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| 1 | Special Section:SARS-CoV-2 Preliminary evidence from a multicenter prospective observational study of the safety and efficacy of chloroquine for the treatment of COVID-19显示文摘Effective therapies are urgently needed for the SARS-CoV-2 pandemic.Chloroquine has been proved to have antiviral effect against coronavirus in vitro.In this study,we aimed to assess the efficacy and safety of chloroquine with different doses in COVID-19.In this multicenter prospective observational study,we enrolled patients older than 18 years old with confirmed SARS-CoV-2 infection excluding critical cases from 12 hospitals in Guangdong and Hubei Provinces.Eligible patients received chloroquinephosphate s00 mg,orally,once(half dose)or twice(full dose)daily.Patients treated with non-chloroquine therapy were included as historical controls.The primary endpoint is the time to undetectable viral RNA.Secondary outcomes include the proportion of patients with undetectable viral RNA by day 10 and 14,hospitalization time,duration of fever,and adverse events.A total of 197 patients completed chloroquine treatment,and 176patients were included as historical controls.The median time to achieve an undetectable viral RNA was shorter in chloroquine than in non-chloroquine(absolute difference in medians-6.0 days;95%CI-6.0 to—4.0).The duration of fever is shorter in chloroquine(geometric mean ratio 0.6;95%CIO.5 to 0.8).No serious adverse events were observed in the chloroquine group.Patients treated with half dose experienced lower rate of adverse events than with full dose.Although randomized trials are needed for further evaluation,this study provides evidence for safety and efficacy of chloroquine in COVID-19 and suggests that chloroquine can be a cost-effective therapy for combating the COVID-19 pandemic. | Mingxing Huang Man Li Fei Xiao Pengfei Pang Jiabi Liang Tiantian Tang Shaoxuan Liu Binghui Chen Jingxian Shu Yingying You Yang Li Meiwen Tang Jianhui Zhou Guanmin Jiang Jingfen Xiang Wenxin Hong Songmei He Zhaoqin Wang Jianhua Feng Changqing Lin Yinong Ye Zhilong Wu Yaocai Li Bei Zhong Ruilin Sun Zhongsi Hong Jing Liu Huili Chen Xiaohua Wang Zhonghe Li Duanqing Pei Lin Tian Jinyu Xia Shanping Jiang Nanshan Zhong Hong Shan | 2020 | National Science Review2020，7，9： | 20 |
| 2 | Comparative genomic and transcriptomic analyses uncover the molecular basis of high nitrogen-use efficiency in the wheat cultivar Kenong 9204显示文摘Studying the regulatory mechanisms that drive nitrogen-use efficiency(NUE)in crops is important for sustainable agriculture and environmental protection.In this study,we generated a high-quality genome assembly for the high-NUE wheat cultivar Kenong 9204 and systematically analyzed genes related to nitrogen uptake and metabolism.By comparative analyses,we found that the high-affinity nitrate transporter gene family had expanded in Triticeae.Further studies showed that subsequent functional differentiation endowed the expanded family members with saline inducibility,providing a genetic basis for improving the adaptability of wheat to nitrogen deficiency in various habitats.To explore the genetic and molecular mechanisms of high NUE,we compared genomic and transcriptomic data from the high-NUE cultivar Kenong 9204(KN9204)and the low-NUE cultivar Jing 411 and quantified their nitrogen accumulation under high-and low-nitrogen conditions.Compared with Jing 411,KN9204 absorbed significantly more nitrogen at the reproductive stage after shooting and accumulated it in the shoots and seeds.Transcriptome data analysis revealed that nitrogen deficiency clearly suppressed the expression of genes related to cell division in the young spike of Jing 411,whereas this suppression of gene expression was much lower in KN9204.In addition,KN9204 