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| 1 | Cryo-EM structure of human mTOR complex 2显示文摘 | Xizi Chen Mengjie Liu Yuan Tian Jiabei Li Yilun Qi Dan Zhao Zihan Wu Min Huang Catherine C. L. Wong Hong-Wei Wang Jiawei Wang Huirong Yang Yanhui Xu | 2018 | Cell Research2018，28，5： | 8 |
| 2 | Rational design of hierarchically porous Fe-N-doped carbon as efficient electrocatalyst for oxygen reduction reaction and Zn-air batteries显示文摘The rational design and construction of hierarchically porous nanostructure for oxygen reduction reaction (ORR) electrocatalysts is crucial to facilitate the exposure of accessible active sites and promote the mass/electron transfer under the gas-solid-liquid triple-phase condition. Herein, an ingenious method through the pyrolysis of creative polyvinylimidazole coordination with Zn/Fe salt precursors is developed to fabricate hierarchically porous Fe-N-doped carbon framework as efficient ORR electrocatalyst. The volatilization of Zn species combined with the nanoscale Kirkendall effect of Fe dopants during the pyrolysis build the hierarchical micro-, meso-, and macroporous nanostructure with a high specific surface area (1,586 m^(2)·g^(−1)), which provide sufficient exposed active sites and multiscale mass/charge transport channels. The optimized electrocatalyst exhibits superior ORR activity and robust stability in both alkaline and acidic electrolytes. The Zn-air battery fabricated by such attractive electrocatalyst as air cathode displays a higher peak power density than that of Pt/C-based Zn-air battery, suggesting the great potential of this electrocatalyst for Zn-air batteries. | Zihan Meng Neng Chen Shichang Cai Jiawei Wu Rui Wang Tian Tian Haolin Tang | 2021 | Nano Research2021，14，12： | 4 |
| 3 | Uplift mechanism for a shallow-buried structure in liquefi able sand subjected to seismic load: centrifuge model test and DEM modeling显示文摘Based on a centrifuge model test and distinct element method(DEM), this study provides new insights into the uplift response of a shallow-buried structure and the liquefaction mechanism for saturated sand around the structure under seismic action. In the centrifuge test, a high-speed microscopic camera was installed in the structure model, by which the movements of particles around the structure were monitored. Then, a two-dimensional digital image processing technology was used to analyze the microstructure of saturated sand during the shaking event. Herein, a numerical simulation of the centrifuge experiment was conducted using a two-phase(solid and fl uid) fully coupled distinct element code. This code incorporates a particle-fl uid coupling model by means of a 'fi xed coarse-grid' fl uid scheme in PFC3D(Particle Flow Code in Three Dimensions), with the modeling parameters partially calibrated based on earlier studies. The physical and numerical models both indicate the uplifts of the shallow-buried structure and the sharp rise in excess pore pressure. The corresponding micro-scale responses and explanations are provided. Overall, the uplift response of an underground structure and the occurrence of liquefaction in saturated sand are predicted successfully by DEM modeling. However, the dynamic responses during the shaking cannot be modeled accurately due to the restricted computer power. | Zhou Jian Wang Zihan Chen Xiaoliang Zhang Jiao | 2014 | Earthquake Engineering and Engineering Vibration2014，13，2： | 4 |
| 4 | Generation-expansion planning with linearized primary frequency response constraints显示文摘As renewable energy resources increasingly penetrate the electric grid,the inertia capability of power systems has become a developmental bottleneck.Nevertheless,the importance of primary frequency response(PFR)when making generation-expansion plans has been largely ignored.In this paper,we propose an optimal generation-expansion planning framework for wind and thermal power plants that takes PFR into account.The model is based on the frequency equivalent model.It includes investment,startup/shutdown,and typical operating costs for both thermal and renewable generators.The linearization constraints of PFR are derived theoretically.Case studies based on the modified IEEE 39-bus system demonstrate the efficiency and effectiveness of the proposed method.Compared with methods that ignore PFR,the method proposed in this paper can effectively reduce the cost of the entire planning and operation cycle,improving the accommodation rate of renewable energy. | Zihan Wang Jianxiao Wang Gengyin Li Ming Zhou | 2020 | Global Energy Interconnection2020，3，4： | 4 |
