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| 1 | Small molecule inhibitors reveal allosteric regulation of USP14 via steric blockade显示文摘The ubiquitin system is important for drug discovery,and the discovery of selective small-molecule inhibitors of deubiquitinating enzymes (DUBs) remains an active yet extremely challenging task. With a few exceptions,previously developed inhibitors have been found to bind the evolutionarily conserved catalytic centers of DUBs,resulting in poor selectivity. The small molecule IU1 was the first-ever specific inhibitor identified and exhibited surprisingly excellent selectivity for USP14 over other DUBs. However,the molecular mechanism for this selectivity was elusive. Herein,we report the high-resolution co-crystal structures of the catalytic domain of USP14 bound to IU1 and three IU1 derivatives. All the structures of these complexes indicate that IU1 and its analogs bind to a previously unknown steric binding site in USP14,thus blocking the access of the C-terminus of ubiquitin to the active site of USP14 and abrogating USP14 activity. Importantly,this steric site in USP14 is very unique,as suggested by structural alignments of USP14 with several known DUB X-ray structures. These results,in conjunction with biochemical characterization,Indicate a coherent steric blockade mechanism for U5P14 inhibition by compounds of the IU series. In light of the recent report of steric blockade of USP7 by FT671,this work suggests a potential generally applicable allosteric mechanism for the regulation of DUBs via steric blockade,as showcased by our discovery of IU1-248 which is 10-fold more potent than IU1. | Yiwei Wang Yuxuan Jiang Shan Ding Jiawang Li Ningjing Song Yujing Ren Danning Hong Cai Wu Bin Li Feng Wang Wei He Jiawei Wang Ziqing Mei | 2018 | Cell Research2018，28，12： | 15 |
| 2 | Bacterial Particle Swarm Optimization显示文摘 | JI Zhen WANG Yiwei CHU Ying WU Qinghua | 2009 | Chinese Journal of Electronics2009，18，2： | 5 |
| 3 | Reservoir Stochastic Modeling Constrained by Quantitative Geological Conceptual Patterns显示文摘This paper discusses the principles of geologic constraints on reservoir stochastic modeling. By using the system science theory, two kinds of uncertainties, including random uncertainty and fuzzy uncertainty, are recognized. In order to improve the precision of stochastic modeling and reduce the uncertainty in realization, the fuzzy uncertainty should be stressed, and the “geological genesis-controlled modeling” is conducted under the guidance of a quantitative geological pattern. An example of the Pingqiao horizontal-well division of the Ansai Oilfield in the Ordos Basin is taken to expound the method of stochastic modeling. | Wu Shenghe Zhang Yiwei Jan Einar Ringas | 2006 | Petroleum Science2006，3，1： | 4 |
| 4 | Parametric Problems in Power System Analysis:Recent Applications of Polynomial Approximation Based on Galerkin Method显示文摘In power systems, there are many uncertainty factors such as power outputs of distributed generations and fluctuations of loads. It is very beneficial to power system analysis to acquire an explicit function describing the relationship between these factors(namely parameters) and power system states(or performances). This problem, termed as parametric problem(PP) in this paper, can be solved by Galerkin method,which is a powerful and mathematically rigorous method aiming to seek an accurate explicit approximate function by projection techniques. This paper provides a review of the applications of polynomial approximation based on Galerkin method in power system PPs as well as stochastic problems. First, the fundamentals of polynomial approximation and Galerkin method are introduced. Then, the process of solving three types of typical PPs by polynomial approximation based on Galerkin method is elaborated. Finally, some application examples as well as several potential applications of power system PPs solved by Galerkin method are presented, namely the probabilistic power flow, approximation of static voltage stability region boundary, and parametric time-domain dynamic simulation. | Hao Wu Danfeng Shen Bingqing Xia Yiwei Qiu Yongzhi Zhou Yonghua Song | 2021 | Journal of Modern Power Systems and Clean Energy2021，9，1： | 4 |
