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| 1 | Atorvastatin attenuates surgery-induced BBB disruption and cognitive impairment partly by suppressing NF-κB pathway and NLRP3 inflammasome activation in aged mice显示文摘In clinic,perioperative neurocognitive disorder is becoming a common complication of surgery in old patients.Neuroinflammation and blood-brain barrier(BBB)disruption are important contributors for cognitive impairment.Atorvastatin,as a strong HMG-CoA reductase inhibitor,has been widely used in clinic.However,it remains unclear whether atorvastatin could prevent anesthesia and surgery-induced BBB disruption and cognitive injury by its anti-inflammatory property.In this study,aged C57BL/6J mice were used to address this question.Initially,the mice were subject to atorvastatin treatment for 7 days(10 mg/kg).After a simple laparotomy under 1.5%isoflurane anesthesia,Morris water maze was performed to assess spatial learning and memory.Western blot analysis,immunohistochemistry,and enzyme-linked immunosorbent assay were used to examine the inflammatory response,BBB integrity,and cell apoptosis.Terminal-deoxynucleotidyl transferase mediated nick end labeling assay was used to assess cell apoptosis.The fluorescein sodium and transmission electron microscopy were used to detect the permeability and structure of BBB.The results showed that anesthesia and surgery significantly injured hippocampal-dependent learning and memory,which was ameliorated by atorvastatin.Atorvastatin could also reverse the surgery-induced increase of systemic and hippocampal cytokines,including IL-1β,TNF-α,and IL-6,accompanied by inhibiting the nuclear factor kappa-B(NF-κB)pathway and Nucleotide-Binding Oligomerization Domain,or Leucine Rich Repeat and Pyrin Domain Containing 3(NLRP3)inflammasome activation,as well as hippocampal neuronal apoptosis.In addition,surgery triggered an increase of BBB permeability,paralleled by a decrease of the ZO-1,occludin,and Claudin 5 proteins in the hippocampus.However,atorvastatin treatment could protect the BBB integrity from the impact of surgery,by up-regulating the expressions of ZO-1,occludin,and Claudin 5.These findings suggest that atorvastatin exhibits neuroprotective effects on cognition in aged mice undergoing surgery. | Pengfei Liu Quansheng Gao Lei Guan Yanting Hu Jingwen Jiang Teng Gao Weixuan Sheng Xinying Xue Hui Qiao Tianzuo Li | 2021 | Acta Biochimica et Biophysica Sinica2021，53，5： | 6 |
| 2 | Towards an entropy-based detached-eddy simulation显示文摘A concept of entropy increment ratio()is introduced for compressible turbulence simulation through a series of direct numerical simulations(DNS). represents the dissipation rate per unit mechanical energy with the benefit of independence of freestream Mach numbers.Based on this feature,we construct the shielding function fs to describe the boundary layer region and propose an entropy-based detached-eddy simulation method(SDES).This approach follows the spirit of delayed detached-eddy simulation(DDES)proposed by Spalart et al.in 2005,but it exhibits much better behavior after their performances are compared in the following flows,namely,pure attached flow with thick boundary layer(a supersonic flat-plate flow with high Reynolds number),fully separated flow(the supersonic base flow),and separated-reattached flow(the supersonic cavity-ramp flow).The Reynolds-averaged Navier-Stokes(RANS)resolved region is reliably preserved and the modeled stress depletion(MSD)phenomenon which is inherent in DES and DDES is partly alleviated.Moreover,this new hybrid strategy is simple and general,making it applicable to other models related to the boundary layer predictions. | ZHAO Rui YAN Chao LI XinLiang KONG WeiXuan | 2013 | Science China(Physics,Mechanics & Astronomy)2013，56，10： | 3 |
| 3 | On Mineralize-halo-forming Mechanism of Sareke Glutenite-type Copper Deposit in Xinjiang显示文摘1 Introduction Sareke glutenite-type copper deposit is located in the Sarekebayi basin,a sub-basin of southwest margin of the Tuoyun Mesozoic hinterland basin in the northwestern part of the Tarim Basin.The Tuoyun Mesozoic | YU Wangjie FANG Weixuan Guo Yuqian Wang Lei Li Tiancheng Lu Jia | 2017 | Acta Geologica Sinica(English Edition)2017，91，S1： | 3 |
