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| 1 | Biological drug and drug delivery-mediated immunotherapy显示文摘The initiation and development of major infammatory diseases,i.e.,cancer,vascular infammation,and some autoimmune diseases are closely linked to the immune system.Biologics-based immunotherapy is exerting a critical role against these diseases,whereas the usage of the immunomodulators is always limited by various factors such as susceptibility to digestion by enzymes in vivo,poor penetration across biological barriers,and rapid clearance by the reticuloendothelial system.Drug delivery strategies are potent to promote their delivery.Herein,we reviewed the potential targets for immunotherapy against the major infammatory diseases,discussed the biologics and drug delivery systems involved in the immunotherapy,particularly highlighted the approved therapy tactics,and finally offer perspectives in this feld. | Qingqing Xiao Xiaotong Li Yi Li Zhenfeng Wu Chenjie Xu Zhongjian Chen Wei He | 2021 | Acta Pharmaceutica Sinica B2021，11，4： | 15 |
| 2 | An effective method for improving the accuracy of Argo objective analysis显示文摘基于南船座数据的最佳的插值目的分析,改进被做到广泛地在数据吸收和客观分析系统使用的一个背景错误协变性矩阵的实验公式。明确地,关联的一个评价可伸缩那能有效地改善南船座客观分析的精确性被开发了。这个方法能自动地适应一个变量的坡度变化并且被叫作坡度依赖者关联规模方法。它南船座客观分析上的效果与 Gaussian 脉搏和光谱分析理论上被验证。一个维的模拟实验的结果证明坡度依赖者关联规模能改进客观分析系统的适应性,为充分吸收在有更大的海洋学的坡度的区域的观察的短波信息的分析计划使它可能。新计划在太平洋被用于南船座数据目的分析系统。结果显然被改进。 | ZHANG Chunling XU Jianping BAO Xianwen WANG Zhenfeng | 2013 | Acta Oceanologica Sinica2013，32，7： | 11 |
| 3 | Effects of litter quality and climate change along an elevational gradient on litter decomposition of subalpine forests, Eastern Tibetan Plateau, China显示文摘Temperature and freeze-thaw events are two key factors controlling litter decomposition in cold biomes.Predicted global warming and changes in freeze-thaw cycles therefore may directly or indirectly impact litter decomposition in those ecosystems. Here, we conducted a2-year-long litter decomposition experiment along an elevational gradient from 3000 to 3600 m to determine the potential effects of litter quality, climate warming and freeze-thaw on the mass losses of three litter types [dragon spruce(Picea asperata Mast.), red birch(Betula albosinensis Burk.), and minjiang fir(Abies faxoniana Rehd. et Wild)]. Marked differences in mass loss were observed among the litter types and sampling dates. Decay constant(k) values of red birch were significantly higher than those of the needle litters. However, mass losses between elevations did not differ significantly for any litter type.During the winter, lost mass contributed 18.3–28.8 % of the net loss rates of the first year. Statistical analysis showed that the relationships between mass loss and litter chemistry or their ratios varied with decomposition periods. Our results indicated that short-term field incubations could overestimate the k value of litter decomposition.Considerable mass was lost from subalpine forest litters during the wintertime. Potential future warming may not affect the litter decomposition in the subalpine forest ecosystems of eastern Tibetan Plateau. | Zhenfeng Xu Jianxiao Zhu Fuzhong Wu Yang Liu Bo Tan Wanqin Yang | 2016 | Journal of Forestry Research2016，27，3： | 6 |
| 4 | Acetyl salicylic acid attenuates cardiac hypertrophy through Wnt signaling显示文摘室的肥大是心血管的疾病的事件的一个强大、独立的预言者。低剂量的乙酰水杨酸酸(阿司匹林) 的脉管的性质通过血小板 cyclooxygenase 的不可逆的抑制提供心血管的好处 1;然而,可能的 anti-hypertrophic 性质和阿司匹林的潜在的机制没详细被调查。在这研究,健康野类型的雄的老鼠随机被划分成三个组并且使遭到了到横向的大动脉的收缩(TAC ) 或假冒的操作。操作 TAC 的老鼠与低剂量的阿司匹林的人的等价物被对待(10 mg 吗? | Samuel Chege Gitau Xuelian Li Dandan Zhao Zhenfeng Guo Haihai Liang Ming Qian Lifang Lv Tianshi Li Bozhi Xu Zhiguo Wang Yong Zhang Chaoqian Xu Yanjie Lu Zhiming Du Hongli Shan Baofeng Yang | 2015 | Frontiers of Medicine2015，9，4： | 6 |