| 5 | Serum macrophage migration inhibitory factor as a potential biomarker to evaluate therapeutic response in patients with allergic asthma:an exploratory study显示文摘Background:Previous studies have shown that macrophage migration inhibitory factor(MIF)is involved in the pathogenesis of asthma.This study aimed to investigate whether serum MIF reflects a therapeutic response in allergic asthma.Methods:We enrolled 30 asthmatic patients with mild-to-moderate exacerbations and 20 healthy controls,analyzing the parameter levels of serum MIF,serum total immunoglobulin E(tIgE),peripheral blood eosinophil percentage(EOS%),and fractional exhaled nitric oxide(FeNO).Lung function indices were used to identify disease severity and therapeutic response.Results:Our study showed that all measured parameters in patients were at higher levels than those of controls.After one week of treatment,most parameter levels decreased significantly except for serum tIgE.Furthermore,we found that serum MIF positively correlated with EOS%as well as FeNO,but negatively correlated with lung function indices.Receiver operator characteristic(ROC)curve analysis indicated that among the parameters,serum MIF exhibited a higher capacity to evaluate therapeutic response.The area under the curve(AUC)of MIF was 0.931,with a sensitivity of 0.967 and a specificity of 0.800.Conclusions:Our results suggested that serum MIF may serve as a potential biomarker for evaluating therapeutic response in allergic asthma with mild-to-moderate exacerbations. | Huiyuan ZHU Shaochun YAN Jingshuo WU Zhong ZHANG Xiaolin LI Zheng LIU Xing MA Lina ZHOU Lin ZHANG Mingming FENG Yiwei GENG Aixin ZHANG Sabina JANCIAUSKIENE Aiguo XU | 2021 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2021，22，6： | 3 |
| 6 | Confined Ni-In intermetallic alloy nanocatalyst with excellent coking resistance for methane dry reforming显示文摘Carbon dioxide and methane are two main greenhouse gases which are contributed to serious global warming.Fortunately,dry reforming of methane(DRM),a very important reaction developed decades ago,can convert these two major greenhouse gases into value-added syngas or hydrogen.The main problem retarding its industrialization is the seriously coking formation upon the nickel-based catalysts.Herein,a series of confined indium-nickel(In-Ni)intermetallic alloy nanocatalysts(In_(x)Ni@SiO_(2))have been prepared and displayed superior coking resistance for DRM reaction.The sample containing 0.5 wt.%of In loading(In_(0.5)Ni@SiO_(2))shows the best balance of carbon deposition resistance and DRM reactivity even after 430 h long term stability test.The boosted carbon resistance can be ascribed to the confinement of core–shell structure and to the transfer of electrons from Indium to Nickel in In-Ni intermetallic alloys due to the smaller electronegativity of In.Both the silica shell and the increase of electron cloud density on metallic Ni can weaken the ability of Ni to activate C–H bond and decrease the deep cracking process of methane.The reaction over the confined InNi intermetallic alloy nanocatalyst was conformed to the Langmuir-Hinshelwood(L-H)mechanism revealed by in situ diffuse reflectance infrared Fourier transform spectroscopy(in-situ DRIFTS).This work provides a guidance to design high performance coking resistance catalysts for methane dry reforming to efficiently utilize these two main greenhouse gases. | Wenming Liu Le Li Sixue Lin Yiwei Luo Zhenghong Bao Yiru Mao Kongzhai Li Daishe Wu Honggen Peng | 2022 | Journal of Energy Chemistry2022，31，2： | 3 |