maintained relatively high expression of NPF genes for a longer time than Jing 411 during seed maturity.Physiological and transcriptome data revealed that KN9204 was more tolerant of nitrogen deficiency than Jing 411,especially at the reproductive stage.The high NUE of KN9204 is an integrated effect controlled at different levels.Taken together,our data provide new insights into the molecular mechanisms of NUE and important gene resources for improving wheat cultivars with a higher NUE trait. | Xiaoli Shi Fa Cui Xinyin Han Yilin He Long Zhao Na Zhang Hao Zhang Haidong Zhu Zhexin Liu Bin Ma Shusong Zheng Wei Zhang Jiajia Liu Xiaoli Fan Yaoqi Si Shuiquan Tian Jianqing Niu Huilan Wu Xuemei Liu Zhuo Chen Deyuan Meng Xiaoyan Wang Liqiang Song Lijing Sun Jie Han Hui Zhao Jun Ji Zhiguo Wang Xiaoyu He Ruilin Li Xuebin Chi Chengzhi Liang Beifang Niu Jun Xiao Junming Li Hong-Qing Ling | 2022 | Molecular Plant2022，15，9： | 6 |
| 3 | Deubiquitinase JOSD2 stabilizes YAP/TAZ to promote cholangiocarcinoma progression显示文摘Cholangiocarcinoma(CCA)has emerged as an intractable cancer with scanty therapeutic regimens.The aberrant activation of Yes-associated protein(YAP)and transcriptional co-activator with PDZ-binding motif(TAZ)are reported to be common in CCA patients.However,the underpinning mechanism remains poorly understood.Deubiquitinase(DUB)is regarded as a main orchestrator in maintaining protein homeostasis.Here,we identified Josephin domain-containing protein 2(JOSD2)as an essential DUB of YAP/TAZ that sustained the protein level through cleavage of polyubiquitin chains in a deubiquitinase activity-dependent manner.The depletion of JOSD2 promoted YAP/TAZ proteasomal degradation and significantly impeded CCA proliferation in vitro and in vivo.Further analysis has highlighted the positive correlation between JOSD2 and YAP abundance in CCA patient samples.Collectively,this study uncovers the regulatory effects of JOSD2 on YAP/TAZ protein stabilities and profiles its contribution in CCA malignant progression,which may provide a potential intervention target for YAP/TAZ-related CCA patients. | Meijia Qian Fangjie Yan Weihua Wang Jiamin Du Tao Yuan Ruilin Wu Chenxi Zhao Jiao Wang Jiabin Lu Bo Zhang Nengming Lin Xin Dong Xiaoyang Dai Xiaowu Dong Bo Yang Hong Zhu Qiaojun He | 2021 | Acta Pharmaceutica Sinica B2021，11，12： | 5 |
| 4 | Prevalence, risk factors, and survival associated with pulmonary hypertension and heart failure among patients with underlying coronary artery disease: a national prospective, multicenter registry study in China显示文摘Background: Coronary artery disease (CAD) is the commonest cause of heart failure (HF), whereas pulmonary hypertension (PH) has not been established or reported in this patient population. Therefore, we assessed the prevalence, risk factors, and survival in CAD-associated HF (CAD-HF) complicated with PH.Methods: Symptomatic CAD-HF patients were continuously enrolled in this prospective, multicenter registry study. Echocardiography, coronary arteriography, left and right heart catheterization (RHC), and other baseline clinical data were recorded. Patients were followed up and their survival was recorded.Results: One hundred and eighty-two CAD-HF patients were enrolled, including 142 with HF with a preserved ejection fraction (heart failure with preserved ejection fraction [HFpEF];left ventricular ejection fraction [LVEF] ≥50%) and 40 with a reduced ejection fraction (heart failure with reduced ejection fraction [HFrEF];LVEF < 50%). PH was diagnosed with RHC in 77.5% of patients. Patients with PH showed worse hemodynamic parameters and higher mortality. HFrEF-PH patients had worse survival than HFpEF-PH patients. CAD-HF patients with an enlarged left ventricular end-diastolic diameter and reduced hemoglobin were at higher risk of PH. Nitrate