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| 1 | Statistics-based Optimization of the Polarimetric Radar Hydrometeor Classification Algorithm and Its Application for a Squall Line in South China显示文摘A modified hydrometeor classification algorithm(HCA) is developed in this study for Chinese polarimetric radars. This algorithm is based on the U.S. operational HCA. Meanwhile, the methodology of statistics-based optimization is proposed including calibration checking, datasets selection, membership functions modification, computation thresholds modification,and effect verification. Zhuhai radar, the first operational polarimetric radar in South China, applies these procedures. The systematic bias of calibration is corrected, the reliability of radar measurements deteriorates when the signal-to-noise ratio is low, and correlation coefficient within the melting layer is usually lower than that of the U.S. WSR-88D radar. Through modification based on statistical analysis of polarimetric variables, the localized HCA especially for Zhuhai is obtained,and it performs well over a one-month test through comparison with sounding and surface observations. The algorithm is then utilized for analysis of a squall line process on 11 May 2014 and is found to provide reasonable details with respect to horizontal and vertical structures, and the HCA results—especially in the mixed rain–hail region—can reflect the life cycle of the squall line. In addition, the kinematic and microphysical processes of cloud evolution and the differences between radardetected hail and surface observations are also analyzed. The results of this study provide evidence for the improvement of this HCA developed specifically for China. | Chong WU Liping LIU Ming WEI Baozhu XI Minghui YU | 2018 | Advances in Atmospheric Sciences2018，35，3： | 32 |
| 2 | Discovery of biclonal origin and a novel oncogene SLC12A5 in colon cancer by single-cell sequencing显示文摘单个房间的定序是为描出的一个强大的工具为个性化的癌症管理的同种细胞的关系和识别关键司机基因。这里,我们执行了结肠癌的一个盒子的单个房间的定序的分析。人口遗传分析在肿瘤房间人口识别了二独立克隆。主要肿瘤克隆作为早 oncogenic 事件怀有 APC 和 TP53 变化,而次要的克隆包含了优势的 CDC27 和 PABPC1 变化。在这二克隆的次要的克隆支持的 APC 和 TP53 变化的缺席从二细胞的起源被导出。体的变化等位基因频率系列的检查另外 21 个整个织物的定序 exome 的盒子在结肠癌揭示了同种细胞的起源的异质。下次,我们识别了在单个房间的水平显示出变化的高频率,但是在人口水平展出了低流行的变异的基因 SLC12A5。变异的 SLC12A5 的功能的描述在结肠癌揭示了它的潜在的 oncogenic 效果。我们的学习在单个房间的水平支持提供第一条 exome 宽的证据那结肠癌能具有 biclonal 起源,并且建议在一个队的低流行的变化可以也在单个水平起重要 protumorigenic 作用。 | Chang Yu Jun Yu Xlaotlan Yao Wllham KK Wu Youyong Lu Senwel Tang Xiangchun Li Li Bao Xiaoxing Li Yong Hou Renhua Wu Min Jian Ruoyan Chen Fan Zhang Lixia Xu Fan Fan Jun He Qiaoyi Liang Hongyi Wang Xueda Hu Minghui He Xiang Zhang Hancheng Zheng Qibin Li Hanjie Wu Yan Chen Xu Yang Shida Zhu Xun Xu Huanming Yang Jian Wang Xiuqing Zhang Joseph JY Sung Yingrui Li Jun Wang | 2014 | Cell Research2014，，6： | 16 |
| 3 | SIDT1-dependent absorption in the stomach mediates host uptake of dietary and orally administered microRNAs显示文摘Dietary microRNAs have been shown to be absorbed by mammals and regulate host gene expression,but the absorption mechanism remains unknown.Here,we show that SIDT1 expressed on gastric pit cells in the stomach is required for the absorption of dietary microRNAs.SIDT1-deficient mice show reduced basal levels and impaired dynamic absorption of dietary microRNAs.Notably,we identified the stomach as the primary site for dietary microRNA absorption,which is dramatically attenuated in the stomachs of SIDT1-deficient mice.Mechanistic analyses revealed that the uptake of exogenous microRNAs by gastric pit cells is SIDT1 and low-pH dependent.Furthermore,oral administration of plant-derived miR2911 retards liver fibrosis,and this protective effect was abolished in SIDT1-deficient mice.Our findings reveal a major mechanism underlying the absorption of dietary microRNAs,uncover an unexpected role of the stomach and shed light on developing small RNA therapeutics by oral delivery. | Qun Chen Fan Zhang Lei Dong Huimin Wu Jie Xu Hanqin Li Jin Wang Zhen Zhou Chunyan Liu Yanbo Wang Yuyan Liu Liangsheng Lu Chen Wang Minghui Liu Xi Chen Cheng Wang Chunni Zhang Dangsheng Li Ke Zen Fangyu Wang Qipeng Zhang Chen-Yu Zhang | 2021 | Cell Research2021，31，3： | 10 |
