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| 1 | Ythdc2 is an N^6-methyladenosine binding protein that regulates mammalian spermatogenesis显示文摘N 6-methyladenosine (m 6 一) 是在真核细胞的 mRNA 的最普通的内部修正。它动态地被安装并且搬迁,并且充当 mRNA 新陈代谢,包括干细胞 pluripotency 的调整生物过程,房间区别,和精力动态平衡的新层。m 6 A 被选择有约束力的蛋白质认出;YTHDF1 和 YTHDF3 在音乐会工作影响 m 6包含 A 的 mRNAs, YTHDF2 帮助 mRNA 腐烂,和 YTHDC1 影响它的目标的原子处理。YTHDC2 的生物功能, YTH 蛋白质家庭,的最后的成员仍然保持未知。我们报导 YTHDC2 有选择地绑 m 6 在它的一致主题的 A。YTHDC2 提高它的目标的翻译效率并且也减少他们的 mRNA 丰富。Ythdc2 猛烈老鼠是不肥沃的;男性们让显著地更小的睾丸和女性同窝出生的人与那些相比有显著地更小的卵巢。Ythdc2 猛烈老鼠的细菌房间不经过 zygotene 阶段发展,因此,当成熟分裂开始, Ythdc2 是在睾丸的 upregulated。因此, YTHDC2 是 m 6 在精子发生期间起关键作用的 A 绑定蛋白质。 | Phillip J Hsu Yunfei Zhu Honghui Ma Yueshuai Guo Xiaodan Shi Yuanyuan Liu Meijie Qi Zhike Lu Hailing Shi Jianying Wang Yiwei Cheng Guanzheng Luo Qing Dai Mingxi Liu Xuejiang Guo Jiahao Sha Bin Shen Chuan He | 2017 | Cell Research2017，27，9： | 96 |
| 2 | Trichosanthin enhances anti-tumor immune response in a murine Lewis lung cancer model by boosting the interaction between TSLC1 and CRTAM显示文摘Trichosanthin(TCS),extracted from the Chinese medicinal herb Trichosanthes kirilowi,has shown promise for the inhibition of tumor growth.However,its immunomodulatory effect on tumor–host interaction remains unknown.In this study,we focused on the effect of TCS on murine anti-tumor immune response in the 3LL Lewis lung carcinoma tumor model and explored the possible molecular pathways involved.In addition to inhibiting cell proliferation and inducing apoptosis in the 3LL tumor,TCS retarded tumor growth and prolonged mouse survival more significantly in C57BL/6 immunocompetent mice than in nude mice.This reflected the fact that the host immune system was involved in tumor eradication.Using FACS analysis,we found that TCS increased the percentage of effector T cells,particularly Interferon-gamma(IFN-c)producing CD41 and CD81 T cells from tumor-bearing mice.TCS also promoted the vigorous proliferation of antigen-specific effector T cells,markedly increased Th1 cytokine secretion and elicited more memory T cells in tumor-bearing mice,consequently enhancing the anti-tumor response and inducing immune protection.Furthermore,we found that TCS upregulated the expression of tumor suppressor in lung cancer 1(TSLC1)in 3LL tumor cells and the expression of its ligand,class I-restricted T cell-associated molecule(CRTAM),in effector T cells.Blocking TSLC1 expression with small interfering RNA(siRNA)significantly eliminated the effects of TCS on the proliferation and cytokine secretion of effector T cells,suggesting that TCS enhances anti-tumor immune response at least partially by boosting the interaction between TSLC1 and CRTAM.Collectively,our data demonstrate that TCS not only affects tumor cells directly,but also enhances anti-tumor immunity via the interaction between TSLC1 and CRTAM.These findings may lead to the development of a novel approach for tumor regression. | Yuchan Cai Shudao Xiong Yijie Zheng Feifei Luo Pei Jiang Yiwei Chu | 2011 | Cellular & Molecular Immunology2011，8，4： | 12 |
| 3 | Abnormal expression of bHLH3 disrupts a flavonoid homeostasis network,causing differences in pigment composition among mulberry fruits显示文摘Mulberry fruits with high concentrations of anthocyanins are favored by consumers because of their good taste,bright color,and high nutritional value.However,neither the regulatory mechanism controlling flavonoid biosynthesis in mulberry nor the molecular basis of different mulberry fruit colors is fully understood.Here,we report that a flavonoid homeostasis network comprising activation and feedback regulation mechanisms determines mulberry fruit color.In vitro and in vivo assays showed that MYBA-bHLH3-TTG1 regulates the biosynthesis of anthocyanins,while TT2L1 and TT2L2 work with bHLH3 or GL3 and form a MYB-bHLH-WD40(MBW)complex with TTG1 to regulate proanthocyanidin(PA)synthesis.Functional and expression analyses showed that bHLH3 is a key regulator of the regulatory network controlling mulberry fruit coloration and that MYB4 is activated by MBW complexes and participates in negative feedback control of the regulatory network to balance the accumulation of anthocyanins and proanthocyanidins.Our research demonstrates that the interaction