| 4 | Seasonal variation of gut Cyanophyta contents and liver GST expression of mud carp(Cirrhina molitorella) and Nile tilapia(Oreochromis niloticus) in the tropical Xiangang Reservoir(Huizhou,China)显示文摘Liver glutathione S-transferase(GST) plays a major role in the detoxification of microcystins(MCs) via conjugation to glutathione(GSH).We evaluated the relationship between seasonal variation in fish gut contents and the expression of GST isoforms in mud carp(Cirrhina molitorella) and Nile tilapia(Oreochromis niloticus).We quantified the abundance and diversity of plankton in the water column and foregut of mud carp and Nile tilapia in the tropical Xiangang Reservoir between October 2007 and July 2008.The mRNA expression of 7 liver GST isoforms was determined by real-time RT-PCR.The gut contents of both species were dependent on the amount and type of phytoplankton and zooplankton in the water.The expression of liver GST genes in Nile tilapia and mud carp was positively and negatively correlated,respectively,with the abundance of toxic cyanobacteria in the fore-gut.The expression of liver GST mRNA was correlated to the abundance of toxic cyanobacteria in the gut contents of both species,suggesting that mRNA expression of GST isoforms could be used as a biomarker in Nile tilapia and mud carp to monitor cyanobacteria blooms in reservoirs. | CHENG WeiXuan LIANG XuFang SHEN Dan ZHOU Qiong HE Yan HE Shan LI GuangYu | 2012 | Chinese Science Bulletin2012，57，6： | 3 |
| 5 | Studies on Cataclastic Lithofacies and Copper Metallogenic Regularity for the Glutenite-type Sareke Copper deposit, Xinjiang显示文摘1 Introduction Large-size glutenite-type copper deposit was controlled by the Mesozoic Sarekebayi intracontinental pull-apart basin in Xinjiang.Strata exposed in the study area include the Mesoproterozoic Akesu Group Complex, | HAN Wenhua FANG Weixuan ZHANG Guishan Lu jia Wang lei JIA Runxing LI Tiancheng | 2017 | Acta Geologica Sinica(English Edition)2017，91，S1： | 3 |
| 6 | Integration of high-throughput phenotyping,GWAS,and predictive models reveals the genetic architecture of plant height in maize显示文摘Plant height(PH)is an essential trait in maize(Zea mays)that is tightly associated with planting density,biomass,lodging resistance,and grain yield in the field.Dissecting the dynamics of maize plant architecture will be beneficial for ideotype-based maize breeding and prediction,as the genetic basis controlling PH in maize remains largely unknown.In this study,we developed an automated high-throughput phenotyping platform(HTP)to systematically and noninvasively quantify 77 image-based traits(i-traits)and 20 field traits(f-traits)for 228 maize inbred lines across all developmental stages.Time-resolved i-traits with novel digital phenotypes and complex correlations with agronomic traits were characterized to reveal the dynamics of maize growth.An i-trait-based genome-wide association study identified 4945 traitassociated SNPs,2603 genetic loci,and 1974 corresponding candidate genes.We found that rapid growth of maize plants occurs mainly at two developmental stages,stage 2(S2)to S3 and S5 to S6,accounting for the final PH indicators.By integrating the PH-association network with the transcriptome profiles of specific internodes,we revealed 13 hub genes that may play vital roles during rapid growth.The candidate genes and novel i-traits identified at multiple growth stages may be used as potential indicators for final PH in maize.One candidate gene,ZmVATE,was functionally validated and shown to regulate PH-related traits in maize using genetic mutation.Furthermore,machine learning was used to build predictive models for final PH based on i-traits,and their performancewas assessed across developmental stages.Moderate,strong,and very strong correlations between predictions and experimental datasets were achieved from the early S4(tenth-leaf)stage.Colletively,our study provides a valuable tool for dissecting the spatiotemporal formation of specific internodes and the genetic architecture of PH,as well as resources and predictive models that are useful for molecular design breeding and predicting maize varieties with ideal plant architectures. | Weixuan Wang Weijun Guo Liang Le Jia Yu Yue Wu Dongwei Li Yifan Wang Huan Wang Xiaoduo Lu Hong Qiao Xiaofeng Gu Jian Tian Chunyi Zhang Li Pu | 2023 | Molecular Plant2023，16，2： | 1 |