| 7 | Early monitoring of response to antimetabolic treatment of gemcitabine:A comparison of ^(18)F-FLT and ^(18)F-FDG uptake in Patu 8988 human pancreatic carcinoma cells显示文摘It is essential to predict the treatment efficacy of pancreatic carcinoma early.The purpose of this study was to examine whether ^(18)F-FDG(2'-deoxy-2'-[^(18)F]fiuoro-D-glucose) or ^(18)F-FLT(3'-deoxy-3'-^(18)F-fluorothymidine) PET can be used for chemosensitivity testing by investigating the binding characteristic of ^(18)F-FDG or ^(18)F-FLT with Patu 8988 human pancreatic carcinoma cell and the influence of gemcitabine in the uptake of ^(18)F-FDG or ^(18)F-FLT on Patu 8988.Under the conditions of 1×10~6 cells,3.7 kBq ^(18)F-FDG or ^(18)F-FLT,and incubation at 37℃for 100 min,the cell uptake of ^(18)F-FDG and ^(18)F-FLT was(60.60±3.05)%and(50.57±2.81)%,respectively.There was a significant decrease in TKl-LI(thymidine kinase 1 labeling index) 24 h after administration of gemcitabine.The uptakes of ^(18)F-FDG and ^(18)F-FLT were negatively correlated with the doses of gemcitabine(r= -0.928 for ^(18)F-FDG,r= -0.876 for ^(18)F-FLT,P<0.01).When same doses of gemcitabine were administered,the ^(18)F-FLT uptake inhibition rate was significantly higher than that of ^(18)F-FDG(P<0.01).These results indicate that the response to gemcitabine could be predicted as early as 24 h by ^(18)F-FDG or ^(18)F-FLT PET scans.^(18)F-FLT is more sensitive than ^(18)F-FDG to predict the response to therapy. | DENG Shengming ZHANG Bin WU Yiwei ZHANG Wei | 2011 | Nuclear Science and Techniques2011，22，5： | 2 |
| 8 | Cyclin-dependent kinase 4 is a novel target in micoRNA-195-mediated cell cycle arrest in bladder cancer cells显示文摘 | Yiwei Lin Jian Wu Hong Chen Yeqing Mao Yunfu Liu Qiqi Mao Kai Yang Xiangyi Zheng Liping Xie | 2012 | FEBS Letters2012，，4： | 2 |
| 9 | BRAF and EGFR inhibitors synergize to increase cytotoxic effects and decrease stem cell capacities in BRAF(V600E)-mutant colorectal cancer cells显示文摘在 oncogene BRAF (V600E ) 的变化在 ~ 被发现 10% colorectal 癌症(CRC ) 并且与穷人被联系预后。然而, BRAF (V600E ) 有有限回答到小分子的药, vemurafenib,一个 BRAF 禁止者,和 BRAF 抑制被认为引起反馈 EGFR 发信号的激活支持继续增长。在这研究,我们探索了 dabrafenib,一个 BRAF 禁止者,和 cetuximab 的联合使用的效果,一个 EGFR 禁止者,在 BRAF (V600E ) 上变异的 CRC 干细胞和它的可能的机制。通过房间生存能力分析,流动 cytometry,形成的范围,和西方的污点分析,我们发现 dabrafenib 与 cetuximab 装 synergize 减少房间生存能力,导致提高的 apoptotic 率和房间周期在 BRAF (V600E ) 的拘捕变异的 HT-29 房间并且禁止干细胞能力。进一步,西方的污点分析表明那条 PTEN/Src/c-Myc 小径可能涉及在 dabrafenib 和 cetuximab 之间的协同。总的来说,我们的学习证明 dabrafenib 和 cetuximab 的联合在 BRAF (V600E ) 导致增加的 antitumor 活动和减少的干细胞能力变异的 CRC 房间。 | Zhenhua Wu Mingzhu Huang Yiwei Gong Chen Lin Weijian Guo | 2018 | Acta Biochimica et Biophysica Sinica2018，50，4： | 2 |
| 10 | A simple fabricated thickness-based stiffness gradient for cell studies显示文摘In this work, we developed a simple method to fabricate a thickness-based continuous stiffness gradient for biological studies. It was made by glass slides, polydimethylsiloxane(PDMS) pre-polymer, spacer and clips only, without any sophisticated equipment. It is easy to fabricate in any general biological and pharmaceutical laboratories. The stiffness gradient was characterized in terms of apparent Young's modulus by atomic force microscopy(AFM) and the Young's modulus along the gradient was found to be 8.5–120 k Pa, which is within the physiological relevant range. He La-C3 cells were cultured on the gradient to study their morphological behavior according to the substrate stiffness. Furthermore, the drug efficiency of etoposide, an anti-cancer drug, was studied along the substrate stiffness gradient. It was found that He La-C3 cells cultured on the soft region of the gradient(8.5–11 k Pa) are more sensitive to etoposide. We believe the proposed device could promote cell investigations and drug screenings on a substrate with comparable stiffness to the native tissue. | Yiwei Shu HO Nam Chan Dongshi Guan Hongkai Wu Lan Ma | 2017 | Science Bulletin2017，62，3： | 2 |