| 4 | A high-quality Actinidia chinensis(kiwifruit)genome显示文摘Actinidia chinensis(kiwifruit)is a perennial horticultural crop species of the Actinidiaceae family with high nutritional and economic value.Two versions of the A.chinensis genomes have been previously assembled,based mainly on relatively short reads.Here,we report an improved chromosome-level reference genome of A.chinensis(v3.0),based mainly on PacBio long reads and Hi-C data.The high-quality assembled genome is 653 Mb long,with 0.76%heterozygosity.At least 43%of the genome consists of repetitive sequences,and the most abundant long terminal repeats were further identified and account for 23.38%of our novel genome.It has clear improvements in contiguity,accuracy,and gene annotation over the two previous versions and contains 40,464 annotated protein-coding genes,of which 94.41%are functionally annotated.Moreover,further analyses of genetic collinearity revealed that the kiwifruit genome has undergone two whole-genome duplications:one affecting all Ericales families near the K-T extinction event and a recent genus-specific duplication.The reference genome presented here will be highly useful for further molecular elucidation of diverse traits and for the breeding of this horticultural crop,as well as evolutionary studies with related taxa. | Haolin Wu Tao Ma Minghui Kang Fandi Ai Junlin Zhang Guanyong Dong Jianquan Liu | 2019 | Horticulture Research2019，6，1： | 10 |
| 5 | Population Genomic Analysis and De Novo Assembly Reveal the Origin of Weedy Rice as an Evolutionary Game显示文摘Crop weediness,especially that of weedy rice(Oryza sativa f.spontanea),remains mysterious.Weedy rice possesses robust ecological adaptability;however,how this strain originated and gradually formed proprietary genetic features remains unclear?Here,we demonstrate that weedy rice at Asian high latitudes(WRAH)is phylogenetically well defined and possesses unselected genomic characteristics in many divergence regions between weedy and cultivated rice.We also identified novel quantitative trait loci underlying weedy-specific traits,and revealed that a genome block on the end of chromosome 1 is associated with rice weediness.To identify the genomic modifications underlying weedy rice evolution,we generated the first de novo assembly of a high-quality weedy rice genome(WR04-6),and conducted a comparative genomics study between WR04-6 with other rice reference genomes.Multiple lines of evidence,including the results of demographic scenario comparisons,suggest that differentiation between weedy rice and cultivated rice was initiated by genetic improvement of cultivated rice and that the essence of weediness arose through semi-domestication.A plant height model further implied that the origin of WRAH can be modeled as an evolutionary game and indicated that strategy-based selection driven by fitness shaped its genomic diversity. | Jian Sun Dianrong Ma Liang Tang Minghui Zhao Guangchen Zhangh Wenjia Wang Jiayu Song Xiang Li Zimeng Liu Wenxing Zhang Quan Xu Yuncheng Zhou Jianzhong Wu Toshio Yamamoto Fei Dai Yan Lei Song Li Gang Zhou Hongkun Zheng Zhengjin Xu Wenfu Chen | 2019 | Molecular Plant2019，12，5： | 9 |
| 6 | A chromosome-scale genome assembly of Isatis indigotica,an important medicinal plant used in traditional Chinese medicine显示文摘Isatis indigotica(2n=14)is an important medicinal plant in China.Its dried leaves and roots(called Isatidis Folium and Isatidis Radix,respectively)are broadly used in traditional Chinese medicine for curing diseases caused by bacteria and viruses such as influenza and viral pneumonia.Various classes of compounds isolated from this species have been identified as effective ingredients.Previous studies based on transcriptomes revealed only a few candidate genes for the biosynthesis of these active compounds in this medicinal plant.Here,we report a high-quality chromosome-scale genome assembly of I.indigotica with a total size of 293.88 Mb and scaffold N50=36.16 Mb using single-molecule real-time long reads and high-throughput chromosome conformation capture techniques.We annotated 30,323 highconfidence protein-coding genes.Based