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| 1 | Analysis of Pathological data of renal biopsy at one single center in China from 1987 to 2012显示文摘 | Zhang Xueguang Liu Shuwen Tang Li Wu Jie Chen Pu Yin Zhong Li Minxia Xie Yuansheng Cai Guangyan Wei Ribao Qiu Qiang Wang Yuanda Shi Suozhu Chen Xiangmei | 2014 | Chinese Medical Journal2014，，9： | 30 |
| 2 | A facile fabrication of novel stuff with antibacterial property and osteogenic promotion utilizing red phosphorus and near-infrared light显示文摘Bone-implant materials are important for bone repairing and orthopedics surgery,which include bone plates and bone nails.These materials need to be designed not only considering its biostability and biocompatibility,but also their by-products induced infection after therapy or long-time treatment in vivo.Thus,the development of novel implant materials is quite urgent.Red phosphorus has great biocompatibility and exhibits efficient photothermal ability.Herein,a red phosphorus/IR780/arginine-glycine-asparticacid-cysteine(RGDC)coating on titanium bone-implant was prepared.The temperature sensitivity of Staphylococcus aureus biofilm is enhanced in the presence of ROS produced by IR780 with 808 nm light irradiation.With keeping the cells and tissues normal,a high antibacterial performance can be realized by near-infrared(808 nm)irradiated within 10 min at 50℃.Besides the high effective antibacterial efficacy provided by photothermal therapy(PTT)and photodynamic therapy(PDT),the RGDC decorated surface can also possess an excellent performance in osteogenesis in vivo. | Bo Huang Lei Tan Xiangmei Liu Jun Li Shuilin Wu | 2019 | Bioactive Materials2019，4，1： | 12 |
| 3 | Controlled release and biocompatibility of polymer/titania nanotube array system on titanium implants显示文摘Bacterial infection and tissue inflammation are the major causes of early failure of titanium-based orthopedic implants;thus,surgical implants with tunable drug releasing properties represent an appealing way to address some of these problems of bacterial infection and tissue inflammation in early age of orthopedic implants.In this work,a hybrid surface system composed of biodegradable poly(lactic-coglycolic acid)(PLGA)and titania nanotubes(TNTs)has been successfully constructed on Ti implants with the aim of preventing bacterial infection via long-term drug release.By varying the size of the TNTs and the thickness of the polymer film,the drug release profile can be tuned to achieve the optimal therapeutic action throughout the treatment time.The size of TNTs plays a dominant role in the drug loading dose of TNTs/PLGA hybrid coatings.In this work,TNTs with an average size of 80 nm can achieve the largest loading dose.Depending on the polymer thickness,significant improvement in the drug release characteristics is attained,for instance,reduced burst release(from 84%to 27%)and overall release time extended from 5 to over 40 days.In addition,the PLGA layers may favor the proliferation and osteogenesis of MC3T3-E1 mouse cells at an earlier stage.Therefore,this TNT/PLGA hybrid surface system can be employed as an effective bioplatform for improving both self-antibacterial performance and biocompatibility of Ti-based biomaterials. | Tingting Wang Zhengyang Weng Xiangmei Liu Kelvin W.K.Yeung Haobo Pan Shuilin Wu | 2017 | Bioactive Materials2017，2，1： | 8 |
| 4 | The role of transcriptional factor D-site-binding protein in circadian CCL2 gene expression in anti-Thy1 nephritis显示文摘Mesangial proliferative glomerulonephritis(MsPGN)is an inflammatory disease,but both the nature of disease progression and its regulation remain unclear.In the present study,we monitored the course of anti-Thy1 nephritis from days 1 to 5 and established gene expression profiles at each time point using microarrays to explore the development of inflammation.According to the gene expression profiles,macrophage infiltration(triggered by CCL2 activation)was evident on day 1 and enhanced inflammation over the next few days.We screened for genes with