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| 1 | Graphene-enabled electrically controlled terahertz meta-lens显示文摘Metasurfaces have become a new photonic structure for providing potential applications to develop integrated devices with small thickness, because they can introduce an abrupt phase change by arrays of scatterers. To be applied more widely, active metasurface devices are highly desired. Here, a tunable terahertz meta-lens whose focal length is able to be electrically tuned by ~4.45λ is demonstrated experimentally. The lens consists of a metallic metasurface and a monolayer graphene. Due to the dependence of the abrupt phase change of the metasurface on the graphene chemical potential, which can be modulated using an applied gate voltage, the focal length is changed from 10.46 to 12.24 mm when the gate voltage increases from 0 to 2.0 V. Experimental results are in good agreement with the theoretical hypothesis. This type of electrically controlled meta-lens could widen the application of terahertz technology. | WEIGUANG LIU BIN HU ZONGDUO HUANG HONGYU GUAN HETING LI XINKE WANG YAN ZHANG HONGXING YIN XIAOLU XIONG JUAN LIU YONGTIAN WANG | 2018 | Photonics Research2018，6，7： | 8 |
| 2 | Effects of 12C6+ heavy ion beam irradiation on the p53 signaling pathway in HepG2 liver cancer cells显示文摘重离子横梁被认为是为放射疗法的理想的来源。细胞内部的 apoptosis 表明的 p53 肿瘤 suppressor 基因感觉 DNA 损坏和 transducts。以前的报告证明重离子横梁能触发细胞的 DNA 的损坏的复杂形式,导致房间周期拘捕和 HepG2 人的肝癌症房间的 apoptosis;然而,机制充分仍然保持不清楚。为了探索内在或外来的小径是否参与这,处理, HepG2 房间在 0 的剂量(控制)与12C6+ HIB 照耀被对待,有各种各样的方法的 1 , 2 , 4 ,和 6 Gy 采用了理解相关机制例如 apoptosis 的察觉,由流动 cytometry 的房间周期,和船边交货表示,由扫描共焦的显微镜学,并且屏蔽差别的电子显微镜学和激光的 apoptotic 形态学的分析表示了关于旁边表明小径的 p53 的基因这研究显示出在 6 Gy 的剂量的重离子横梁照耀导致的那 12C6+ 经由 synergistic 的人的 HepG2 房间的内长的 DNA 双海滨损坏, G2/M 房间周期拘捕,和 apoptosis 外来、内在的小径完成。差别在表明与 DNA 损坏修理, apoptosis,周期规定,转移,恶化和辐射抵抗有关的小径的 p53 表示了基因也被发现。因而,船边交货, TP53BP2, TP53AIP1,和 CASP9 的表情是在 12C6+ HIB 照耀处理以后的证实的 upregulated。在结论,这研究表明了 12C6+ 导致的抑制和 apoptosis 的机制 HepG2 癌症房间上的重离子横梁照耀被表明小径包括的 p53 的生物功能的开始调停外来、内在的 apoptosis 小径(吗?作者 2017。代表生物化学和房间生物学的研究所由牛津大学出版社出版了,为生物科学的上海研究所,中国科学院。版权所有。为权限,请发邮件:journals.permissions@oup.com。) | Kai Liu Xinke Zhao Jing Gu Jianjun Wu Hong Zhang Yingdong Li | 2017 | Acta Biochimica et Biophysica Sinica2017，49，11： | 5 |
| 3 | Monolithic integration of MoS2-based visible detectors and GaN-based UV detectors显示文摘With the increasing demand for high integration and multi-color photodetection for both military and civilian applications, the research of multi-wavelength detectors has become a new research hotspot. However, current research has been mainly in visible dual-or multi-wavelength detectors, while integration of both visible light and ultraviolet(UV) dual-wavelength detectors has rarely been studied. In this work, large-scale and high-quality monolayer MoS2 was grown by the chemical vapor deposition method on transparent free-standing GaN substrate. Monolithic integration of MoS2-based visible detectors and GaN-based UV detectors was demonstrated using common semiconductor fabrication technologies such as photolithography, argon plasma etching, and metal deposition. High performance of a 280 nm and 405 nm dual-wavelength photodetector was realized.The responsivity of the UV detector reached 172.12 A/W, while that of the visible detector reached 17.5 A/W.Meanwhile, both photodetectors achieved high photocurrent gain, high external quantum efficiency, high normalized detection rate, and low noise equivalent power. Our study extends the future application of dual-wavelength detectors for image sensing and optical communication. | YOU WU ZHIWEN LI KAH-WEE ANG YUPING JIA ZHIMING SHI ZHI HUANG WENJIE YU XIAOJUAN SUN XINKE LIU DABING LI | 2019 | Photonics Research2019，7，10： | 4 |
