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| 1 | 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents显示文摘Syncope belongs to the transient loss of consciousness(TLOC), characterized by a rapid onset, short duration, and spontaneous complete recovery. It is common in children and adolescents, accounting for 1% to 2% of emergency department visits.Recurrent syncope can seriously affect children's physical and mental health, learning ability and quality of life and sometimes cardiac syncope even poses a risk of sudden death. The present guideline for the diagnosis and treatment of syncope in children and adolescents was developed for guiding a better clinical management of pediatric syncope. Based on the globally recent development and the evidence-based data in China, 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents was jointly prepared by the Pediatric Cardiology Society, Chinese Pediatric Society, Chinese Medical Association(CMA)/Committee on Pediatric Syncope, Pediatricians Branch, Chinese Medical Doctor Association(CMDA)/Committee on Pediatric Cardiology, Chinese College of Cardiovascular Physicians, Chinese Medical Doctor Association(CMDA)/Pediatric Cardiology Society, Beijing Pediatric Society, Beijing Medical Association(BMA). The present guideline includes the underlying diseases of syncope in children and adolescents, the diagnostic procedures, methodology and clinical significance of standing test and headup tilt test, the clinical diagnosis vasovagal syncope, postural orthostatic tachycardia syndrome, orthostatic hypotension and orthostatic hypertension, and the treatment of syncope as well as follow-up. | Cheng Wang Yaqi Li Ying Liao Hong Tian Min Huang Xiangyu Dong Lin Shi Jinghui Sun Hongfang Jin Junbao Du Jindou An Jie Chen Mingwu Chen Qi Chen Sun Chen Yonghong Chen Zhi Chen Adolphus Kai-tung Chau Junbao Du Zhongdong Du Junkai Duan Hongyu Duan Xiangyu Dong Lin Feng Lijun Fu Fangqi Gong Yonghao Gui Ling Han Zhenhui Han Bing He Zhixu He Xiufen Hu Yimin Hua Guoying Huang Min Huang Ping Huang Yujuan Huang Hongfang Jin Mei Jin Bo Li Fen Li Tao Li Xiaohui Li Xiaoyan Liu Yan Li Haitao Lv Tiewei Lv Zipu Li Luyi Ma Silin Pan Yusheng Pang Hua Peng Yuming Qin Jie Shen Lin Shi Kun Sun Jinghui Sun Hong Tian Jie Tian Cheng Wang Hong Wang Lei Wang Jinju Wang Wendi Wang Yuli Wang Rongzhou Wu Tianhe Xia Yanyan Xiao Chunhong Xie Yanlin Xing Zhenyu Xiong Baoyuan Xu Yi Xu Hui Yan Shiwei Yang Qijian Yi Xia Yu Xianyi Yu Yue Yuan Hongyan Zhang Huili Zhang Li Zhang Qingyou Zhang Xi Zhang Yanmin Zhang Zhiwei Zhang Cuifen Zhao Bin Zhou Hua Zhu | 2018 | Science Bulletin2018，63，23： | 54 |
| 2 | Rasl CA overexpression in the posterior silk gland improves silk yield显示文摘 | Li Ma Hanfu Xu Jinqi Zhu Sanyuan Ma Yan Liu Rong-Jing Jiang Qingyou Xia Sheng Li | 2011 | Cell Research2011，21，6： | 19 |
| 3 | A detailed procedure for CRISPR/Cas9-mediated gene editing in Arabidopsis thaliana显示文摘The newly developed CRISPR(Clustered Regularly Interspaced Short Palindromic Repeats)/Cas(CRISPR-associated) system has emerged as an efficient tool for genome-editing, providing an alternative to classical mutagenesis and transgenic methods to study gene function and improve crop traits. CRISPR/Cas facilitates targeted gene editing through RNA-guided DNA cleavage followed by cellular DNA repair mechanisms that introduce sequence changes at the site of cleavage. Here we describe a detailed procedure for our previously developed and highly efficient CRISPR/Cas9 method that allows the generation of heritable-targeted gene mutations andcorrections in Arabidopsis. This protocol describes the strategies and steps for the selection of targets, design of single-guide RNA(sg RNA), vector construction and analysis of transgenic lines. We also offer a method to target two loci simultaneously using vectors containing two different sg RNAs. The principles described in this protocol can be applied to other plant species to generate stably inherited DNA modifications. | Wenshan Liu Xiaohong Zhu Mingguang Lei Qingyou Xia Jose Ramon Botella Jian-Kang Zhu Yanfei Mao | 2015 | Science Bulletin2015，60，15： | 18 |
