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1Towards 6G wireless communication networks:vision,enabling technologies,and new paradigm shifts显示文摘The fifth generation(5G)wireless communication networks are being deployed worldwide from 2020 and more capabilities are in the process of being standardized,such as mass connectivity,ultra-reliability,and guaranteed low latency.However,5G will not meet all requirements of the future in 2030 and beyond,and sixth generation(6G)wireless communication networks are expected to provide global coverage,enhanced spectral/energy/cost efficiency,better intelligence level and security,etc.To meet these requirements,6G networks will rely on new enabling technologies,i.e.,air interface and transmission technologies and novel network architecture,such as waveform design,multiple access,channel coding schemes,multi-antenna technologies,network slicing,cell-free architecture,and cloud/fog/edge computing.Our vision on 6G is that it will have four new paradigm shifts.First,to satisfy the requirement of global coverage,6G will not be limited to terrestrial communication networks,which will need to be complemented with non-terrestrial networks such as satellite and unmanned aerial vehicle(UAV)communication networks,thus achieving a space-airground-sea integrated communication network.Second,all spectra will be fully explored to further increase data rates and connection density,including the sub-6GHz,millimeter wave(mmWave),terahertz(THz),and optical frequency bands.Third,facing the big datasets generated by the use of extremely heterogeneous networks,diverse communication scenarios,large numbers of antennas,wide bandwidths,and new service requirements,6G networks will enable a new range of smart applications with the aid of artificial intelligence(AI)and big data technologies.Fourth,network security will have to be strengthened when developing 6G networks.This article provides a comprehensive survey of recent advances and future trends in these four aspects.Clearly,6G with additional technical requirements beyond those of 5G will enable faster and further communications to the extent that the boundary between physical and cyber worlds disappears.Xiaohu YOU Cheng-Xiang WANG Jie HUANG Xiqi GAO Zaichen ZHANG Mao WANG Yongming HUANG Chuan ZHANG Yanxiang JIANG Jiaheng WANG Min ZHU Bin SHENG Dongming WANG Zhiwen PAN Pengcheng ZHU Yang YANG Zening LIU Ping ZHANG Xiaofeng TAO Shaoqian LI Zhi CHEN Xinying MA Chih-Lin I Shuangfeng HAN Ke LI Chengkang PAN Zhimin ZHENG Lajos HANZO Xuemin(Sherman)SHEN Yingjie Jay GUO Zhiguo DING Harald HAAS Wen TONG Peiying ZHU Ganghua YANG Jun WANG Erik GLARSSON Hien Quoc NGO Wei HONG Haiming WANG Debin HOU Jixin CHEN Zhe CHEN Zhangcheng HAO Geoffrey Ye LI Rahim TAFAZOLLI Yue GAO HVincent POOR Gerhard P.FETTWEIS Ying-Chang LIANG 2021Science China(Information Sciences)2021,64,1:122
2Current status of diagnosis and treatment of bladder cancer in China-Analyses of Chinese Bladder Cancer Consortium database显示文摘Objective:To investigate current status of diagnosis and treatment of bladder cancer in China.Methods:A database was generated by Chinese Bladder Cancer Consortium(CBCC).From January 2007 to December 2012,14,260 cases from 44 CBCC centers were included.Data of diagnosis,treatment and pathology were collected.Results:The average age was 63.5 year-old and most patients were male(84.3%).The most common histologic types were urothelial carcinoma(91.4%),adenocarcinoma(1.8%),and squamous carcinoma(1.9%).According to 1973 and 2004 WHO grading system,42.0%,41.0%,and 17.0% of patients were grade 1,2,and 3,and 16.0%,48.7%,and 35.3% of patients were papillary urothelial neoplasms of low malignant potential,low,and high grade,respectively.Non-muscle invasive bladder cancer(NMIBC)and muscle invasive bladder cancer(MIBC)were 25.2% and 74.1%,respectively(0.8% not clear).Carcinoma in situ was only 2.4%.Most patients were diagnosed by white-light cystoscopy with biopsy(74.3%).Fluorescence and narrow band imaging cystoscopy had additional detection rate of 1.0% and 4.0%,respectively.Diagnostic transurethral resection(TUR)provided detection rate of 16.9%.Most NMIBCs were treated with TUR(89.2%).After initial TUR,2.6%accepted second TUR,and 