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| 1 | Transplantation of UC-MSCs on collagen scaffold activates follicles in dormant ovaries of POF patients with long history of infertility显示文摘Premature ovarian failure(POF) is a refractory disease for clinical treatment with the goal of restoring fertility. In this study,umbilical cord mesenchymal stem cells on a collagen scaffold(collagen/UC-MSCs) can activate primordial follicles in vitro via phosphorylation of FOXO3 a and FOXO1. Transplantation of collagen/UC-MSCs to the ovaries of POF patients rescued overall ovarian function, evidenced by elevated estradiol concentrations, improved follicular development, and increased number of antral follicles. Successful clinical pregnancy was achieved in women with POF after transplantation of collagen/UC-MSCs or UC-MSCs. In summary, collagen/UC-MSC transplantation may provide an effective treatment for POF. | Lijun Ding Guijun Yan Bin Wang Lu Xu Yan Gu Tong Ru Xiaoying Cui Lei Lei Jingyu Liu Xiaoqiang Sheng Bin Wang Chunxue Zhang Yanjun Yang Ruiwei Jiang Jianjun Zhou Na Kong Feifei Lu Huaijun Zhou Yannan Zhao Bing Chen Yali Hu Jianwu Dai Haixiang Sun | 2018 | Science China(Life Sciences)2018，61，12： | 43 |
| 2 | The rational design of multiple molecular module-based assemblies for simultaneously improving rice yield and grain quality显示文摘Rice is one of the most important staple food for over half of the world's population,and a substantial increase in productivity and quality of rice grain will be required to feed a growing human population.Grain size and shape are the two important components contributing to grain yield and quality,because they impact both yield potential and end-use quality.Over the past 50 years。 | Kun Wu Xiaopeng Xu Nan Zhong Haixiang Huang Jianping Yu Yafeng Ye Yuejin Wu Xiangdong Fu | 2018 | Journal of Genetics and Genomics2018，45，6： | 4 |
| 3 | Challenges and strategies in high-accuracy manufacturing of the world’s largest SiC aspheric mirror显示文摘In the process of manufacturing the world’s largest silicon carbide(SiC)aspheric mirror,the primary difficulties are mirror blank preparation,asphere fabrication,and testing,as well as cladding and coating.Specifically,the challenges include the homogeneity of the complicated structure casting,accuracy and efficiency of the fabrication process,print-through effect,fidelity and precision of test procedure,stress and denseness of cladding process,the dynamic range of interferometric measurement,and air turbulence error due to the long optical path.To break through such a barrier of difficulties,we proposed the water-soluble room temperature vanishing mold and gel casting technology,homogeneous microstructure reaction-formed joint technology,nano-accuracy efficient compound fabrication,gravity unloading technology,high-denseness low-defect physical vapor deposition(PVD)Si-cladding technology,test data fusion method,and time-domain averaging method,etc.Based on the proposed technologies and methods,we have accomplished the world’s largest SiC aspheric mirror with a size of φ4.03 m.The impressive performance of the SiC aspheric mirror is validated by the characteristics of the fabricated SiC aspheric mirror.The aerial density of the SiC blank is less than 120 kg/m^(2),surface shape test accuracy is better than 6 nm RMS,thickness inhomogeneity of the cladding layer is less than 5%,and the final surface figure error and roughness are 15.2 nm RMS and 0.8 nm RMS,respectively. | Xuejun Zhang Haixiang Hu Xiaokun Wang Xiao Luo Ge Zhang Wenxing Zhao Xiaoyi Wang Zhenyu Liu Ling Xiong Erhui Qi Congcong Cui Yanchao Wang Yingjie Li Xu Wang Longxiang Li Yang Bai Qiang Cheng Zhiyu Zhang Ruigang Li Wa Tang Xuefeng Zeng Weijie Deng Feng Zhang | 2022 | Light(Science & Applications)2022，11，12： | 3 |
| 4 | Inverse Optimal Control for Speed-varying Path Following of Marine Vessels with Actuator Dynamics显示文摘A controller which is locally optimal near the origin and globally inverse optimal for the nonlinear system is proposed for path following of over actuated marine crafts with actuator dynamics. The motivation is the existence of undesired signals sent to the actuators, which can result in bad behavior in path following. To attenuate the oscillation of the control signal and obtain smooth thrust outputs, the actuator dynamics are added into the ship maneuvering model. Instead of modifying the Line-of-Sight (LOS) guidance law, this proposed controller can easily adjust the vessel speed to minimize the large cross-track error caused by the high vessel speed when it is turning. Numerical simulations demonstrate the validity of this proposed controller. | Yang Qu Haixiang Xu Wenzhao Yu Hui Feng Xin Han | 2017 | Journal of Marine Science and Application2017，16，2： | 3 |