| 5 | Searching for the Nano-Hertz Stochastic Gravitational Wave Background with the Chinese Pulsar Timing Array Data ReleaseⅠ显示文摘Observing and timing a group of millisecond pulsars with high rotational stability enables the direct detection of gravitational waves(GWs).The GW signals can be identified from the spatial correlations encoded in the times-of-arrival of widely spaced pulsar-pairs.The Chinese Pulsar Timing Array(CPTA)is a collaboration aiming at the direct GW detection with observations carried out using Chinese radio telescopes.This short article serves as a“table of contents”for a forthcoming series of papers related to the CPTA Data Release 1(CPTA DR1)which uses observations from the Five-hundred-meter Aperture Spherical radio Telescope.Here,after summarizing the time span and accuracy of CPTA DR1,we report the key results of our statistical inference finding a correlated signal with amplitude logA_(c)=-14.4_(-2.8)^(+1.0)for spectral index in the range ofα∈[-1.8,1.5]assuming a GW background(GWB)induced quadrupolar correlation.The search for the Hellings–Downs(HD)correlation curve is also presented,where some evidence for the HD correlation has been found that a 4.6σstatistical significance is achieved using the discrete frequency method around the frequency of 14 n Hz.We expect that the future International Pulsar Timing Array data analysis and the next CPTA data release will be more sensitive to the n Hz GWB,which could verify the current results. | Heng Xu Siyuan Chen Yanjun Guo Jinchen Jiang Bojun Wang Jiangwei Xu Zihan Xue RNicolas Caballero Jianping Yuan Yonghua Xu Jingbo Wang Longfei Hao Jingtao Luo Kejia Lee Jinlin Han Peng Jiang Zhiqiang Shen Min Wang Na Wang Renxin Xu Xiangping Wu Richard Manchester Lei Qian Xin Guan Menglin Huang Chun Sun Yan Zhu | 2023 | Research in Astronomy and Astrophysics2023，23，7： | 3 |
| 6 | PD-L1:expression regulation显示文摘Programmed death-ligand 1(PD-L1),expressed on the surface of tumor cells,can bind to programmed cell death-1(PD-1)on T cells.The interaction of PD-1 and PD-L1 can inhibit T-cell responses by decreasing T-cell activity and accelerating their apoptosis.Various cancers express high levels of PD-L1 and exploit PD-L1/PD-1 signaling to evade T-cell immunity,and immunotherapies targeting the PD-1/PD-L1 axis have been shown to exert remarkable anti-tumor effects;however,not all tumor patients benefit from these therapies.Therefore,study of the mechanisms regulating PD-L1 expression are imperative.In this review,we explore regulation of PD-L1 expression in the contexts of gene transcription,signaling pathways,histone modification and remodeling,microRNAs,long noncoding RNAs,and post-translational modification.Current developments in studies of agents that block PD-L1 and correlations between immunotherapies targeting PD-1/PD-L1 and PD-L1 expression are also summarized.Our review will assist in understanding of PD-L1 expression regulation and discusses the implications of reported findings in cancer diagnosis and immunotherapy. | Yu-Jie Zhou Guoli Li Jiyin Wang Mengyuan Liu Zihan Wang Yu Song Xulong Zhang Xi Wang | 2023 | Blood Science2023，5，2： | 3 |
| 7 | Large piezoelectric response in a family of metal-free perovskite ferroelectric compounds from first-principles calculations显示文摘Metal-free organic perovskite ferroelectric materials have been shown recently to have a number of attractive properties,including high spontaneous polarization and piezoelectric coefficients.In particular,slow evaporation of solutions containing organic amines,inorganic ammoniums,and dilute hydrohalogen acid has been shown to produce several attractive materials in the MDABCO-NH_(4)-I_(3) family(MDABCO is N-methyl-N’-diazabicyclo[2,2,2]octonium).In the present work,we study by first-principles calculations the origin of polarizaiton,electronic density of state,piezoelectric response,and elastic properties of MDABCO-NH_(4)-X_(3)(X=Cl,Br,I).We find that the dipole moments of the MDABCO and NH_(4) groups are negligible,and the large spontaneous polarization of MDABCONH_(4)-I_(3) mainly results from MDABCO and NH_(4) being off-center relative to I ions.Although the piezoelectric response of organic materials is usually very weak,we observe large piezoelectric strain components,d_(x4) and d_(x5);the calculated d_(x5) is 119 pC/N for MDABCO-NH_(4)-Cl_(3),248 pC/N for MDABCO-NH_(4)-Br_(3) and 178 pC/N for MDABCO-NH_(4)-I_(3).The large value of dx5 is found to be closely related with the large value of elastic compliance tensor,s44.These results show that MDABCO-NH_(4)-X_(3) metal-free organic perovskites have large piezoelectric response with soft elastic properties. | Hui Wang Huihui Liu Zeyu Zhang Zihan Liu Zhenlong Lv Tongwei Li Weiwei Ju Haisheng Li Xiaowu Cai Han Han | 2019 | npj Computational Materials2019，，1： | 3 |