45.7%,69.9%,and 58.7% accepted immediate,induced,and maintenance chemotherapy instillation,respectively.Most MIBCs were treated with radical cystectomy(RC,59.7%).Laparoscopic RCs were 35.1%,while open RC 63.4%.Extended and standard pelvic lymph node dissection were 7% and 66%,respectively.Three most common urinary diversions were orthotopic neobladder(44%),ileal conduit(31%),and ureterocutaneostomy(23%).Only 2.3% of patients accepted neo-adjuvant chemotherapy and only 18%of T3 and T4 patients accepted adjuvant chemotherapy.Conclusion:Disease characteristics are similar to international reports,while differences of diagnosis and treatment exist.This study can provide evidences for revisions of the guideline on bladder cancer in China.Kaiwen Li Tianxin Lin Wei Xue Xin Mu Enci Xu Xu Yang Fubao Chen Guangyong Li Lulin Ma Guoliang Wang Chaozhao Liang Haoqiang Shi Ming Li Mao Tang Xueyi Xue Yisong Lv Yaoliang Deng Chengyang Li Zhiwen Chen Xiaozhou Zhou Fengshuo Jin Xudong Liu Jinxin Wei Lei Shi Xin Gou Weiyang He Liqun Zhou Lin Cai Baiye Jin Guanghou Fu Xiangbo Kong Hongyan Sun Ye Tian Lang Feng Tiejun Pan Yiyi Wu Dongwen Wang Hailong Hao Benkang Shi Yaofeng Zhu Qiang Wei Ping Han Changli Wu Dawei Tian Zhangqun Ye Zheng Liu Zhiping Wang Junqiang Tian Lin Qi Minfeng Chen Wei Li Jinchun Qi Gongxian Wang Longlong Fu Zhaolin Sun Guangheng Luo Zhoujun Shen Zhaowei Zhu Jinchun Xing Zhun Wu Dong Wei Xin Chen Yanqun Na Hongfeng Guo Chunxi Wang Zhihua Lu Chuize Kong Yang Liu Jin Yang Jianyun Hu Xin Gao Jielin Li Changjun Yin Pu Li Shan Chen Zhen Du Jiongming Li Yongji Yan Xu Zhang Shuang Huang Fangjian Zhou Zhiling Zhang Yinghao Sun Shuxiong Zeng Song Cen Jiaquan Zhou Hanzhong Li Jin Wen Jian Huang 2015Asian Journal of Urology2015,2,2:21
3Millennial-centennial Scales Climate Changes of Holocene Indicated by Magnetic Susceptibility of High-resolution Section in Salawusu River Valley, China显示文摘The upmost segment (Holocene series) of the Milanggouwan stratigraphic section (MGS1) in the Salawusu River valley shows 11 sedimentary cycles of dune sands and fluvio-lacustrine facies, or dune sands and paleosols. The analysis of the magnetic susceptibility of this segment suggests that there are 11 magnetic susceptibility cycles with the value alternating from low to high, in which the layers of the dune sands correspond to the lower value of the magnetic susceptibility and the layers of fluvio-lacustrine facies and paleosols correspond to the higher peaks. The study reveals that the low and high magnetic susceptibility values indicate the climate dominated by cold-arid winter monsoon and warm-humid summer monsoon of East Asia, respectively, and the study area has experienced at least 22 times of millennial-centennial scales climate alternation from the cold-arid to the warm-humid during the Holocene. In terms of the time and the climate nature, the variations basically correspond to those of the North Atlantic and some records of cold-warm changes in China as well. They might be caused by the alternation of winter and summer monsoons in the Mu Us Desert induced by global climate fluctuations in the Holocene.LU Yingxia LI Baosheng WEN Xiaohao QIU Shifan WANG Fengnian NIU Dongfeng LI Zhiwen 2010Chinese Geographical Science2010,20,3:19
4Nanocellulose Composites—Properties and Applications显示文摘Nanocellulose composites combine the advantages of nanocellulose and composites. Recently, nanocellulose composites have been received more attentions due to their improved properties and promising broad applications. In the past, rapid progress has been made in the synthesis, properties, and mechanism of nanocellulose composites and potential applications were reported. There are a few reports on the increasing applications of nanocellulose composites with focus on the biomedical field, environmental field, electrode and sensor applications. In this article, the recent development of nanocellulose composites was reviewed via some typical examples. In addition to the synthesis methods, improved properties and potential applications were discussed. The problems and future applications of nanocellulose composites were also suggested.Chang Ma MingGuo Ma ZhiWen Li Bin Wang 2018Paper And Biomaterials2018,3,2:19