| 4 | Construction of van der Waals substrates for largely mismatched heteroepitaxy systems using first principles显示文摘The high density of defects induced by large strains in largely mismatched heteroepitaxy systems, such as AlN and GaN, because of the large lattice and thermal mismatch between substrates and epilayers is the bottleneck problem. Graphene-assisted van der Waals(vdW) heteroepitaxy offers a new opportunity to resolve this problem. However, it suffers from the difficulty of nucleation. Here we theoretically assess the effects of five 2D materials for vdW heteroepitaxy of AlN and GaN, including graphene, hBN, MoS2, gC3N, and gC3N4, and provide physical insights using first-principle calculations. MoS2 and gC3N exhibit significant potential to overcome the shortcomings of graphene owing to their appropriate binding strengths and Al(or Ga)diffusion barriers. Moreover, the interface behavior between the epilayers and the substrates are carefully analyzed. Our findings are helpful not only for obtaining high-quality AlN and GaN films but also for developing new criterions to discover effective 2D materials for vdW heteroepitaxy. | ZhiMing Shi XiaoJuan Sun YuPing Jia XinKe Liu ShanLi Zhang ZhanBin Qi DaBing Li | 2019 | Science China(Physics,Mechanics & Astronomy)2019，62，12： | 3 |
| 5 | Highly efficient vectorial field manipulation using a transmitted tri-layer metasurface in the terahertz band显示文摘Polarization is a basic characteristic of electromagnetic waves that conveys much optical information owing to its many states.The polarization state is manipulated and controlled for optical information security,optical encryption,and optical communication.Metasurface devices provide a new way to manipulate wave-fronts of light.A single ultrathin metasurface device can generate and modulate several differently polarized light fields,and thus carries optical information in several different channels.Terahertz(THz)waves have become widely used as carrier waves for wireless communication.Compact and functional metasurface devices are in high demand for THz elements and systems.This paper proposes a tri-layer metallic THz metasurface for multi-channel polarization generation and phase modulation with a high efficiency of approximately 80%.An azimuthally polarized THz vectorial beam generator is realized and characterized for use as a THz polarization analyzer.The incident polarization angle can be observed graphically with high accuracy.Moreover,a vectorial hologram with eight channels for different linear polarization states is demonstrated experimentally.The information in different holograms can be hidden by choosing the polarization channel for detection.This work contributes to achieving multi-functional metasurface in the THz band and can benefit THz communication and optical information security. | Huan Zhao Xinke Wang Shutian Liu Yan Zhang | 2023 | Opto-Electronic Advances2023，6，2： | 2 |
| 6 | Micro-LED backlight module by deep reinforcement learning and micro-macro-hybrid environment control agent显示文摘This paper proposes a micro-LED backlight module with a distributed Bragg reflector(DBR) structure to achieve excellent micro-LED backlight module quality and uses deep reinforcement learning(DRL) architecture for optical design. In the DRL architecture, to solve the computing environment problems of the two extreme structures of micro-scale and macro-scale, this paper proposes an environment control agent and virtual-realistic workflow to ensure that the design environment parameters are highly correlated with experimental results. This paper successfully designed a micro-LED backlight module with a DBR structure by the abovementioned methods.The micro-LED backlight module with a DBR structure improves the uniformity performance by 32% compared with the micro-LED backlight module without DBR, and the design calculation time required by the DRL method is only 17.9% of the traditional optical simulation. | Che-Hsuan Huang Yu-Tang Cheng Yung-Chi Tsao Xinke Liu Hao-Chung Kuo | 2022 | Photonics Research2022，10，2： | 2 |
| 7 | Application and Experience of Putting People First in Hospital Human Resource Management显示文摘The recent years have witnessed the rapid economic growth of our country.The medical industry has also come to a new era.The number of hospital staff continues to increase,while some problems of managing human resource have gradually emerged.These problems have a bad impact on the functions of the hospital.We must attach great importance to solve them.In the process of managing the human resources of hospital,we must insist to put people first.That is how we can better boost the working initiative of medical staff,setting the foundation for the development of hospital in a long run.This article has conducted deepening research on this issue.First of all,it briefly introduced the theory of putting people first.And then it stated the connotation of the theory of putting people first applied in managing human resources of hospital.At last,it explored the strategies on applying the theory of putting people first in managing human resources of hospital in accordance to the concrete conditions. | Tao Zhou Xiaoxuan Liu Wei Yu Xinke Wang Hao Teng | 2020 | Proceedings of Anticancer Research2020，4，6： | 2 |