expression levels similar to CCL2 and found that the upregulation of the circadian gene albumin D-site-binding protein(DBP)was involved in CCL2 activation in mesangial cells.More importantly,CCL2 expression showed oscillatory changes similar to DBP,and DBP induced peak CCL2 expression at 16:00 a clock on day 1 in the anti-Thy1 nephritis model.We knocked down DBP through transfection with a small interfering RNA(siRNA)and used RNA sequencing to identify the DBP-regulated TNF-α-CCL2 pathway.We performed chromatin immunoprecipitation sequencing(ChIP-Seq)and the dual luciferase assay to show that DBP bound to the TRIM55 promoter,regulating gene expression and in turn controlling the TNF-α-CCL2 pathway.In conclusion,DBP-regulated circadian CCL2 expression by the TRIM55-TNF pathway in injured mesangial cells at an early stage,which promoted macrophage recruitment and in turn triggered infiltration and inflammation in a model of anti-Thy1 nephritis. | Yang Lu Yan Mei Lei Chen Lingling Wu Xu Wang Yingjie Zhang Bo Fu Xizhao Chen Yuansheng Xie Guangyan Cai Xueyuan Bai Qinggang Li Xiangmei Chen | 2019 | Cellular & Molecular Immunology2019，16，9： | 7 |
| 5 | Ce and Er Co-doped TiO2 for rapid bacteria- killing using visible light显示文摘Bacterial infection and related diseases are threatening the health of human beings.Photocatalytic disinfection as a simple and low-cost disinfection strategy is attracting more and more attention.In this work,TiO2 nanoparticles(NPs)were modified by co-doping of Ce and Er using the sol-gel method,which endowed TiO2 NPs with enhanced visible light photocatalytic performance but not pure ultraviolet photocatalytic properties compared the untreated TiO2.Our results disclosed that as the doping content of Er increased,the photocatalytic activity of modified TiO2 NPs initially increased and subsequently decreased.The same trend occurred for Ce doping.When the doping dose of Er and Ce is 0.5 mol%and 0.2 mol%,the 0.5Ce0.2Ti-O calcined at 800℃ presented the best antibacterial properties,with the antibacterial efficiency of 91.23%and 92.8%for Staphylococcus aureus and Escherichia coli,respectively.The existence of Er ions is thought to successfully turn the near-infrared radiation into visible region,which is easier to be absorbed by TiO2 NPs.Meanwhile,the addition of Ce ions can effectively extend spectral response range and inhibit the recombination of electrons and holes,enhancing the photocatalytic disinfection activity of co-doped TiO2. | Yawei Ren Yajing Han Zhaoyang Li Xiangmei Liu Shengli Zhu Yanqin Liang Kelvin Wai Kwok Yeung Shuilin Wu | 2020 | Bioactive Materials2020，5，2： | 7 |
| 6 | Enhanced osteogenesis and therapy of osteoporosis using simvastatin loaded hybrid system显示文摘Postmenopausal osteoporosis is a common chronic dynamic bone disorder,caused by estrogen deficiency.To address this issue,we constructed a controlled drug-release system composed of poly(N-isopropylacrylamide)brush modified mesoporous hydroxyapatite(MHA-SIM-P)loaded with simvastatin(SIM)using an ovariectomised(OVX)rat model.Quantitative alkaline phosphatase activity assay,alizarin red staining and RT-PCR were tested to evaluate the osteogenic ability in vitro.The results showed that the MHA-SIM-P nanoparticles significantly improved the osteogenic differentiation of OVX bone marrow stromal cells(BMSCs)in vitro.In osteoporotic animal model,the therapeutic efficiency for bone defect was evaluated byμCT analysis,tartrateresistant acid phosphatase,haematoxylin and eosin staining,which showed improved bone formation and less osteoclastic response in OVX rats after surgery for 3 and 6 weeks.This polymer brush modified MHA system provided a sustained release system of hydrophobic SIM to inhibit osteoporosis together with MHA nanoparticle promoting the osteogenesis.Thus,this novel strategy exhibited great potential for promoting osteogenic ability and treating local osteoporotic defects. | Tao Wu Jing Sun Lei Tan Qi Yan Lei Li Liangwen Chen Xiangmei Liu Shi Bin | 2020 | Bioactive Materials2020，5，2： | 5 |