5Progress of the key materials for organic solar cells显示文摘Organic solar cells have attracted academic and industrial interests due to the advantages like lightweight,flexibility and roll-to-roll fabrication.Nowadays,18%power conversion efficiency has been achieved in the state-of-the-art organic solar cells.The recent rapid progress in organic solar cells relies on the continuously emerging new materials and device fabrication technologies,and the deep understanding on film morphology,molecular packing and device physics.Donor and acceptor materials are the key materials for organic solar cells since they determine the device performance.The past 25 years have witnessed an odyssey in developing high-performance donors and acceptors.In this review,we focus on those star materials and milestone work,and introduce the molecular structure evolution of key materials.These key materials include homopolymer donors,D-A copolymer donors,A-D-A small molecular donors,fullerene acceptors and nonfullerene acceptors.At last,we outlook the challenges and very important directions in key materials development.Yang Tong Zuo Xiao Xiaoyan Du Chuantian Zuo Yuelong Li Menglan Lv Yongbo Yuan Chenyi Yi Feng Hao Yong Hua Ting Lei Qianqian Lin Kuan Sun Dewei Zhao Chunhui Duan Xiangfeng Shao Wei Li Hin-Lap Yip Zhengguo Xiaol Bin Zhang Qingzhen Bian Yuanhang Cheng Shengjian Liu Ming Cheng Zhiwen Jin Shangfeng Yang Liming Ding 2020Science China Chemistry2020,63,6:15
6Interface engineering gifts CsPbI2.25Br0.75 solar cells high performance显示文摘Organic-inorganic halide perovskite (ABX3) solar cells (PSCs)have made great progress in recent years [1]. The power conversion efficiency (PCE) has increased up to 25.2%(NREL Best Research-Cell Efficiency Chart, http://gffzz8798726073dc471csknkfo66b5q5b6qkn.ffgz.tsg.suse.edu.cn/pv/cell-efficiency.html, Accessed August 2019). However, they suffer from poor thermal stability due to the volatile A-site organic cations.Zhimin Fang Xianyi Meng Chuantian Zuo Dan Li Zuo Xiao Chenyi Yi Mingkui Wang Zhiwen Jin Shangfeng Yang Liming Ding 2019Science Bulletin2019,64,23:11
7Hydrochemical Characteristics and Solute Dynamics of Meltwater Runoff of Urumqi Glacier No.1,Eastern Tianshan,Northwest China显示文摘Hydrochemical characteristics and solute dynamics of bulk meltwater draining from Urumqi Glacier No.1 were investigated in years 2006 and 2007.The glacial meltwater was slightly alkaline with the mean pH of 7.64 and 7.61 in 2006 and 2007,respectively.In the meltwater,the dominant anions were the bicarbonate and sulphate,and the dominant cation was calcium.The concentration of major cations were varied as c(Ca2+) > c(Mg2+) > c(K+) > c(Na+),while the order for the cations was c(HCO3) > c(SO42) > c(NO3) > c(Cl).The total dissolved solids(TDS) in meltwater had inverse relationships with the diurnal discharge.The major ion composition of meltwater was mainly controlled by rock weathering as inferred from the Gibbs model.Furthermore,the ion ratios and Piper diagram indicated that the main processes controlling the meltwater chemistry were carbonate weathering,pyrite weathering and feldspar weathering in rocks,and Ca2+ and HCO3 were the dominant ions during the carbonate weathering process.Solute flux calculation at Glacier No.1 station suggested that chemical denudation rates were 11.46 and 13.90 ton.km 2.yr 1 in 2006 and 2007,respectively.FENG Fang LI Zhongqin JIN Shuang DONG Zhiwen WANG Feiteng 2012Journal of Mountain Science2012,9,4:10
8Mesozoic and Cenozoic uplift and exhumation of the Bogda Mountain,NW China: Evidence from apatite fission track analysis显示文摘Apatite fission track(AFT)analysis on samples collected from a Paleozoic series is used to constrain the cooling history of the Bogda Mountain,northwest China.AFT ages range from 136.2 to 85.6 Ma and are younger than rock depositional ages and the mean confined track lengths(11.0e13.2 mm)mostly showing unimodal distribution are shorten,indicating significant track-annealing.Thermal histories modeling based on the distribution of fission-track lengths combined with the regional geological data show that two rapid cooling phases occurred in the latest Jurassiceearly Cretaceous and the OligoceneeMiocene.Those new data together with previous published data show