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| 1 | Digital Twins and Cyber Physical Systems toward Smart Manufacturing and Industry 4.0:Correlation and Comparison显示文摘State-of-the-art technologies such as the Internet of Things(IoT),cloud computing(CC),big data analytics(BDA),and artificial intelligence(AI)have greatly stimulated the development of smart manufacturing.An important prerequisite for smart manufacturing is cyber-physical integration,which is increasingly being embraced by manufacturers.As the preferred means of such integration,cyber-physical systems(CPS)and digital twins(DTs)have gained extensive attention from researchers and practitioners in industry.With feedback loops in which physical processes affect cyber parts and vice versa,CPS and DTs can endow manufacturing systems with greater efficiency,resilience,and intelligence.CPS and DTs share the same essential concepts of an intensive cyber-physical connection,real-time interaction,organization integration,and in-depth collaboration.However,CPS and DTs are not identical from many perspectives,including their origin,development,engineering practices,cyber-physical mapping,and core elements.In order to highlight the differences and correlation between them,this paper reviews and analyzes CPS and DTs from multiple perspectives. | Fei Tao Qinglin Qi Lihui Wang A.Y.C.Nee | 2019 | Engineering2019，5，4： | 84 |
| 2 | Dynamic downscaling of near-surface air temperature at the basin scale using WRF-a case study in the Heihe River Basin, China显示文摘一般发行量模型(GCM ) 的空间决定太粗糙,不能代表地区性的气候变化在地区性,为许多环境建模和影响评价要求的盆,和本地规模。天气研究和预报模型(WRF ) 是一下一代,充分可压缩,有运行时刻的 Euler 非静水力学的 mesoscale 预报模型静水力学的选择。这个模型在从一公里的规模为 downscaling 天气和气候是有用的到几千公里,并且为导出也为水文学模拟要求的气象学的参数是有用的。这篇论文的目的是验证由中国气象学的管理(CMA ) 车站的每日的观察数据,并且由模仿 5 km/1 h 空气温度的 WRF 时时,在原处,分水岭的数据结盟了遥感勘测试验性的研究工程。每日的确认证明 WRF 模拟与观察数据有好同意;R ^ 啜在 WRF 模拟和每个车站之间的 2 ^ 是超过 0.93;为每个车站的 meanbias 错误(MBE ) 绝对是不到 | Xiaoduo PAN Xin Li Xiaokang SHI Xujun HAN Lihui LUO Liangxu WANG | 2012 | Frontiers of Earth Science2012，6，3： | 24 |
| 3 | 智能制造场景的5G应用展望显示文摘为满足智能制造领域物联网当前发展的需求,研究了相应制造场景的5G应用技术。介绍了5G的关键技术,包括5G支持的应用场景、网络切片、网络功能虚拟化(NFV)/软件定义网络(SDN)、多接入边缘计算、设备对设备通信技术等;给出了基于扩展的信息物理系统5层框架,基于该框架分析了多个智能制造场景的5G应用(包括人机界面和生产信息技术、流程自动化、工厂自动化、物流和仓储、设备监控和维护等);给出了以上应用的5G边缘计算开发框架,以集成上述场景;探讨了5G应用于智能制造场景所面临的多个挑战,以助于5G使能智能制造的落地应用。 | 史彦军 韩俏梅 沈卫明 WANG Lihui WANG Xianbin | 2020 | 中国机械工程2020，31，2： | 22 |
| 4 | 薄壁件铣削过程加工变形研究进展显示文摘机床加工性能和刀具切削性能的发展使得薄壁件的高效率和高精密加工成为可能,也使得薄壁件在航空航天领域得到更广泛应用。薄壁零件结构复杂、刚度低,在铣削过程中易发生变形,因此精准预测与控制薄壁件的加工变形是机加工领域亟需解决的工艺难题。通过对薄壁件分类以及加工工艺分析,归纳总结引起薄壁件加工变形的因素,对加工变形影响最为关键的铣削力计算模型进行简述;结合国内外薄壁件变形预测与控制方法的研究,以弹塑性和数值模拟方法对薄壁件加工变形进行预测,通过加工工艺优化、辅助支撑技术、高速切削技术和数控补偿技术等方法对薄壁件加工过程的变形量进行控制;基于数据驱动数字孪生体的更新迭代,实现薄壁件实际加工过程的孪生及薄壁件变形预测与控制,构建了以数字孪生为平台的薄壁件加工变形预测与控制理论框架;最后对数字孪生在薄壁件加工变形预测及控制的发展与应用提出展望。 | 岳彩旭 张俊涛 刘献礼 陈志涛 Steven Y.LIANG Lihui WANG | 2022 | 航空学报2022，43，4： | 22 |
| 5 | Fasudil hydrochloride hydrate, a Rho-kinase inhibitor, ameliorates hepatic fibrosis in rats with type 2 diabetes显示文摘 | Zhou Hong Fang Caixia Zhang Lihui Deng Yonggui Wang Mian Meng Fengling | 2014 | Chinese Medical Journal2014，，2： | 20 |