treatment reduced the risk of PH. Elevated creatinine and mean pulmonary arterial pressure (mPAP), diastolic pressure gradient (DPG) ≥7 mmHg, and previous myocardial infarction (MI) entailed a higher risk of mortality in CAD-HF patients with PH.Conclusions: PH is common in CAD-HF and worsens the hemodynamics and survival in these patients. Left ventricle enlargement and anemia increase the risk of PH in CAD-HF. Patients may benefit from nitrate medications. Renal impairment, elevated mPAP, DPG ≥7 mmHg, and previous MI are strong predictors of mortality in CAD-HF-PH patients.Trial Registration: ClinicalTrials.gov, NCT02164526. | Li Huang Lingpin Pang Qing Gu Tao Yang Wen Li Ruilin Quan Weiqing Su Weifeng Wu Fangming Tang Xiulong Zhu Jieyan Shen Jingzhi Sun Guangliang Shan Changming Xiong Shian Huang Jianguo He | 2022 | Chinese Medical Journal2022，，15： | 4 |
| 5 | Clinical characteristics of 96 patients with drug-induced acute liver failure:a comparison between Traditional Chinese and Western Medicine显示文摘OBJECTIVE: To compare the causes, clinical symptoms, laboratory test results, and prognosis in patients with acute liver failure(ALF) induced by traditional Chinese medicines(TCM) and by Western Medicines(WM).METHODS: The medical histories of patients who were diagnosed with drug-induced ALF(DALF)(n =96) after hospitalization in the 302 Military Hospital between January 2010 and December 2015 were retrospectively examined.RESULTS: Fifty-eight of the 96 DALF patients(60.4%) had a hepatocellular pattern of DALF, 16 patients(16.7%) had a cholestatic pattern, and 22 patients(22.9%) had a mixed pattern. DALF resolved in 24 patients(25.0%). Twenty-five patients(26.0%)developed chronic liver injury, 43 patients(44.8%)died, and 4 patients(4.2%) underwent liver transplantation. There were 42 ALF patients(43.8%) who received WM, and 32 ALF patients(33.3%) who received TCM. TCM-induced ALF patients had a higher average age [42.4 ± 18.4) vs(33.5 ± 17.9) years,P = 0.04] and higher creatinine and urine nitrogen levels [(155.2 ± 108.8) vs(97.5 ± 130.4) mmol/L, P =0.047;(9.1 ± 7.7) vs(4.3 ± 5.0) mmol/L, P = 0.002, respectively]. Patients with TCM-induced ALF exhibited an increased risk of renal injury [odds ratio(OR),3.75; 95% confidence interval(CI), 1.330-10.577].The 14 patients with TCM-induced ALF who died exhibited higher creatinine levels than the 18 patients with TCM-induced ALF patients who survived[(218.7 ± 111.6) vs(105.8 ± 78.4) mmol/L, P =0.002]. They were also more likely to exhibit ascites(85.7% vs 44.4%, P = 0.017) and hepatorenal syndrome(78.6% vs 22.2%, P = 0.002).CONCLUSION: TCM-induced ALF was more likely to be accompanied by renal injury than was WM-induced ALF, especially in TCM-induced ALF patients who died. | He Tingting Zhu Yun Wang Jiabo Gong Man Wang Ruilin Niu Ming Jing Jing Wang Lifu Wang Zhongxia Zhang Ning Bai Zhaofang Bai Yunfeng Li Yonggang Xiao Xiaohe | 2017 | Journal of Traditional Chinese Medicine2017，37，3： | 3 |
| 6 | Structure and technology character of robot automation stamping production line 显示文摘 | He Ruilin Liu Jihui Miao Jinzhong | 2012 | Ma- chinist Metal Forming2012，，5： | 1 |
| 7 | Incorporating the variability of wind power with electric heat pumps显示文摘 | LONG Hongyu XU Ruilin HE Jianjun | | 0，，10： | 1 |
| 8 | Study on Surface Treatments on CdSe Wafers显示文摘The surface treatments on CdSe wafers were studied by means of SEM, XPS and micro-current test instrument. The relations between electrical properties of CdSe wafers and surface topography, composition and structure were analyzed. The results show that the change of surface composition by etching is beneficial to decrease leakage current. Meanwhile, the increase of oxygen on surface caused by passivation can largely decrease leakage current. When passivating time is 40 min, the wafers surface appears smooth and compact, which will decrease the density of surface state, the optimal electrical property of the wafer is therefore obtained. | Ren Rui Zhao Beijun Zhu Shifu He Zhiyu Wang Ruilin Wen Cai Ye Linsen Zhong Yuhang Zhu Xinghua | 2006 | Journal of Rare Earths2006，24，z1： | 1 |