that the AFT ages become younger from the southwest to northeast in the western Bogda Mountain and its adjacent areas.The fission-track ages of the southwest area are relatively older(>100 Ma),recording the earlier rapid uplift phase during the late JurassiceCretaceous,while the ages in the north piedmont of the Bogda Mountain(namely the northeast part)are younger(<60 Ma),mainly reflecting the later rapid uplift phase in the OligoceneeMiocene.The trend of younger AFT ages towards the northeast might be explained by post-Cretaceous large-scale crustal tilting towards the southwest.In the thrust fault-dominated northern limbs of the Bogda Mountain,AFT ages reveal a discontinuous pattern with age-jumps across the major fault zones,showing a possible strata tilting across each thrust faults due to the thrust ramps during the Cenozoic.The two rapid uplift stages might be related to the accretion and collision in the southern margin of the Asian continent during the late Jurassic and late Cenozoic,respectively.Wenhao Tang Zhicheng Zhang Jianfeng Li Ke Li Zhiwen Luo Yan Chen 2015Geoscience Frontiers2015,6,4:9
9Wavelength and oscillator strength of dipole transition 1s^22p—1s^2nd for Mn^(22+) ion显示文摘The transition energies, wavelengths and dipole oscillator strengths of 1s22p-1s2nd (3≤n≤9) for Mn22+ ion are calculated. The fine structure splittings of 1s2nd (n≤9) states for this ion are also evaluated. In calculating energy, the higher-order relativistic contribution is estimated under a hydrogenic approximation. The quantum defect of Rydberg series 1s2nd is determined according to the quantum defect theory. The results obtained in this paper excellently agree with the experi-mental data available in literatures.WANG ZhiWen, WANG YaNan, HU MuHong, LI XinRu & LIU Ying School of Physics and Electronic Technology, Liaoning Normal University, Dalian 116029, China 2008Science China(Physics,Mechanics & Astronomy)2008,51,11:8
10Nanostructuring gold wires as highly durable nano- catalysts for selective reduction of nitro compounds and azides with organosilanes显示文摘一个一般方法被开发由 nanostructuring 准备持久的混合 nanocatalysts 经由简单 alloying 和 dealloying 的金电线的表面。产生 nanoporous gold/Au NPG/Au 电线催化剂在以一种高度可控制的方式指定的柔韧的金属电线上与他们的厚度拥有 nanoporous 皮肤。作为示范,同样获得的 NPG/Au 被显示是一高度活跃, chemo 选择,并且为把 organosilanes 用作减少代理人的 nitro 混合物和叠氮化物的减小的 recyclable 催化剂。Huifang Guo Xiulinq Yan Yun Zhi Zhiwen Li Cai Wu Chunliang Zhao Jing Wang Zhixin Yu Yi Ding Wei He Yadong Li 2015Nano Research2015,8,4:8
11A unified algorithm for mobility load balancing in 3GPP LTE multi-cell networks显示文摘3GPP long term evolution (LTE) is a promising candidate for the next-generation wireless network, which is expected to achieve high spectrum efficiency by using advanced physical layer techniques and flat network structures. However, the LTE network still faces the problem of load imbalance as in GSM/WCDMA networks, and this may cause significant deterioration of system performance. To deal with this problem, mobility load balancing (MLB) has been proposed as an important use case in 3GPP self-organizing network (SON), in which the serving cell of a user can be selected to achieve load balancing rather than act as the cell with the maximum received power. Furthermore, the LTE network aims to serve users with different quality-of-service (QoS) requirements, and the network-wide objective function for load balancing is distinct for different kinds of users. Thus, in this paper, a unified algorithm is proposed for MLB in the LTE network. The load balancing problem is first formulated as an optimization problem with the optimizing variables being cell-user connections. Then the complexity and overhead of the optimal solution is analyzed and a practical and distributed algorithm is given. After that, the proposed algorithm is evaluated for users with different kinds of QoS requirements, i.e., guaranteed bit rate (GBR) users with the objective function of load balance index and non-GBR (nGBR) users with the objective function of total utility, respectively. Simulation results show that the proposed algorithm leads to significantly balanced load distribution for GBR users to decrease the new call blocking rate, and for nGBR users to improve the cell-edge throughput at the cost of only slight deterioration of total throughput.WANG Hao LIU Nan LI ZhiHang WU Ping PAN ZhiWen YOU XiaoHu 2013Science China(Information Sciences)2013,56,2:7
