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| 1 | Effects of several amendments on rice growth and uptake of copper and cadmium from a contaminated soil显示文摘在可变费用土壤的重金属是高度对进植物的转移可得到、容易的简历。因为完全消除在污染土壤上种的大米是不可能的,一些补习和缓解技术是必要的由大米减少金属简历可获得性和举起。这盆栽试验从被铜和镉污染的水稻土在米饭的生长和重金属的举起上调查了七个修正案的效果。结果从增加了谷物的石灰石的申请的最好在谷物由 12.5 16.5 褶层,和减少的 Cu 和 Cd 集中让步由 23.0%50.4% 。钙镁磷酸盐,钙硅酸盐,猪粪肥,和泥炭的申请也由 0.3 15.3 褶层增加了谷物收益,并且有效地减少了在谷物的 Cu 和 Cd 集中。在谷物的 Cd 集中稍微在紫云英和锌硫酸盐的处理被减少。在谷物和稻草的 Cu 和 Cd 的集中在土壤依赖于可得到的 Cu 和 Cd,并且玷污可得到的 Cu 和 Cd 被土壤 pH 显著地影响。 | LI Ping WANG Xingxiang ZHANG Taolin ZHOU Dongmei HE Yuanqiu | 2008 | Journal of Environmental Sciences2008，20，4： | 72 |
| 2 | New evidence for the Qinghai-Xizang (Tibet) Plateau as a pilot region of climatic fluctuation in China显示文摘Over 40 a observed temperature data in 172 stations in China and historical proxy data were analyzed. Evidence suggested that during 1980-1994, the warmest year appeared first in southeastern part of the Qinghai_Xizang (Tibet) Plateau (henceforth SETP) and then gradually spread northwards and eastwards to eastern China. The climatic change on century time scale in recent 600 a shows 3 relatively warm and clod stages in China. Each warm and cold stage appeared first in Tibet Plateau (henceforth TP) and then in the Qilian Mountains, then in the eastern parts of China. The warm and cold stages in TP were 10-60 a earlier than in the eastern China. The facts show that TP is a pilot region of climatic fluctuation in China on the time scale shorter than 10\+3a. | Song Feng Maocang Tang Dongmei Wang | 1998 | Chinese Science Bulletin1998，43，20： | 35 |
| 3 | A scientometric review of biochar research in the past 20 years(1998-2018)显示文摘Biochar is the carbon-rich product obtained from the thermochemical conversion of biomass under oxygen-limited conditions.Biochar has attained extensive attention due to its agronomical and environmental benefits in agro-ecosystems.This work adopts the scientometric analysis method to assess the development trends of biochar research based on the literature data retrieved from the Web of Science over the period of 1998-2018.By analysing the basic characteristics of 6934 publications,we found that the number of publications grew rapidly since 2010.Based on a keyword analysis,it is concluded that scholars have had a fundamental recognition of biochar and preliminarily found that biochar application had agronomic and environmental benefits during the period of 1998-2010.The clustering results of keywords in documents published during 2011-2015 showed that the main research hotspots were“biochar production”,“biochar and global climate change”,“soil quality and plant growth”,“organic pollutants removal”,and“heavy metals immobilization”.While in 2016-2018,beside these five main research hotspots,“biochar and composting”topic had also received greater attention,indicating that biochar utilization in organic solid waste composting is the current research hotspot.Moreover,updated reactors(e.g.,microwave reactor,fixed-bed reactor,screw-feeding reactor,bubbling fluidized bed reactor,etc.)or technologies(e.g.,solar pyrolysis,Thermo-Catalytic Reforming process,liquefaction technology,etc.)applied for efficient energy production and modified biochar for environmental remediation have been extensively studied recently.The findings may help the new researchers to seize the research frontier in the biochar field. | Ping Wu Syed Tahir Ata-Ul-Karim Bhupinder Pal Singh Hailong Wang Tongliang Wu Cun Liu Guodong Fang Dongmei Zhou Yujun Wang Wenfu Chen | 2019 | Biochar2019，1，1： | 36 |