| 8 | Systematic dissection of disease resistance to southern corn rust by bulked-segregant and transcriptome analysis显示文摘Southern corn rust(SCR) is a destructive maize disease caused by Puccinia polysora Underw. To investigate the mechanism of SCR resistance in maize, a highly resistant inbred line, L119 A, and a highly susceptible line, Lx9801, were subjected to gene mapping and transcriptome analysis. Bulked-segregant analysis coupled with whole-genome sequencing revealed several quantitative trait loci(QTL) on chromosomes 1, 6, 8, and 10. A set of 25 genes, including two coiled-coil nucleotide-binding site leucine-rich repeat(CC-NBS-LRR) genes, were identified as candidate genes for a major-effect QTL on chromosome 10. To investigate the mechanism of SCR resistance in L119 A, RNA-seq of P. polysorainoculated and non-inoculated plants of L119 A and Lx9801 was performed. Unexpectedly, the number of differentially expressed genes in inoculated versus non-inoculated L119 A plants was about 10 times that of Lx9801, with only 29 common genes identified in both lines, suggesting extensive gene expression changes in the highly resistant but not in the susceptible line. Based on the transcriptome analysis, one of the CC-NBS-LRR candidate genes was confirmed to be upregulated in L119 A relative to Lx9801 independently of P. polysora inoculation. Gene Ontology and Kyoto Encyclopedia of Genes and Genomes analyses indicated that transcription factors, as well as genes involved in defense responses and metabolic processes, were dominantly enriched, with the phenylpropanoid biosynthesis pathway most specifically activated. Consistently, accumulation of phenylpropanoid-derived lignin, especially S lignin, was drastically increased in L119 A after P. polysora inoculation, but remained unchanged in Lx9801, suggesting a critical role of lignin in SCR resistance. A regulatory network of defense activation and metabolic change in SCR-resistant maize upon P. polysora infection is described. | Xiaohuan Mu Zhuangzhuang Dai Zhanyong Guo Hui Zhang Jianping Yang Xinke Gan Jiankun Li Zonghua Liu Jihua Tang Mingyue Gou | 2022 | The Crop Journal2022，10，2： | 1 |
| 9 | Strain enhancement for a MoS2-on-GaN photodetector with an Al2O3 stress liner grown by atomic layer deposition显示文摘Strain regulation as an effective way to enhance the photoelectric properties of two dimensional(2D)transition metal dichalcogenides has been widely employed to improve the performance of photovoltaic devices.In this work,tensile strain was introduced in multilayer MoS2 grown on GaN by depositing 3 nm of Al2O3 on the surface.The temperature dependent Raman spectrum shows that the thermal stability of MoS2 is improved by Al2O3.Theoretical simulations confirmed the existence of tensile strain on MoS2 covered with Al2O3,and the bandgap and electron effective mass of six layers of MoS2 decreased due to tensile strain,which resulted in an increase of electron mobility.Due to the tensile strain ffect,the photodetector with the Al2O3 stress liner achieved better performance under the illumination of 365 nm wavelength,including a higher responsivity of 24.6 A/W,photoconductive gain of 520,and external quantum fficiency of 8381%,which are more than twice the corresponding values of photodetectors without Al2O3.Our work provides an effective technical way for improving the performance of 2D material photodetectors. | ZHIWEN LI JIANGLIU LUO SHENGQUN HU QIANG LIU WENJIE Yu YOUMING LU XINKE LIU | 2020 | Photonics Research2020，8，6： | 1 |
| 10 | Hematopoietic effects and mechanisms of Fufang E?jiao Jiang on radiotherapy and chemotherapy-induced myelosuppressed mice显示文摘 | Maoxuan Liu Haining Tan Xinke Zhang Zhang Liu Yanna Cheng Dongliang Wang Fengshan Wang | 2014 | Journal of Ethnopharmacology2014，，： | 1 |