| 4 | Analysis of cytochrome P450 genes in silkworm genome (Bombyx mori)显示文摘We have searched the Bombyx mori genome for members of the major enzyme family, the Cytochrome P450s, which carry out multiple reactions to enable organisms to rid themselves of foreign compounds. As a result, 86 putative P450s were discovered in silkworm genome, which are thought to belong to 32 subfamilies. A comparative genomic analysis with Drosophila melanogaster reveals that the two insects have some similar P450 distribution pat-terns but still have some obvious differences. Especially, the diverse distribution exists in 7 p450 subfamilies, which are CYP4A, CYP4C, CYP4D, CYP6A, CYP6AE, CYP6B and CYP9A. Fur-thermore, we collected expression sequence tag (EST) evidence for 49 putative P450s genes, which are expressed at the transcriptional level and more likely to be true P450s. | LI Bin XIA Qingyou LU Cheng ZHOU Zeyang XIANG Zhonghuai | 2005 | Science China(Life Sciences)2005，48，4： | 7 |
| 5 | Haplotype-resolved genome of diploid ginger (Zingiber officinale) and its unique gingerol biosynthetic pathway显示文摘Ginger(Zingiber officinale),the type species of Zingiberaceae,is one of the most widespread medicinal plants and spices.Here,we report a high-quality,chromosome-scale reference genome of ginger‘Zhugen’,a traditionally cultivated ginger in Southwest China used as a fresh vegetable,assembled from PacBio long reads,Illumina short reads,and high-throughput chromosome conformation capture(Hi-C)reads.The ginger genome was phased into two haplotypes,haplotype 1(1.53 Gb with a contig N50 of 4.68 M)and haplotype 0(1.51 Gb with a contig N50 of 5.28 M).Homologous ginger chromosomes maintained excellent gene pair collinearity.In 17,226 pairs of allelic genes,11.9%exhibited differential expression between alleles.Based on the results of ginger genome sequencing,transcriptome analysis,and metabolomic analysis,we proposed a backbone biosynthetic pathway of gingerol analogs,which consists of 12 enzymatic gene families,PAL,C4H,4CL,CST,C3’H,C3OMT,CCOMT,CSE,PKS,AOR,DHN,and DHT.These analyses also identified the likely transcription factor networks that regulate the synthesis of gingerol analogs.Overall,this study serves as an excellent resource for further research on ginger biology and breeding,lays a foundation for a better understanding of ginger evolution,and presents an intact biosynthetic pathway for species-specific gingerol biosynthesis. | Hong-Lei Li Lin Wu Zhaoming Dong Yusong Jiang Sanjie Jiang Haitao Xing Qiang Li Guocheng Liu Shuming Tian Zhangyan Wu Bin Wu Zhexin Li Ping Zhao Yan Zhang Jianmin Tang Jiabao Xu Ke Huang Xia Liu Wenlin Zhang Qinhong Liao Yun Ren Xinzheng Huang Qingzhi Li Chengyong Li Yi Wang Baskaran Xavier-Ravi Honghai Li Yang Liu Tao Wan Qinhu Liu Yong Zou Jianbo Jian Qingyou Xia Yiqing Liu | 2021 | Horticulture Research2021，8，1： | 2 |
| 6 | A Draft Sequence for the Genome of the Domesticated Silkworm (Bombyx mori)显示文摘 | Xia Qingyou Zhou Zeyang Lu Cheng | 2004 | Science2004，306，： | 1 |
| 7 | Advances in Silkworm Studies Accelerated by the Genome Sequencing of Bombyx mori *显示文摘 | Qingyou Xia Sheng Li Qili Feng | 2014 | Annual Review of Entomology2014，，： | 1 |
