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| 1 | Preparation of polyclonal antibody specific for NOR1 and detection of its expression pattern in human tissues and nasopharyngeal carcinoma显示文摘包含蛋白质 1 的 Oxidored-nitro 领域(NOR1 ) 基因是首先从鼻咽的癌(NPC ) 孤立的新奇 nitroreductase 基因。它为它的 nitrosation 功能在化学致癌物的形成和 NPC 的 carcinogenesis 起一个重要作用。在鼻咽的癌细胞的野类型的 NOR1 基因的 Overexpression 是有效的禁止细胞生长和增长。在这研究,第一次,我们产生了高度特定的 NOR1 抗体并且在人的纸巾和 NPC 活体检视分析了 NOR1 分发。结果证明那 NOR1 蛋白质主要在人的鼻咽和气管的纸巾被表示。人的心,肝,怒气,胃,冒号,肾,骨胳的肌肉,胸腺,和胰都 NOR1 蛋白质是缺乏的。更重要地,我们在 NPC 纸巾执行了 NOR1 蛋白质表示的 immunohistochemistry 试金,并且结果证明那 NOR1 蛋白质在 NPC 经常是下面表示的。这些数据使 NOR1 的潜在的生理的函数的选择清楚些并且提供不可缺少的引用给 NPC 的 carcinogenesis 进程并且到识别或验证织物特定的药目标。 | Bo Xiang Mei Yi Li Wang Wei Liu Wenling Zhang Jue Ouyang Ya Peng Wenjuan Li Ming Zhou Huaying Liu Minghua Wu Rong Wan Xiaoling Li Guiyuan Li | 2009 | Acta Biochimica et Biophysica Sinica2009，41，9： | 10 |
| 2 | Microstructure and properties of silane monomer-modified styrene-acrylate nanocoatings显示文摘 | Tao Wan Chuan Wu XiaoLing Ma Lan Wang Jie Yao Kuai Lu | 2009 | Polymer Bulletin2009，，6： | 1 |
| 3 | Oil Spill Risk Assessment of Offshore Pipeline in the Bohai Sea Under the Perspective of Ecological Protection显示文摘In recent decades,the exploration and development of marine oil and gas resources have increased significantly to meet the increasing energy demand of mankind.The Bohai Sea is a semi-closed continental sea that has a weak water exchange capacity and high ecological fragility.However,at present,more than 200 oil platforms have been built in the Bohai Sea,with more than 270 offshore oil pipelines having a length exceeding 1600 km.The oil spill pollution of offshore platforms has a great impact on the marine environment and ecosystems.Therefore,a comprehensive assessment of its risks is of great practical significance.This paper systematically constructs a comprehensive oil spill risk assessment model that combines the oil spill risk probability model and the ocean hydrodynamic model.This paper uses the Bohai Sea offshore pipeline as an example to assess its oil spill risk.The high-risk-value areas of the Bohai Sea offshore pipeline are mainly distributed at the bottom of Liaodong Bay,the bottom of Bohai Bay,near the Caofeidian area,and the northern part of the Yellow River Estuary. | ZHANG Kuncheng WANG Xing LIU Ying TIAN Shizheng WU Lunyu WAN Xiaole | 2023 | Journal of Ocean University of China2023，22，3： | 1 |
| 4 | Saline solution absorbency and structure study of poly (AA-AM) water superabsorbent by inverse microemulsion polymerization显示文摘 | Tao Wan Lan Wang Jie Yao XiaoLing Ma QingSheng Yin TianShun Zang | 2008 | Polymer Bulletin2008，，4： | 1 |
| 5 | Preparation of poly (AA-AM) water superabsorbent by inverse microemulsion polymerization显示文摘 | Wan Tao Yao Jie Ma Xiaoling | 2008 | Journal of Applied Polymer Science2008，110，6： | 1 |
| 6 | Seismotectonics of the Taiwan Shoal Region in the Northeastern South China Sea:Insights from the Crustal Structure显示文摘A cluster of earthquakes occurred in the Taiwan Shoal region on the outer rise of the Manila Trench. Although most were of small to medium magnitudes, one strong earthquake occurred on September 16, 1994. Several previous studies have provided important information to progress our understanding of this single earthquake. However, little is currently known about the earthquake cluster, and it is necessary to investigate the deep crustal structure of the Taiwan Shoal region to understand the mechanisms involved in controlling and generating it. This study presents a two-dimensional seismic tomographic image of the crustal structure along the OBS2012 profile based on ocean-bottom seismograph(OBS) data, which exhibits a high-velocity anomaly flanked by low-velocity anomalies in the upper crust beneath the Taiwan Shoal. In this study, 765 earthquakes(Richter magnitude ML > 1.5) occurring between 1991 and 2015 were studied and analyses of earthquake epicenters, regional faults, and the crustal structure provides an improved understanding of