12Pleniglacial millennium-scale climate variations in northern China based on records from the Salawusu River Valley显示文摘Situated in the Salawusu River Valley, southeast of China's Mu Us Desert, the MGS2 (Milanggouwan section) portion of the Milanggouwan stratigraphic section records 5.5 sedimentary cycles consisting of alternations between dune sand deposits and fluvial or lacustrine facies. We analyzed the grain-size and CaCO 3 distributions in MGS2, and found that Mz (mean particle diameter) and σ (standard deviation) displayed clear variations in peaks and valleys within different sedimentary facies. The CaCO 3 content averaged 0.4% in the dune sand deposits, 1.43% in the fluvial facies, and 8.82% in the lacustrine facies. Both the grain-size distribution and CaCO 3 contents, which equal the indicators for the alternation among the sedimentary facies, suggest the occurrence of 5.5 cycles. These results suggest that the observed cycles mainly resulted from fluctuations between a cold and dry winter monsoon climate and a warm and humid summer monsoon climate, and that the MGS2 portion experienced at least 5.5 fluctuations between these two extremes. This high-frequency climatic fluctuation indicates a strong influence of millennium-scale variations in the strength of the East Asian winter and summer monsoons in our study area during the Pleniglacial.FengNian WANG BaoSheng LI JiangLong WANG XiaoHao WEN DongFeng NIU ZhiWen LI YueJun SI YiHua GUO ShuHuan DU 2012Journal of Arid Land2012,4,3:7
13Variations in the equilibrium line altitude of Urumqi Glacier No.1,Tianshan Mountains,over the past 50 years显示文摘The glacier ELA is one of the important parameters reflecting climate change.Based on observations of the equilibrium line altitude(ELA) of Urumqi Glacier No.1 in the Tianshan Mountains,we established a statistical model between ELA and its major influencing factors,warm season air temperature(air temperature averages for May,June,July and August) and annual precipitation.Result showed that,warm season air temperature was the leading climatic factor influencing ELA variations.The glacier ELA ascends(descends) 61.7 m when warm season air temperature increases(decreases) by 1°C,and ascends(descends) 13.1 m when cold season precipitation decreases(increases) by 10%.In the period 1959-2008,the glacier ELA showed a general increasing trend,ascending108 m and reaching its highest altitude in 2008 at 4168 m a.s.l.,close to the glacier summit.If future climate is similar to that in the past 50 years,the ELA of Urumqi Glacier No.1 will still ascend with a speed of 2.16 m/a.However,If future climate is similar to that in the period 2000-2008,the ELA will still ascend with a speed of 6.5 m/a before it is stable.As a result of ELA variation,the accumulation area ratio(AAR) of the glacier showed a decreasing trend during the past 50 years.DONG ZhiWen QIN DaHe REN JiaWen LI KaiMing LI ZhongQin 2012Chinese Science Bulletin2012,57,36:7
14Expert Consensus on the Care and Management of Patients with Cognitive Impairment in China显示文摘The cognitive disease consensus was prepared by panels of health and public representatives based on actual clinical practice in Geriatric Departments in Chinese hospitals and a systematic literature review. This consensus reflects the medical knowledge accumulated by those experts and provides information about professional medical care and advice.A multidisciplinary panel of specialists(neurologists,psychiatrists, and nursing specialists) reports an expert consensus on the medical knowledge accumulated from those experts and provides information about professional medical care and advice. The recommendations focus on the care and management of older adults with mild cognitive impairment,the objectives and methods of maintaining cognition and training, the assessments and measures of daily care for patients at different stages of dementia, the assessments and coping strategies for the behavioral and psychological symptoms of dementia, principles and suggestions for an appropriate living environment, arrangements for recreational activities, the care and management of patients with endstage dementia, and suggestions for addressing stress in caregivers. Yuliang Han Jianjun Jia Xia Li Yang Lv Xuan Sun Shanshan Wang Yongjun Wang Zhiwen Wang Jintao Zhang Jiong Zhou Yuying Zhou 2020Neuroscience Bulletin2020,36,3:7