| 4 | Fractionation of Heavy Metals in Soils as Affected by Soil Types and Metal Load Quantity显示文摘Two series of soil subsamples, by spiking copper(Cu),lead(Pb),zinc(Zn)and cadmium(Cd)in an orthogonal design,were prepared using red soil and brown soil,respectively.The results indicated that heavy metal fractions in these soil subsamples depended not only on soil types,but also on metal loading quantity as well as on interactions among metals in soil.Lead and Cu in red soil appeared mostly in weakly specifically adsorbed(WSA),Fe and Mn oxides bound(OX),and residual(RES)fractions.Zine cxisted in all fractions except organic bound one,and Cd was major in water soluble plus exchangeable(SE)one.Different from the results of red soil,Pb and Cu was present in brown soil in all fractions except organic one,but over 75% of Zn and 90% of Cd existed only in SE fraction.Meanwhile,SE fraction for any metal in red soil was lower than that in brown soil and WSA and OX fractions were higher.It is in agreernent with low cation exchange capacity and large amounts of metal oxides included in red soil.Metal fractions in soil,especially for water soluble plus exchangeable one ,were obviously influenced by other coexisting metals.The SE fraction of heavy metals increased with increasing loading amounts of metals in red soil but not obviously in brown soil,which suggest that metal availability be easily affected by their total amounts spiked in red soil.In addition,more metals in red soil were extracted with 0.20 mol L^-1 NH4Cl(pH5.40)than that with 1.0 mol L^-1 Mg(NO3)2(pH7.0),but the reverse happened in brown soil,implicating significantly different mechanisms of metal desorption from red soil and brown soil. | ZHOU DONGMEI, CHEN HUAIMAN, HAO XIUZHEN and WANG YUJUNInstitute of Soil Science, the Chinese Academy of Sciences, Nanjing 210008 (China) | 2002 | Pedosphere2002，12，4： | 33 |
| 5 | OUT-OF-PLANE COMPRESSIVE PROPERTIES OF HEXAGONAL PAPER HONEYCOMBS显示文摘The compressive behaviour of paper honeycombs is studied by means of an experimental analysis. Experiment results show how geometry aspects of hexagonal paper honeycombs,e.g. the height of paper honeycomb,the thickness and length of honeycomb cell-wall,the drawing ratio of hexagonal honeycomb,affect the compressive properties of the paper honeycombs. It is in good agreement with the theory model. The constraint factor K of the critical buckling stress is mainly determined by the length of honeycomb cell-wall. It can be described as K=1.54 for B type paper honeycombs and K=3.32 for D type paper honeycombs. The plateau stress is the power exponent function of the thickness to length ratio of honeycomb cell-wall,and the experiment results show that the constant is 13.2 and the power exponent is 1.77. The research results can be used to characterize and improve efficiently the compressive properties of paper honeycombs. | WANG Dongmei WANG Zhiwei | 2007 | Chinese Journal of Mechanical Engineering2007，20，2： | 28 |
| 6 | The antitumor effect of tanshinone IIA on antiproliferation and decreasing VEGF/VEGFR2 expression on the human non-small cell lung cancer A549 cell line显示文摘The effects of tanshinone IIA on the proliferation of the human non-small cell lung cancer cell line A549 and its possible mechanism on the VEGF/VEGFR signal pathway were investigated.The exploration of the interaction between tanshinone IIA and its target proteins provides a feasible platform for studying the anticancer mechanism of active components of herbs.The CCK-8 assay was used to evaluate the proliferative activity of A549 cells treated with tanshinone IIA(2.5 80 μmol/L) for 24,48 and 72 h,respectively.Flow cytometry was used for the detection of cell apoptosis and cell cycle perturbation.VEGF and VEGFR2 expression were studied by Western blotting.The binding mode of tanshinone IIA within thecrystal structure of the VEGFR2 protein was evaluated with molecular docking analysis by