| 8 | Microarry-based gene expression profiles in multiple tissues of domesticated silkworm (BombTx mot/) 显示文摘 | Qingyou Xia Daojun Cheng Jun Duan | 2007 | Genome Biology2007，8，8： | 1 |
| 9 | A draft sequence for the genome of the domesticated silkworm (Bombyx mori)显示文摘 | Xia Qingyou Zhou Zeyang Lu Cheng | 2004 | Science2004，306，： | 1 |
| 10 | Construction of a cDNA library from female adult of Toxocara canis , and analysis of EST and immune-related genes expressions显示文摘 | Rongqiong Zhou Qingyou Xia Hancheng Huang Min Lai Zhenxin Wang | 2011 | Experimental Parasitology2011，，2： | 1 |
| 11 | Sequence structure and expression pattern of a novel anionic defensin-like gene from silkworm (Bombyx mori)显示文摘 | Hongxiu Wen Xiqian Lan Tingcai Cheng Ningjia He Kunihiro Shiomi Zenta Kajiura Zeyang Zhou Qingyou Xia Zhonghuai Xiang Masao Nakagaki | 2009 | Molecular Biology Reports2009，，4： | 1 |
| 12 | Complete Resequencing of 40 Genomes Reveals Domestication Events andGenes in Silkworm (Bombyx)显示文摘 | Qingyou Xia Yiran Guo Ze Zhang | 2009 | Science2009，326，5951： | 1 |
| 13 | Fatigue prediction for pump end of high pressure fracturing pump 显示文摘 | Xia He QingYou Liu Min Zhao | 2011 | Advanced Materials Research2011，337，： | 1 |
| 14 | A draft sequence for the genome of the domesticated si]k worm( bombyxmori) 显示文摘 | Qingyou Xia Zeyang Zhou Cheng Lu | 2004 | Science2004，306，5703： | 1 |
| 15 | A draft sequence for the genome of the domesticated silkworm ( bombyx mori) 显示文摘 | Xia Qingyou Zhou Zeyang Lu Cheng etal | 2004 | Science2004，306，： | 1 |
| 16 | A draft sequence for the genome of the domesticated silkworm (Bombyx mari)显示文摘 | XIA QINGYOU ZHOU ZEYANG LU CHENG | 2004 | Science2004，，306： | 1 |
| 17 | A draft sequence for the genome of the domesticated silkworm (Bombyx mori)显示文摘 | Qingyou Xia Zeyang Zhou Cheng Lu | 2004 | Science2004，，306： | 1 |
| 18 | A Draft Sequence for the Genome of the Domesticated Silkworm显示文摘 | Qingyou Xia Zeyang Zhou Cheng Lu etal | 2004 | SCIENCE2004，306，： | 1 |
| 19 | Developing an efficient and visible prime editing system to restore tobacco 8-hydroxy-copalyl diphosphate gene for labdane diterpene Z-abienol biosynthesis显示文摘Prime editing(PE)is a versatile CRISPR-Cas based precise genome-editing platform widely used to introduce a range of possible base conversions in various organisms.However,no PE systems have been shown to induce heritable mutations in tobacco,nor in any other dicot.In this study,we generated an efficient PE system in tobacco that not only introduced heritable mutations,but also enabled anthocyanin-based reporter selection of transgene-free T_(1) plants.This system was used to confer Zabienol biosynthesis in the allotetraploid tobacco cultivar HHDJY by restoring a G>T conversion in the NtCPS2 gene.High levels of Z-abienol were detected in the leaves of homozygous T_(1) plants at two weeks after topping.This study describes an advance in PE systems and expands genome-editing toolbox in tobacco,even in dicots,for use in basic research and molecular breeding.And restoring biosynthesis of Z-abienol in tobacco might provide an efficient way to obtain Z-abienol in plants. | Jianduo Zhang Lu Zhang Chengwei Zhang Yongxing Yang Huayin Liu Lu Li Shengxue Zhang Xianggan Li Xinxiang Liu Ya Liu Jin Wang Guangyu Yang Qingyou Xia Weiguang Wang Jinxiao Yang | 2023 | Science China(Life Sciences)2023，66，12： | 1 |
| 20 | A draft sequence for the genome of the domesticated silkworm (Bombyx mori) 显示文摘 | Qingyou Xia Zeyang Zhou Cheng Lu | 2004 | Science2004，306，： | 1 |
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