between bHLH3 and MYB4 in the homeostasis regulatory network ensures that the fruits accumulate desirable flavonoids and that this network is stable in pigmentrich mulberry fruits.However,the abnormal expression of bHLH3 disrupts the balance of the network and redirects flavonoid metabolic flux in pale-colored fruits,resulting in differences in the levels and proportions of anthocyanins,flavones,and flavonols among differently colored mulberry fruits(red,yellow,and white).The results of our study reveal the molecular basis of the diversity of mulberry fruit colors. | Han Li Zhen Yang Qiwei Zeng Shibo Wang Yiwei Luo Yan Huang Youchao Xin Ningjia He | 2020 | Horticulture Research2020，7，1： | 8 |
| 4 | Genome-wide identification and expression analyses of cytochrome P450 genes in mulberry(Morus notabilis)显示文摘Cytochrome P450 S play critical roles in the biosynthesis of physiologically important compounds in plants.These compounds often act as defense toxins to prevent herbivory.In the present study,a total of 174 P450 genes of mulberry(Morus notabilis C.K.Schn) were identified based on bioinformatics analyses.These mulberry P450 genes were divided into nine clans and 47 families and were found to be expressed in a tissue-preferential manner.These genes were compared to the P450 genes in Arabidopsis thaliana.Families CYP80,CYP92,CYP728,CYP733,CYP736,and CYP749 were found to exist in mulberry,and they may play important roles in the biosynthesis of mulberry secondary metabolites.Analyses of the functional and metabolic pathways of these genes indicated that mulberry P450 genes may participate in the metabolism of lipids,other secondary metabolites,xenobiotics,amino acids,cofactors,vitamins,terpenoids,and poiyketides.These results provide a foundation for understanding of the structures and biological functions of mulberry P450 genes. | Bi Ma Yiwei Luo Ling Jia Xiwu Qi Qiwei Zeng Zhonghuai Xiang Ningjia He | 2014 | Journal of Integrative Plant Biology2014，56，9： | 5 |
| 5 | Effective Improvement of the Photovoltaic Performance of Carbon-Based Perovskite Solar Cells by Additional Solvents显示文摘A solvent-assisted methodology has been developed to synthesize CH_3NH_3 PbI_3perovskite absorber layers.It involved the use of a mixed solvent of CH_3NH_3 I,PbI_2,c-butyrolactone,and dimethyl sulfoxide(DMSO) followed by the addition of chlorobenzene(CB).The method produced ultra-flat and dense perovskite capping layers atop mesoporous TiO_2 films,enabling a remarkable improvement in the performance of free hole transport material(HTM) carbon electrode-based perovskite solar cells(PSCs).Toluene(TO) was also studied as an additional solvent for comparison.At the annealing temperature of 100 °C,the fabricated HTM-free PSCs based on drop-casting CB demonstrated power conversion efficiency(PCE) of 9.73 %,which is 36 and 71 % higher than those fabricated from the perovskite films using TO or without adding an extra solvent,respectively.The interaction between the PbI_2–DMSO–CH_3NH_3I intermediate phase and the additional solvent was discussed.Furthermore,the influence of the annealing temperature on the absorber film formation,morphology,and crystalline structure was investigated and correlated with the photovoltaic performance.Highly efficient,simple,and stable HTM-free solar cells with a PCE of 11.44 % were prepared utilizing the optimum perovskite absorbers annealed at 120 °C. | Chenxi Zhang Yudan Luo Xiaohong Chen Yiwei Chen Zhuo Sun Sumei Huang | 2016 | Nano-Micro Letters2016，8，4： | 4 |
| 6 | Recent advances in acid-resistant zeolite T membranes for dehydration of organics显示文摘Zeolite membranes offer outstanding potentials in separation of many molecular mixtures due to their molecular sieving selectivity and the high thermal and mechanical stability that allow them to operate at harsh conditions.Development of durable and high separation performance membranes with lower fabrication and operation cost are highly demanded for industrial applications. Zeolite T membrane possesses good acid-resistance with excellent hydrophilic properties as compared to NaA zeolite membrane and can be extended to industrial organic dehydrations under an acidic environment. In the present review the research advances in development of zeolite T membranes for the dehydration of organic mixtures in acidic conditions are summarized. Especially the low temperature synthesis, and epitaxial growth of the zeolite membrane with high performance are well addressed, besides emphasis is particularly placed on ensemble synthesis of hollow fiber zeolite T membrane module and its future prospects for industrial separations. | Yiwei Luo Waseem Raza Jianhua Yang Liangqing Li Ying Lu | 2019 | Chinese Journal of Chemical Engineering2019，27，6： | 4 |