| 7 | Ensemble-based uncertainty quantification for coordination and control of thermostatically controlled loads显示文摘This work investigates an uncertainty quantification(UQ)framework that analyses the uncertainty involved in modelling control systems to improve control strategy performance.The framework involves solving four problems:identifying uncertain parameters,propagating uncertainty to the quantity of interest,data assimilation and making decisions under quantified uncertainties.A specific group of UQ approaches,known as the ensemble-based methods,are adopted to solve these problems.This UQ framework is applied to coordinating a group of thermostatically controlled loads,which relies on simulating a second-order equivalent thermal parameter model with some uncertain parameters.How this uncertainty affects the prediction and the control of total power is examined.The study shows that uncertainty can be effectively reduced using the measurement of air temperatures.Also,the control objective is achieved fairly accurately with a quantification of the uncertainty. | Weixuan Li Jianming Lian Dave Engel Hong Wang | 2018 | Journal of Control and Decision2018，5，2： | 1 |
| 8 | Emerging low-density polyethylene/paraffin wax/aluminum composite as a form-stable phase change thermal interface material显示文摘Thermal interface materials(TIMs) play a vital role in the thermal management of electronic devices and can significantly reduce thermal contact resistance(TCR). The TCR between the solid–liquid contact surface is much smaller than that of the solid–solid contact surface, but conventional solid–liquid phase change materials are likely to cause serious leakage. Therefore, this work has prepared a new formstable phase change thermal interface material. Through the melt blending of paraffin wax(PW) and low-density polyethylene(LDPE), the stability is improved and it has an excellent coating effect on PW. The addition of aluminum(Al) powder improves the low thermal conductivity of PW/LDPE, and the addition of 15wt% Al powder improves the thermal conductivity of the internal structure of the matrix by 67%. In addition, the influence of the addition of Al powder on the internal structure, thermal properties, and phase change behavior of the PW/LDPE matrix was systematically studied. The results confirmed that the addition of Al powder improved the thermal conductivity of the material without a significant impact on other properties, and the thermal conductivity increased with the increase of Al addition. Therefore, morphologically stable PW/LDPE/Al is an important development direction for TIMs. | Chuanchang Li Weixuan Wang Xiaoliang Zeng Chunxuan Liu Rong Sun | 2023 | International Journal of Minerals,Metallurgy and Materials2023，30，4： | 1 |
| 9 | Rapid CO_(2)-laser scribing fabrication of an electrochemical sensor for the direct detection of Pb^(2+) and Cd^(2+)显示文摘Laser-induced graphene(LIG)is a highly promising preparation material for electrochemical sensors;however,its preparation speed and nanomaterial modification steps significantly limit its mass production.Herein,this study proposed a new laser printing strategy that considerably improved the preparation speed of LIG with excellent electrochemical performance.Using the optimal parameters(laser power of 1%,scribing spacing of 0.12 mm,scribing speed of 100 mm·s^(−1)),it took only 14.2 s to complete the preparation of the detection electrode.Thus,we successfully detected Cd^(2+)and Pb^(2+)without any toxic reagents or electrode modification steps.The limits of detection of the sensor were 0.914 and 0.916μg·L^(−1)for Cd^(2+)and Pb^(2+),respectively,which are significantly lower than the required values for drinking-water quality,according to the World Health Organization guidelines.This study provides a novel approach for the rapid detection of heavy-metal ions. | Guanglei Chu Yanyan Zhang Zhongrui Zhou Weixuan Zeng Dongfei Chen Siping Yu Jiemin Wang Yemin Guo Xia Sun Ming Li | 2023 | Nano Research2023，16，5： | 1 |