| 11 | Age-related changes in cerebral angiogenesis and fetal liver kinase-1 expression after cerebral ischemia/reperfusion显示文摘Cerebral angiogenesis in the early stages after cerebral ischemia injury is essential for the recovery of nerve function, in which fetal liver kinase-1 (Flk-1), as a major regulator of vasculogenesis and angiogenesis, plays a very important role. Microvessel density (MVD) was greater in an aged model group compared with the young sham operated group (P < 0.01). MVD and the sum of the lumen area were decreased in the aged group at 1, 3, 6 and 12 days following ischemia/reperfusion (I/R) injury compared with the young model group (P < 0.05 and P < 0.01, respectively). Flk-1 protein and mRNA expression was greater in the aged model group when compared with the young sham operated group (P < 0.01). Flk-1 protein and mRNA expression was lower in the aged group at 1, 3, 6 and 12 days after I/R compared with the young model group (P < 0.01). Flk-1 expression in aged rats attenuated rapidly, but was still maintained at relatively higher levels at 12 days following I/R in younger rats. The results suggest that angiogenesis was weakened after cerebral I/R in aged rats, and the mechanism of which might be correlated with attenuated expression of Flk-1 protein and mRNA. | Jiansheng Li Ke Liu Xinke Yang Jianfeng Gao Youlong Zhou Yuewu Zhao Zhengguo Liu Jingxia Liu | 2010 | Neural Regeneration Research2010，5，17： | 0 |
| 12 | A Pressure-Drop Model for Oil-Gas Two-Phase Flow in Horizontal Pipes显示文摘The accurate prediction of the pressure distribution of highly viscous fluids in wellbores and pipelines is of great significance for heavy oil production and transportation.The flow behavior of high-viscosity fluids is quite different with respect to that of low-viscosity fluids.Currently,the performances of existing pressure-drop models seem to be relatively limited when they are applied to high-viscosity fluids.In this study,a gas-liquid two-phase flow experiment has been carried out using a 60 mm ID horizontal pipe with air and white oil.The experimental results indicate that viscosity exerts a significant influence on the liquid holdup and pressure drop.At the same gas and liquid volume,both the liquid holdup and pressure drop increase with an increase in the viscosity.Combining two existing models,a modified pressure drop method is developed,which is applicable to horizontal pipes for different viscosities and does not depend on the flow pattern.This new method displays a high accuracy in predicting the new experimental data presented here and other published data in literature. | Xinke Yang Shanzhi Shi Hui Zhang Yuzhe Yang Zilong Liu Ruiquan Liao Joseph X.F.Ribeiro | 2021 | Fluid Dynamics & Materials Processing2021，17，2： | 0 |
| 13 | Hourly energy consumption characteristics of metro rail transit:Train traction versus station operation显示文摘The electricity consumption of the urban metro system can be mainly divided into the following two categories:the electricity consumption for train traction(E_(t))and the electricity consumption for station operation(E_(s)).Although understanding the hourly fluctuation characteristics of E_(t) and E_(s) contributes to renewable energy inte-gration and achieving carbon emission reduction of the metro system,the hourly fluctuation characteristics have been poorly reported in the literature.Thus,a typical underground non-transfer metro station of a city’s metro system in the North China Plain is selected in this study,and E_(t) and E_(s) were monitored to portray their hourly fluctuation characteristics.Results reveal that the hourly E_(t) shows a significant intraday“U”shape on weekdays,indicating two symmetric peaks in morning and evening rush hours.While the hourly E_(s) shows an intraday“flat”shape,indicating it is nearly free from the effect of rush hour.Moreover,it is statistically proved that the train frequency is the core influencing factor resulting in the intraday fluctuation of hourly E_(t).In the case study,when the train frequency increases from the mean(20 trains per hour)to maximum(32 trains per hour),the hourly E_(t) will increase by 53.4%. | Bowen Guan Xiaohua Liu Tao Zhang Xinke Wang | 2023 | Energy and Built Environment2023，4，5： | 0 |