the nature of active tectonics in this region. Results of analyses indicate firstly that the high-velocity area represents major asperities that correspond to the location of the earthquake cluster and where stress is concentrated. It is also depicted that the earthquake cluster was influenced by fault interactions. However, the September 1994 earthquake occurred independently of these seismic activities and was associated with reactivation of a preexisting fault. It is also determined that slab pull is resisted by the exposed precollision accretionary prism, and the resistive force is causing accumulation of inplane compressive-stress. This may trigger a future damaging earthquake in the Taiwan Shoal region. | WAN Kuiyuan SUN Jinlong XU Huilong XIE Xiaoling XIA Shaohong ZHANG Xiang CAO Jinghe ZHAO Fang FAN Chaoyan | 2018 | Journal of Ocean University of China2018，17，1： | 1 |
| 7 | Preparation of poly (AA-AM) water superabsorbent by inverse microemulsionpolymerization显示文摘 | Wan Tao Yao Jie Ma Xiaoling | 2008 | Journal of Applied Polymer Science2008，110，6： | 1 |
| 8 | The intestinal microbiome of an Indo-Pacific humpback dolphin(Sousa chinensis)stranded near the Pearl River Estuary,China显示文摘The mammalian intestinal microbiome is critical for host health and disease resistance.However,the cetacean intestinal microbiota remains relatively unexplored.By using high-throughput 16S rRNA gene sequencing,we analyzed intestinal bacterial samples from an Indo-pacific humpback dolphin(Sousa chinensis)stranded near the Pearl River Estuary in China.The samples included 3 anatomical regions(foregut,midgut,and rectum)and 2 anatomical locations(content and mucus).Our analyses revealed that the dolphin intestinal bacteria contained 139 operational taxonomic units(OTUs),dominated at the phyla level by Firmicutes(47.05%in the content;94.77%in the mucus),followed by Bacteroidetes(23.63%in the content;1.58%in the mucus)and Gammaproteobacteria(14.82%in the content;2.05%in the mucus).The intestinal bacteria had a small core community(15 OTUs,accounting for 99.74%of the reads),some of which could be potentially pathogenic to both human and dolphins.As an alternative to sampling the dolphin intestinal bacteria,fecal sampling could be used.Additionally,function potentials such as,xenobiotics biodegradation,beta-lactam resistance,and human disease-related pathways,were detected in the dolphin intestinal bacteria.These findings provide the first baseline knowledge of the intestinal microbiome of the Indo-Pacific humpback dolphin,which may offer new insights into cetacean conservation by using microbial surveillance. | Xiaoling WAN Jia LI Zhaolong CHENG Mengxue AO Renmao TIAN Richard William MCLAUGHLIN Jinsong ZHENG Ding WANG | 2021 | Integrative Zoology2021，16，3： | 1 |
| 9 | 显示文摘 | Wan Ying Lu Xiaoling Da Siqin | 2009 | Thermochimica Acta2009，487，12： | 1 |
| 10 | Effects of triptolide on degeneration of dendritic spines induced by AI31-40 injection in rat hippocampus 显示文摘 | Wan Bin Hu Xiaoling Nie Jing | 2014 | Journal of the Neurological Science2014，35，1： | 1 |
| 11 | Tumor suppressor gene Oxidored-nitro domain-containing protein 1 regulates nasopharyngeal cancer cell autophagy, metabolism, and apoptosis in vitro显示文摘 | Wenjuan Li Xiaoling Li Wei Wan Mei Yi Yanhong Zhou Pan Zheng Wei Xiong Jianbo Yang Shuping Peng James B. McCarthy Bo Xiang Guiyuan Li | 2013 | International Journal of Biochemistry and Cell Biology2013，，： | 1 |