on homolog searching and functional annotations,we identified many candidate genes involved in the biosynthesis of main active components such as indoles,terpenoids,and phenylpropanoids.In addition,we found that some key enzyme-coding gene families related to the biosynthesis of these components were expanded due to tandem duplications,which likely drove the production of these major active compounds and explained why I.indigotica has excellent antibacterial and antiviral activities.Our results highlighted the importance of genome sequencing in identifying candidate genes for metabolite synthesis in medicinal plants. | Minghui Kang Haolin Wu Qiao Yang Li Huang Quanjun Hu Tao Ma Zaiyun Li Jianquan Liu | 2020 | Horticulture Research2020，7，1： | 9 |
| 7 | Synthesis and Characterization of Condensed Polynuclear Aromatic Resin Derived from Ethylene Tar显示文摘As a kind of low-cost and readily available industrial byproduct, ethylene tar (ET) was for the first time utilized for the preparation of heat-resistant condensed polynuclear aromatic resin (COPNAR). The basic properties of ET and the resulted COPNAR were characterized by FT-IR, 1H-NMR, TGA and elemental analysis. The test results showed that ET with high aromatic content (>50%) was suitable for the synthesis of COPNAR with superior heat resistance. The average molecular structure of ET was obtained by means of the improved Brown-Ladner method, and the reaction mechanism was considered as an acid-catalyzed positive ion-typed polymerization. Our findings have provided a new route to develop ET into technology-added heat-resistant resins. | Wu Mingbo Shi Yangyang Li Shibin Wang Yuwei Tan Minghui Wang Ding Zheng Jingtang Tsubaki Noritatsu | 2012 | China Petroleum Processing & Petrochemical Technology2012，14，4： | 7 |
| 8 | Isorhapontigenin protects against doxorubicin-induced cardiotoxicity via increasing YAP1 expression显示文摘As an effective anticancer drug, the clinical limitation of doxorubicin(Dox) is the time-and dose-dependent cardiotoxicity. Yes-associated protein 1(YAP1) interacts with transcription factor TEA domain 1(TEAD1) and plays an important role in cell proliferation and survival. However, the role of YAP1 in Dox-induced cardiomyopathy has not been reported. In this study, the expression of YAP1 was reduced in clinical human failing hearts with dilated cardiomyopathy and Dox-induced in vivo and in vitro cardiotoxic model. Ectopic expression of Yap1 significantly blocked Dox-induced cardiomyocytes apoptosis in TEAD1 dependent manner. Isorhapontigenin(Isor) is a new derivative of stilbene and responsible for a wide range of biological processes. Here, we found that Isor effectively relieved Doxinduced cardiomyocytes apoptosis in a dose-dependent manner in vitro. Administration with Isor(30 mg/kg/day, intraperitoneally, 3 weeks) significantly protected against Dox-induced cardiotoxicity in mice. Interestingly, Isor increased Dox-caused repression in YAP1 and the expression of its target genes in vivo and in vitro. Knockout or inhibition of Yap1 blocked the protective effects of Isor on Dox-induced cardiotoxicity. In conclusion, YAP1 may be a novel target for Dox-induced cardiotoxicity and Isor might be a new compound to fight against Dox-induced cardiotoxicity by increasing YAP1 expression. | Panxia Wang Minghui Wang Yuehuai Hu Jianxing Chen Yanjun Cao Cui Liu Zhongkai Wu Juan Shen Jing Lu Peiqing Liu | 2021 | Acta Pharmaceutica Sinica B2021，11，3： | 7 |
| 9 | Seismic traveltime inversion of 3D velocity model with triangulated interfaces显示文摘Seismic traveltime tomographic inversion has played an important role in detecting the internal structure of the solid earth. We use a set of blocks to approximate geologically complex media that cannot be well described by layered models or cells. The geological body is described as an aggregate of arbitrarily shaped blocks,which are separated by triangulated interfaces. We can describe the media as homogenous or heterogeneous in each block. We define the velocities at the given rectangle grid points for each block,and the heterogeneous velocities in each block can be calculated by a linear interpolation algorithm. The