| 14 | Development and validation of a nomogram to predict cardiac death after radiotherapy for esophageal cancer显示文摘Background:Patients frequently die from cardiac causes after radiotherapy for esophageal cancer.Early detection of cardiac death risk in these patients is crucial to improve clinical decision‐making and prognosis.Thus,we modeled the risk of cardiac death after irradiation for esophageal cancer.Methods:A retrospective analysis of 37,599 esophageal cancer cases treated with radiotherapy in the SEER database between 2000 and 2018 was performed.The selected cases were randomly assigned to the model development group(n=26,320)and model validation group(n=11,279)at a ratio of 7:3.We identified the risk factors most commonly associated with cardiac death by least absolute shrinkage and selection operator regression analysis(LASSO).The endpoints for model development and validation were 5‐and 10‐year survival rates.The net clinical benefit of the models was evaluated by decision curve analysis(DCA)and concordance index(C‐index).The performance of the models was further assessed by creating a receiver operating characteristic curve(ROC)and calculating the area under the curve(AUC).Kaplan‐Meier(K‐M)survival analysis was performed on the probability of death.Patients were classified according to death probability thresholds.Five‐and ten‐year survival rates for the two groups were shown using K‐M curves.Results:The major risk factors for cardiac death were age,surgery,year of diagnosis,sequence of surgery and radiotherapy,chemotherapy and a number of tumors,which were used to create the nomogram.The C‐indexes of the nomograms were 0.708 and 0.679 for the development and validation groups,respectively.DCA showed the good net clinical benefit of nomograms in predicting 5‐and 10‐year risk of cardiac death.The model exhibited moderate predictive power for 5‐and 10‐year cardiac mortality(AUC:0.833 and 0.854,respectively),and for the development and validation cohorts(AUC:0.76 and 0.813,respectively).Conclusions:Our nomogram may assist clinicians in making clinical decisions about patients undergoing radiotherapy for esophageal cancer based on early detection of cardiac death risk. | Xinfang Lv Xue Wu Kai Liu Xinke Zhao Chenliang Pan Jing Zhao Juan Chang Huan Guo Xiang Gao Xiaodong Zhi Chunzhen Ren Qilin Chen Hugang Jiang Chunling Wang Ying‐Dong Li | 2023 | Cancer Innovation2023，2，5： | 0 |
| 15 | Constructing recombinant replication-defective adenoviral vectors that express glucose transporter-1 through in vitro ligation显示文摘BACKGROUND: We constructed a homologous recombination bacterial method based on the pAdEasy system, a widely used system, for generating recombinant adenoviral vectors that express glucose transporter-1 (GLUT1) in rats. OBJECTIVE: This study was designed to investigate the feasibility of generating recombinant replication-defective adenoviral vectors that express GLUT1 in rats by in vitro ligation based on the Adeno-XTM system. DESIGN: An in vitro cell-based experiment. SETTING: This study was performed at the Linbaixin Medical Research Center of the Second Hospital Affiliated to Sun Yat-sen University and Central Laboratory for Prevention and Treatment of Tumor, Sun Yat-sen University between January and August 2004. MATERIALS: Male, adult, Sprague Dawley rats were used to extract total RNA from brain tissue. E. coli DH5 α and human embryonic kidney 293 cells (HEK293 cells) used in the present study were cryo-preserved by the Second Hospital Affiliated to Sun Yat-sen University. Rabbit anti-rat GLUT1 polyclonal antibody (Chemicon, U.S.A.) and primers (Shanghai Boya Bioengineering Co., Ltd) were also used. METHODS: E1/E3-deleted replication-defective adenoviral vectors were used. Using in vitro ligation, the target gene was first sub-cloned into a shuttle vector plasmid to obtain the fragment containing target gene expression cassettes by enzyme digestion. Subsequently, the fragment was co-transformed with linearized adenoviral backbone vector into the E. coli strain. The recombinant adenoviral plasmid was transfected into