| 12 | Osteocyte Egln1/Phd2 links oxygen sensing and biomineralization via FGF23显示文摘Osteocytes act within a hypoxic environment to control key steps in bone formation.FGF23,a critical phosphate-regulating hormone,is stimulated by low oxygen/iron in acute and chronic diseases,however the molecular mechanisms directing this process remain unclear.Our goal was to identify the osteocyte factors responsible for FGF23 production driven by changes in oxygen/iron utilization.Hypoxia-inducible factor-prolyl hydroxylase inhibitors(HIF-PHI)which stabilize HIF transcription factors,increased Fgf23 in normal mice,as well as in osteocyte-like cells;in mice with conditional osteocyte Fgf23 deletion,circulating i FGF23 was suppressed.An inducible MSC cell line(‘MPC2’)underwent FG-4592 treatment and ATACseq/RNAseq,and demonstrated that differentiated osteocytes significantly increased HIF genomic accessibility versus progenitor cells.Integrative genomics also revealed increased prolyl hydroxylase Egln1(Phd2)chromatin accessibility and expression,which was positively associated with osteocyte differentiation.In mice with chronic kidney disease(CKD),Phd1-3 enzymes were suppressed,consistent with FGF23 upregulation in this model.Conditional loss of Phd2 from osteocytes in vivo resulted in upregulated Fgf23,in line with our findings that the MPC2 cell line lacking Phd2(CRISPR Phd2-KO cells)constitutively activated Fgf23 that was abolished by HIF1αblockade.In vitro,Phd2-KO cells lost iron-mediated suppression of Fgf23 and this activity was not compensated for by Phd1 or-3.In sum,osteocytes become adapted to oxygen/iron sensing during differentiation and are directly sensitive to bioavailable iron.Further,Phd2 is a critical mediator of osteocyte FGF23 production,thus our collective studies may provide new therapeutic targets for skeletal diseases involving disturbed oxygen/iron sensing. | Megan L.Noonan Pu Ni Emmanuel Solis Yamil G.Marambio Rafiou Agoro Xiaona Chu Yue Wang Hongyu Gao Xiaoling Xuei Erica L.Clinkenbeard Guanglong Jiang Sheng Liu Steve Stegen Geert Carmeliet William R.Thompson Yunlong Liu Jun Wan Kenneth E.White | 2023 | Bone Research2023，11，1： | 1 |
| 13 | METTL3-mediated m^(6)A modification of HMGA2 mRNA promotes subretinal fibrosis and epithelial-mesenchymal transition显示文摘Subretinal fibrosis is a major cause of the poor visual prognosis for patients with neovascular age-related macular degeneration(nAMD).Myofibroblasts originated from retinal pigment epithelial(RPE)cells through epithelial-mesenchymal transition(EMT)contribute to the fibrosis formation.N^(6)-Methyladenosine(m^(6)A)modification has been implicated in the EMT process and multiple fibrotic diseases.The role of m^(6)A modification in EMT-related subretinal fibrosis has not yet been elucidated.In this study,we found that during subretinal fibrosis in the mouse model of laser-induced choroidal neovascularization,METTL3 was upregulated in RPE cells.Through m^(6)A epitranscriptomic microarray and further verification,high-mobility group AT-hook 2(HMGA2)was identified as thekey downstream target of METTL3,subsequently activating potent EMT-inducing transcription factor SNAIL.Finally,by subretinal injections of adeno-associated virus vectors,we confirmed that METTL3 deficiency in RPE cells could efficiently attenuate subretinal fibrosis in vivo.In conclusion,our present research identified an epigenetic mechanism of METTL3-m^(6)A-HMGA2 in subretinal fibrosis and EMT of RPE cells,providing a novel therapeutic target for subretinal fibrosis secondary to nAMD. | Yuwei Wang Yuhong Chen Jian Liang Mei Jiang Ting Zhang Xiaoling Wan Jiahui Wu Xiaomeng Li Jieqiong Chen Junran Sun Yifan Hu Peirong Huang Jingyang Feng Te Liu Xiaodong Sun | 2023 | Journal of Molecular Cell Biology2023，15，3： | 1 |
| 14 | Marine Ranching Engineering Collaborative Innovation from the Perspective of Ecological Environment显示文摘As a resource development model with both economic and ecological functions,the environmental friendliness of marine ranching products meets the environmental needs of consumers.However,the lack of technological innovation ability limits the development of marine ranching.Therefore,this research builds a marine ranching collaborative innovation system with multi-agent participation.Evolutionary game theory is used to analyze strategic choices of all parties and the conditions of system equilibrium,and numerical simulation is used to analyze the effect of relevant factors.This paper integrates the benefits from the improvement of environmental friendliness into the payoff matrix,and