| 5 | Updating preconditioner for iterative method in time domain simulation of power systems显示文摘The numerical solution of the differential-algebraic equations(DAEs) involved in time domain simulation(TDS) of power systems requires the solution of a sequence of large scale and sparse linear systems.The use of iterative methods such as the Krylov subspace method is imperative for the solution of these large and sparse linear systems.The motivation of the present work is to develop a new algorithm to efficiently precondition the whole sequence of linear systems involved in TDS.As an improvement of dishonest preconditioner(DP) strategy,updating preconditioner strategy(UP) is introduced to the field of TDS for the first time.The idea of updating preconditioner strategy is based on the fact that the matrices in sequence of the linearized systems are continuous and there is only a slight difference between two consecutive matrices.In order to make the linear system sequence in TDS suitable for UP strategy,a matrix transformation is applied to form a new linear sequence with a good shape for preconditioner updating.The algorithm proposed in this paper has been tested with 4 cases from real-life power systems in China.Results show that the proposed UP algorithm efficiently preconditions the sequence of linear systems and reduces 9%-61% the iteration count of the GMRES when compared with the DP method in all test cases.Numerical experiments also show the effectiveness of UP when combined with simple preconditioner reconstruction strategies. | WANG Ke XUE Wei LIN HaiXiang XU ShiMing ZHENG WeiMin | 2011 | Science China(Technological Sciences)2011，54，4： | 3 |
| 6 | Tool wear during high speed turning in situ TiC_p/TiB_w hybrid reinforced Ti-6Al-4V matrix composite显示文摘Chipping, adhesive wear, abrasive wear and crater wear are prevalent for both the polycrystalline diamond(PCD) and the carbide tools during high speed turning of TiC_p/TiB_w hybrid reinforced Ti-6Al-4V(TC4) matrix composite(TMCs). The combined effects of abrasive wear and diffusion wear caused the big crater on PCD and carbide tool rake face. Compared to the PCD, bigger size of crater was found on the carbide tool due to much higher cutting temperature and the violent chemical reaction between the Ti element in the workpiece and the WC in the tool.However, the marks of the abrasive wear looked much slighter or even could not be observed on the carbide tool especially when low levels of cutting parameters were used, which attributes to much lower hardness and smaller size of WC combined with more significant chemical degradation of carbide. When cutting TC4 using PCD tool, notch wear was the most significant wear pattern which was not found when cutting the TMCs. However, chipping, adhesive wear and crater wear were much milder when compared to the cutting of titanium matrix composite. Due to the absence of abrasive wear when cutting TC4, the generated titanium carbide on the PCD protected the tool from fast wear, which caused that the tool life for TC4 was 6–10 times longer than that for TMCs. | Ge Yingfei Xu Jiuhua Huan Haixiang | 2016 | Chinese Journal of Aeronautics2016，29，5： | 2 |
| 7 | Optimization of phenazine-1-carboxylic acid production by a gacA/qscR-inactivated Pseudomonas sp. M18GQ harboring pME6032Phz using response surface methodology显示文摘 | Quan Zhou Jinjiang Su Haixiang Jiang Xianqing Huang Yuquan Xu | 2010 | Applied Microbiology and Biotechnology2010，，6： | 1 |
| 8 | Development of a Novel Kilowatt Microwave Plasma Torch Source for Atomic Emission Spectrometry显示文摘 | ZHU Dan JIN Wei YU Bingwen YING Yangwei YU Haixiang SHAN Jin YAN Yuwei XU Chen WANG Baolai JIN Qinhan | 2017 | Chemical Research in Chinese Universities2017，33，5： | 1 |
| 9 | Effect of surfactant headgroups on the oil/water interface: An interfacial tension measurement and simulation study显示文摘 | Jiafang Xu Yang Zhang Haixiang Chen Pan Wang Zhenhua Xie Yongji Yao Youguo Yan Jun Zhang | 2013 | Journal of Molecular Structure2013，，： | 1 |
