lucas Barbara T. Felt Timothy F. Hoban Deborah L. Ruzicka Ruth Jordan Kenneth Guire Ronald D. Chervin | 2011 | Sleep Medicine2011，，7： | 1 |
| 9 | Valve-Sparing Aortic Root Replacement in Loeys-Dietz Syndrome显示文摘 | Nishant D. Patel George J. Arnaoutakis Timothy J. George Jeremiah G. Allen Diane E. Alejo Harry C. Dietz Duke E. Cameron Luca A. Vricella | 2011 | The Annals of Thoracic Surgery2011，，2： | 1 |
| 10 | Surgical Management of Patients with Synchronous Colorectal Liver Metastasis: A Multi-Center International Analysis显示文摘 | Skye C. Mayo Carlo Pulitano Hugo Marques Christopher L. Wolfgang Wassila de Saussure Michael A. Choti Isabelle Gindrat Luca Aldrighetti Eduardo Barrosso Gilles Mentha Timothy M. Pawlik | 2012 | Journal of the American College of Surgeons2012，，： | 1 |
| 11 | Rates and Patterns of Recurrence Following Curative Intent Surgery for Colorectal Liver Metastasis: An International Multi-Institutional Analysis of 1669 Patients显示文摘 | Mechteld C. de Jong Carlo Pulitano Dario Ribero Jennifer Strub Gilles Mentha Richard D. Schulick Michael A. Choti Luca Aldrighetti Lorenzo Capussotti Timothy M. Pawlik | 2009 | Annals of Surgery2009，，3： | 1 |
| 12 | Conditional Survival after Surgical Resection of Colorectal Liver Metastasis: An International Multi-Institutional Analysis of 949 Patients显示文摘 | Hari Nathan Mechteld C. de Jong Carlo Pulitano Dario Ribero Jennifer Strub Gilles Mentha Jean-Fran?ois Gigot Richard D. Schulick Michael A. Choti Luca Aldrighetti Lorenzo Capussotti Timothy M. Pawlik | 2010 | Journal of the American College of Surgeons2010，，5： | 1 |
| 13 | Incidence of Finding Residual Disease for Incidental Gallbladder Carcinoma: Implications for Re-resection显示文摘 | Timothy M. Pawlik Ana Luiza Gleisner Luca Vigano David A. Kooby Todd W. Bauer Andrea Frilling Reid B. Adams Charles A. Staley Eduardo N. Trindade Richard D. Schulick Michael A. Choti Lorenzo Capussotti | 2007 | Journal of Gastrointestinal Surgery2007，，11： | 1 |
| 14 | The surgical treatment of metastatic disease of the spine 显示文摘 | Hatrick NC Lucas JD Timothy AR | 2000 | Radiother Oncol2000，56，3： | 1 |
| 15 | Microfabricated intracortical extracellular matrix-microelectrodes for improving neural interfaces显示文摘Intracortical neural microelectrodes,which can directly interface with local neural microcircuits with high spatial and temporal resolution,are critical for neuroscience research,emerging clinical applications,and brain computer interfaces(BCI).However,clinical applications of these devices remain limited mostly by their inability to mitigate inflammatory reactions and support dense neuronal survival at their interfaces.Herein we report the development of microelectrodes primarily composed of extracellular matrix(ECM)proteins,which act as a bio-compatible and an electrochemical interface between the microelectrodes and physiological solution.These ECM-microelectrodes are batch fabricated using a novel combination of micro-transfer-molding and excimer laser micromachining to exhibit final dimensions comparable to those of commercial silicon-based microelectrodes.These are further integrated with a removable insertion stent which aids in intracortical implantation.Results from electrochemical models and in vivo recordings from the rat’s cortex indicate that ECM encapsulations have no significant effect on the electrochemical impedance characteristics of ECM-microelectrodes at neurologically relevant frequencies.ECM-microelectrodes are found to support a dense layer of neuronal somata and neurites on the electrode surface with high neuronal viability and exhibited markedly diminished neuroinflammation and glial scarring in early chronic experiments in rats. | Wen Shen Suradip Das Flavia Vitale Andrew Richardson Akshay Ananthakrishnan Laura A.Struzyna Daniel P.Brown Naixin Song Murari Ramkumar Timothy Lucas DKacy Cullen Brian Litt Mark G.Allen | 2018 | Microsystems & Nanoengineering2018，4，1： | 1 |
| 16 | Physician surveys to assess customary care in medical malpractice cases显示文摘 | Dr. Arthur Hartz MD PhD Joshua Lucas BS Timothy Cramm MD Michael Green JD Suzanne Bentler MS John Ely MD MSPH Steven Wolfe MD Paul James MD | 2002 | Journal of General Internal Medicine2002，，7： | 1 |
| 17 | Repeat Curative Intent Liver Surgery is Safe and Effective for Recurrent Colorectal Liver Metastasis: Results from an International Multi-institutional Analysis显示文摘 | Mechteld C. Jong Skye C. Mayo Carlo Pulitano Serena Lanella Dario Ribero Jennifer Strub Catherine Hubert Jean-Fran?ois Gigot Richard D. Schulick Michael A. Choti Luca Aldrighetti Gilles Mentha Lorenzo Capussotti Timothy M. Pawlik | 2009 | Journal of Gastrointestinal Surgery2009，，12： | 1 |
| 18 | Colorectal Liver Metastasis in the Setting of Lymph Node Metastasis: Defining the Benefit of Surgical Resection显示文摘 | Carlo Pulitanò Martin Bodingbauer Luca Aldrighetti Michael A. Choti Federico Castillo Richard D. Schulick Thomas Gruenberger Timothy M. Pawlik | 2012 | Annals of Surgical Oncology2012，，2： | 1 |
| 19 | Inhibition of betaine-homocysteine S -methyltransferase in rats causes hyperhomocysteinemia and reduces liver cystathionine β -synthase activity and methylation capacity显示文摘 | Jana Strakova Sapna Gupta Warren D. Kruger Ryan N. Dilger Katherine Tryon Lucas Li Timothy A. Garrow | 2011 | Nutrition Research2011，，7： | 1 |
| 20 | Small-Scale Household Biogas Digesters as a Viable Option for Energy Recovery and Global Warming Mitigation--Vietnam Case Study显示文摘 | Thanh Ba Ho Timothy Kilgour Roberts Steven Lucas | 2015 | Journal of Agricultural Science and Technology(A)2015，5，6： | 0 |
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