use of the CDOCKER algorithm in Discovery Studio 2.1.The CCK-8 results showed that tanshinone IIA can significantly inhibit A549 cell proliferation in a dose-and time-dependent manner.Flow cytometry results showed that the apoptosis rate of tested group was higher than the vehicle control,and tanshinone IIAtreated cells accumulated at the S phase,which was higher than the vehicle control.Furthermore,the expression of VEGF and VEGFR2 was decreased in Western blot.Finally,molecular docking analysis revealed that tanshinone IIA could be stably docked into the kinase domain of VEGFR2 protein with its unique modes to form H-bonds with Cys917 and π–π stacking interactions with Val848.In conclusion,tanshinone IIA may suppress A549 proliferation,induce apoptosis and cell cycle arrest at the S phase.This drug may suppress angiogenesis by targeting the protein kinase domains of VEGF/VEGFR2. | Jun Xie Jiahui Liu Heng Liu Shihui Liang Meigui Lin Yueyu Gu Taoli Liu Dongmei Wang Hui Gee Sui-lin Mo | 2015 | Acta Pharmaceutica Sinica B2015，5，6： | 26 |
| 7 | Generation of haploid embryonic stem cells from Macaca fascicularis monkey parthenotes显示文摘在从经由单性生殖和男性单性生殖的老鼠的胚胎的干细胞(haESCs ) 启用了在修改基因的动物的哺乳动物的房间和代的基因屏蔽的 haploid 的推导的最近的成功。然而, haESCs 是否能从首领被导出,仍然保持未知。这里,我们从 Macaca fascicularis 猴子的单性生殖的胚囊报导 haESCs 的推导。这些房间,作为 PG-haESCs 称为,是 pluripotent 并且能在 vitro 或在 vivo 区分到三胚胎的细菌层的房间。有趣地,一根猴子 PG-haESC 线(MPH1 ) 的 haploidy 与另一个(MPH2 ) 的相比是更稳定的,作为没有排序的激活荧光的房间(FACS ) ,由 haploid 房间的存在出现超过 140 天 haploid 房间的丰富。重要地,转基因的猴子 PG-haESC 线能被 lentivirus- 和 piggyBac 产生调停 transposon 的基因转移。而且,基因屏蔽在猴子 PG-haESCs 是可行的。我们的结果证明 PG-haESCs 能从猴子被产生,提供为在首领的基因分析的一个理想的工具。 | Hui Yang Zhen Liu Yu Ma Cuiqing Zhong Qi Yin Chikai Zhou Linyu Shi Yijun Cai Hanzhi Zhao Hui Wang Fan Tang Yan Wang Chenchen Zhang Xin-yuan Liu Dongmei Lai Ying Jin Qiang Sun Jinsong Li | 2013 | Cell Research2013，23，10： | 22 |
| 8 | Chromosome-scale genome assembly provides insights into the evolution and flavor synthesis of passion fruit (Passiflora edulis Sims)显示文摘Passion fruit(Passiflora edulis Sims)is an economically valuable fruit that is cultivated in tropical and subtropical regions of the world.Here,we report an~1341.7Mb chromosome-scale genome assembly of passion fruit,with 98.91%(~1327.18Mb)of the assembly assigned to nine pseudochromosomes.The genome includes 23,171 protein-coding genes,and most of the assembled sequences are repetitive sequences,with long-terminal repeats(LTRs)being the most abundant.Phylogenetic analysis revealed that passion fruit diverged after Brassicaceae and before Euphorbiaceae.Ks analysis showed that two whole-genome duplication events occurred in passion fruit at 65 MYA and 12 MYA,which may have contributed to its large genome size.An integrated analysis of genomic,transcriptomic,and metabolomic data showed that‘alpha-linolenic acid metabolism’,‘metabolic pathways’,and‘secondary metabolic pathways’were the main pathways involved in the synthesis of important volatile organic compounds(VOCs)in passion fruit,and this analysis identified some candidate genes,including GDP-fucose Transporter 1-like,Tetratricopeptide repeat protein 33,protein NETWORKED 4B isoform X1,and Golgin Subfamily A member 6-like protein 22.In addition,we identified 13 important gene families in fatty acid pathways and eight important gene families in terpene pathways.Gene family analysis showed that the ACX,ADH,ALDH,and HPL gene families,especially ACX13/14/15/20,ADH13/26/33,ALDH1/4/21,and HPL4/6,were the key genes for ester synthesis,while the TPS gene family,especially PeTPS2/3/4/24,was the key gene family for terpene synthesis.This work provides insights into genome evolution and flavor trait biology and offers valuable resources for the improved cultivation of passion fruit. | Zhiqiang Xia Dongmei Huang Shengkui Zhang Wenquan Wang Funing Ma Bin Wu Yi Xu Bingqiang Xu Di Chen Meiling Zou Huanyu Xu Xincheng Zhou Rulin Zhan Shun Song | 2021 | Horticulture Research2021，8，1： | 15 |