explains the significance of collaborative innovation to the development of marine ranching from the perspective of ecological environment.The results showed:the participation willingness of marine ranching enterprises is positively related to open innovation subject,while the participation willingness of the other two parties is negatively related to the government;The incentive effect of collaboration is negatively correlated with the government’s will,positively correlated with the other two parties;The incentive effect of government subsidies positively affects the willingness of the three parties to participate.Finally,suggestions are provided for each participant to maintain the strategic choice of marine ranching collaborative innovation system. | WAN Xiaole ZHANG Guixian LI Qianqian | 2023 | Journal of Ocean University of China2023，22，4： | 0 |
| 15 | A tunable genome editing system of the prime editor mediated by dihydrofolate reductase显示文摘The clustered regularly interspaced short palindromic repeats(CRISPR)/CRISPR-associated protein(CRISPR/Cas)system was discovered in bacteria and archaea as an adaptive immunity system to protect against exogenous DNA(Barrangou et al.,2007).This system has been developed into a powerful gene editing tool for eukaryotic genome manipulation that has therapeutic opportunities against hereditary diseases(Cong et al.,2013),especially monogenic diseases. | Shu Liu Xiaoyue Duan Feng Peng Yafang Wang Yang Liu Xiaoling Wan Jingfa Zhang Xiaosa Li Xiaodong Sun | 2023 | Journal of Genetics and Genomics2023，50，3： | 0 |
| 16 | Record of a juvenile Omura's whale live stranded in Hainan Island:Evidence of a potential breeding ground in the South China Sea?显示文摘On January 12,2011,a very young juvenile Bryde's-like baleen whale was found stranded alive on the east coast of Hainan Island,in the South China Sea.Unfortunately,it died the next morning.This baleen whale showed some unique external morphology and skull features of the Omura's whale(Balaenoptera omurai).Subsequently,it was genetically identified as an Omura's whale using two different mitochondrial DNA markers.This study documents the first confirmed live stranding of a juvenile Omura's whale on Hainan Island,China.Our findings expand the known distribution range of this species in Chinese waters and may indicate that waters around Hainan Island in the South China Sea could be a potential breeding ground for the Omura's whale. | Ruilin He Xiaoling Wan Minmin Chen Fei Fan Ding Wang Jinsong Zheng | 2022 | Water Biology and Security2022，1，3： | 0 |
| 17 | Heterostructuring 2D Co_(2)P nanosheets with 0D CoP via a saltassisted strategy for boosting hydrogen evolution from ammonia borane hydrolysis显示文摘Ammonia borane(NH3BH3,AB)holds promise for chemical storage of hydrogen.However,designing superb and low-cost photocatalyst to drive hydrogen evolution from AB under visible light irradiation is highly desirable but remains a major challenge for promoting the practical utilization of AB.Herein,we demonstrated a heterostructure photocatalyst consisting of zerodimensional(0D)CoP nanoparticles immobilized on two-dimensional(2D)Co_(2)P nanosheets(CoP/Co_(2)Ps)as a high-performance and low-cost catalyst for hydrogen evolution from AB hydrolysis,in which 0D/2D heterostructure was synthesized using the saltinduced phase transformation strategy.Interestingly,the optimized CoP/Co_(2)Ps exhibit a robust H_(2) evolution rate of 32.1 L∙min^(−1)∙g_(Co)^(−1),corresponding to a turnover frequency(TOF)value of 64.1 min^(−1),being among the highest TOF for non-noblemetal catalysts ever reported,even outperforming some precious metal catalysts.This work not only opens a new avenue to accelerate hydrogen evolution from AB by regulating the electronic structures of heterointerfaces,but also provides a novel strategy for the construction of precious-metal-free materials for hydrogen-related energy catalysis in the future. | Chao Wan Xiaoling Liu Jiapei Wang Fengqiu Chen Dang-Guo Cheng | 2023 | Nano Research2023，16，5： | 0 |