| 10 | An invasive zone in human liver cancer identified by Stereo-seq promotes hepatocyte–tumor cell crosstalk,local immunosuppression and tumor progression显示文摘Dissecting and understanding the cancer ecosystem,especially that around the tumor margins,which have strong implications for tumor cell infiltration and invasion,are essential for exploring the mechanisms of tumor metastasis and developing effective new treatments.Using a novel tumor border scanning and digitization model enabled by nanoscale resolution-SpaTial Enhanced REsolution Omics-sequencing(Stereo-seq),we identified a 500µm-wide zone centered around the tumor border in patients with liver cancer,referred to as“the invasive zone”.We detected strong immunosuppression,metabolic reprogramming,and severely damaged hepatocytes in this zone.We also identified a subpopulation of damaged hepatocytes with increased expression of serum amyloid A1 and A2(referred to collectively as SAAs)located close to the border on the paratumor side.Overexpression of CXCL6 in adjacent malignant cells could induce activation of the JAK-STAT3 pathway in nearby hepatocytes,which subsequently caused SAAs’overexpression in these hepatocytes.Furthermore,overexpression and secretion of SAAs by hepatocytes in the invasive zone could lead to the recruitment of macrophages and M2 polarization,further promoting local immunosuppression,potentially resulting in tumor progression.Clinical association analysis in additional five independent cohorts of patients with primary and secondary liver cancer(n=423)showed that patients with overexpression of SAAs in the invasive zone had a worse prognosis.Further in vivo experiments using mouse liver tumor models in situ confirmed that the knockdown of genes encoding SAAs in hepatocytes decreased macrophage accumulation around the tumor border and delayed tumor growth.The identification and characterization of a novel invasive zone in human cancer patients not only add an important layer of understanding regarding the mechanisms of tumor invasion and metastasis,but may also pave the way for developing novel therapeutic strategies for advanced liver cancer and other solid tumors. | Liang Wu Jiayan Yan Yinqi Bai Feiyu Chen Xuanxuan Zou Jiangshan Xu Ao Huang Liangzhen Hou Yu Zhong Zehua Jing Qichao Yu Xiaorui Zhou Zhifeng Jiang Chunqing Wang Mengnan Cheng Yuan Ji Yingyong Hou Rongkui Luo Qinqin Li Liang Wu Jianwen Cheng Pengxiang Wang Dezhen Guo Waidong Huang Junjie Lei Shang Liu Yizhen Yan Yiling Chen Sha Liao Yuxiang Li Haixiang Sun Na Yao Xiangyu Zhang Shiyu Zhang Xi Chen Yang Yu Yao Li Fengming Liu Zheng Wang Shaolai Zhou Huanming Yang Shuang Yang Xun Xu Longqi Liu Qiang Gao Zhaoyou Tang Xiangdong Wang Jian Wang Jia Fan Shiping Liu Xinrong Yang Ao Chen Jian Zhou | 2023 | Cell Research2023，33，8： | 1 |
| 11 | Experimental Wave Attenuation Study over Flexible Plants on a Submerged Slope显示文摘Using plants is a kind of environmentally-friendly coastal protection to attenuate wave energy. In this paper, a set of experiments were conducted to investigate the wave attenuation performance using flexible grasses on a submerged slope, and the wave attenuation coefficient for these experiments was calculated for different still water depths, slope and grass configurations. It was found that the slope plays a significant role in wave attenuation. The wave attenuation coefficient increases with increasing relative row number and relative density. For a small relative row number, the two configurations from the slope top to its toe and from the slope toe to its top performed equally to a large extent. For a medium relative row number, the configuration from the slope toe to its top performed more poorly than that from the slope top to its toe; however, it performed better than that from the slope top to its toe for a high relative row number. With a single row of grasses close to the slope top from the slope toe, the wave attenuation coefficient shows double peaks. With increasing grass rows or still water depth, the grass location corresponding to the maximum wave attenuation coefficient is close to the slope top. The dimensional analysis and the least square method were used to derive an empirical equation of the wave attenuation coefficient considering the effect of relative density, the slope, the relative row number and the relative location of the middle row, and the equation was validated to experimental data. | YIN Zegao YANG Xiaoyu XU Yuanzhao DING Meiling LU Haixiang | 2017 | Journal of Ocean University of China2017，16，6： | 1 |
| 12 | Optimization of phenazine-1-carboxylic acid production by a gacA/qscR-inactivated Pseudomonas sp. M18GQ harboring pME6032Phz using response surface methodology显示文摘 | Quan Zhou Jinjiang Su Haixiang Jiang Xianqing Huang Yuquan Xu | 2010 | Applied Microbiology and Biotechnology2010，，6： | 1 |
| 13 | Adaptive fuzzy switching filter for images corrupted by impulse noise显示文摘 | Haixiang Xu Guangxi Zhu Haoyu Peng | 2004 | Pattern Recognition Letters2004，25，5： | 1 |