| 7 | SORPTION BEHAVIOR AND MECHANISM OF SAMARIUM(III) ON AMINO METHYLENE PHOSPHONIC ACID RESIN显示文摘Sm(III) was quantitatively adsorbed by amino methylene phosphonic acid resin (APAR) in the medium of pH=5.0. The statically saturated sorption capacity is 251mg/g·resin. Sm(III) adsorbed on APAR can be reductively eluted by 2.0mol/L HCl. The sorption rate constant is k298= 1.35×10-5s-1. The sorption behavior of APAR for Sm(III) obeys the Freundlich isotherm. The enthalpy change △H of sorption is 24.9kJ/mol. The apparent activation energy is Ea=11.7kJ/mol. The sorption mechanism shows that the nitrogen and oxygen atoms of the functional group of APAR coordinated with Sm(III) to form coordination bond. | Wang Yongjiang WU Xiangmei Xiong Chunhua** Department of Chemistry, Lishui Teachers College, Lishui, Zhejiang 323000 | 2001 | Chinese Journal of Reactive Polymers2001，10，2： | 5 |
| 8 | Photo-controlled degradation of PLGA/Ti3C2 hybrid coating on Mg-Sr alloy using near infrared light显示文摘A PLGA/Ti_(3)C_(2) hybrid coating was successfully deposited on the surface of magnesium-strontium(Mg-Sr)alloys.Compared with the corrosion current density(icorr)of the Mg-Sr alloy(7.13×10^−5 A/cm^2),the modified samples(Mg/PLGA/Ti_(3)C_(2))was lower by approximately four orders of magnitude(7.65×10^−9 A/cm^2).After near infrared 808 nm laser irradiation,the icorr of the modified samples increased to 3.48×10^−7 A/cm^2.The mechanism is that the local hyperthermia induced the free volume expansion of PLGA,and the increase in intermolecular gap enhanced the penetration of electrolytes.Meanwhile,the cytotoxicity study showed that the hybrid coating endowed the Mg-Sr alloy with enhanced biocompatibility. | Li Liu Bo Huang Xiangmei Liu Wei Yuan Yufeng Zheng Zhaoyang Li Kelvin Wai Kwok Yeung Shengli Zhu Yanqin Liang Zhenduo Cui Shuilin Wu | 2021 | Bioactive Materials2021，6，2： | 4 |
| 9 | A Virulent PEDV Strain FJzz1 with Genomic Mutations and Deletions at the High Passage Level Was Attenuated in Piglets via Serial Passage In Vitro显示文摘Highly virulent porcine epidemic diarrhea virus(PEDV)strains re-emerged and circulated in China at the end of 2010,causing significant economic losses in the pork industry worldwide.To understand the genetic dynamics of PEDV during its passage in vitro,the PEDV G2 strain FJzzl was serially propagated in Vero cells for up to 200 passages.The susceptibility and adaptability of the FJzzl strain increased gradually as it was serially passaged in vitro.Sequence analysis revealed that amino acid(aa)changes were mainly concentrated in the S glycoprotein,which accounted for 72.22%-85.71%of all aa changes.A continuous aa deletion(^(55)I^(56)G^(57)E→^(55)K^(56)Δ^(57)Δ)occurred in the N-terminal domain of S1(Sl-NTD).To examine how the aa changes affected its virulence,FJzzl-F20 and FJzzl-F200 were selected to simultaneously evaluate their pathogenicity in suckling piglets.All the piglets in the FJzzl-F20-infected group showed typical diarrhea at 24 h postinfection,and the piglets died successively by 48 h postinfection.However,the clinical signs of the piglets in the FJzzl-F200-infected group were significantly weaker,and no deaths occurred.The FJzzl-F200-infected group also showed a lower level of fecal viral shedding and lower viral loads in the intestinal tissues,and no obvious histopathological lesions.TypeⅠandⅢinterferon were induced in the FJzzl-F200 infection group,together with pro-inflammatory cytokines,such as TNF-α,IL-1βand IL-8.These results indicate that the identified genetic changes may contribute to the attenuation of FJzzl strain,and the attenuated FJzzl-F200 may have the potential for developing PEDV live-attenuated vaccines. | Pengfei Chen Xiongwei Zhao Shuting Zhou Tianxing Zhou Xiangmei Tan Xia Wu Wu Tong Fei Gao Lingxue Yu Yifeng Jiang Hai Yu Zhibiao Yang Guangzhi Tong Yanjun Zhou | 2021 | Virologica Sinica2021，36，5： | 4 |