| 9 | The effect of ureabond on structure and properties of toughened epoxy resins显示文摘 | Fang Jianglin Zuo Ruilin He Peng | 2010 | Journal of Applied Polymer Science2010，118，4： | 1 |
| 10 | Metabolomic analysis of the response of growing pigs to dietary l-arginine supplementation显示文摘 | Qinghua He Xiangfeng Kong Guoyao Wu Pingping Ren Huiru Tang Fuhua Hao Ruilin Huang Tiejun Li Bie Tan Peng Li Zhiru Tang Yulong Yin Yongning Wu | 2009 | Amino Acids2009，，1： | 1 |
| 11 | Incorporating the variability of wind power with electric heat pumps 显示文摘 | Long Hongyu Xu Ruilin He Jianjun | 2011 | Energies2011，4，10： | 1 |
| 12 | Surface etching induced ultrathin sandwich structure realizing enhanced photocatalytic activity显示文摘Photocatalytic conversion efficiency is limited by serious charge carrier recombination. Efficient carrier separation is usually achieved by elegantly-designed multi-component structures connected by directional electric field. Herein, we developed a twodimensional(2 D) sandwich structure, as a new photocatalytic system, to realize high-efficiency carrier separation. This strategy integrated multifunction into a single structure for the first time, which successfully introduces a stable built-in electric field,realizing high-effective carrier separation. Besides, the carrier concentration is dramatically increased due to dimensional confinement. Benefiting from above synergic advantages, 2 D sandwich photocatalyst achieves the highest nitrogen fixation rate(435 μmol g^(-1) h^(-1)) in inorganic solid photocatalysts under visible light irradiation. We anticipate that 2 D sandwich photocatalyst holds promises for the application and expansion of 2 D materials in photocatalysis research. | Bo Yang Wentuan Bi Yangyang Wan Xiaogang Li Mingcan Huang Ruilin Yuan Huanxin Ju Wangsheng Chu Xiaojun Wu Linghui He Changzheng Wu Yi Xie | 2018 | Science China Chemistry2018，61，12： | 1 |
| 13 | Prophylaxis of intermittent diazepam in children with FC显示文摘 | He Guangzu Chen Zhengqi | 1995 | J Xi''an med niv1995，7，2： | 1 |
| 14 | Metabolomic analysis of the response of growing pigs to dietary l-arginine supplementation显示文摘 | Qinghua He Xiangfeng Kong Guoyao Wu Pingping Ren Huiru Tang Fuhua Hao Ruilin Huang Tiejun Li Bie Tan Peng Li Zhiru Tang Yulong Yin Yongning Wu | 2009 | Amino Acids2009，，1： | 1 |
| 15 | Promoting the protonation step on the interface of titanium dioxide for selective photocatalytic reduction of CO_(2)to CH_(4)by using red phosphorus quantum dots显示文摘Enhancing the selectivity of hydrocarbon in CO_(2)is a great challenge.Herein,taking widely-used and highly-stable TiO_(2)as an example,we found that the protonation step,the key step for CH_(4)production,can change from endoergic to exoergic by using red phosphorus quantum dots.Consequently,the main product in CO_(2)reduction can be shifted from CO into CH_(4).The preparation method is very simple,which just ultrasonically treating the red P in the presence of TiO_(2).With an initial rate of CH_(4)production of 4.69μmol·g^(-1)·h^(-1),under simulated solar light,it manifests a significant 49.4-fold enhancement of CH_(4)yield over TiO_(2).Density functional calculation indicates that the red P optimizes the surface electronic structure.The Gibbs free energy for CHO^(*)formation(^(-1).12 eV)becomes lower than the desorption energy of the CO(-0.01 eV)when red P is introduced.This indicates that the CO intermediates on the surface are rapidly protonated to produce CHO^(*).Subsequently,the CHO^(*)will be converted into CH_(4)instead of being desorbed from the surface to produce CO.This study demonstrates that red P quantum dot is a promising candidate for the development of efficient photocatalyst for CO_(2)photoreduction to CH_(4)under solar light irradiation. | Yinglong Lu Minghao Liu Ningchao Zheng Xi He Ruiting Hu Ruilin Wang Quan Zhou Zhuofeng Hu | 2022 | Nano Research2022，15，4： | 1 |
