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| 1 | Photoperiod- and thermo-sensitive genic male sterility in rice are caused by a point mutation in a novel noncoding RNA that produces a small RNA显示文摘光周期敏感、 thermo 敏感的遗传因子的男绝育(PGMS 和 TGMS ) 是为在庄稼的混合繁殖的核心部件。基于使用的较普通活字大一倍的系统, PGMS 和 TGMS 衬里的混合大米是成功地在农业广泛地发展了并且适用。然而,位于 PGMS 和 TGMS 的控制下面的分子的机制仍然保持阴暗。在这研究,我们印射并且克隆一个主要地点, p/tms12-1 (染色体 12 上的感光性或 thermo 敏感的遗传因子的男绝育地点) 它在装饰用的梨树米饭线 Nongken 58S (NK58S ) 授与 PGMS 和在 indica 米饭的 TGMS 衬里 Peiai 64S (PA64S,源于 NK58S ) 。包含野类型的等位基因 P/TMS12-1 的 A 2.4-kb DNA 碎片能在基因互补恢复 NK58S 和 PA64S 植物的花粉富饶。P/TMS12-1 编码唯一的 noncoding RNA,它生产 21 核苷酸我们说出 osa-smR5864w 的小 RNA。在 p/tms12-1 的 C-to-G 的替换,相对 P/TMS12-1 的唯一的多型性,在变异的小 RNA 是在场的,也就是 osa-smR5864m。而且,在转基因的 NK58S 和 PA64S 植物的 P/TMS12-1 的一个 375-bp 序列的 overexpression 也生产了 osa-smR5864w 并且恢复了花粉富饶。小 RNA 在年轻圆锥花序优先地被表示,但是它的表示没被不同的天长度或温度显著地影响。我们的结果表明在 p/tms12-1 的点变化,可能为 osa-smR5864m 导致 loss-of-function,分别地在装饰用的梨树和 indica 线为 PGMS 和 TGMS 组成一个普通原因。我们的调查结果因此建议那小 RNA 基因是的这 noncoding 男开发的一个重要管理者由在基因网络和环境条件之间的串音控制了。 | Hai Zhou Qinjian Liu Jing Li Dagang Jiang Lingyan Zhou Ping Wu Sen Lu Feng Li Liya Zhu Zhenlan Liu Letian Chen Yao-Guang Liu Chuxiong Zhuang | 2012 | Cell Research2012，22，4： | 99 |
| 2 | Progress in research on Chinese urbanization显示文摘 | Chaolin GU Liya WU lan Cook | 2012 | Frontiers of Architectural Research2012，1，2： | 26 |
| 3 | Frequent Mutation of rs13281615 and Its Association with PVT1 Expression and Cell Proliferation in Breast Cancer显示文摘The q24 band of chromosome 8(8q24)is frequently amplified in human cancers including breast cancer,and several SNPs(single nucleotide polymorphisms)at 8q24,including rs13281615,have been identified for their association with cancer risks.These SNPs are in a'gene desert'region,and their functions in cancer development remain to be illustrated,although several of the SNPs appear to influence the genes in the'desert'in a long-range manner,including the v-myc avian myelocytomatosis viral oncogene homolog(MYC)and the nonprotein coding plasmacytoma variant translocation 1(PVT1),both of which have been implicated in human cancers.In the current study,we examined rs13281615 for its potential role in breast cancer using normal and cancer tissues from 121 Chinese women with breast cancer.In addition to confirming the association of the GG genotype of rs13281615 with breast cancer risk,we found that germline GG genotype was significantly associated with estrogen receptor(ER)positivity,higher tumor grade and higher proliferation index.We also found frequent somatic mutations(22/121 or 18.2%)of this SNP in breast cancer.Interestingly,the majority of the mutations(17/22 or 77%)involved a G/A change,resulting in a decrease in the number of cancers with the GG risk genotype and subsequent loss of GG association with higher tumor grade and proliferation index in cancers.Furthermore,PVT1 expression was increased in cancers,and the increase was associated with the GG genotype of rs13281615.These results suggest that the GG genotype of SNP rs13281615 plays a role in breast cancer likely by influencing PVT1 expression,and that during oncogenesis,'protective'mutations could occur. | Zhiqian Zhang Zhengmao Zhu Baotong Zhang Weidong Li Xin Li Xiao Wu Lijuan Wang Liya Fu Li Fu Jin-Tang Dong | 2014 | Journal of Genetics and Genomics2014，41，4： | 12 |