parameters of the velocity grid positions are independent of the model parameterization,which is advantageous in the joint inversion of the velocities and the node depths of an interface. We implement a segmentally iterative ray tracer to calculate traveltimes in the 3D heterogeneous block models.The damped least squares method is employed in seismic traveltime inversion,which includes the partial derivatives of traveltime with respect to the depths of nodes in the triangulated interfaces and velocities defined in rectangular grids. The numerical tests indicate that the node depths of a triangulated interface and homogeneous velocity distributions can be well inverted in a stratified model. | Fei Li Tao Xu Minghui Zhang Zhenbo Wu Chenglong Wu Zhongjie Zhang Jiwen Teng | 2014 | Earthquake Science2014，27，2： | 5 |
| 10 | Remote-mode microsphere nano-imaging:new boundaries for optical microscopes显示文摘Optical microscope is one of the most popular characterization techniques for general purposes in many fields. It is distinguishedfrom the vacuum or tip-based imaging techniques for its flexibility, low cost, and fast speed. However, its resolutionlimits the functionality of current optical imaging performance. While microspheres have been demonstrated forimproving the observation power of optical microscope, they are directly deposited on the sample surface and thus theapplications are greatly limited. We develop a remote-mode microsphere nano-imaging platform which can scan freelyand in real-time across the sample surfaces. It greatly increases the observation power and successfully characterizesvarious practical samples with the smallest feature size down to 23 nm. This method offers many unique advantages,such as enabling the detection to be non-invasive, dynamic, real-time, and label-free, as well as leading to more functionalitiesin ambient air and liquid environments, which extends the nano-scale observation power to a broad scope inour life. | Lianwei Chen Yan Zhou Mengxue Wu Minghui Hong | 2018 | Opto-Electronic Advances2018，1，1： | 4 |
| 11 | Intermingled fates of the South China Sea and Philippine Sea plate显示文摘Recent studies have shown the extent and nature of the South China Sea(SCS)at the end of spreading by unfolding(i.e.structurally restoring)the Manila slab,which is the subducted part of the SCS,and by identifying the nature of the crustlithosphere(oceanic or thinned continental)from mid-slab P-wave velocity perturbations(dVp)[1,2]. | Minghui Zhao Jean-Claude Sibuet Jonny Wu | 2019 | National Science Review2019，6，5： | 4 |
| 12 | STUDY ON TYPHOON DISASTER LOSS AND RISK PREDICTION AND BENEFIT ASSESSMENT OF DISASTER PREVENTION AND MITIGATION显示文摘Based on the meteorological monitoring data of Typhoon Nesat and Haitang in Fujian Province in 2017, the data of the typhoon disaster situation and third-party evaluation of typhoon disaster prevention and mitigation benefit were investigated. By using the mean value anomaly estimation method in the similarity analysis method, it is estimated that typhoon Nesat and Haitang will cause direct economic losses of 0.8 ~ 1.8 billion yuan, and the typhoon disaster risk index evaluation model is used. The disaster risk pre-assessment of Typhoon Nesat and Haitang is carried out. The results of the study and analysis show that the pre-assessment results of Typhoon Nesat and Haitang are basically consistent with the actual disaster situation. The disaster loss was reduced to the minimum. According to the third party evaluation and investigation, it was concluded that the contribution rate of reducing economic benefits was 75% in Fujian Province for preventing and landing double typhoons Nesat and Haitang. Mainly reflected in the ship return to the port to avoid the wind, geological hazards prone to the site construction and cage culture danger removal reinforcement and other links; The contribution rate of reducing casualties is 86, mainly reflected in fishermen disembarkation and personnel transfer to safety emergency shelter and other links. The benefit of this double typhoon disaster prevention and mitigation in Fujian Province is about 0.6 billion yuan to