| 6 | From Intelligence Science to Intelligent Manufacturing显示文摘1.Introduction The aim of intelligent manufacturing is to establish flexible and adaptive manufacturing operations locally or globally by using integrated information technology(IT)and artificial intelligence(AI)that can combine advanced computing power with manufacturing equipment.Intelligent manufacturing depends on the timely acquisition,distribution,and utilization of real-time data from both machines and processes on manufacturing shop floors[1]and even across product life-cycles.Effective information sharing can improve production quality,reliability,resource efficiency,and the recyclability of end-of-life products.Intelligent manufacturing built on digitalization is also intended to be more sustainable and to contribute to the factories of the future.However,intelligent manufacturing depends extensively on AI.To better grasp the future of intelligent manufacturing,it is necessary to understand AI.This paper provides the author’s perspective on AI from intelligence science to intelligent manufacturing. | Lihui Wang | 2019 | Engineering2019，5，4： | 18 |
| 7 | Genetic analysis and molecular mapping of a presenescing leaf gene psll in rice (Oryza sativa L.)显示文摘A rice psl1 (presenescing leaf) mutant was obtained from a japonica variety Zhonghua 11 via radiation of 60Co-γ in M2 generation. Every leaf of the mutant began to wither after it reached the big-gest length,while the leaves of the wild variety could keep green for 25―35 d. In this study,genetic analysis and gene mapping were carried out for the mutant identified. The SSR marker analysis showed that the mutant was controlled by a single recessive gene (psl1) located on chromosome 2. Fine mapping of the psl1 locus was conducted with 34 new STS markers developed around psl1 anchored region based on the sequence diversity between Nippon-bare and 93-11. The psl1 was further mapped be-tween two STS markers,STS2-19 and STS2-26,with genetic distances of 0.43 and 0.11 cM,respectively,while cosegregated with STS2-25. A BAC contig was found to span the psl1 locus,the region being delim-ited to 48 kb. This result was very useful for cloning of the psl1 gene. | WANG dun WU Shujun ZHOU Yong ZHOU Lihui XU Jiefen HU Jing FANG Yunxia GU Minghong LIANG Guohua | 2006 | Chinese Science Bulletin2006，51，24： | 16 |
| 8 | Down.regulation of E.cadherin enhances prostate cancer chemoresistance via Notch signaling显示文摘Background:The chemoresistance of prostate cancer(PCa)is invariably associated with the aggressiveness and metastasis of this disease.New emerging evidence indicates that the epithelial-to-mesenchymal transition(EMT)may play pivotal roles in the development of chemoresistance and metastasis.As a hallmark of EMT,E-cadherin is suggested to be a key marker in the development of chemoresistance.However,the molecular mechanisms underlying PCa chemoresistance remain unclear.The current study aimed to explore the association between EMT and chemoresistance in PCa as well as whether changing the expression of E-cadherin would affect PCa chemoresistance.Methods:Parental PC3 and DU145 cells and their chemoresistant PC3-Tx R and DU145-Tx R cells were analyzed.PC3-Tx R and DU145-Tx R cells were transfected with E-cadherin-expressing lentivirus to overexpress E-cadherin;PC3 and DU145 cells were transfected with small interfering RNA to silence E-cadherin.Changes of EMT phenotype-related markers and signaling pathways were assessed by Western blotting and quantitative real-time polymerase chain reaction.Tumor cell migration,invasion,and colony formation were then evaluated by wound healing,transwell,and colony formation assays,respectively.The drug sensitivity was evaluated using MTS assay.Results:Chemoresistant PC3-Tx R and DU145-Tx R cells exhibited an invasive and metastatic phenotype that associated with EMT,including the down-regulation of E-cadherin and up-regulation of Vimentin,Snail,and N-cadherin,comparing with that of parental PC3 and DU145 cells.When E-cadherin was