| 10 | A weighted Lq adaptive least squares support vector machine classi- fiers-Robust and sparse approximation 显示文摘 | Liu Jingli Li Jianping Xu Weixuan | 2011 | Expert Sys- tems with Applications2011，38，3： | 1 |
| 11 | Miura-ori enabled stretchable circuit boards显示文摘Origami,an ancient form of papercraft,provides a way to develop functional structures for engineering applications.In this paper,we report an approach to design and manufacture a stretchable circuit board(SCB)with origami structures.The benefits of developable,flat-foldable,and rigid-foldable origami-based structures as SCBs are discussed,and a representative structure,Miura fold(or Miura-ori),is chosen to be investigated.Under the constraints induced by the mounted components’dimensions,the Miura-ori structures for specific applications can be defined.We propose three methods for better fabrication,including direct folding,stiffness modification,and kirigami enhancement,to improve a planar sheet’s foldability.A wearable ECG(electrocardiogram)system based on MO-SCB(Miura-ori enabled SCB)technology is built,and the stretchable portion is made of commercial FPCBs(flexible printed circuit board),providing desired stretchability and reliability.The proposed technology routine is compatible with industrial production and may pave the application of stretchable electronics. | Yongkai Li Weixuan Liu Yang Deng Wei Hong Hongyu Yu | 2021 | npj Flexible Electronics2021，5，1： | 1 |
| 12 | A weighted Lq adaptive least squares support vector machine Classifiers Robust and sparse approximation显示文摘 | IAU Jingli LI Jingping XU Weixuan | 2011 | Expert Systems with Applications2011，38，3： | 1 |
| 13 | Complexity and Geodynamics of Ore-accumulating Basins in the Qinling Orogenic Belt,China显示文摘Researches were made of different continental-margin and intraplate basin systems in the Qinling mi-croplate in terms of hydrothermal deposition, geodynamics of basin formation, hydrothermal sedimentary rock facies, syntectonics in the basins, and the styles of ore accumulation in the basins. | FANG Weixuan ZHANG Guowei LU Jiying LI Yaling | 2000 | Acta Geologica Sinica(English Edition)2000，74，3： | 1 |
| 14 | Simulation Analysis of Torsion Beam Hydroforming Based on the Fluid-Solid Coupling Method显示文摘Hydroformed parts are widely used in industrial automotive parts because of their higher stiffness and fatigue strength and reduced weight relative to their corresponding cast and welded parts.This paper reports a hydraulicforming experimental platform for rectangular tube fittings that was constructed to conduct an experiment on the hydraulic forming of rectangular tube fittings.A finite element model was established on the basis of the fluid–solid coupling method and simulation analysis.The correctness of the simulation analysis and the feasibility of the fluid–solid coupling method for hydraulic forming simulation analysis were verified by comparing the experimental results with the simulation results.On the basis of the simulation analysis of the hydraulic process of the torsion beam using the fluid–solid coupling method,a sliding mold suitable for the hydroforming of torsion beams was designed for its structural characteristics.The effects of fluid characteristics,shaping pressure,axial feed rate,and friction coefficient on the wall thicknesses of torsions beams during formation were investigated.Fluid movement speed was related to tube deformation.Shaping pressure had a significant effect on rounded corners and straight edges.The axial feed speed was increased,and the uneven distribution of wall thicknesses was effectively improved.Although the friction coefficient had a nonsignificant effect on the wall thickness of the ladder-shaped region,it had a significant influence on a large deformation of wall thickness in the V-shaped area.In this paper,a method of fluid-solid coupling simulation analysis and sliding die is proposed to study the high pressure forming law in torsion beam. | Yu Huang Jian Li Jiachun Yang Yongdong Peng Weixuan Zhang | 2023 | Chinese Journal of Mechanical Engineering2023，36，1： | 1 |