| 11 | Correlation between antioxidant depletion kinetic model and ageing behaviour of cross-linked polyethylene cable insulation显示文摘A concise kinetic model catering for the antioxidant reaction of thermally aged crosslinked polyethylene(XLPE)cable insulation before its abrupt performance deterioration is proposed for life prediction and condition assessment.The alternating current breakdown strength,elongation at break,carbonyl index,and pyrolysis activation energy of XLPE insulation are found to consistently display an abrupt change at a certain point of ageing time.This is strongly correlated to the depletion of the antioxidant whose content gradually decreases with ageing time and drops to a critical value,after which the abrupt degradation of the above macroscopic performances happens.Based on the simplified chain reactions of XLPE during thermal-oxidative ageing,a concise kinetic model about antioxidant prediction is accordingly established by solving the chemical kinetics equations.It indicates that the antioxidant content decays with the reciprocal of time before the abrupt degradation occurs.Results of antioxidant content predicted by the kinetic model at different temperatures matches well with the experimental results,and its reliability can also be proved by the Arrhenius relationship of the obtained results.The kinetic model proposed herein demonstrates satisfying conciseness and thus can be highly feasible in ageing condition assessment and life predicting of XLPE insulation. | Yingying Zheng Yiwei Long Delun Yi Haoran Zhang Jian Gao Kangning Wu Jianying Li | 2023 | High Voltage2023，8，2： | 2 |
| 12 | Composition engineering of Sb_2S_3 film enabling high performance solar cells显示文摘Sb_2S_3 is a kind of stable light absorption materials with suitable band gap, promising for practical applications. Here we demonstrate that the engineering on the composition ratio enables significant improvement in the device performance. We found that the co-evaporation of sulfur or antimony with Sb_2S_3 is able to generate sulfur-or antimony-rich Sb_2S_3. This composition does not generate essential influence on the crystal structure, optical band and film formability, while the carrier concentration and transport dynamics are considerably changed. The device investigations show that sulfur-rich Sb_2S_3 film is favorable for efficient energy conversion, while antimony-rich Sb_2S_3 leads to greatly decreased device performance. With optimizations on the sulfur-rich Sb_2S_3 films, the final power conversion efficiency reaches5.8%, which is the highest efficiency in thermal evaporation derived Sb_2S_3 solar cells. | Yiwei Yin Chunyan Wu Rongfeng Tang Chenhui Jiang Guoshun Jiang Weifeng Liu Tao Chen Changfei Zhu | 2019 | Science Bulletin2019，64，2： | 2 |
| 13 | The C_(6)D_(6)detector system on the Back-n beam line of CSNS显示文摘Introduction The neutron capture cross sections are very important in the field of nuclear device design and basic physics research.Hydrogen-free liquid scintillator such as C_(6)D_(6)detectors are widely used in the neutron capture cross-sectional measurements for the low neutron sensitivity and fast time response.The Back-n white neutron source at China Spallation Neutron Source is the first spallation white neutron source in China,and it is suitable for neutron capture cross-sectional measurement.Materials and methods A C_(6)D_(6)detector system was built in the Back-n experimental station.The pulse height weighting technique was used to determine the system’s detection efficiency.The