overexpressed in PC3-Tx R and DU145-Tx R cells,the expression of Vimentin and Claudin-1 was down-regulated,and tumor cell migration and invasion were inhibited.In particular,the sensitivity to paclitaxel was reactivated in E-cadherin-overexpressing PC3-Tx R and DU145-Tx R cells.When E-cadherin expression was silenced in parental PC3 and DU145 cells,the expression of Vimentin and Snail was up-regulated,and,particularly,the sensitivity to paclitaxel was decreased.Interestingly,Notch-1 expression was up-regulated in PC3-Tx R and DU145-Tx R cells,whereas the E-cadherin expression was down-regulated in these cells comparing with their parental cells.The use ofγ-secretase inhibitor,a Notch signaling pathway inhibitor,significantly increased the sensitivity of chemoresistant cells to paclitaxel.Conclusion:The down-regulation of E-cadherin enhances PCa chemoresistance via Notch signaling,and inhibiting the Notch signaling pathway may reverse PCa chemoresistance. | Wenchu Wang Lihui Wang Atsushi Mizokami Junlin Shi Chunlin Zou Jinlu Dai Evan T. Keller Yi Lu Jian Zhang | 2017 | Chinese Journal of Cancer2017，36，3： | 16 |
| 9 | 机床智能控制系统体系架构及关键技术研究进展显示文摘机床智能控制系统是未来智能机床领域的重要组成部分,对提高制造业核心竞争力具有重要意义。相比传统数控系统,机床智能控制系统具有更高效、稳定地加工质量,以及可代替人工经验智能判断等优点。针对现有机床智能控制系统方面的综述性讨论较少的情况,通过分析机床控制系统发展历程中四个阶段的特点,提出机床控制系统的智能化体系和架构。然后,从先进技术角度,详细阐述了人工智能技术、数字孪生技术以及云服务等关键技术,在机床智能控制系统中的应用。最后,通过分析智能机床面临的几大严峻挑战与应对之策,展望了未来机床智能化控制系统的发展趋势。 | 孟博洋 李茂月 刘献礼 WANG Lihui LIANG S Y 王志学 | 2021 | 机械工程学报2021，57，9： | 16 |
| 10 | Mapping of two new brown planthopper resistance genes from wild rice显示文摘A brown planthopper (BPH) resistance line, B5, derived its resistance genes from the wild rice Oryza offici-nalis Wall exwatt, was hybridized with Taichung Native 1, a cultivar highly susceptible to BPH. A mapping population composed of randomly selected 167 F2 individuals was used for determining the BPH resistance genes by the restriction fragment length polymorphism analysis (RFLP). Bulked segregant analysis was conducted to identify RFLP makers linked to the BPH resistance genes in B5. The results indicated that the markers linked to BPH resistance are located at two genomic regions on the long arm of chromosome 3 and the short arm of chromosome 4, respectively. The existence of the two loci was further assessed by the quantitative trait locus (QTL) analysis. We located the two loci at a 3.2 cM interval between G1318 and R1925 on chromosome 3 and a 1.2 cM interval between C820 and S11182 on chromosome 4. Comparison with the BPH genes that have been reported indicated that the BPH resistance genes | WANG Buna HUANG Zhen SHU Lihui REN Xiang LI Xianghua HE Guangcun | 2001 | Chinese Science Bulletin2001，46，13： | 14 |
| 11 | Anti-fibrotic role and mechanism of Periplaneta americana extracts in CCl4-induced hepatic fibrosis in rats显示文摘 | Dingchun Li Wu Li Yihui Chen Lihui Liu Dehong Ma Hongtu Wang Lu Zhang Shenjun Zhao Qin Peng | 2018 | Acta Biochimica et Biophysica Sinica2018，50，5： | 14 |
| 12 | A review of chatter vibration research in milling显示文摘Chatter is a self-excited vibration of parts in machining systems. It is widely present across a range of cutting processes, and has an impact upon both efficiency and quality in production processing. A great deal of research has been dedicated to the development of technologies that are able to predict and detect chatter. The purpose of these technologies is to facilitate the avoidance of chatter during cutting processes, which leads to better surface precision, higher productivity,and longer tool life. This paper summarizes the