15Temporal and spatial evolution of coastline and subaqueous geomorphology in muddy coast of the Yellow River Delta显示文摘基于海岸线和 bathometry 的测量数据,由遨游者和 Mapinfo 的软件处理了,并且与在在 Lijin 估计车站,海岸线的时间、空间的进化和在黄河三角洲的泥泞海岸的水下的地形学被分析的不同阶段的沉积负担结合了。结果证明 68% 沉积被从 1953 ~ 2000 绕河嘴并且在沿岸的区域扔的黄河交付。在不同海岸的海岸线响应河路线的移动有特殊变化。海岸线在 Diaokou 河嘴的西方是稳定的。从到 Gudong 油矿的北方的 Diaokou 河嘴的东方的海岸线与海墙保存经历了 siltation,然后严肃的侵蚀,和最后保留的马厩。通常, Qingshuigou 河功课的熬过的河嘴的海岸线拉长了朝海的方向,而在 Qingshuigou 旧河嘴的沙吐痰的南方方面在 Qing 8 在在位置附近注入的黄河以后被侵蚀。离开熬过的河嘴的水下的地形学从 1976 ~ 1996 展出了 siltation,与扁平的 topset 床和更陡峭的 foreset 床。从 1996 ~ 2005,离开 Qingshuigou 旧河嘴的水下的地形学在 topset 和 foreset 被侵蚀在 bottomset 床上的床,而是 silted。离开新河嘴的水下的地形学顺序与 19761996 的相比与小度执行了 siltation。PENG Jun MA Suisui CHEN Hongquan LI Zhiwen 2013Journal of Geographical Sciences2013,23,3:6
16QoS and channel state aware load balancing in 3GPP LTE multi-cell networks显示文摘In this paper,we investigate the load balancing problem with the consideration of different qualityof-service(QoS) and channel state in 3GPP long term evolution(LTE) multi-cell networks.Load imbalance among nearby cells often causes inefficient utilization of the system resources.Then in overloaded cells,users cannot get satisfied services for short resources,while in idle cells,there is plenty of unoccupied resources.However,switching users only for load balancing with no consideration of channel state often results in aggressive handover of users,which may occupy too many resources in their target cells and deteriorate the network efficiency.Thus,how to efficiently perform load balancing with the consideration of channel state becomes an important issue.Meanwhile,LTE network aims to serve users with different QoS requirements,which should be taken into account when performing load balancing.Thus we propose a multi-objective optimization problem,whose objectives are load balancing index and network average load for users with QoS requirements and a unified utility function for users without QoS requirements.The constraints are physical resource limits and users' QoS demands.Then we analyze its complexity and propose a practical algorithm,load balancing,with the consideration of different QoS requirements and channel state services(LBQC).Extensive simulations are conducted.The results show that the proposed algorithm can approximate the optimal algorithm efficiently,and leads to significantly better performances than load balancing with no consideration of channel state,e.g.a lower new call blocking rate with a fewer system resources occupation for users with QoS requirements,a higher cell edge throughput and total throughput for users without QoS requirements.LI ZhiHang WANG Hao PAN ZhiWen LIU Nan YOU XiaoHu 2013Science China(Information Sciences)2013,56,4:6
17Event-triggered encirclement control of multi-agent systems with bearing rigidity显示文摘In recent years, the problem of multi-agent encirclement has attained much attention and was extensively studied. However, few work consider the factor that the on-board calculation as well as the communication capacity in the multi-agent system is limited. We investigate the encirclement control by employing the newly developed bearing rigidity theory and event-triggered mechanism. Firstly, in order to reduce the onboard loads,the event-triggered mechanism is considered in the framework and further an event-triggered control law based on bearing rigidity is proposed. The input-to-state stability(ISS) of networked agents is also analyzed by using the Lyapunov method and the cyclic-small-gain theory. In addition, the lower bound for the inter-event times is provided. Finally, to verify the efficiency and feasibility of the proposed encirclement control law, numerical experiments are investigated.Yangguang YU Zhiwen ZENG Zhongkui LI Xiangke WANG Lincheng SHEN 2017Science China(Information Sciences)2017,60,11:6