| 16 | How Big Data and High-performance Computing Drive Brain Science显示文摘Brain science accelerates the study of intelligence and behavior,contributes fundamental insights into human cognition,and offers prospective treatments for brain disease.Faced with the challenges posed by imaging technologies and deep learning computational models,big data and high-performance computing(HPC)play essential roles in studying brain function,brain diseases,and large-scale brain models or connectomes.We review the driving forces behind big data and HPC methods applied to brain science,including deep learning,powerful data analysis capabilities,and computational performance solutions,each of which can be used to improve diagnostic accuracy and research output.This work reinforces predictions that big data and HPC will continue to improve brain science by making ultrahigh-performance analysis possible,by improving data standardization and sharing,and by providing new neuromorphic insights. | Shanyu Chen Zhipeng He Xinyin Han Xiaoyu He Ruilin Li Haidong Zhu Dan Zhao Chuangchuang Dai Yu Zhang Zhonghua Lu Xuebin Chi Beifang Niu | 2019 | Genomics, Proteomics & Bioinformatics2019，17，4： | 0 |
| 17 | Record of a juvenile Omura's whale live stranded in Hainan Island:Evidence of a potential breeding ground in the South China Sea?显示文摘On January 12,2011,a very young juvenile Bryde's-like baleen whale was found stranded alive on the east coast of Hainan Island,in the South China Sea.Unfortunately,it died the next morning.This baleen whale showed some unique external morphology and skull features of the Omura's whale(Balaenoptera omurai).Subsequently,it was genetically identified as an Omura's whale using two different mitochondrial DNA markers.This study documents the first confirmed live stranding of a juvenile Omura's whale on Hainan Island,China.Our findings expand the known distribution range of this species in Chinese waters and may indicate that waters around Hainan Island in the South China Sea could be a potential breeding ground for the Omura's whale. | Ruilin He Xiaoling Wan Minmin Chen Fei Fan Ding Wang Jinsong Zheng | 2022 | Water Biology and Security2022，1，3： | 0 |
| 18 | 中国环境温度对不同伤害死亡的影响(摘译)显示文摘伤害是一个严重的公共卫生问题,据世界卫生组织估计,全球每年有440万人死于伤害,接近总死亡人数的8.0%。在中国,伤害防控也是重要的公共卫生问题之一。在经济快速发展的背景下,虽然中国在过去三十年的伤害死亡率和伤残调整生命年(disability adjusted life years,DALYs)均呈下降趋势,但伤害仍是第五大死亡原因,以2017年为例,伤害占全国死亡人数的7.0%、占全死因DALYs的10.0%。 | 胡建雄 黄兴凤(摘译) 马文军(审校) HE Guanhao MENG Ruilin | 2023 | 伤害医学(电子版)2023，12，4： | 0 |
| 19 | Redetermination of the Crystal Structure of Vesignieite显示文摘Vesignieite, Cu3Ba(VO4)2(OH)2, crystallizes in space group C2 / m with a°=1.0270(2), b°=0.5911(1),c°=0.7711(2)nm and β=116.42(3)°. The intensity data were collected with the RIGAKU RASA-IISsingle-crystal four-circle diffractometer. The structure was determined by Patterson and Fourier methods andrefined by the least-square technique to a final R index of 0.051 for 614 independent diffraction points with|F? |>3σ|F?|. The crystal structure analysis shows that vesignieite has a layer structure parallel to (001). The powder diffraction lines were reindexed. | Ma Zhesheng He Ruilin Zhu Xiaoling China University of Geosciences Institute of Geology and Mineral Resources, Shaanxi Institute of Mineral Depostis, Chinese Academy of Geological Sciences | 1991 | Acta Geologica Sinica(English Edition)1991，65，2： | 0 |
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