| 10 | The enhanced photocatalytic sterilization of MOF-Based nanohybrid for rapid and portable therapy of bacteria-infected open wounds显示文摘Open wounds are prone to infection and difficult to heal,which even threatens the life of patients because bacterial infections can induce other lethal complications without prompt treatment.The commonly used antibiotics treatment for bacterial infections has been reported to cause globally bacterial resistance and even the occurrence of superbacteria.The highly effective and antibiotic-independent therapeutic strategies are urgently needed for treating various kinds of bacteria-infected diseases.In this work,we synthesized an eco-friendly nanohybrid material(ZnDMZ)consisting of a kind of biodegradable metal organic framework(MOF,ZIF-8)combined with Zn-doped MoS_(2)(Zn-MoS_(2))nanosheets,which exhibited great ability to kill bacteria and promote the healing of bacteria-infected wounds under 660 nm light irradiation.The underlying mechanism is that besides the local hyperthermia,the nanohybrid material exhibits enhanced photocatalytic performance than single component in it,i.e.,it can also be excited by 660 nm light to produce more oxygen radical species(ROS)due to the following factors.On one hand,the Zn doping can reduce the work function and the band gap of MoS_(2),which promotes the movement of photoexcited electrons to the surface of the material.On the other hand,the combination between Zn-MoS_(2) and MOF induces the formation of a built-in electric field due to their work function difference,thus accelerating the separation of photoexcited electron-hole pairs.Because of the synergy of photocatalytic effect,photothermal effect and the released Zn ions,the synthesized ZnDMZ possessed a highly effective antibacterial efficacy of 99.9%against Staphylococcus aureus under 660 nm light irradiation for 20 min without cytotoxicity.In vivo tests showed that this nanohybrid material promoted the wound healing due to the released Zn ions.This nanohybrid will be promising for rapid and portable treatment of bacteria-infected open wounds in pathogenic bacteria contaminated environments. | Chaofeng Wang Yue Luo Xiangmei Liu Zhenduo Cui Yufeng Zheng Yanqin Liang Zhaoyang Li Shengli Zhu Jie Lei Xiaobo Feng Shuilin Wu | 2022 | Bioactive Materials2022，7，7： | 3 |
| 11 | A Z-scheme heterojunction of ZnO/CDots/C_(3)N^(4) for strengthened photoresponsive bacteria-killing and acceleration of wound healing显示文摘The abuse of antibiotics is leading to the emergence of resistant bacteria.In this work,a drug-free composite of ZnO/CDots/g-C3N4 with Z-scheme heterojunction was developed,which was employed to kill bacteria effectively within a very short time under the irradiation of visible light due to the enhanced photocatalytic and photothermal effects.In this system,the CDots acted as a bridge between g-C3N4 and ZnO,effectively inhibiting the recombination of photo-generated electrons with holes and consequently enhancing the photocatalytic properties.In addition,CDots endowed the system with excellent photothermal effects.As a result,the antibacterial efficacy of ZnO/CDots/g-C3N4 composite against S.aureus and E.coli reached up to 99.97%and 99.99%respectively,after 15 min of visible light irradiation,due to the synergistic action of photo-inspired radical oxygen species and hyperthermia.The Zn ions released from the composite promoted the growth of fibroblasts,which accelerated the wound healing process. | Yiming Xiang Qilin Zhou Zhaoyang Li Zhenduo Cui Xiangmei Liu Yanqin Liang Shengli Zhu Yufeng Zheng Kelvin Wai Kwok Yeung Shuilin Wu | 2020 | Journal of Materials Science & Technology2020，54，22： | 2 |