| 8 | MARVEL:Multi-Agent Reinforcement Learning for VANET Delay Minimization显示文摘In urban Vehicular Ad hoc Networks(VANETs),high mobility of vehicular environment and frequently changed network topology call for a low delay end-to-end routing algorithm.In this paper,we propose a Multi-Agent Reinforcement Learning(MARL)based decentralized routing scheme,where the inherent similarity between the routing problem in VANET and the MARL problem is exploited.The proposed routing scheme models the interaction between vehicles and the environment as a multi-agent problem in which each vehicle autonomously establishes the communication channel with a neighbor device regardless of the global information.Simulation performed in the 3GPP Manhattan mobility model demonstrates that our proposed decentralized routing algorithm achieves less than 45.8 ms average latency and high stability of 0.05%averaging failure rate with varying vehicle capacities. | Chengyue Lu Zihan Wang Wenbo Ding Gang Li Sicong Liu Ling Cheng | 2021 | China Communications2021，18，6： | 2 |
| 9 | AGRICULTURAL GREEN DEVELOPMENT TO ACHIEVE FOOD SECURITY AND CARBON REDUCTION IN THE CONTEXT OF CHINA'S DUAL CARBON GOALS显示文摘The agricultural sector,a major source of greenhouse gas emissions,and emissions from agriculture must be reduced substantially to achieve carbon(C)neutrality.Based on a literature analysis and other research results,this study investigated the effects and prospects of C reduction in agricultural systems under different scenarios(i.e.,methods and approaches)in the context of China's dual C goals,as those working in the agricultural sector have yet to reach a consensus on how to move forward.Different views,standards,and countermeasures were analyzed to provide a reference for agricultural action supporting China's C neutrality goal. | Yulong YIN Kai HE Zhong CHEN Yangyang LI Fengling REN Zihan WANG Yingcheng WANG Haiqing GONG Qichao ZHU Jianbo SHEN Xuejun LIU Zhenling CUI | 2023 | Frontiers of Agricultural Science and Engineering2023，10，2： | 2 |
| 10 | Hybrid-integrated high-performance microwave photonic filter with switchable response显示文摘The integrated microwave photonic filter(MPF),as a compelling candidate for next-generation radio-frequency(RF)applications,has been widely investigated for decades.However,most integrated MPFs reported thus far have merely incorporated passive photonic components onto a chip-scale platform,while all necessary active devices are still bulk and discrete.Though few attempts to higher photonic integration of MPFs have been executed,the achieved filtering performances are fairly limited,which impedes the pathway to practical deployments.Here,we demonstrate,for the first time to our knowledge,an all-integrated MPF combined with high filtering performances,through hybrid integration of an In P chip-based laser and a monolithic silicon photonic circuit consisting of a dual-drive Mach–Zehnder modulator,a high-Q ring resonator,and a photodetector.This integrated MPF exhibits a high spectral resolution as narrow as 360 MHz,a wide-frequency tunable range covering the S-band to K-band(3 to 25 GHz),and a large rejection ratio of>40 d B.Moreover,the filtering response can be agilely switched between the bandpass and band-stop function with a transient respond time(48μs).Compared with previous MPFs in a similar integration level,the obtained spectral resolution in this work is dramatically improved by nearly one order of magnitude,while the valid frequency tunable range is broadened more than twice,which can satisfy the essential filtering requirements in actual RF systems.As a paradigm demonstration oriented to real-world scenarios,high-resolution RF filtering of realistic microwave signals aiming for interference rejection and channel selection is performed.Our work points out a feasible route to a miniaturized,high-performance,and cost-effective MPF leveraging hybrid integration approach,thus enabling a range of RF applications from wireless communication to radar toward the higher-frequency region,more compact size,and lower power consumption. | YUANSHENG TAO HAOWEN SHU XINGJUN WANG MING JIN ZIHAN TAO FENGHE YANG JINGBO SHI JUN QIN | 2021 | Photonics Research2021，9，8： | 2 |