| 14 | Milling Machinability of TiC Particle and TiB Whisker Hybrid Reinforced Titanium Matrix Composites显示文摘The milling machinabilities of titanium matrix composites were comprehensively evaluated to provide a theoretical basis for cutting parameter determination.Polycrystalline diamond(PCD)tools with different grain sizes and geometries,and carbide tools with and without coatings were used in the experiments.Milling forces,milling temperatures,tool lifetimes,tool wear,and machined surface integrities were investigated.The PCD tool required a primary cutting force 15%smaller than that of the carbide tool,while the uncoated carbide tool required a primary cutting force 10% higher than that of the TiAlN-coated tool.A cutting force of 300 Nper millimeter of the cutting edge(300N/mm)was measured.This caused excessive tool chipping.The cutting temperature of the PCD tool was 20%—30%lower than that of the carbide tool,while that of the TiAlN-coated tool was 12%lower than that of the uncoated carbide tool.The cutting temperatures produced when using water-based cooling and minimal quantity lubrication(MQL)were reduced by 100°C and 200°C,compared with those recorded with dry cutting,respectively.In general,the PCD tool lifetimes were 2—3 times longer than the carbide tool lifetimes.The roughness Raof the machined surface was less than 0.6μm,and the depth of the machined surface hardened layer was in the range of 0.15—0.25 mm for all of the PCD tools before a flank wear land of 0.2mm was reached.The PCD tool with a 0.8mm tool nose radius,0°rake angle,10°flank angle,and grain size of(30+2)μm exhibited the best cutting performance.For this specific tool,a lifetime of 16 min can be expected. | Huan Haixiang Xu Jiuhua Su Honghua Ge Yingfei Liang Xinghui | 2017 | Transactions of Nanjing University of Aeronautics and Astronautics2017，34，4： | 1 |
| 15 | Anti-periodic solutions for semilinear evolution equa- tions显示文摘 | CHEN Yingqing WANG Xiangdong XU Haixiang | 2002 | Journal Mathematical Analysis and Applica- tion2002，273，： | 1 |
| 16 | Electromagnetic Properties of a New Microwave Plasma Torch with Double Resonance Configuration显示文摘 | YU Bingwen JIN Wei ZHU Dan YING Yangwei YU Haixiang SHAN Jin XU Chen LIU Wenlong JIN Qinhan | 2016 | Chemical Research in Chinese Universities2016，32，4： | 1 |
| 17 | Adaptive Fuzzy Wwitching Filter for Images Corrupted by Impulse Noise 显示文摘 | Xu Haixiang Zhu Guangxi Peng Haoyu | 2004 | Pattern Recognition Letters2004，25，15： | 1 |
| 18 | An environmental friendly approach for the synthesis of the ionic liquid 1-ethyl-3-methylimidazolium acetate and its dissolubility to 1, 3,5-triamino-2, 4, 6-trinitrobenzene显示文摘 | ZHU Haixiang LI Jinshan XU Rong | 2012 | Journal of Molecular Liquids2012，165，： | 1 |
| 19 | Structural Strength Analysis of a Tri-Floater Floating Foundation for Offshore VAWT显示文摘Vertical axis wind turbines(VAWTs) are advantageous for the development of large-scale offshore wind power because the drive system is located at the bottom of the turbine. This study investigates the structural strength of a tri-floater floating foundation supporting a 2.6 MW Darrieus VAWT. Finite element models of the floating foundation were developed using space plate-beam elements. The environmental loads, such as the aerodynamic loads, static wind loads, and wave-current loads, were considered. The general strengths of the floating foundation were calculated for the normal operating case(a cut-out wind speed of 25 m s^(-1) and blade rotation of 12 r min^(-1) were used to analyze the most unfavorable loads) and an extreme case(wind speed of 40 m s^(-1) and parked blades), and the weak components of the structure were analyzed. The results show that the floating foundation meets the strength requirements and the structural stress is highest when the wave, wind, and current are in a collinear direction. The main and secondary supporting bars transmit the loads between the stand columns and the tower foundation, and their stresses are higher than those in the other components. In the actual design, these supporting bars should be strengthened. The aerodynamic loads are very important and should be considered in the structural strength analysis of the floating foundation and the floating wind turbine system. | LIU Liqin ZHAO Haixiang XU Wanhai YUAN Rui GUO Ying | 2018 | Journal of Ocean University of China2018，17，4： | 1 |
| 20 | Bioreduction of para -ebloronitrobenzene in a hydrogen -based hollow-fiber membrane biofilm reactor: effects of nitrate and sulfate 显示文摘 | LI Haixiang ZHANG Zhiqiang XU Xiaoyin | 2014 | Biodegradation2014，25，2： | 1 |
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