| 4 | Counteraction of ABA-Mediated Inhibition of Seed Germination and Seedling Establishment by ABA Signaling Terminator in Arabidopsis显示文摘Seed germination and seedling establishment are important for the reproductive success of plants,but seeds and seedlings typically encounter constantly changing environmental conditions.By inhibiting seed germination and post-germinative growth through the PYR1/PYL/RCAR ABA receptors and PP2C co-receptors,the phytohormone abscisic acid(ABA)prevents premature germination and seedling growth under unfavorable conditions.However,little is known about how the ABA-mediated inhibition of seed germination and seedling establishment is thwarted.Here,we report that ABA Signaling Terminator(ABT),a WD40 protein,efficiently switches off ABA signaling and is critical for seed germination and seedling establishment.ABT is induced by ABA in a PYR1/PYL/RCAR-PP2C-dependent manner.Overexpression of ABT promotes seed germination and seedling greening in the presence of ABA,whereas knockout of ABT has the opposite effect.We found that ABT interacts with the PYR1/PYL/RCAR and PP2C proteins,interferes with the interaction between PYR1/PYL4 and ABI1/ABI2,and hampers the inhibition of ABI1/ABI2 by ABA-bound PYR1/PYL4,thereby terminating ABA signaling.Taken together,our results reveal a core mechanism of ABA signaling termination that is critical for seed germination and seedling establishment in Arabidopsis. | Zhijuan Wang Ziyin Ren Chunhong Cheng Tao Wang Hongtao Ji Yang Zhao Zhiping Deng Liya Zhi Jingjing Lu Xinying Wu Shimin Xu Mengmeng Cao Hongtao Zhao Liu Liu Jiankang Zhu Xia Li | 2020 | Molecular Plant2020，13，9： | 10 |
| 5 | Autologous hematopoietic stem cell transplantation in chemotherapy-sensitive lymphoblastic lymphoma: treatment outcome and prognostic factor analysis显示文摘Objective: The study evaluated the effectiveness of autologous hematopoietic stem cell transplantation(AHSCT) in the treatment of lymphoblastic lymphoma(LL).Methods: We retrospectively analyzed the data from 41 patients with chemotherapy-sensitive LL who underwent hematopoietic stem cell transplantation(HSCT) from December 1989 to December 2009 in a single institution.Results: HSCT was conducted as first-line consolidation therapy and salvage therapy in 36 and 5 patients, respectively. The median follow-up was 97.1 months(range, 24.6-173.1 months). The 5-year overall survival(OS) and event-free survival(EFS) rate were 64% and 47% for the initially treated patients, respectively, and were both 20% for the relapsed ones. Bone marrow(BM) involvement and chemotherapy cycles prior to transplantation were identified as significant prognostic factors for EFS in multivariate analysis.Conclusions: These results confirm that AHSCT is a reasonable option for chemotherapy-sensitive LL patients in first complete remission(CR1). | Youwu Shi Shengyu Zhou Xiaohui He Xiaohong Han Shikai Wu Feng Pan Peng Liu Yinyu Liu Yingheng Lei Hongzhi Zhang Jianliang Yang Yan Qin Changgong Zhang Sheng Yang Liya Zhao Kehuan Luo Guanqing Wu Yan Sun Yuankai Shi | 2015 | Chinese Journal of Cancer Research2015，27，1： | 9 |
| 6 | Molecular kinetic theory of boundary slip on textured surfaces by molecular dynamics simulations显示文摘A theoretical model extended from the Frenkel-Eyring molecular kinetic theory(MKT)was applied to describe the boundary slip on textured surfaces.The concept of the equivalent depth of potential well was adopted to characterize the solid-liquid interactions on the textured surfaces.The slip behaviors on both chemically and topographically textured surfaces were investigated using molecular dynamics(MD)simulations.The extended MKT slip model is validated by our MD simulations under various situations,by constructing different complex surfaces and varying the surface wettability as well as the shear stress exerted on the liquid.This slip model can provide more comprehensive understanding of the liquid flow on atomic scale by considering the influence of the solid-liquid interactions and the applied shear stress on the nano-flow.Moreover,the slip velocity shear-rate dependence can be predicted using this slip model,since the nonlinear increase of the slip velocity under high shear stress can be approximated by a hyperbolic sine function. | WANG LiYa WANG FengChao YANG FuQian WU HengAn | 2014 | Science China(Physics,Mechanics & Astronomy)2014，57，11： | 4 |