| 11 | Fabrication of nanozyme@DNA hydrogel and its application in biomedical analysis显示文摘Nanozymes 由于容易的准备和低费用的优点收到了大注意。不同于乐意地适应生理的环境的自然的酶,人工的 nanozymes 是容易的在复杂临床的样品使钝化(例如,浆液) ,它可以损坏催化能力并且因而在生物医学的分析限制申请。为了征服这个问题,在这研究,我们由把 nanozymes 合并到纯 DNA hydrogel 制作了新奇 nanozyme@DNA hydrogel 建筑学。金 nanoparticles (AuNPs ) 作为模型 nanozyme 被采用。当他们被 hydrogel 保护,结果显示在 DNA hydrogel 合并的 AuNPs 在浆液保留他们的催化能力,而 AuNPs 完全独自在浆液失去催化能力。在浆液的氢过氧化物和葡萄糖的察觉基于 AuNPs@DNA hydrogel 的催化作用被完成。分别地,各个的察觉限制到达 1.7 和 38 M 它等于用自然的酶获得的价值。除机制以外,一些另外的优点例如再循环能力和可获得性,也被探索了。这 nanozyme@DNA hydrogel 体系结构可以在复杂生理的样品为生物医学的分析象 nanozymes 的申请一样为 nanozymes 的利用有一个大潜力。 | Xiaoli Zhu Xiaoxia Mao Zihan Wang Chang Feng Guifang Chen Genxi Li | 2017 | Nano Research2017，10，3： | 2 |
| 12 | Rock crevices determine woody and herbaceous plant cover in the karst critical zone显示文摘The study of the critical zones(CZs) of the Earth link the composition and function of aboveground vegetation with the characteristics of the rock layers, providing a new way to study how the unique rock and soil conditions in karst regions affect the aboveground vegetation. Based on survey results of the rocks, soils and vegetation in the dolomite and limestone distribution areas in the karst area of central Guizhou, it was found that woody plant cover increases linearly with the number of cracks with a width of more than 1 mm, while the cover of herbaceous plants shows the opposite trend(p<0.01). The dolomite distribution area is characterized by undeveloped crevices, and the thickness of the soil layer is generally less than 20 cm, which is suitable for the distribution of herbaceous plants with shallow roots. Due to the development of crevices in the limestone distribution area, the soil is deeply distributed through the crevices for the deep roots of trees, which leads to a diversified species composition and a complicated structure in the aboveground vegetation. Based on moderate resolution imaging spectroradiometer(MODIS) remote sensing data from 2001 to 2010, the normalized differentiated vegetation index(NDVI) and annual net primary productivity(NPP) results for each phase of a 16-day interval further indicate that the NDVI of the limestone distribution area is significantly higher than that in the dolomite distribution area, but the average annual NPP is the opposite. The results of this paper indicate that in karst CZs, the lithology determines the structure and distribution of the soil, which further determines the cover of woody and herbaceous plants in the aboveground vegetation. Although the amount of soil in the limestone area may be less than that in the dolomite area, the developed crevice structure is more suitable for the growth of trees with deep roots, and the vegetation activity is strong. At present, the treatment of rocky desertification in karst regions needs to fully consider the rock-soilvegetation-air interactions in karst CZs and propose vegetation restoration measures suitable for different lithologies. | Hongyan LIU Zihan JIANG Jingyu DAI Xiuchen WU Jian PENG Hongya WANG Jeroen MEERSMANS Sophie M.GREEN Timothy A.QUINE | 2019 | Science China Earth Sciences2019，62，11： | 2 |
| 13 | Surface coal mining impacts on land use change and ecological service value:a case study in Shengli coalfield,Inner Mongolia显示文摘Coal plays a crucial role in global economic development and remains the most common and widely distributed fossil fuel worldwide.As the world's largest developing country,China's mining and utilization of coal resources have contributed signifcantly to the country’s rapid economic growth.Inner Mongolia is an ecologically fragile arid and semi-arid area of China.The exploitation of opencast mining has seriously hindered the sustainable use of regional land and the residents'well-being.Using ENVI-based remote sensing images from 2000,2005,2010,2015,and 2020,this study employed a random forest algorithm to divide land utilization types into construction land,vegetation,cultivated land,bare land,and water areas and analyzed the characteristics of land use and ecosystem service value changes over the past 20 years.The results were as follows:(1)Construction land in the mining area changed minimally from 2000 to 2020;vegetation and water bodies showed a decreasing trend,whereas bare and cultivated lands showed an increasing trend.Bare land exhibited the largest change in area proportion and water bodies the smallest.