| 18 | Increased maternal consumption of methionine as its hydroxyl analog promoted neonatal intestinal growth without compromising maternal energy homeostasis显示文摘Background: To determine responses of neonatal intestine to maternal increased consumption of DL-methionine(DLM) or DL-2-hydroxy-4-methylthiobutanoic acid(HMTBA), eighteen primiparous sows(Landrace × Yorkshire) were allocated based on body weight and backfat thickness to the control, DLM and HMTBA groups(n = 6), with the nutritional treatments introduced from postpartum d0 to d14.Results: The DLM-fed sows showed negative energy balance manifested by lost bodyweight, lower plasma glucose, subdued tricarboxylic acid cycle, and increased plasma lipid metabolites levels. Both villus height and ratio of villus height to crypt depth averaged across the small intestine of piglets were higher in the DLM and HMTBA groups than in the control group. Piglet jejunal oxidized glutathione concentration and ratio of oxidized to reduced glutathione were lower in the HMTBA group than in the DLM and control groups. However, piglet jejunal aminopeptidase A, carnitine transporter 2 and IGF-II precursor m RNA abundances were higher in the DLM group than in the HMTBA and control groups.Conclusion: Increasing maternal consumption of methionine as DLM and HMTBA promoted neonatal intestinal growth by increasing morphological development or up-regulating expression of genes responsible for nutrient metabolism. And increasing maternal consumption of HMTBA promoted neonatal intestinal antioxidant capacity without compromising maternal energy homeostasis during early lactation. | Heju Zhong Hao Li Guangmang Liu Haifeng Wan Yves Mercier Xiaoling Zhang Yan Lin Lianqiang Che Shengyu Xu Li Tang Gang Tian Daiwen Chen De Wu Zhengfeng Fang | 2017 | Journal of Animal Science and Biotechnology2017，8，1： | 0 |
| 19 | Compound Planting of Bletilla striata under Forest in the Three Gorges Dam Area显示文摘[Objectives] The aim was to study the artificial cultivation of Bletilla striata to realize large scale and standardization planting. [Methods] The comparison tests were conducted on B. striata with different canopy densities of the Magnolia officinalis forests,different compound planting densities and different tending measures and management. [Results] When the stand canopy density was 0. 4-0. 6,the per unit yield of B. striata was 5. 4%,6. 8% higher than that at the canopy density of less than 0. 4 and more than 0. 6,respectively. When the planting density was 30 cm × 30 cm,the per unit yield increased by 16. 1%,12. 0%,13. 1% respectively compared with the planting density of 20 cm × 20 cm,25 cm × 25 cm,35 cm × 35 cm. When B. striata was planted from October to November,the per unit yield was 5. 6% higher than that planted from December to January of the following year,and 21. 3% higher than that from February to March of the second year. When farmyard manure was applied during the cultivation,the per unit yield was 31. 7% and 18. 4% higher than the application of chemical fertilizer and compound fertilizer. When weeding 4 times per year,the per unit yield increased by 240. 1%,137. 0% and 43. 9% respectively from that weeding 1 times,2 times,3 times per year. [Conclusions]When planting B. striata,the stand canopy density of 0. 4-0. 6 could make it receive absolutely shelters and the lighting conditions required for the growth,thereby bringing in high emergence rate,good growth potential and high yield. The best planting effect of B. striata could achieve by planting from October to November with the planting density of 30 cm × 30 cm,which can play the maximum benefit of individual plants. Moreover,weeding 4 times per year combined with the use of farmyard manure can promote the development and growth of tubers,which can greatly improve the yield of B. striata. | Yongming WAN Xiaoling ZHAO Dan ZHOU Shibin CHEN Zumei LI Bo ZHOU | 2018 | Agricultural Biotechnology2018，7，3： | 0 |
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