| 7 | Methylesterification of cell-wall pectin controls the diurnal flower-opening times in rice显示文摘Flowers are the core reproductive organ of plants, and flowering is essential for cross-pollination. Diurnal flower-opening time is thus a key trait influencing reproductive isolation, hybrid breeding, and thermostability in plants. However, the molecular mechanisms controlling this trait remain unknown. Here, we report that rice Diurnal Flower Opening Time 1 (DFOT1) modulates pectin methylesterase (PME) activity to regulate pectin methylesterification levels of the lodicule cell walls, which affect lodicule swelling to control diurnal flower-opening time. DFOT1 is specifically expressed in the lodicules, and its expression gradually increases with the approach to flowering but decreases with flowering. Importantly, a knockout of DFOT1 showed earlier diurnal flower opening. We demonstrate that DFOT1 interacts directly with multiple PMEs to promote their activity. Knockout of PME40 also resulted in early diurnal flower opening, whereas overexpression of PME42 delayed diurnal flower opening. Lower PME activity was observed to be associated with higher levels of pectin methylesterification and the softening of cell walls in lodicules, which contribute to the absorption of water by lodicules and cause them to swell, thus promoting early diurnal flower opening. Higher PME activity had the opposite effect. Collectively, our work uncovers a molecular mechanism underlying the regulation of diurnal flower-opening time in rice, which would help reduce the costs of hybrid breeding and improve the heat tolerance of flowering plants by avoiding higher temperatures at anthesis. | Mumei Wang Xiaopei Zhu Guoqing Peng Minglong Liu Shuqing Zhang Minghao Chen Shitang Liao Xiaoying Wei Peng Xu Xiyu Tan Fangping Li Zhichuan Li Li Deng Ziliang Luo Liya Zhu Shuai Zhao Dagang Jiang Jing Li Zhenlan Liu Xianrong Xie Shaokui Wang Aimin Wu Chuxiong Zhuang Hai Zhou | 2022 | Molecular Plant2022，15，6： | 2 |
| 8 | Grey-ey-RBF Neural Network Prediction Model for City Electricity Demand Forecasting显示文摘 | Liu Hongyan Cai Liya Wu Xiaojuan | | 0，，： | 1 |
| 9 | Removal of stron- tium from liquid waste using a hydraulic pellet co-precipitation microfiltration ( HPC-MF ) process 显示文摘 | Wu Liya Zhang Guanghui Wang Quanzhen | 2014 | Desalination2014，349，5： | 1 |
| 10 | Trends of visibility on sunny days in China in the recent 50 years显示文摘 | Jian Wu Chuanbo Fu Liya Zhang Jianping Tang | 2012 | Atmospheric Environment2012，，： | 1 |
| 11 | Lysosomal Hydrolase Cathepsin D Non-proteolytically Modulates Dendritic Morphology in Drosophila显示文摘The main lysosomal protease cathepsin D(cathD)is essential for maintaining tissue homeostasis via its degradative function,and its loss leads to ceroid accumulation in the mammalian nervous system,which results in progressive neurodegeneration.Increasing evidence implies non-proteolytic roles of cathD in regulating various biological processes such as apoptosis,cell proliferation,and migration.Along these lines,we here showed that cathD is required for modulating dendritic architecture in the nervous system independent of its traditional degradative function.Upon cathD depletion,class I and class III arborization(da)neurons in Drosophila larvae exhibited aberrant dendritic morphology,including overbranching,aberrant turning,and elongation defects.Reintroduction of wild-type cathD or its proteolyticallyinactive mutant dramatically abolished these morphological defects.Moreover,cathD knockdown also led to dendritic defects in the adult mushroom bodies,suggesting that cathD-mediated processes are required in both the peripheral and central nervous systems.Taken together,our results demonstrate a critical role of cathD in shaping dendritic architecture independent of its proteolytic function. | Ting Zhang Daxiao Cheng Cunjin Wu Xingyue Wang Qiang Ke Huifang Lou Liya Zhu Xiao-Dong Wang Shumin Duan Yi-Jun Liu | 2020 | Neuroscience Bulletin2020，36，10： | 1 |