| 9 | Indirect mineral carbonation of titanium-bearing blast furnace slag coupled with recovery of TiO_2 and Al_2O_3显示文摘Large quantities of CO_2 and blast furnace slag are discharged in the iron and steel industry. Mineral carbonation of blast furnace slag can offer substantial CO_2 emission reduction and comprehensive utilization of the solid waste.This paper describes a novel route for indirect mineral carbonation of titanium-bearing blast furnace(TBBF) slag,in which the TBBF slag is roasted with recyclable(NH_4)_2SO_4(AS) at low temperatures and converted into the sulphates of various valuable metals, including calcium, magnesium, aluminium and titanium. High value added Ti-and Al-rich products can be obtained through stepwise precipitation of the leaching solution from the roasted slag. The NH_3 produced during the roasting is used to capture CO_2 from flue gases. The NH_4HCO_3 and(NH_4)_2CO_3 thus obtained are used to carbonate the CaSO_4-containing leaching residue and MgSO_4-rich leaching solution, respectively. In this study, the process parameters and efficiency for the roasting, carbonation and Ti and Al recovery were investigated in detail. The results showed that the sulfation ratios of calcium,magnesium, titanium and aluminium reached 92.6%, 87% and 84.4%, respectively, after roasting at an AS-to-TBBF slag mass ratio of 2:1 and 350 °C for 2 h. The leaching solution was subjected to hydrolysis at 102 °C for 4 h with a Ti hydrolysis ratio of 95.7% and the purity of TiO_2 in the calcined hydrolysate reached 98 wt%.99.7% of aluminium in the Ti-depleted leaching solution was precipitated by using NH_3. The carbonation products of Ca and Mg were CaCO_3 and(NH_4)_2 Mg(CO_3)_2·4H_2O, respectively. The latter can be decomposed into MgCO_3 at 100–200 °C with simultaneous recovery of the NH_3 for reuse. In this process, approximately 82.1% of Ca and 84.2%of Mg in the TBBF slag were transformed into stable carbonates and the total CO_2 sequestration capacity per ton of TBBF slag reached up to 239.7 kg. The TiO_2 obtained can be used directly as an end product, while the Al-rich precipitate and the two carbonation products can act, respectively, as raw materials for electrolytic aluminium,cement and light magnesium carbonate production for the replacement of natural resources. | Lin Wang Weizao Liu Jingpeng Hu Qiang Liu Hairong Yue Bin Liang Guoquan Zhang Dongmei Luo Heping Xie Chun Li | 2018 | Chinese Journal of Chemical Engineering2018，26，3： | 14 |
| 10 | Comparison of Postoperative Pain Following Laser-assisted Subepithelial Keratectomy and Transepithelial Photorefractive Keratectomy:a Prospective,Random Paired Bilateral Eye Study显示文摘Purpose:To compare postoperative pain following laser-assisted subepithelial keratectomy(LASEK) and transepithelial photorefractive keratectomy(T-PRK, two-step surgery) and alleviate postoperative subjective pain.Methods:.Thirty patients(60 eyes) with myopia or myopic astigmatism were consecutively recruited into this prospective,randomized paired study..Patients underwent LASEK in one eye,and T-PRK in the other. The degree of pain was rated on a scale of 0-10 on postoperative days 1,2 and 3..Uncorrected visual acuity(UCVA) and subepithelial corneal haze were assessed at postoperative 1 and 3 months.Results:.The pain was relieved on the 4th postoperative day in all patients,.healing of corneal epithelium was observed at4-5 days after surgery and contact lenses were removed promptly.At postoperative 1 day,.the mean subjective pain score in the LASEK group was 3.2±1.88 and 4.43±1.61 in TPRK group(P=0.008).No significant difference was found between two groups on postoperative 2 and 3 days. At postoperative 3 months, the percentage of UCVA ≥0.8 in the LASEK group was 100% and 96.7% in the T-PRK group.