reduce the direct economic loss. According to the investigation, the overall satisfaction of the double typhoon meteorological service is 91.0 points. Typhoon early warning information service convenience satisfaction is 91.4 points, early warning information accuracy satisfaction is 87.2 points, government departments strong anti-Taiwan disaster reduction organization, linkage departments participate in disaster prevention and mitigation high. However, there is a gap between public awareness and participation in typhoon disasters. | LIN YANG CHUNRONG CAO DEHUI WU HONGHUA QIU MINGHUI LU LING LIU | 2018 | Tropical Cyclone Research and Review2018，7，4： | 4 |
| 13 | Highly-anisotropic optical and electrical properties in layered SnSe显示文摘因为他们极化依赖者或方向依赖者的唯一的联合,各向异性的材料具有可观的兴趣电、光、热电的性质。低对称二维(2D ) covalently 结合的原子层叠的货车 der Waals 形成的材料内在地是各向异性的。分层的 SnSe 展出格子对称的低度,与弄歪的 NaCl 结构和在里面飞机 anisotropy。这里,我们报导在里面飞机的系统的研究在分层的 SnSe 的各向异性的性质用散布的解决角度的拉曼,光吸收,和电的运输学习。光、电的描述是方向依赖者,并且成功地在分层的 SnSe 识别了水晶的取向。而且, SnSe 薄片厚度和刺激波长上的 Raman 紧张 anisotropy 的依赖被实验和理论计算调查。最后,电的运输研究证明很少层 SnSe 地效果晶体管(联邦货物税) 有在扶手椅和之字形方向之间的搬运人活动性(5.8 ) 的大各向异性的比率,它是高价值为 2D 报导了的一个记录各向异性的材料。分层的 SnSe 的高度各向异性的性质在新窗户中为各向异性的光学,电子学,和 optoelectronics.Open | Shengxue Yang Yuan Liu Minghui Wu Li-Dong Zhao Zhaoyang Lin Hung-chieh Cheng Yiliu Wang Chengbao Jiang Su-Huai Wei Li Huang Yu Huang Xiangfeng Duan | 2018 | Nano Research2018，11，1： | 4 |
| 14 | From deep basin gas to diagenetic trap—An example from the Yulin Gas Field in the Ordos Basin显示文摘In the updip portion of the Yulin Gas Field in the Ordos Basin, there are no any structural, stratigraphic and sedimentary lithologic seals. Using thin-section petrography, ultraviolet fluorescence microscopy, micro-thermometry and Raman microspectrometry, this paper finds out the diagenetic trap and studies the diagenetic history of this field. It was revealed that three phases of diagenesis and hydrocarbon charging happened in late Triassic, late Jurassic and the end of early Cretaceous respectively. In the first two phases, acid geofluid entered the reservoir and caused dissolution and cementation. Although the porosities had been increased, further compaction accompanying re-subsidence resulted in tight sandstone and conglomerates. Till the end of the early Cretaceous, bulk of gas migrated into the tight reservoir. Cementation, however, kept on in the updip portion of this field due to low gas saturation and formed the diagenetic trap. The mechanism for gas accumulation was changed from deep basin gas to diagenetic trap, which offers a sealing condition that can retain gas for much longer time. | ZHANG LiuPing LUO XiaoRong MA XinHua CHEN MengJin WU MingHui | 2007 | Chinese Science Bulletin2007，52，21： | 4 |
| 15 | Distribution and identification of the low-velocity layer in the northern South China Sea显示文摘低速度的层(LVL ) ,与构造活动和动态背景密切相关,总是是在深外壳的结构研究的一个热话题。深地震(OBS/OBH ) 并且自从 1990 年代,向陆近海的实验广泛地在北华南海(SCS ) 被实现了。六地震侧面被国内、国际的合作在 SCS 的北边缘上完成。外壳的结构的特征被揭示,五速度倒置层被发现。在他们之中,有 3.0-3.5 km · s -1 速度的三 LVL 位于 Yinggehai 盆和珀尔河嘴盆的沉积结构(深入地的 2.0-6.0km 和在厚度的 2.0-4.6 km ) 。他们被反射、折射的阶段为他们的浅深度识别。有 5.5-6.0 km · s -1 速度的另外的二 LVL 通常在东北、西北的 SCS 的过渡外壳的结构与大约 2.5-6.0 km 厚度在中间的外壳(深入地的 7.0-18.0 km ) 中存在。他们被折射阶段检测从他们的覆盖并且内在的层。我们探索了与以前报导的结果结合的可能的构造形成机制,它为 SCS 的形成和进化提供了证据。 | Zhao Minghui Qiu Xuelin Xu Huilong Shi Xiaobin Wu Shimin Ye Chunming Xia Shaohong | 2007 | Progress in Natural Science:Materials International2007，17，5： | 3 |
| 16 | Identification of Molecular Subtypes of Gastric Cancer with Different Responses to PI3-Kinase Inhibitors and 5-Fluorouracil显示文摘 | Zhengdeng Lei Iain Beehuat Tan Kakoli Das Niantao Deng Hermioni Zouridis Sharon Pattison Clarinda Chua Zhu Feng Yeoh Khay Guan Chia Huey Ooi Tatiana Ivanova Shenli Zhang Minghui Lee Jeanie Wu Anna Ngo Sravanthy Manesh Elisabeth Tan Bin Tean Teh Jimmy Bok | 2013 | Gastroenterology2013，，： | 2 |