current state of the art in research regarding the problems of how to arrive at stable chatter prediction, chatter identification, and chatter control/-suppression, with a focus on milling processes. Particular focus is placed on the theoretical relationship between cutting chatter and process damping, tool runout, and gyroscopic effect, as well as the importance of this for chatter prediction. The paper concludes with some reflections regarding possible directions for future research in this field. | Caixu YUE Haining GAO Xianli LIU Steven Y.LIANG Lihui WANG | 2019 | Chinese Journal of Aeronautics2019，32，2： | 12 |
| 13 | The mechanism for fuzzy-ball working fluids for controlling & killing lost circulation显示文摘Lost circulation controlling & killing material has been a focused issue since a long time ago.A novel leak resistance fluid with the raw materials such as SDS,SDBS,HES,PAM and proprietary productions has been developed from laboratory.The experiment and application shows that the new leak resistance fluid can plug leaking passage of different sizes simultaneously.Observing with 1000 to 2000 time microscope,it is found that the working liquid contains a kind of spherical material which has the microstructure of 'one core,two layers,and three membranes'.When it is in a static state,the inside of the material looks like an airbag and the outside looks like some fuzzy things which has high gel strength.While when it is in a dynamic state,the fuzzy thing is cut or scattered and flow ability becomes much better.That is the reason why it is called fuzzy-ball.When the diameter or the width of the leak passage is greater than the fuzzy-ball's,the fuzzy-ball accumulates in conical shape to decompose the working fluid pressure of liquid column to achieve blocking;when the diameter or the width of the leak passage is equivalent to the fuzzy-ball's,the fuzzy-ball changes from sphere to oval-shape to increase the resistance to the leak passage and plug the holes;when the diameter or the width of the leak passage is smaller than the fuzzy-ball's,the leaks could be blocked up by the non-permeable membrane formed by the gel of high strength in the working fluid.In these cases,the leak passages of different sizes could be blocked comprehensively. | ZHENG LiHui KONG LingChen CAO Yuan WANG HuiYun HE XiaoQing | 2010 | Chinese Science Bulletin2010，55，35： | 12 |
| 14 | Anti-diabetic effects and mechanisms of action of a Chinese herbal medicine preparation JQ-R in vitro and in diabetic KKAy mice显示文摘Refined-JQ(JQ-R) is a mixture of refined extracts from Coptis chinensis(Ranunculaceae),Astragalus membranaceus(Leguminosae) and Lonicera japonica(Caprifoliaceae), the three major herbs of Jin Qi-Jiang Tang tablet, a traditional Chinese medicine(TCM) formula. The mechanisms by which JQ-R regulates glucose metabolism and improves insulin sensitivity were studied in type 2 diabetic KK^(Ay)mice and insulin-resistant L6 myotubes. To investigate the mechanisms by which JQ-R improves insulin sensitivity, a model of insulin-resistant cells induced with palmitic acid(PA) was established in L6 myotubes. Glucose uptake and expression of factors involved in insulin signaling, stress, and inflammatory pathways were detected by immunoblotting. JQ-R showed beneficial effects on glucose homeostasis and insulin resistance in a euglycemic clamp experiment and decreased fasting insulin levels in diabetic KK^(Ay)mice. JQ-R also improved the plasma lipid profiles. JQ-R directly increased the activity of superoxide dismutase(SOD) and decreased