| 7 | Instability identification on large scale underground mined-out area in the metal mine based on the improved FRBFNN显示文摘To identify the instability on large scale underground mined-out area in the metal mine effectively,the parameters of radial basis function were determined through clustering method and the improved fuzzy radial basis function neural network(FRBFNN)model of instability identification model about large scale underground mined-out area in the metal mine was built.The improved FRBFNN model was trained and tested.The results show that the improved FRBFNN model has high training accuracy and generalization ability.Parameters such as pillar area ratio,filling level and the value of rock quality designation have strong influence on instability of large scale underground mined-out area.Correctness of analysis about the improved FRBFNN model was proved by the practical application results about instability discrimination of surrounding rock in large-scale underground mined-out area of a metal mine in south China. | Luo Zhouquan Zuo Hongyan Jia Nan Wang Yiwei | 2013 | International Journal of Mining Science and Technology2013，23，6： | 4 |
| 8 | Confined Ni-In intermetallic alloy nanocatalyst with excellent coking resistance for methane dry reforming显示文摘Carbon dioxide and methane are two main greenhouse gases which are contributed to serious global warming.Fortunately,dry reforming of methane(DRM),a very important reaction developed decades ago,can convert these two major greenhouse gases into value-added syngas or hydrogen.The main problem retarding its industrialization is the seriously coking formation upon the nickel-based catalysts.Herein,a series of confined indium-nickel(In-Ni)intermetallic alloy nanocatalysts(In_(x)Ni@SiO_(2))have been prepared and displayed superior coking resistance for DRM reaction.The sample containing 0.5 wt.%of In loading(In_(0.5)Ni@SiO_(2))shows the best balance of carbon deposition resistance and DRM reactivity even after 430 h long term stability test.The boosted carbon resistance can be ascribed to the confinement of core–shell structure and to the transfer of electrons from Indium to Nickel in In-Ni intermetallic alloys due to the smaller electronegativity of In.Both the silica shell and the increase of electron cloud density on metallic Ni can weaken the ability of Ni to activate C–H bond and decrease the deep cracking process of methane.The reaction over the confined InNi intermetallic alloy nanocatalyst was conformed to the Langmuir-Hinshelwood(L-H)mechanism revealed by in situ diffuse reflectance infrared Fourier transform spectroscopy(in-situ DRIFTS).This work provides a guidance to design high performance coking resistance catalysts for methane dry reforming to efficiently utilize these two main greenhouse gases. | Wenming Liu Le Li Sixue Lin Yiwei Luo Zhenghong Bao Yiru Mao Kongzhai Li Daishe Wu Honggen Peng | 2022 | Journal of Energy Chemistry2022，31，2： | 3 |
| 9 | Improving the performance of ducted fans for VTOL applications:A review显示文摘Ducted fans have been widely used in VTOL aircraft due to the high propulsion efficiency and safety.The efficiency and stability of ducted fans deteriorate in some flight conditions such as hovering in crosswinds or ground effect.It is necessary to optimize the ducted fan’s structures or apply flow control methods for better adaptions to the typical conditions.This paper presents a detailed review on the ducted fan technology for VTOL applications,especially the methods for improving its efficiency and stability.We first simplified the classification categories based on boundary conditions instead of flight conditions,since the new classification method covers more situations and is easier