| 17 | Non-symmetrical levee breaching processes in a channel bend due to overtopping显示文摘A series of experiments were done to reveal the overtopping breaching process of non-cohesive and cohesive levees in a U-bend flume. The flood hydrograph and breaching geometry were measured and analyzed in detail. The results show that the levee breaching processes can be briefly divided into four stages: slope erosion, longitudinal headward gully-cutting, lateral erosion, and relative stabilization. For non-cohesive levees, non-symmetrical lateral development of the breach occurs throughout the four stages, and the final non-symmetrical coefficient is approximately 2.2-2.6. Larger flow discharge or higher water level can accelerate the breaching process, while coarser sands tend to accelerate the process initially but depress the process at the end. The fluvial erosion rate of a non-cohesive breach shows a power-function relation with the excess wall shear stress. For cohesive levees, a plateau forms in the breach partially blocking the flow in the first two stages. The breach flow is approximately perpendicular to the levee body, and, thus, the erosion rates of the two breach sides are almost the same.Non-symmetrical lateral development mainly occurs in the third stage when the deep gully forms. The final non-symmetrical coefficient is approximately 2.7-3.3. It is expected that these findings can provide a valuable experimental dataset and a theoretical basis for breach closure and flood alleviation. | Songbai Wu Minghui Yu Hongyan Wei Yanjie Liang Jing Zeng | 2018 | International Journal of Sediment Research2018，33，2： | 2 |
| 18 | Stability of superconducting Nd_(0.8)Sr_(0.2)NiO_(2) thin films显示文摘The discovery of superconducting states in the nickelate thin film with infinite-layer structure has paved a new way for studying unconventional superconductivity.So far,research in this field is still very limited due to difficulties in sample preparation.Here we report the successful preparation of the superconducting state of Nd_(0.8)Sr_(0.2)NiO_(2)thin film(T_(c)=8.0-11.1 K)and study the stability of such films in the ambient environment,water,and under electrochemical conditions.Our work demonstrates that the superconducting state of Nd_(0.8)Sr_(0.2)NiO_(2)is remarkably stable,which can last for at least 47-day continuous exposure to air at 20°C and 35%relative humidity.We also show that the superconductivity disappears after being immersed in de-ionized water at room temperature for 5 h.Surprisingly,it can also survive under ionic liquid gating conditions with an applied voltage of about 4 V,which is even more stable than conventional perovskite complex oxides. | Xiang Ding Shengchun Shen Huaqian Leng Minghui Xu Yan Zhao Junrui Zhao Xuelei Sui Xiaoqiang Wu Haiyan Xiao Xiaotao Zu Bing Huang Huiqian Luo Pu Yu Liang Qiao | 2022 | Science China(Physics,Mechanics & Astronomy)2022，65，6： | 2 |
| 19 | Integrated Analysis of Long Noncoding RNA and Coding RNA Expression in Esophageal Squamous Cell Carcinoma显示文摘 | Wei Cao Wei Wu Fachun Shi Xiaobing Chen Lihua Wu Ke Yang Fu Tian Minghui Zhu Guoyong Chen WeiWei Wang Fred G. Biddle Jianqin Gu Soraya E. Gutierrez | 2013 | International Journal of Genomics2013，，： | 1 |
| 20 | A Variational Binary Level Set Method for Structural Topology Optimization显示文摘This paper proposes a variational binary level set method for shape and topology optimization of structural.First,a topology optimization problem is presented based on the level set method and an algorithm based on binary level set method is proposed to solve such problem.Considering the difficulties of coordination between the various parameters and efficient implementation of the proposed method,we present a fast algorithm by reducing several parameters to only one parameter,which would substantially reduce the complexity of computation and make it easily and quickly to get the optimal solution.The algorithm we constructed does not need to re-initialize and can produce many new holes automatically.Furthermore,the fast algorithm allows us to avoid the update of Lagrange multiplier and easily deal with constraints,such as piecewise constant,volume and length of the interfaces.Finally,we show several optimum design examples to confirm the validity and efficiency of our method. | Xiaoxia Dai Peipei Tang Xiaoliang Cheng Minghui Wu | 2013 | Communications in Computational Physics2013，13，5： | 1 |
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