(P =0.24),93.3% of patients in the LASEK with UCVA ≥1.0 and 90%in the T-PRK group(P=0.64). In the LASEK group, the value of corneal haze was 0.26 ±0.21 and 0.27 ±0.25 in the T-PRK group(P=0.877).Conclusion:.Good visual acuity was obtained in both groups at postoperative 3 months. Compared with those in the T-PRKgroup, patients undergoing had less discomfort in the LASEK group, which may be associated with corneal epithelial activity. The changing curve of subjective pain in the T-PRK group was relatively flat and stable at postoperative 3 days. | Dongmei Wang Guangsheng Chen Liusong Tang Qiaoling Li | 2014 | Eye Science2014，29，3： | 14 |
| 11 | Producing Designer Oils in Industrial Microalgae by Rational Modulation of Co-evolving Type-2 Diacylglycerol Acyltransferases显示文摘Microalgal 上油,取决于他们 unsaturation 的度,能作为也营养的补充被利用或造成;因此,一件化工物品与遗传上设计了并且 unsaturation 的悦耳的度是合乎需要的最大化过程效率和产品通用性。前的系统的介绍? vivo (在酵母),在里面? vitro ,并且在里面?经由反向的遗传,在 Nannochloropsis 大洋洲( NoDGAT2s 或 NoDGTTs )的 type-2 diacylglycerol acyltransferases 的 vivo 活动表明 NoDGAT2A 比较喜欢浸透的丰满的酸( SFA ), NoDGAT2D 比较喜欢 monounsaturated 丰满的酸( MUFA ),和 NoDGAT2C 展览向多元不堡和的最强壮的活动丰满的酸( PUFA )。作为 NoDGAT2A , 2C ,和 2D 从绿水藻,红水藻,和真核细胞的主人发源第二等的 endosymbiosis 的祖先的参加者分别地,产油的一个机械学的模型被揭开,在哪个土生土长、采用的 NoDGAT2s 提出了功能的补充和位于僵硬 SFA 下面的特定的抄本丰富比率: MUFA :在 triacylglycerol (标签)的 PUFA 层次。由讲道理地 modulating NoDGAT2A:2C:2D 抄本的比率, N 的一个银行。与 unsaturation 的大量度为营养的补充或燃料生产优化的大洋洲紧张被创造,在哪个在 1.3- , 3.7- ,和 11.2 褶层分别地改变的标签的 SFA, MUFA,和 PUFA 的比例。这建立了新奇策略同时从工业 microalgae 改进油的生产率和质量。 | Yi Xin Yandu Lu Yi-Ying Lee Li Wei Jing Jia Qintao Wang Dongmei Wang Fali Bai Hanhua Hu Qiang Hu Jin Liu Yantao Li Jian Xu | 2017 | Molecular Plant2017，10，12： | 14 |
| 12 | A versatile cooperative template-directed coating method to synthesize hollow and yolk-shell mesoporous zirconium titanium oxide nanospheres as catalytic reactors显示文摘 | Buyuan Guan Tao Wang Shangjing Zeng Xue Wang Dong An Dongmei Wang Yu Cao Dingxuan Ma Yunling Liu Qisheng Huo | 2014 | Nano Research2014，7，2： | 12 |
| 13 | A RISK ASSESSMENT METHOD OF THE WIRELESS NETWORK SECURITY显示文摘The core of network security is the risk assessment. In this letter,a risk assessment method is introduced to estimate the wireless network security. The method,which combines Analytic Hier-archy Process (AHP) method and fuzzy logical method,is applied to the risk assessment. Fuzzy logical method is applied to judge the important degree of each factor in the aspects of the probability,the influence and the uncontrollability,not to directly judge the important degree itself. The risk as-sessment is carved up 3 layers applying AHP method,the sort weight of the third layer is calculated by fuzzy logical method. Finally,the important degree is calculated by AHP method. By comparing the important degree of each factor,the risk which can be controlled by taking measures is known. The study of the case shows that the method can be easily used to the risk assessment of the wireless network security and its results conform to the actual situation. | Zhao Dongmei Wang Changguang Ma Jianfeng | 2007 | Journal of Electronics(China)2007，24，3： | 11 |