| 12 | Conformational Transition and Liquid Crystalline State of Regenerated Silk Fibroin in Water 显示文摘 | LI Xingui WU Liya HUANG Meirong | 2008 | Biopolymers2008，89，6： | 1 |
| 13 | Potential red-emitting phosphor for white LED solid-state lighting显示文摘 | ZHOU liya WEI Jianshe WU Jingrong | 2009 | JAlloys Compd2009，476，12： | 1 |
| 14 | Biocompatibility of Fe3O4/DNR magnetic nanoparticles in the treatment of hematologic malignancies显示文摘 | Baoan Chen Feng Gao Jing Chen Jun Wang Wei Hulai Jian Cheng Xia Guohua Baoan Chen Liu Lijie Chuanlu Xu Wu Weiwei Bao wen Zhang Yi Ding Jiahua Yang Liya Shen Huiling Yang Mimgming Xu Wenlin Xuemei Wang | 2010 | 2010 (defa)2010，，： | 1 |
| 15 | Development, dilemma and potential strategies for the application of nanocatalysts in wastewater catalytic ozonation: A review显示文摘With the continuous development of nanomaterials in recent years,the application of nanocatalysts in catalytic ozone oxidation has attracted more and more researchers’attention due to their excellent catalytic properties.In this review,we systematically summarized the current research status of nanocatalysts mainly involving material categories,mechanisms and catalytic efficiency.Based on summary and analysis,we found most of the reported nanocatalysts were in the stage of laboratory research,which was caused by the nanocatalysts defects such as easy aggregation,difficult separation,and easy leakage.These defects might result in severe resource waste,economic loss and potentially adverse effects imposed on the ecosystem and human health.Aiming at solving these defects,we further analyzed the reasons and the existing reports,and revealed that coupling nano-catalyst and membrane,supported nanocatalysts and magnetic nanocatalysts had promising potential in solving these problems and promoting the actual application of nanocatalysts in wastewater treatment.Furthermore,the advantages,shortages and our perspectives of these methods are summarized and discussed. | Xiaoguang Jin Changyong Wu Liya Fu Xiangmiao Tian Panxin Wang Yuexi Zhou Jiane Zuo | 2023 | Journal of Environmental Sciences2023，，2： | 1 |
| 16 | A tailored and rapid approach for ozonation catalyst design显示文摘Catalytic ozonation is widely employed in advanced wastewater treatment owing to its high mineralization of refractory organics.The key to high mineralization is the compatibility between catalyst formulation and wastewater quality.Machine learning can greatly improve experimental efficiency,while fluorescence data can provide additional wastewater quality information on the composition and concentration of organics,which is conducive to optimizing catalyst formulation.In this study,machine learning combined with fluorescence spectroscopy was applied to develop ozonation catalysts(Mn/g-Al_(2)O_(3)catalyst was used as an example).Based on the data collected from 52 different catalysts,a machine-learning model was established to predict catalyst performance.The correlation coefficient between the experimental and model-predicted values was 0.9659,demonstrating the robustness and good generalization ability of the model.The range of the catalyst formulations was preliminarily