(2)The total ecosystem service value of the mining area declined from 10.939 to 9.527 billion Yuan.Vegetation ecosystem service value was the highest,followed by cultivated land and water,with the bare land ecosystem service value the lowest.(3)On a spatial scale,the total ecosystem service value of the Shengli mining area decreased year by year,indicating that land use changes in the mining area do have an impact on ecosystem service value. | Lijia Zhang Xu Zhou Yan Zhou Ji Zhou Jiwang Guo Zihan Zhai Yan Chen Xiangyan Su Lingxiao Ying Liwei Wang Ying Qiao | 2022 | International Journal of Coal Science & Technology2022，9，5： | 1 |
| 14 | Analysis of the Role of General Practitioners Services in Rural Areas during the COVID-19 Epidemic显示文摘Since the outbreak of the COVID-19,various regions of China have been rapidly deployed under the leadership of the Central Committee of the Party to actively prevent and control the COVID-19.The rural areas of my country have weak links to the prevention and management of public health emergencies.Problems include lack of medical and health resources and farmers’low awareness of epidemic prevention.Situations that correspond to the prevention and management of the COVID-19 are more serious.As the patient’s first contact and“gatekeeper”in the fight against the epidemic,the general practitioner is responsible for the“first visit-subsequent ongoing intervention”.This article is about the prevention and control of the COVID-19 epidemics and epidemic prevention in terms of dissemination of knowledge,informed crowd control,joint prevention and control,and standardized management of people.This is a summary of the efforts of general practitioners.Quarantine at home,interactive referrals to medical consortiums,special care for contracted families.The function during the management period aims to analyze the role played by general practitioners during the epidemic and to provide new ideas for the prevention and management of the epidemic.Provide more targeted general practitioner-style services in rural areas to promote the implementation and improvement of health and poverty alleviation.The health level of the rural population provides a theoretical standard. | Zuohua Liu Feiya Li Zihan Liu Qiuxia Wu Xiangyu Li Qiang Wang | 2021 | Journal of Advances in Medicine Science2021，4，2： | 1 |
| 15 | Freestanding Pt nanosheets with high porosity and improved electrocatalytic performance toward the oxygen reduction reaction显示文摘Because of the intriguing electronic properties, high specific surface areas and confinement effect, two-dimensional(2D) noble metal nanosheets usually exhibit fascinating physicochemical properties and thus hold great promises in fuel cell devices and beyond. Herein, 2D porous Pt nanosheets composed by interweaved ultrathin nanowires are successfully fabricated via a facile NaCl-templated process. Controlled experiments demonstrate that the adoption of NaCl and appropriate ratio of NaCl and Pt precursor are indispensable for the formation of porous Pt nanosheets. Impressively, the cost-effective NaCl template can be recyclable through a simple recrystallization procedure, which may greatly reduce the synthetic cost. By virtue of their structural merits, including high porosity, 2D anisotropy and abundant defects, the resultant porous Pt nanosheets exhibit superior activity and enhanced stability towards the oxygen reduction reaction(ORR) compared to the commercial Pt black in alkaline medium. The present study not only offers a high-performance electrocatalyst for fuel cell devices, but also provides a new perspective toward the rational synthesis of 2D noble metal nanosheets with high porosity and diverse functionalities. | Chuang Fan Zihan Huang Xianyu Hu Zhaoping Shi Tianyang Shen Yawen Tang Xiaojun Wang Lin Xu | 2018 | Green Energy & Environment2018，3，4： | 1 |