malondialdehyde(MDA) as well as inducible nitric oxide synthase(iNOS) levels in insulin-resistant L6 cells, and elevated the insulin-stimulated glucose uptake with upregulated phosphorylation of AKT. The phosphorylation levels of nuclear factor kappa B(NF-κB p65), inhibitor of NF-κB(IκBα), c-Jun N-terminal kinase(JNK1/2) and extracellular-signal-regulated kinases(ERK1/2) were also changed after JQ-R treatment compared with the control group. Together these findings suggest that JQ-R improved glucose and lipid metabolism in diabetic KK^(Ay)mice. JQ-R directly enhanced insulin-stimulated glucose uptake in insulin-resistant myotubes with improved insulin signalling and inflammatory response and oxidative stress. JQ-R could be a candidate to achieve improved glucose metabolism and insulin sensitivity in type 2 diabetes mellitus. | Quan Liu Shuainan Liu Lihui Gao Sujuan Sun Yi Huan Caina Li Yue Wang Nan Guo Zhufang Shen | 2017 | Acta Pharmaceutica Sinica B2017，7，4： | 11 |
| 15 | A human circulating immune cell landscape in aging and COVID-19显示文摘Age-associated changes in immune cells have been linked to an increased risk for infection.However,a global and detailed characterization of the changes that human circulating immune cells undergo with age is lacking.Here,we combined scRNA-seq,mass cytometry and sCATAC-seq to compare immune cell types in peripheral blood collected from young and old subjects and patients with COVID-19.We found that the immune cell landscape was reprogrammed with age and was characterized by T cell polarization from naive and memory cells to effector,cytotoxic,exhausted and reg-ulatory cells,along with increased late natural killer cells,age-associated B cells,inflammatory monocytes and age-associated dendritic cells.In addition,the expression of genes,which were implicated in coron-avirus susceptibility,was upregulated in a cell subtype-specific manner with age.Notably,COVID-19 promoted age-induced immune cell polarization and gene expression related to inflammation and cellular senes-cence.Therefore,these findings suggest that a dysreg-ulated immune system and increased gene expression associated with SARS-CoV-2 susceptibility may at least partially account for COVID-19 vulnerability in the elderly. | Yingfeng Zheng Xiuxing Liu Wenqing Le Lihui Xie He Li Wen Wen Si Wang Shuai Ma Zhaohao Huang Jinguo Ye Wen Shi Yanxia Ye Zunpeng Liu Moshi Song Weiqi Zhang Jing-Dong J.Han Juan Carlos lzpisua Belmonte Chuanle Xiao Jing Qu Hongyang Wang Guang-Hui Liu Wenru Su | 2020 | Protein & Cell2020，11，10： | 10 |
| 16 | The Occurrence of Oleananes in the Beibuwan Basin and Its Application to the Study of Maturity and Oil-Source Rock Correlation显示文摘摘要: oleanane 参数,即,在 Beibuwan 盆的二沉积的列的 OP (oleananes/( oleananes+C30hopanes )),华南海,能被用来限定油产生窗户的顶,与在井 M1 的 0.53 的 Ro (/%)并且 0.55 在井 H1/Hd1/Hd2 ,分别地。与 vitrinite 反射(Ro/%) 作比较, OP 展示一个动态范围和罐头更精确显示油产生窗户。由使用 OP 和另外的 geochemical 索引,油来源关联也被进行。它建议在井 M1 和 M2 的油在 situ 从来源岩石被导出。在 Huachang 的 mudstone 高举不是为在这个区域的油的主要来源岩石。OP 也是在一些第三级的湖的盆的一个有用油来源关联参数。 | LI Meijun WANG Tieguan LIU Ju ZHANG Meizhu LU Hong MA Qinglin GAO Lihui | 2008 | Acta Geologica Sinica(English Edition)2008，82，3： | 9 |
| 17 | Clinical implications and prognostic value of single and combined biomarkers in endometrial carcinoma显示文摘 | Li Mingzhu Zhao Lijun Shen Danhua Li Xiaoping Wang Jianliu Wei Lihui | 2014 | Chinese Medical Journal2014，，8： | 8 |