| 15 | Nitrogen-enriched micro-mesoporous carbon derived from polymers organic frameworks for high-performance capacitive deionization显示文摘Nitrogenization is an effective method for improving the capacitive deionization(CDI)performance of porous carbon materials.In particular,polymer organic frameworks with heteroatom doping,containing an ordered pore structure and excellent electrochemical stability,are ideal precursors for carbon materials for high-performance CDI.In this study,a nitrogen-enriched micro-mesoporous carbon(NMC)electrode was fabricated by carbonizing a Schiff base network-1 at 500,600,and 700℃.Scanning electron microscopy,Fourier transform infrared spectroscopy,X-ray diffraction,N_(2) adsorption-desorption,the contact angle of water,cyclic voltammetry,and electrochemical impedance spectroscopy were used to characterize the morphological structure,wettability,Brunauer–Emmett–Teller surface areas,and electrochemical performance of the NMCs.The results showed that the NMC carbonized at 600℃ achieved the best specific capacitance(152.33 F/g),as well as a high electrosorption capacity(25.53 mg/g)because of its chemical composition(15.57%N)and surface area(312 m^(2)/g).These findings prove that NMC is viable as an electrode material for desalination by high-performance CDI applications. | Jianpei Zhang Xun-an Ning Danping Li Yi Wang Xiaojun Lai Weixuan Ou | 2022 | Journal of Environmental Sciences2022，34，1： | 0 |
| 16 | Poverty Decentralization or Reconcentration: An Empirical Study of the Effects of Collected Public Rental Housing in Changzhou, Jiangsu Province显示文摘Based on the supply-side reform objective, it is a great transformation of housing welfare measures in China to collect private unoccupied houses as public rental housing instead of building new ones. Through an empirical study of the Collecting Houses as Public Rental Housing Program in Changzhou, this paper finds that the collected houses is relatively scattered in the city, which is beneficial to avoiding over-centralization and marginalization of the poor families. However, it has resulted in poverty reconcentration in some old communities, probably further leading to spatial solidification of the poor as well as a further decline of old communities. Therefore it may not effectively solve the housing problems of the poor population by providing this alternative public rental housing, which is collected according to economic efficiency. Accordingly, the paper argues that it is necessary to reinforce community development and to renovate the declined communities in time, as an important supplement to housing welfare improvement. | Sun Jie Zhu Xigang Song Weixuan Liu Fengbao Li Min | 2018 | China City Planning Review2018，27，2： | 0 |
| 17 | Dual-engineered cartilage-targeting extracellular vesicles derived from mesenchymal stem cells enhance osteoarthritis treatment via miR-223/NLRP3/pyroptosis axis:Toward a precision therapy显示文摘Osteoarthritis(OA)is the most common disabling joint disease with no effective disease modifying drugs.Extracellular vesicles released by several types of mesenchymal stem cells could promote cartilage repair and ameliorate OA pathology in animal models,representing a novel therapeutic strategy.In this study,we demonstrated that extracellular vesicles derived from human umbilical cord mesenchymal stem cells(hUC-EVs)could maintain chondrocyte homeostasis and alleviate OA,and further revealed a novel molecular mechanism of this therapeutic effect.miR-223,which could directly bind with the 3′UTR of NLRP3 mRNA,was found to be a key miRNA for hUC-EVs to exert beneficial effects on inflammation inhibiting and cartilage protecting.For enhancing the effect on mitigating osteoarthritis,exogenous miR-223 was loaded into hUC-EVs by electroporation,and a collagen II-targeting peptide(WYRGRL)was modified onto the surface of hUC-EVs by genetic engineering to achieve a more targeted and efficient RNA delivery to the cartilage.The dual-engineered EVs showed a maximal effect on inhibiting the NLRP3 inflammasome activation and chondrocyte pyroptosis,and offered excellent results for the treatment of OA.This study provides a novel theoretical basis and a promising therapeutic strategy for the application of engineered extracellular vesicles in OA treatment. | Weixuan Liu Anqi Liu Xujun Li Ziyang Sun Zhenghua Sun Yaru Liu Gang Wang Dan Huang Hao Xiong Shiyang Yu Xintao Zhang Cunyi Fan | 2023 | Bioactive Materials2023，，12： | 0 |