to distinguish flow field characteristics.The flow characteristics,thrust properties and the optimal structures under different boundary conditions were summarized and discussed.Finally,new configurations and flow control methods for increasing the efficiency and stability were introduced.The newly proposed integration design between the ducted fan and the motor was emphasized for increasing the power density of the ducted fans.This review would be helpful to improve our understanding of the relationship between the structures,flow characteristics and thrust properties of ducted fans under different flight conditions,and inspires scientists to design high-efficiency and high-stability propulsion systems with ducted fans. | QIAN YuPing LUO YiWei HU XuanYang ZENG ZeZhi ZHANG YangJun | 2022 | Science China(Technological Sciences)2022，65，11： | 3 |
| 10 | Phospholipid Transfer Protein Deficiency Decreases the Content of S1P in HDL via the Loss of its Transfer Capability显示文摘 | Yang Yu Shoudong Guo Yumei Feng Lei Feng Yingjie Cui Guohua Song Tian Luo Ke Zhang Yiwei Wang Xian-Cheng Jiang Shucun Qin | 2014 | Lipids2014，，2： | 2 |
| 11 | A high-performance bio-tissue imaging method using air flow-assisted desorption electrospray ionization coupled with a high-resolution mass spectrometer显示文摘Mass spectrometry imaging (MSI) technology can simultaneously obtain the spatial distribution of thousands of chemical compounds and has unique advantages compared to other techniques that allow mapping the surface of bio-tissue. Here, we combined an air flow-assisted desorption electrospray ionization (AFADESI) MSI device with a high-resolution mass spectrometer to optimize the system parameters and achieve more accurate spatial distribution characteristics for compounds of interest while investigating bio-tissue sections. The platform set-up, required instrumentation, sample pretreatment, parameter optimization and bio-tissue characterization are described and discussed.Finally, the parameter conditions that can provide optimal ionic intensity and enhanced resolution were confirmed. The reasonable resolution and sensitivity improvements of AFADESI-MSI have been achieved through tandem a high-resolution mass spectrometer system, therefore, it would be a promising technique for the bio-tissue imaging analysis. | Yiwei Lv Tiegang Li Chengan Guo Chenglong Sun Fei Tang Luojiao Huang Zhigang Luo Xin Li Ruiping Zhang Qingce Zang Jiuming He Zeper AbliZ | 2019 | Chinese Chemical Letters2019，30，2： | 2 |
| 12 | Self-adhesive lubricated coating for enhanced bacterial resistance显示文摘Limited surface lubrication and bacterial biofilm formation pose great challenges to biomedical implants.Although hydrophilic lubricated coatings and bacterial resistance coatings have been reported,the harsh and tedious synthesis greatly compromises their application,and more importantly,the bacterial resistance property has seldom been investigated in combination with the lubrication property.In this study,bioinspired by the performances of mussel and articular cartilage,we successfully synthesized self-adhesive lubricated coating and simultaneously achieved optimal lubrication and bacterial resistance properties.Additionally,we reported the mechanism of bacterial resistance on the nanoscale by studying the adhesion interactions between biomimetic coating and hydrophilic/hydrophobic tip or living bacteria via atomic force microscopy.In summary,the self-adhesive lubricated coating can effectively enhance lubrication and bacterial resistance performances based on hydration lubrication and hydration repulsion,and represent a universal and facial strategy for surface functionalization of biomedical implants. | Ying Han Weiwei Zhao Yiwei Zheng Haimang Wang Yulong Sun Yifei Zhang Jing Luo Hongyu Zhang | 2021 | Bioactive Materials2021，6，8： | 2 |
| 13 | Solid-state foaming of isotactic polypropylene and its composites with spherical or fibrous poty (butylenes terephthalate) 显示文摘 | Luo Yiwei Xin Chunling Yang Zhaoping | 2015 | Jour- nal of Applied Polymer Science2015，132，15： | 1 |