| 16 | Occurrence and risk assessment of triclosan in freshwater lakes in the middle Yangtze River basin (Wuhan, Central China)显示文摘Triclosan(TCS)is an endocrine disrupting chemical which is commonly used as a disinfectant in pharmaceuticals and personal care products(PPCP's).Since early 2020,the worldwide outbreak of COVID-19 has increased the use of PPCP's,so the occurrence and impact of TCS on freshwater lakes should be considered.However,little attention has been given to the effect of TCS on freshwater lakes in China.This study is the first attempt at a risk assessment focusing on the temporal and spatial occurrence of TCS in freshwater lakes in the middle Yangtze River basin.The surface water and sediments of Donghu Lake and Liangzi Lake(Wuhan,Central China)were collected from October 2020 to August 2021.The maximum concentrations of TCS were 466 ng/L and 239 ng/L in surface water,71 ng/g and 25 ng/g(dry weight)in sediments of Donghu Lake and Liangzi Lake,respectively.Significant temporal and spatial differences of TCS were observed within and between the lakes,with the highest concentrations measured in winter.Furthermore,higher concentrations of TCS were observed in areas that are more impacted by human activities.There was a significant positive correlation between TCS and nitrogen in the surface water.A risk assessment using the risk quotient(RQ)method showed that a potentially high risk(RQ>1)was found only in surface waters from Donghu Lake,and that the sediments posed a lower risk than the surface waters.These results provide timely data on the temporal and spatial occurrence of TCS in freshwater lakes in China following the outbreak of COVID-19 and demonstrate a possible high risk of exposure to TCS for aquatic biota. | Yuewei Wang Deshou Cun Zihan Zhang Dongwei Pu Xiaohui Li Wei Liang Tao Fang | 2022 | Water Biology and Security2022，1，4： | 1 |
| 17 | Multiscale evolution mechanism of sandstone under wet-dry cycles of deionized water:From molecular scale to macroscopic scale显示文摘Water is the most abundant molecule found on the earth’s surface and is a key factor in multiscale rock destruction.However,given the fine-grained nature of rock and the complexity of its internal structure,the microstructural evolution of rock under the action of water has not yet been elucidated in detail,and little is understood about the relationship between the rock structure and solideliquid unit.A variety of techniques were used in this study to track the mechanical properties,pore and crack characteristics,and mineral structure degradation characteristics of sandstone at different stages under the action of deionized water,and the evolution mechanisms of the microstructure were analyzed at the molecular scale.The results showed that during the watererock interaction process,water was adsorbed onto the surface of dolomite minerals and the hydrophilic surface of clay minerals,forming a high-density hydrogen bond network.However,different mineral surface structures had different water adsorption structures,resulting in the strain of the dense clay mineral aggregates under expansion action.Stress concentrated at crack tips under the capillary force of dolomite minerals(very weak dolomite dissolution).These effects resulted in a substantial increase in the number of small pores and enhancements in poreecrack connectivity,and the rock strength exhibited varying degrees of decline at different stages of wet-dry cycles.In general,the results of this paper will help to further elucidate the internal connections between molecular-scale and macroscale processes in rock science. | Jie Meng Changdong Li Jia-Qing Zhou Zihan Zhang Shengyi Yan Yahui Zhang Dewei Huang Guihua Wang | 2023 | Journal of Rock Mechanics and Geotechnical Engineering2023，15，5： | 1 |
| 18 | Triboelectric nanogenerators enabled internet of things:A survey显示文摘As pioneering information technology,the Internet of Things(IoT)targets at building an infrastructure of embedded devices and networks of connected objects,to offer omnipresent ecosystem and interaction across billions of smart devices,sensors,and actuators.The deployment of IoT calls for decentralized power supplies,selfpowered sensors,and wireless transmission technologies,which have brought both opportunities and challenges to the existing solutions,especially when the network scales up.The Triboelectric Nanogenerators(TENGs),recently developed for mechanical energy harvesting and mechanical-to-electrical signal conversion,have the natural properties of energy and information,which have demonstrated high potentials in various applications of IoT.This context provides a comprehensive review of TENG enabled IoT and discusses the most popular and significant divisions.Firstly,the basic principle of TENG is re-examined in this article.Subsequently,a comprehensive and detailed review is given to the concept of IoT,followed by the scientific development of the TENG enabled IoT.Finally,the future of this evolving area is addressed. | Jiarong Li Changsheng Wu Ishara Dharmasena Xiaoyue Ni Zihan Wang Haixu Shen Shao-Lun Huang Wenbo Ding | 2020 | Intelligent and Converged Networks2020，1，2： | 1 |