| 14 | Comparison of Persulfate Activation and Fenton Reaction in Remediating an Organophosphorus Pesticides-Polluted Soil显示文摘Organophosphorus pesticides(OPs) are one of the most regular pollutants and frequently detected in the contaminated sites,so developing an efficient method for the treatment of OPs is highly required. The aim of the present study was to compare the effectiveness of persulfate(PS) activation and Fenton reaction in remediating the soil polluted with OPs. The polluted soil used in this study was sampled from an abandoned insecticide factory in Nantong, Jiangsu Province of China, mainly containing chloropyrifos(CP) and 4-bromo-2-chlorophenol(BCP, the raw material of profenofos) with total concentration of about 30 000 mg kg^(-1). The results showed that both BCP and CP were efficiently degraded by base activation of PS, and increasing the ratio of Na OH/PS enhanced CP degradation, but slightly decreased BCP degradation. The greatest degradation rates for CP and BCP were 92% and 97%, respectively,with 7.0 mol L^(-1) Na OH and 0.21 mol L^(-1) PS and a soil-to-liquid ratio of 1:1. Furthermore, ferrous iron activation of PS also degraded BCP efficiently, but only 60% of CP was degraded under the same reaction conditions. These results indicated that base activation of PS was more feasible than Fe^(2+) activation and Fenton reaction in remediating the soil polluted with OPs. The high degradation rate for CP may be linked to the initial hydrolyzation of CP by base to 3,5,6-trichloro-2-pyridinol, which can be further rapidly degraded by free radicals generated from base activation of PS. | ZHU Changyin ZHU Fengxiao WANG Fuwang GAO Juan FAN Guangping ZHOU Dongmei FANG Guodong | 2017 | Pedosphere2017，27，3： | 11 |
| 15 | Secondary Crystallization of Na_2CO_3-Modified HZSM-5 Zeolites with Tetrapropylammonium Hydroxide and Their Catalytic Performance in Thiophene Alkylation Reaction显示文摘The Na2CO3-modified HZSM-5 zeolites were further treated by tetrapropylammonium hydroxide(TPAOH) solution. The effect of TPAOH concentration on the secondary crystallization process was investigated. The resulting samples were characterized by a complementary combination of X-ray diffraction, N2 adsorption/desorption, scanning electron microscopy, X-ray fluorescence spectroscopy, XPS, 27 Al and 29 Si magic-angle spinning nuclear magnetic resonance spectroscopy, BET and temperature-programmed desorption techniques. The results showed that the secondary crystallization of the HZSM-5 zeolite could result in migration of non-framework species from the internal channels to the zeolite surface and their transformation into framework species. The catalytic activity of these modified samples for thiophene alkylation was evaluated. Both the activity and stability of the catalysts were improved after secondary crystallization. | Liu Dongmei Kong Feifei Zhai Yuchun Wang Haiyan | 2015 | China Petroleum Processing & Petrochemical Technology2015，17，3： | 10 |
| 16 | Comparative Transcriptome Analysis of Actinidia arguta Fruits Reveals the Involvement of Various Transcription Factors in Ripening显示文摘The fruit of Actinidia arguta is typically climacteric.During ripening,the fruits produce a large amount of ethylene.Although the molecular basis of climacteric fruit ripening has been extensively studied,some aspects such as its transcriptional regulation remain unclear.Here,we compared the transcriptomes of A.arguta fruits collected at commercial harvest(sample d0)and at 6 days after harvest(sample d6)using RNA-seq.A total of 3 659 differentially expressed genes(DEGs)between samples d0 and d6 were detected,of which 2 983 and 1 104 could be functionally annotated with Gene Ontology(GO)and Clusters of Orthologous Groups(COG)pathways.DEGs involved in ethylene biosynthesis and signal transduction were identified,including ACO(c79627),ERF061(c105131),and ERF6(c99193).Transcription factors such as ERF,b HLH,NAC,MADS,and MYB were also differentially expressed between samples d0 and d6.Selected DEGs were subjected to further analysis using quantitative reverse transcription-polymerase chain reaction(q RT-PCR),and the results coincided with those of RNA-seq.Our data revealed additional transcription factors that are involved in the regulation of fruit ripening.These results provide useful information for future research on the transcriptional regulation of fruit ripening. | HUANG Guohui QU Yi LI Tong YUAN Hui WANG Aide TAN Dongmei | 2018 | Horticultural Plant Journal2018，4，1： | 9 |