| 18 | Single-cell analysis reveals bronchoalveolar epithelial dysfunction in COVID-19 patients显示文摘Dear Editor,In 2019,a zoonotic coronavirus named severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)was identified as the causative agent of Coronavirus Disease 2019(COVID-19).As of 8 June 2020,the World Health Organization(WHO)has reported 6,912,751 globally confirmed cases with 400,469 deaths.Although generally causes mild disease,SARS-CoV-2 infection can result in serious outcomes,including acute lung injury(ALI)and acute respiratory distress syndrome(ARDS),the leading cause of mortality in patients with comorbidities.Recent autopsy studies of COVID-19 patients revealed mononuclear infiltration and excessive production of mucus in the infected lung,especially in the damaged small airways and alveoli(Bian and Team,2020;Liu et al.,2020). | Jiangping He Shuijiang Cai Huijian Feng Baomei Cai Lihui Lin Yuanbang Mai Yinqiang Fan Airu Zhu Huang Huang Junjie Shi Dingxin Li' Yuanjie Wei Yueping Li Yingying Zhao’ Yuejun Pan He Liu Xiaoneng Mo Xi He Shangtao Cao FengYu Hu Jincun Zhao Jie Wang Nanshan Zhong Xinwen Chen Xilong Deng Jiekai Chen | 2020 | Protein & Cell2020，11，9： | 7 |
| 19 | Biofilm Microenvironment-Responsive Nanotheranostics for Dual-Mode Imaging and Hypoxia-Relief-Enhanced Photodynamic Therapy of Bacterial Infections显示文摘The formation of bacterial biofilms closely associates with infectious diseases.Until now,precise diagnosis and effective treatment of bacterial biofilm infections are still in great need.Herein,a novel multifunctional theranostic nanoplatform based on MnO_(2)nanosheets(MnO_(2)NSs)has been designed to achieve pH-responsive dual-mode imaging and hypoxia-relief-enhanced antimicrobial photodynamic therapy(aPDT)of bacterial biofilm infections.In this study,MnO_(2)NSs were modified with bovine serum albumin(BSA)and polyethylene glycol(PEG)and then loaded with chlorin e_(6)(Ce_(6))as photosensitizer to form MnO_(2)-BSA/PEG-Ce_(6)nanosheets(MBP-Ce_(6)NSs).After being delivered into the bacterial biofilm-infected tissues,the MBP-Ce_(6)NSs could be decomposed in acidic biofilm microenvironment and release Ce_(6)with Mn^(2+),which subsequently activate both fluorescence(FL)and magnetic resonance(MR)signals for effective dual-mode FL/MR imaging of bacterial biofilm infections.Meanwhile,MnO_(2)could catalyze the decomposing of H2O_(2)in biofilm-infected tissues into O_(2)and relieve the hypoxic condition of biofilm,which significantly enhances the efficacy of aPDT.An in vitro study showed that MBP-Ce_(6)NSs could significantly reduce the number of methicillin-resistant Staphylococcus aureus(MRSA)in biofilms after 635nm laser irradiation.Guided by FL/MR imaging,MRSA biofilm-infected mice can be efficiently treated by MBP-Ce_(6)NSs-based aPDT.Overall,MBP-Ce_(6)NSs not only possess biofilm microenvironment-responsive dual-mode FL/MR imaging ability but also have significantly enhanced aPDT efficacy by relieving the hypoxia habitat of biofilm,which provides a promising theranostic nanoplatform for bacterial biofilm infections. | Weijun Xiu Siyu Gan Qirui Wen Qiu Qiu Sulai Dai Heng Dong Qiang Li Lihui Yuwen Lixing Weng Zhaogang Teng Yongbin Mou Lianhui Wang | 2020 | Research2020，，1： | 7 |
| 20 | 考虑时变性热强度和时变性热量分配比的铣刀前刀面瞬态温度场建模研究显示文摘高速周铣是一种加工范围广和生产效率高的机械加工方式,其加工过程中会出现大量铣削热,尤其是加工导热率较低的工件时更为显著,铣削温度上升和下降的周期性变化会加速刀具磨损,进而降低工件表面加工质量。由于目前在周铣加工研究中缺乏对铣刀前刀面瞬态温度场的研究,为此,综合考虑第二变形区时变性热强度、时变性热量分配比以及前角因素,提出了一种基于'移动热源法'的铣刀前刀面瞬态温度场建模方法。首先建立第一变形区热源影响下的铣刀前刀面瞬态温度场温升模型,其次建立第二变形区热源影响下的铣刀前刀面瞬态温度场温升模型,最后进行温升模型叠加计算,进而建立铣刀前刀面瞬态温度场模型。仿真与试验结果验证了模型的准确性,该模型将进一步为研究铣刀前刀面抗磨设计提供理论支持。 | 岳彩旭 都建标 刘献礼 LIANG S Y WANG Lihui 高海宁 李恒帅 | 2019 | 机械工程学报2019，55，9： | 6 |
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