| 18 | Collision-avoidance path planning for multi-ship encounters considering ship manoeuvrability and COLREGs显示文摘Ship collision prevention has always been a hot topic of research for navigation safety.Recently,autonomous ships have gained much attention as a means of solving collision problems by machine control with a collision-avoidance algorithm.An important question is how to determine optimal path planning for autonomous ships.This paper proposes a path-planning method of collision avoidance for multi-ship encounters that is easy to realize for autonomous ships.The ship course-control system uses fuzzy adaptive proportion-integral-derivative(PID)control to achieve real-time control of the system.The automatic course-altering process of the ship is predicted by combining the ship-motion model and PID controller.According to the COLREGs,ships should take different actions in different encounter situations.Therefore,a scene-identification model is established to identify these situations.To avoid all the TSs,the applicable course-altering range of the OS is obtained by using the improved velocity obstacle model.The optimal path of collision avoidance can be determined from an applicable course-altering range combined with a scene-identification model.Then,the path planning of collision avoidance is realized in the multi-ship environment,and the simulation results show a good effect.The method conforms to navigation practice and provides an effective method for the study of collision avoidance. | Yixiong He Zhaoran Li Junmin Mou Weixuan Hu Liling Li Bing Wang | 2021 | Transportation Safety and Environment2021，3，2： | 0 |
| 19 | Amylin:new insight into pathogenesis,diagnosis,and prognosis of non-insulin-dependent diabetesmellitus-related cardiomyopathy显示文摘Co-secretion with insulin,highly amyloidogenic human amylin is considered to contribute to the initiation and progression of diabetic heart complications,despite other situations such as hypertension and atherosclerosis.In response to insulin resistance,hyperinsulinemia,and consequently hyperamylinemia,is common in prediabetic patients,where highly concentrated amylin is prone to form amylin oligomers,which further assemble into fibrils and amyloids with high b-sheet content.The infusion and deposition of oligomeric amylin in myocytes cause a series of consequences,including cytosolic Ca^(2+)dysregulation,calmodulin activation,myocyte hypertrophy,and ventricular stiffness,eventually leading to heart failure.In this review,we present the latest reports of amylin-related heart complications,provide new insights,and state the underlying pathogenesis,diagnosis,possible treatment,and prevention of diabetic cardiomyopathy. | Jiaying Xie Zhoujie Tong Longfei Shen Yuanyuan Shang Yulin Li Bin Lu Weixuan Ma Wei Zhang Ming Zhong | 2022 | Emergency and Critical Care Medicine2022，2，1： | 0 |
| 20 | Curved display based on programming origami tessellations显示文摘Curved displays have recently become very popular,with wide applications for both industry and consumers.However,built upon initially flat films,most flexible displays are often incompatible with general nondevelopable surfaces.In this paper,we report a method for producing curved displays of nondevelopable shapes by using a structure-mechanics-inspired functional optimization method to design tessellation patterns that fold into the desired shapes.Representative displays in spherical and saddle shapes are demonstrated.The microfabrication process is employed for manufacturing 2D flexible foldable circuit boards,pick-and-place technology is used for placing illuminant elements onto the boards,and mold guidance is used for folding 2-D sheets into curved 3D display prototypes.The proposed technology is feasible for mass production and advances the application of next-generation curved displays. | Yang Deng Weixuan Liu Yik Kin Cheung Yongkai Li Wei Hong Hongyu Yu | 2021 | Microsystems & Nanoengineering2021，7，6： | 0 |
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