| 17 | Efficacy and safety of vitamin D3 in patients with diabetic nephropathy: a meta-analysis of randomized controlled trials显示文摘 | Zhao Junyu Dong Jianjun Wang Haipeng Shang Hongxia Zhang Dongmei Liao Lin | 2014 | Chinese Medical Journal2014，，15： | 9 |
| 18 | Potassium 2-(1-hydroxypentyl)-benzoate attenuates neuronal apoptosis in neuron–astrocyte co-culture system through neurotrophy and neuroinflammation pathway显示文摘Potassium 2-(1-hydroxypentyl)-benzoate(D,L-PHPB), a new drug candidate for ischemic stroke at the phase II clinic trial, has been shown to protect neurons by inhibiting oxidative injury and reducing neuron apoptosis in previous studies. But the mechanisms of D,L-PHPB remain to be studied.In this study, a neuron–astrocytes co-culture system was used to elucidate the roles of astrocytes in neuroprotection of D,L-PHPB under oxygen-glucose deprivation/reoxygenation(OGD/R) condition. Our data showed that D,L-PHPB reduced neuronal apoptosis in mono-culture system and this effect was enhanced in neuron–astrocyte co-culture system under the OGD/R condition. Meanwhile, D,L-PHPB obviously increased the levels of brain-derived neurotrophic factor(BDNF) and nerve growth factor(NGF), which were mainly secreted from astrocytes, in the co-culture system after OGD/R. The PI3K/AKT and ERK signaling pathways as well as the p-TRKA/B receptors were involved in the process. In addition, the levels of TNF-α and IL-1β secreted from astrocytes after OGD/R were markedly reduced after D,L-PHPB treatment, which was mainly due to the suppression of phosphorylated p38. In conclusion, the present study demonstrates that the neuroprotective effects of D,L-PHPB were improved by astrocytes, mainly mediated by increasing the release of BDNF/NGF and attenuating inflammatory cytokines. | Dongmei Liu Man Zhang Xianfang Rong Jiang Li Xiaoliang Wang | 2017 | Acta Pharmaceutica Sinica B2017，7，5： | 8 |
| 19 | Parkin promotes proteasomal degradation of p62: implication of selective vulnerability of neuronal cells in the pathogenesis of Parkinson's disease显示文摘 | Pingping Song Shanshan Li Hao Wu Ruize Gao Guanhua Rao Dongmei Wang Ziheng Chen Biao Ma Hongxia Wang Nan Sui Haiteng Deng Zhuohua Zhang Tieshan Tang Zheng Tan Zehan Han Tieyuan Lu Yushan Zhu Quan Chen | 2016 | Protein & Cell2016，7，2： | 8 |
| 20 | Methane aromatization in the absence of oxygen over extruded and molded MoO_3/ZSM-5 catalysts:Influences of binder and molding method显示文摘The influences of binder and molding method on the catalytic performance of methane aromatization in the absence of O2 over MoO3/ZSM-5 catalysts were investigated.SEM,NH3-TPD,FT-IR of adsorbed pyridine,N2 adsorption-desorption,cyclohexane adsorption and XPS were employed to characterize the physical and chemical properties of the catalysts.It was found that SiO2 was a suitable binder for the catalyst due to its appropriate weak acidity.The laminar catalyst comprising of an inert spherical core and a MoO3/ZSM-5 laminar shell with 0.1 0.2 mm in thickness showed a better catalytic performance than the extruded catalyst.The improved activity of the laminar catalyst could be attributed to the easy carbonization of Mo species and the quick removal of reaction products from the catalyst surface. | Dongmei Ren Xiangsheng Wang Gang Li Xiaojing Cheng Huayun Long Lidong Chen | 2010 | Journal of Natural Gas Chemistry2010，19，6： | 7 |
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