response to gamma rays of the C_(6)D_(6)detector was measured,and the energy resolution function was determined.Monte Carlo simulation with Geant4 code was carried out to get the weighting function of this C_(6)D_(6)detector system.Additionally,the systematic uncertainty of the weighting function was also determined.Conclusion According to the experimental and simulation results,this C_(6)D_(6)detector system can be used to measure neutron capture cross section. | Jie Ren Xichao Ruan Jie Bao Guangyuan Luan Wei Jiang Qi An Huaiyong Bai Ping Cao Qiping Chen Yonghao Chen Pinjing Cheng Zengqi Cui Ruirui Fan Changqing Feng Minhao Gu Fengqin Guo Changcai Han Zijie Han Guozhu He Yongcheng He Yuefeng He Hanxiong Huang Weiling Huang Xiru Huang Xiaolu Ji Xuyang Ji Haoyu Jiang Hantao Jing Ling Kang Mingtao Kang Bo Li Lun Li Qiang Li Xiao Li Yang Li Yang Li Rong Liu Shubin Liu Xingyan Liu Yinglin Ma Changjun Ning Binbin Qi Zhaohui Song Hong Sun Xiaoyang Sun Zhijia Sun Zhixin Tan Hongqing Tang Jingyu Tang Pengcheng Wang Qi Wang Taofeng Wang Yanfeng Wang Zhaohui Wang Zheng Wang Jie Wen Zhongwei Wen Qingbiao Wu Xiaoguang Wu Xuan Wu Likun Xie Yiwei Yang Han Yi Li Yu Tao Yu Yongji Yu Guohui Zhang Jing Zhang Linhao Zhang Liying Zhang Qingmin Zhang Qiwei Zhang Xianpeng Zhang Yuliang Zhang Zhiyong Zhang Yingtan Zhao Liang Zhou Zuying Zhou Danyang Zhu Kejun Zhu Peng Zhu | 2019 | Radiation Detection Technology and Methods2019，3，3： | 1 |
| 14 | Transporting real-time video over the intemet:challenges and approaches显示文摘 | Wu Dapeng Yiwei Thomas Hou Zhang Ya-Qin | 2000 | IEEE2000，88，12： | 1 |
| 15 | Streaming video over the Internet:approaches and directions显示文摘 | WU Dapeng HOU Yiwei ZHU Wenwu | 2001 | IEEE Trans on Circuits and Systems for Video Technology2001，11，3： | 1 |
| 16 | Transporting RealTime Video over the Internet:Challenges and Approaches显示文摘 | Dapeng Wu Yiwei Thomas Hou Yaqin Zhang | 2000 | Procedings of the IEEE2000，88，12： | 1 |
| 17 | Fe3O4@Zr O2nanoparticles magnetic solid phase extraction coupled with flame atomic absorption spectrometry for chromium(III)speciation in environmental and biological samples显示文摘 | Wu Yiwei Zhang Jing Liu Junfeng | 2012 | Applied Surface Science2012，258，18： | 1 |
| 18 | Experiment and numerical simulation on the characteristics of fluid–structure interactions of non-rigid airships显示文摘Fluid–structure interaction is an important issue for non-rigid airships with inflated envelopes. In this study, a wind tunnel test is conducted, and a loosely coupled procedure is correspondingly established for numerical simulation based on computational fluid dynamics and nonlinear finite element analysis methods. The typical results of the numerical simulation and wind tunnel experiment, including the overall lift and deformation, are in good agreement with each other. The results obtained indicate that the effect of fluid–structure interaction is noticeable and should be considered for non-rigid airships. Flowinduced deformation can further intensify the upward lift force and pitching moment, which can lead to a large deformation. Under a wind speed of 15 m/s, the lift force of the non-rigid model is increased to approximately 60% compared with that of the rigid model under a high angle of attack. | Xiaocui Wu Yiwei Wang Chenguang Huang Yubiao Liu Lingling Lu | 2015 | Theoretical & Applied Mechanics Letters2015，5，6： | 1 |
| 19 | On End-to-End Architecture for Transporting MPEG-4 Video over the Internet显示文摘 | Yiwei Thomas Hou Wenwu Zhu | 2000 | IEEE Trans on Circuits and Systems for Video Technology2000，10，6： | 1 |
| 20 | Streaming video over the Internet: approaehes and directions 显示文摘 | Wu D P Yiwei Thomas Hou Zhu W W | 2001 | IEEE Transactionsons Circuits and Systems for Video Technology2001，11，3： | 1 |
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