| 14 | Nicotinamide mononucleotide improves spermatogenic function in streptozotocin-induced diabetic mice via modulating the glycolysis pathway显示文摘Spermatogenic dysfunction is one of the major secondary complications of diabetes;however,the underlying mechanisms remain ill-defined,and there is no available drug or strategy for the radical treatment of diabetic spermatogenic dysfunction.Therefore,the objective of this study is to investigate the protective effects of nicotinamide mononucleotide(NMN)on testicular spermatogenic function in streptozotocin(STZ)-induced diabetic mice.The results show that oral administration of NMN significantly increases the body and testis weight and the number of sperms.Moreover,the abnormal sperm count and the rate of sperm malformation are significantly decreased compared with the saline-treated diabetic mice.Histological analysis reveals that NMN treatment significantly increases the area and diameter of seminiferous tubules,accompanied by an increased number of spermatogenic cells and sperms.Immunohistochemistry and qRT-PCR results show that NMN increases Bcl-2 expression and decreases Bax expression in the testis.NMN also increases the protein expression of Vimentin and the mRNA expressions of WT1 and GATA4.In addition,qRT-PCR,western blot analysis and immunohistochemistry results also show that NMN increases the expressions of glycolysis-related rate-limiting enzymes including HK2,PKM2,and LDHA.In summary,this study demonstrates the protective effects of NMN on the testis in an STZ-induced diabetic mice model.NMN exerts its protective effects via reducing spermatogenic cell apoptosis by regulating glycolysis of Sertoli cells in diabetic mice.This study provides an experimental basis for the future clinical application of NMN in diabetes-induced spermatogenicdysfunction. | Duo Ma Linlin Hu Jinyuan Wang Min Luo Aihong Liang Xiaocan Lei Biyun Liao Meixiang Li Ming Xie Haicheng Li Yiwei Gong Dan Zi Xiangrun Li Xi Chen Xucai Liao | 2022 | Acta Biochimica et Biophysica Sinica2022，54，9： | 1 |
| 15 | Lignin terpolymer for corrosion inhibition of mild steel in 10% hydrochloric acid medium显示文摘 | Ren Yiwei Luo Yi Zhang Kaisong | 2008 | Corrosion Science2008，，： | 1 |
| 16 | The gap-free genome of mulberry elucidates the architecture and evolution of polycentric chromosomes显示文摘Mulberry is a fundamental component of the global sericulture industry,and its positive impact on our health and the environment cannot be overstated.However,the mulberry reference genomes reported previously remained unassembled or unplaced sequences.Here,we report the assembly and analysis of the telomere-to-telomere gap-free reference genome of the mulberry species,Morus notabilis,which has emerged as an important reference in mulberry gene function research and genetic improvement.The mulberry gap-free reference genome produced here provides an unprecedented opportunity for us to study the structure and function of centromeres.Our results revealed that all mulberry centromeric regions share conserved centromeric satellite repeats with different copies.Strikingly,we found that M.notabilis is a species with polycentric chromosomes and the only reported polycentric chromosome species up to now.We propose a compelling model that explains the formation mechanism of new centromeres and addresses the unsolved scientific question of the chromosome fusion-fission cycle in mulberry species.Our study sheds light on the functional genomics,chromosome evolution,and genetic improvement of mulberry species. | Bi Ma Honghong Wang Jingchun Liu Lin Chen Xiaoyu Xia Wuqi Wei Zhen Yang Jianglian Yuan Yiwei Luo Ningjia He | 2023 | Horticulture Research2023，10，7： | 1 |
| 17 | Biodistribution characteristics of ^(188)Re-TSC after TAE in rabbits bearing VX_2 liver tumor显示文摘188Re-tin sulfur colloid(TSC) was prepared to compare its biodistribution characteristics with 188Re-macroaggregates album(MAA) after transhepatic arterial embolization(TAE) in rabbits bearing VX2 liver tumor.Labeling efficiencies of the 188Re-TSC and 188Re-MAA were 99.94%±0.04% and 99.95%±0.03%,respectively,and they were stable for 72 h in human serum.Sintigraphy and biodistribution in 31 rabbits bearing VX2 liver tumor after transcatherter hepatic arterial injection of the radiopharmaceuticals were performed,and relevant activity accumulated mostly in the tumor.The percentage of the injected dose per gram of wet tissue(%ID/g) of 188Re-TSC and 188Re-MAA were calculated.Tumor uptake of 188Re-TSC at 1 h and 24 h were 24.32%±11.93% and 21.88%±18.29%,and the radioactive ratios of tumor/liver were 70.89±19.58 and 17.42±13.96,respectively.Tumor uptake of 188Re-MAA at 1 h and 24 h were 38.78%±30.23% and 15.98%±26.64%,and the radioactive ratio of tumor/liver of 188Re-MAA were 39.71±25.06 and 8.13±4.61,respectively.188Re-TSC is a potential radiopharmaceutical for the therapy of tumors. | ZHANG Bin WU Yiwei JIN Yonghai LIU Yizhi LUO Xianwen FAN Wo | 2009 | Nuclear Science and Techniques2009，20，2： | 1 |