18Computer-aided ionic liquid design for alkane/cycloalkane extractive distillation process显示文摘A computer-aided ionic liquid design(CAILD) study is presented for the frequently encountered alkane/cycloalkane separations in petrochemical industry. Exhaustive experimental data are first collected to extend the UNIFAC-IL model for this system, where the proximity effect in alkanes and cycloalkanes is considered specifically by defining distinct groups. The thermodynamic performances of a large number of ILs for 4 different alkane/cycloalkane systems are then compared to select a representative example of such separations. By applying n-heptane/methylcyclohexane extractive distillation as a case study, the CAILD task is cast as a mixed-integer nonlinear programming(MINLP) problem based on the obtained task-specific UNIFAC-IL model and two semi-empirical models for IL physical properties. The top 5 IL candidates determined by solving the MINLP problem are subsequently introduced into Aspen Plus for process simulation and economic analysis, which finally identify 1-hexadecyl-methylpiperidinium tricyanomethane([C_(16)MPip][C(CN)_3]) as the best entrainer for this separation.Zhen Song Xinxin Li He Chao Fan Mo Teng Zhou Hongye Cheng Lifang Chen Zhiwen Qi 2019Green Energy & Environment2019,4,2:6
19Construction and initial analysis of five Fosmid libraries of mitochondrial genomes of cotton(Gossypium)显示文摘Cotton(Gossypium)is an important crop providing textile fiber and edible oil.To gain the insights into mechanism of the cytoplasmic male sterility(CMS)inheritance,we constructed five fosmid libraries of mitochondrial genomes from mitotype of G.harknessii Brandegee.(one CMS line and its restorer),mitotype of G.hirsutum L.(one CMS line and its maintainer),and G.barbadense L.The numbers of the clones in these libraries ranged from 1152 to 2016 with an average insert size of 36.2 to 38.4 kb,equivalent to 70–119.3 mitogenomes.The libraries were screened with 28 markers derived from the conservative sequences and yielded 22,19,26,21,and 23 positive clones,respectively.These positive clones were used to construct the physical map of G.harknessii Brandegee.CMS line and G.barbadense L.mitogenomes that shared six syntenis regions.A total of 30 genes in nine clusters showed conservative and had high similarity with those in the mitochondrial genomes of cotton,Carica papaya,Cucurbita pepo and Nicotiana tabacum.Further investigation indicated that gene rrn26 had two copies in all five cotton mitogenomes,while genes atp1,rrn5 and rrn18 had two copies only in G.barbadense L.The positive clones and physical map are considered being useful resources in cotton genomics research.LI ShuangShuang LIU GuoZheng CHEN ZhiWen WANG YuMei LI PengBo HUA JinPing 2013Chinese Science Bulletin2013,58,36:5
20Antibody drug conjugate:the“biological missile”for targeted cancer therapy显示文摘Antibody–drug conjugate(ADC)is typically composed of a monoclonal antibody(mAbs)covalently attached to a cytotoxic drug via a chemical linker.It combines both the advantages of highly specific targeting ability and highly potent killing effect to achieve accurate and efficient elimination of cancer cells,which has become one of the hotspots for the research and development of anticancer drugs.Since the first ADC,Mylotarg®(gemtuzumab ozogamicin),was approved in 2000 by the US Food and Drug Administration(FDA),there have been 14 ADCs received market approval so far worldwide.Moreover,over 100 ADC candidates have been investigated in clinical stages at present.This kind of new anti-cancer drugs,known as“biological missiles”,is leading a new era of targeted cancer therapy.Herein,we conducted a review of the history and general mechanism of action of ADCs,and then briefly discussed the molecular aspects of key components of ADCs and the mechanisms by which these key factors influence the activities of ADCs.Moreover,we also reviewed the approved ADCs and other promising candidates in phase-3 clinical trials and discuss the current challenges and future perspectives for the development of next generations,which provide insights for the research and development of novel cancer therapeutics using ADCs.Zhiwen Fu Shijun Li Sifei Han Chen Shi Yu Zhang 2022Signal Transduction and Targeted Therapy2022,7,4:5
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