| 12 | Simultaneously enhancing the photocatalytic and photothermal effect of NH_(2)-MIL-125-GO-Pt ternary heterojunction for rapid therapy of bacteria-infected wounds显示文摘Infections caused by bacteria threaten human health,so how to effectively kill bacteria is an urgent problem.We therefore synthesized a NH_(2)-MIL-125-GO-Pt ternary composite heterojunction with graphene oxide(GO)and platinum(Pt)nanoparticles co-doped with metal-organic framework(NH_(2)-MIL-125)for use in photocatalytic and photothermal synergistic disinfection under white light irradiation.Due to the good conductivity of GO and the Schottky junction between Pt and MOF,the doping of GO and Pt will effectively separate and transfer the photogenerated electron-hole pairs generated by NH_(2)-MIL-125,thereby effectively improving the photocatalytic efficiency of NH_(2)-MIL-125.Meanwhile,NH_(2)-MIL-125-GO-Pt has good photothermal effect under white light irradiation.Therefore,the NH_(2)-MIL-125-GO-Pt composite can be used for effective sterilization.The antibacterial efficiency of NH_(2)-MIL-125-GO-Pt against Staphylococcus aureus and Escherichia coli were as high as 99.94%and 99.12%,respectively,within 20 min of white light irradiation.In vivo experiments showed that NH_(2)-MIL-125-GO-Pt could effectively kill bacteria and promote wound healing.This work brings new insights into the use of NH_(2)-MIL-125-based photocatalyst materials for rapid disinfection of environments with pathogenic microorganisms. | Yue Luo Bo Li Xiangmei Liu Yufeng Zheng Erjing Wang Zhaoyang Li Zhenduo Cui Yanqin Liang Shengli Zhu Shuilin Wu | 2022 | Bioactive Materials2022，7，12： | 2 |
| 13 | Chronic cerebrovascular hypoperfusion affects global DNA methylation and histone acetylation in rat brain显示文摘DNA methylation and histone acetylation can be modified by various pathological or physiological factors such as hypoxia,thus influencing gene expression.In this study,we investigated the changes of global DNA methylation and histone acetylation and the related enzymes in rat brain after chronic cerebrovascular hypoperfusion by bilateral common carotid occlusion(2-VO)surgery.Colorimetric and immunohistochemistry staining were used to evaluate the global DNA methylation and histone acetylation levels,respectively.The expressions of DNA methyltransferase 1/3a(DNMT1/3a),methyl-CpG binding domain protein 2(MBD2),histone deacetylase 3(HDAC3)and acetyltransferase(HAT)were assessed by Western blot.We found that the level of global DNA methylation was decreased to31.7%(P<0.01)of the sham-operated group at 10days and increased by 30%(P<0.01)compared with the sham group at 90 days after 2-VO surgery.DNMT3a expression was down-regulated to 75.7%of the sham group,while MBD2 expression was up-regulated by 95%compared with sham group at 90 days after 2-VO.The histone H3 acetylation level was markedly decreased to 75.3%of the sham group at 10 days and 73.5%at 90 days after2-VO,while no significant change was found for histone H4 acetylation.HDAC3 expression was markedly down-regulated to 36%of the sham group,whereas cAMP-response element binding protein expression was up-regulated by 33.6%compared with the sham group at 90 days after 2-VO.These results suggest that chronic cerebrovascular hypoperfusion influences global DNA methylation and histone acetylation levels through the related enzymes,and therefore might contribute to several neurodegenerative diseases. | Xiangmei Wu Jing Sun Liang Li | 2013 | Neuroscience Bulletin2013，29，6： | 2 |
| 14 | Ag_(3)PO_(4) decorated black urchin-like defective TiO_(2) for rapid and long-term bacteria-killing under visible light显示文摘Both phototherapy via photocatalysts and physical puncture by artificial nanostructures are promising substitutes for antibiotics when treating drug-resistant bacterial infectious diseases.However,the photodynamic therapeutic efficacy of photocatalysts is seriously restricted by the rapid recombination of photogenerated electron-hole pairs.Meanwhile,the nanostructures of physical puncture are limited to two-dimensional(2D)platforms,and they cannot be fully used yet.Thus,this research developed a synergistic system of Ag_(3)PO_(4) nanoparticles(NPs),decorated with black urchin-like defective TiO_(2)(BU-TiO_(2-X)/Ag_(3)PO_(4)).These NPs had a decreased bandgap compared to BU-TiO_(2-X),and BU-TiO_(2)-X/Ag_(3)PO_(4)(3:1)exhibited the lowest bandgap and the highest separation efficiency for photogenerated electron-hole pairs.After combination with BU-TiO_(2-X),the