| 18 | High-throughput“read-on-ski”automated imaging and label-free detection system for toxicity screening of compounds using personalised human kidney organoids显示文摘Organoid models are used to study kidney physiology,such as the assessment of nephrotoxicity and underlying disease processes.Personalized human pluripotent stem cell-derived kidney organoids are ideal models for compound toxicity studies,but there is a need to accelerate basic and translational research in the field.Here,we developed an automated continuous imaging setup with the“read-on-ski”law of control to maximize temporal resolution with minimum culture plate vibration.High-accuracy performance was achieved:organoid screening and imaging were performed at a spatial resolution of 1.1µm for the entire multi-well plate under 3 min.We used the in-house developed multi-well spinning device and cisplatin-induced nephrotoxicity model to evaluate the toxicity in kidney organoids using this system.The acquired images were processed via machine learning-based classification and segmentation algorithms,and the toxicity in kidney organoids was determined with 95%accuracy.The results obtained by the automated“read-on-ski”imaging device,combined with label-free and non-invasive algorithms for detection,were verified using conventional biological procedures.Taking advantage of the close-to-in vivo-kidney organoid model,this new development opens the door for further application of scaled-up screening using organoids in basic research and drug discovery. | Qizheng WANG Jun LU Ke FAN Yiwei XU Yucui XIONG Zhiyong SUN Man ZHAI Zhizhong ZHANG Sheng ZHANG Yan SONG Jianzhong LUO Mingliang YOU Meijin GUO Xiao ZHANG | 2022 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2022，23，7： | 0 |
| 19 | Numerical investigation on unsteady characteristics of ducted fans in ground effect显示文摘Ducted fans are widely used in various applications of Unmanned Aerial Vehicles(UAVs)due to the high efficiency,low noise and high safety.The unsteady characteristics of ducted fans flying near the ground are significant,which may bring stability problems.In this paper,the sliding mesh technology is applied and the Unsteady Reynolds Averaged Navier-Stokes(URANS)method is adopted to evaluate the influence of ground on the aerodynamic performance of ducted fans.The time-averaged results show that the ground leads to the decrease of duct thrust,the increase of rotor thrust and the decrease of total thrust.The transient results show that there exist small-scale stall cells with circumferential movements in ground effect.The stall cells start to appear at the blade root when the height is 0.8 rotor radius distance,and arise at both the blade root and tip when the height drops to 0.2.It is found that the unsteady cells rotate between blade passages with an approximate relative speed of 30%-80%of the fan speed,and lead to thrust fluctuations up to 37%of the total thrust.The results are essential to the flight control design of the ducted fan flying vehicle,to ensure its stability in ground effect. | Yiwei LUO Tianfu AI Yuhang HE Bin XU Yuping QIAN Yangjun ZHANG | 2023 | Chinese Journal of Aeronautics2023，36，9： | 0 |
| 20 | Effects of carrier-attached biofilm on oxygen transfer efficiency in a moving bed biofilm reactor显示文摘有不同搬运人充满比率从 40% ~ 60%的三实验室规模移动床 biofilm 反应堆(MBBR ) 被用来在氧转移效率上学习依附搬运人的 biofilm 的效果。在这研究,我们在降级的化学的氧需求和氨评估了三 MBBR 的表演。三个反应堆在 60 L 的空气流动率移开超过 95% NH 4+-N ???? | Yanling WEI Xunfei YIN Lu QI Hongchen WANG Yiwei GONG Yaqian LUO | 2016 | Frontiers of Environmental Science & Engineering2016，10，3： | 0 |
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