HEK293 cells to assembly recombinant adenoviral vectors with replication capabilities. The procedure was repeated several times for recombinant adenoviral vectors amplification. MAIN OUTCOME MEASURES: Efficiency of recombinant adenoviral vectors to express the target gene was measured by gene and protein expression through polymerase chain reaction and Western Blot assays, respectively. RESULTS: Results demonstrated that recombinant adenoviral vectors successfully expressed GLUT1 protein, with a relative molecular mass of 55000 in HEK293 cells. These results suggest that recombinant adenoviral vectors obtained by homologous bacterial recombination feature high efficiency, rapidness, and simplicity. CONCLUSION: We successfully amplified the rat GLUT1 gene and constructed replication-defective adenoviral vectors expressing GLUT1. The replication-defective adenoviral vectors proved to successfully express the target gene in HEK293 cells. | Fangcheng Li Junliang Li Ranyi Liu Xinke Xu Kaichang Yuan Zhonghua Wu | 2008 | Neural Regeneration Research2008，3，4： | 0 |
| 16 | A novel anti-metastatic extract from Stellera chamaejasme Linn.suppresses breast tumor cell motility through inhibition of focal adhesion kinase显示文摘To the Editor:In breast cancer,it is the metastasis that makes a clear distinction between life and death.^([1,2])However,effective treatment targeted against metastasis remains an unmet clinical need.^([2,3])Accumulating evidence suggests that an essential step in metastasis is tumor cell acquisition of motility.^([2])Furthermore,epithelial-mesenchymal transition(EMT)initiates the early steps of tumor cell spread by endowing them with greater motility and invasiveness. | Xinke Du Li Liu Lina Yang Lidong Sun Qingsen Ran Ying Chen Yujie Li Qing Yang Yajie Wang Xiaogang Weng Weiyan Cai Xiaoxin Zhu Qi Li | 2022 | Chinese Medical Journal2022，135，24： | 0 |
| 17 | Gas-blasting nanocapsules to accelerate carboplatin lysosome release and nucleus delivery for prostate cancer treatment显示文摘To improve therapeutic effect and reduce severely side effects of carboplatin(CBP),the gas-generating nanocapsules were developed to accelerate CBP lysosome release and nucleus delivery.CBP/SB-NC was prepared by co-loading CBP and NaHCO 3(SB)in nanocapsules using w/o/w emulsification solvent evaporation.They exhibited vesicle-like spherical morphology,uniform particle size and negative zeta potential.Reaching the tumor site with a relatively high concentration is the first step for CBP delivery and the results showed that CBP/SB-NC could effectively increase drug accumulation at tumor site.After that,the drug delivery carriers need to be internalized into tumor cells and the in vitro cellular uptake ability results showed CBP/SB-NC could be internalized into RM-1 cells more efficient than CBP solution.After internalized by RM-1 cells,the gas-blasting release process was tested in acid environment.It was demonstrated that 5 mg/ml NaHCO 3 was optimal to achieve pH-responsive gas-blasting release.In vitro release results showed that CBP significantly rapid release in acid environment(pH 5.0)compared to neutral pH(pH 7.4)(P<0.05).Meanwhile,TEM and the change of the concentration of H+results exhibited that the explosion of CBP/SB 5-NC was more easily happened in lysosome acid environment(pH 5.0).The blasting release can accelerate CBP lysosome release to cytoplasm.Furthermore,the nucleus delivery results showed CBP/SB 5-NC can promote pH-triggered rapid nucleus delivery.And the results of Pt-DNA adduct assay showed that the binding efficiency between CBP and DNA of CBP/SB 5-NC was higher than CBP solution.At last,in vitro and in vivo anti-tumor efficacy proved that CBP/SB 5-NC could enhance anti-tumor activity for prostate cancer therapy.CBP/SB 5-NC also showed superior safety in vitro and in vivo by hemolysis assay and histopathological study.All of the results demonstrate that CBP/SB 5-NC would be an efficient gas-blasting release formulation to enhance prostate cancer treatment. | Shunli Fu Shuang Liang Dandan Jiang Rui Yang Zipeng Zhang Lili Chang Xinke Zhang Yongjun Liu Na Zhang | 2021 | Asian Journal of Pharmaceutical Sciences2021，16，2： | 0 |
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