| 19 | Seven new 3,4-dihydro-furanocoumarin derivatives from Angelica dahurica显示文摘Objective:To study the chemical constituents of the roots of Angelica dahurica,a well-known Chinese herbal medicine named Baizhi in Chinese.Methods:Compounds were separated by various chromatographies,and the structures of new compounds were elucidated based on the analysis of their spectroscopic and spectrometric data(1D,2D NMR,HRESI MS,IR,and UV).The absolute configurations of new compounds were determined by the calculated electronic circular dichroism and chemical derivatization.The inhibitory activities of all isolates against nitric oxide(NO)production were evaluated using lipopolysaccharide-activated RAW 264.7macrophage cells.Results:Seven new 3,4-dihydro-furanocoumarin derivatives(1a/1b,2a/2b,3a/3b,4)together with a known furanocoumarin(5)were isolated from the roots of A.dahurica.The new compounds included three pairs of enantiomers,(4S,2’’R)-angelicadin A(1a)/(4R,2’’S)-angelicadin A(1b),(4S,2’’S)-angelicadin A(2a)/(4R,2’’R)-angelicadin A(2b),and(4S,2’’S)-secoangelicadin A(3a)/(4R,2’’R)-secoangelicadin A(3b),together with(4R,2’’R)-secoangelicadin A methyl ester(4).The known xanthotoxol(5)inhibited the NO production with the half-maximal inhibitory concentration(IC50)value of(32.8±0.8)μmol/L,but all the new compounds showed no inhibitory activities at the concentration of100μmol/L.Conclusion:This is the first report of the discovery of 3,4-dihydro-furanocoumarins from A.dahurica.The results are not only meaningful for the understanding of the chemical constituents of A.dahurica,but also enrich the reservoir of natural products. | Yang Wang Fanyu Shi Zihan Lu Mingliang Zhang Zekun Zhang Fangfang Jia Beibei Zhang Lishan Ouyang Zhixiang Zhu Shepo Shi | 2023 | Chinese Herbal Medicines2023，15，3： | 1 |
| 20 | Biomedical applications of the powder-based 3D printed titanium alloys:A review显示文摘3D printing technology is a new type of precision forming technology and the core technology of the third industrial revolution.The powder-based 3D printing technology of titanium and its alloys have received great attention in biomedical applications since its advantages of custom manufacturing,costsaving,time-saving,and resource-saving potential.In particular,the personalized customization of 3D printing can meet specific needs and achieve precise control of micro-organization and structural design.The purpose of this review is to present the most advanced multi-material 3D printing methods for titanium-based biomaterials.We first reviewed the bone tissue engineering,the application of titanium alloy as bone substitutes and the development of manufacturing technology,which emphasized the advantages of 3D printing technology over traditional manufacturing methods.What is more,the optimization design of the hierarchical structure was analyzed to achieve the best mechanical properties,and the biocompatibility and osseointegration ability of the porous titanium alloy after implantation in living bodies was analyzed.Finally,we emphasized the development of digital tools such as artificial intelligence,which provides new ideas for the rational selection of processing parameters.The 3D printing titanium-based alloys will meet the huge market demand in the biomedical field,but there are still many challenges,such as the trade-off between high strength and low modulus,optimization of process parameters and structural design.We believe that the combination of mechanical models,machine learning,and metallurgical knowledge may shape the future of metal printing. | Amy X.Y.Guo Liangjie Cheng Shuai Zhan Shouyang Zhang Wei Xiong Zihan Wang Gang Wang Shan Cecilia Cao | 2022 | Journal of Materials Science & Technology2022，，30： | 1 |
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