screened by fluorescence spectroscopy.When the wastewater was dominated by tryptophan-like and soluble microbial products,the impregnation concentration and time of Mn(NO_(3))_(2) were less than 0.3 mol L^(-1)and 10 h,respectively.Furthermore,the optimized Mn/g-Al_(2)O_(3)formulation obtained by the model was impregnation with 0.155 mol L^(-1)Mn(NO_(3))_(2)solution for 8.5 h and calcination at 600℃ for 3.5 h.The model-predicted and experimental values for total organic carbon removal were 54.48% and 53.96%,respectively.Finally,the improved catalytic performance was attributed to the synergistic effect of oxidation(·OH and ^(1)O_(2))and the Mn/g-Al_(2)O_(3) catalyst.This study provides a rapid approach to catalyst design based on the characteristics of wastewater quality using machine learning combined with fluorescence spectroscopy. | Min Li Liya Fu Liyan Deng Yingming Hu Yue Yuan Changyong Wu | 2023 | Environmental Science and Ecotechnology2023，，3： | 0 |
| 17 | Alterations in the Cytoskeleton and Biological Behavior in Human Lung Cancer Cell Line L9981 by Nm23-H1 gene Transfection显示文摘Objective and Methods The key cause of failure to cure and high mortality in lung cancer. At present, it has been known | Zhe WANG Junke FU Zhihao WU Hongyu LIU Jun CHEN Liya SUN Q inghua ZHOU | 2009 | 中国肺癌杂志2009，12，6： | 0 |
| 18 | Alteration of Gene Expression Profile and Signal Pathway Induced by Methylseleninic Acid in Human Lung Cancer Cell Lines显示文摘Objective and Methods Lung cancer has a fastest growing rate of morbidity and mortality among malignant tumors and poses a great threat to the human health. Chemotherapy, as one | Ting WANG Zhihao WU Hongyu LIU Jun CHEN Liya SUN Qjnghua ZHOU | 2009 | 中国肺癌杂志2009，12，6： | 0 |
| 19 | The noncanonical role of the protease cathepsin D as a cofilin phosphatase显示文摘Cathepsin D(cathD)is traditionally regarded as a lysosomal protease that degrades substrates in acidic compartments.Here we report cathD plays an unconventional role as a cofilin phosphatase orchestrating actin remodeling.In neutral pH environments,the cathD precursor directly dephosphorylates and activates the actin-severing protein cofilin independent of its proteolytic activity,whereas mature cathD degrades cofilin in acidic pH conditions.During development,cathD complements the canonical cofilin phosphatase slingshot and regulates the morphogenesis of actin-based structures.Moreover,suppression of cathD phosphatase activity leads to defective actin organization and cytokinesis failure.Our findings identify cathD as a dual-function molecule,whose functional switch is regulated by environmental pH and its maturation state,and reveal a novel regulatory role of cathD in actin-based cellular processes. | Yi-Jun Liu Ting Zhang Sicong Chen Daxiao Cheng Cunjin Wu Xingyue Wang Duo Duan Liya Zhu Huifang Lou Zhefeng Gong Xiao-Dong Wang Margaret S.Ho Shumin Duan | 2021 | Cell Research2021，31，7： | 0 |
| 20 | GLOBAL ATTRACTIVITY IN AN ALMOST PERIODIC PREDATOR-PREY-MUTUALIST SYSTEM显示文摘In this paper, the almost periodic predator-prey-mutualist model with Holling type II functional response is discussed. A set of sufficient conditions which guarantee the uniform persistence and the global attractivity of the system are obtained. For the almost periodic case, by constructing a suitable Lyapunov function, sufficient conditions which guarantee the existence of a unique globally attractive positive almost periodic solution of the system are obtained. An example together with its numerical simulations shows the feasibility of the main results. | Liya Yang Fengde Chen Chengqiang Wu Xiangdong Xie | 2016 | Annals of Applied Mathematics2016，32，1： | 0 |
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