photostability of Ag_(3)PO_(4) improved because the oxygen vacancy of BU-TiO_(2-X) retards the reduction of Ag^(+) in Ag_(3)PO_(4) into Ag^(0),thus reducing its toxicity.In addition,the nanospikes on the surface of BU-TiO_(2-X) can,from all directions,physically puncture bacterial cells,thus assisting the hybrid’s photodynamic therapeutic effects,alongside the small amount of Ag^(+) released from Ag_(3)PO_(4).This achieves synergy,endowing the hybrid with high antibacterial efficacy of 99.76±0.15%and 99.85±0.09%against Escherichia coli and Staphylococcus aureus,respectively,after light irradiation for 20 min followed by darkness for 12 h.It is anticipated that these findings may bring new insight for developing synergistic treatment strategies against bacterial infectious diseases or pathogenic bacterial polluted environments. | Yingde Xu Xiangmei Liu Yufeng Zheng Changyi Li Kelvin Wai Kwok Yeung Zhenduo Cui Yanqin Liang Zhaoyang Li Shengli Zhu Shuilin Wu | 2021 | Bioactive Materials2021，6，6： | 2 |
| 15 | A Bioactive Polysaccharide Isolated from the Fruits of Chinese Jujube显示文摘 | Zhihui Zhao Jun Li Xiangmei Wu | | 0，，2： | 1 |
| 16 | Adsorption of macroporpus phosphonic acid resin for copper 显示文摘 | Xiong Chunhua Wu Xiangmei | 2003 | Traus Nonferrous Met Soc China2003，13，6： | 1 |
| 17 | Using tea nanoclusters asβ-lactamase inhibitors to cure multidrug-resistant bacterial pneumonia:A promising therapeutic strategy by Chinese materioherbology显示文摘β-lactamase,a kind of hydrolase in multi-drug resistant pathogens,can hydrolyzeβ-lactam antibiotics and make these kinds of antibiotics invalid.Small-molecular inhibitors about the enzyme and their mechanism are widely investigated but they may result in unavoidable adverse reactions and drug-resistance.Herein,we propose a new therapeutic strategy of Chinese materioherbology,in which herbal medicine or traditional Chinese medicinal herbs can be employed as biological functional materials or refreshed/excited by means of materialogy.Nat-ural tea nanoclusters(TNCs)were extracted from tea to inhibitβ-lactamase.Different from the mechanism of small-molecular inhibitors inhibiting enzymes by binding to the corresponding active sites,the TNCs as a cap cover the protein pocket and create a spatial barrier between the active sites and antibiotics,which was named“capping-pocket”effect.TNCs were combined with amoxicillin sodium(Amo)to treat the methicillin-resistant Staphylococcus aureus(MRSA)pneumonia in mice.This combinatorial therapy remarkably outperforms antibiotic monotherapy in reducing MRSA infections and the associated inflammation in mice.The therapeutic strategy exhibited excellent biosafety,without any side effects,even in piglets.Hence,TNCs have great clinical value in potentiatingβ-lactam antibiotic activity for combatting multi-drug resistant pathogen infections and the'pocket capping'effect can guide the design of new enzyme inhibitors in near future. | Ziao Zhou Jun Li Lei Tan Xiangmei Liu Yufeng Zheng Zhenduo Cui Changyi Li Kelvin Wai Kwok Yeung Zhaoyang Li Yanqin Liang Shengli Zhu Shuilin Wu | 2022 | Fundamental Research2022，2，3： | 1 |
| 18 | Hydrometallurgy 显示文摘 | Xiong Chunhua Yao Caiping Wu Xiangmei | 2008 | 90(2/3/4): 221-2262008，90，234： | 1 |
| 19 | Cellular Prion Protein (PrP C ) of the Neuron Cell Transformed to a PK-Resistant Protein Under Oxidative Stress, Comprising Main Mitochondrial Damage in Prion Diseases显示文摘 | Fangzhong Yuan Lifeng Yang Zhuming Zhang Wenyu Wu Xiangmei Zhou Xiaomin Yin Deming Zhao | 2013 | Journal of Molecular Neuroscience2013，，1： | 1 |
| 20 | Simulated Dynamic Evaporation of Yiliping Salt Lake Brine显示文摘1 Introduction There are numerous salt lakes in western China(Zheng Mianping,et al.,2011).Yiliping playa on the western Qaidam Basin is a magnesium sulfate subtype dry salt lake with high concentrations of potassium,boron and lithium. | CUI Xiangmei WU Zhiming WEN Xianming ZHANG Xingru | 2014 | Acta Geologica Sinica(English Edition)2014，88，S1： | 1 |
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