| 5 | Identity Based Threshold Proxy Signature显示文摘 | XU Jing ZHANG Zhenfeng FENG Dengguo | 2006 | Chinese Journal of Electronics2006，15，1： | 6 |
| 6 | Effects of Alloying Elements on Microstructure and Erosion Resistance of Fe-C-Cr Weld Surfacing Layer显示文摘Effects of alloying elements on microstructure and erosion resistance of Fe-C-Cr weld surfacing layer have been studied. The experimental results show that increasing C and Cr content favors improving the erosion resistance of the layer, and the excessive C and Cr result in decreasing the erosion resistance at 90 deg. erosion. That Mo, Nb or Ti improves the erosion resistance of Fe-C-Cr weld surfacing layer is mainly attributed to increasing the amount of M7C3 and forming fine NbC or TiC in austenite matrix, but the excessive Mo, Nb or Ti is unfavorable. The addition of Mo, Nb and Ti in proper combination possesses stronger effect on improving the erosion resistance and the erosion resistance (εA) of Fe-C-Cr weld surfacing layer with fine NbC, TiC and M7C3 distributing uniformly in austenite matrix obviously increases to 2.81 at 15 deg. erosion and 2.88 at 90 deg. erosion when the layer composition is 3.05C, 20.58Cr, 1.88Mo, 2.00Nb and 1.05Ti (in wt pct). | Daqian SUN, Wenquan WANG, Zhaozhi XUAN, Yue XU and Zhenfeng ZHOUSchool of Materials Science and Engineering, Jilin University, Changchun 130025, China | 2003 | Journal of Materials Science & Technology2003，19，4： | 4 |
| 7 | Hypertrophic adenoids in patients with nasopharyngeal carcinoma:appearance at magnetic resonance imaging before and after treatment显示文摘Introduction:Patients with nasopharyngeal carcinoma(NPC) sporadically develop abnormal adenoids.Nasopharyngeal adenoids are usually included in the gross tumor volume(GTV) but may have different therapeutic responses than tumor tissue.Therefore,distinguishing adenoids from tumor tissue may be required for precise and efficient chemoradiotherapy and radiotherapy.We characterized nasopharyngeal adenoids and investigated the therapeutic responses of NPC and nasopharyngeal adenoids using magnetic resonance imaging(MRI).Methods:MRI data from 40 NPC patients with a coexisting adenoid mass before and after treatment were analyzed.The features of the adenoid masses,including location,striped appearance,size,interface,symmetry/asymmetry,and cysts,were evaluated.Treatment response were scored according to the World Health Organization guidelines.Results:A striped appearance was observed in 36 cases before treatment and in all cases after treatment.In these 36 cases,the average GTVs including and excluding the uninvolved adenoids were 19.8 cm^3 and 14.8 cm^3,respectively.The average percentage change after excluding the uninvolved adenoids from the GTV was 31.0%.Stable disease in the adenoids was identified in 27(96.4%) of 28 patients after neoadjuvant chemotherapy,while NPC clearly regressed.Partial adenoid responses were identified in 33(82.5%) of 40 patients at 3 months after chemoradiotherapy or radiotherapy,whereas complete tumor responses were achieved in all patients.Six months after treatment,the adenoids continued to atrophy but did not disappear,and tumor recurrence was not found.Conclusions:Nasopharyngeal adenoids and carcinoma tissue in NPC patients can be distinguished by using MRI and have different responses to chemoradiotherapy and radiotherapy.These findings contribute to better delineating the GTV of NPC,based on which spatially optimized strategies can be developed to render precise and efficient chemoradiotherapy and radiotherapy.Additionally,we observed a clear difference in the responses of these two tissue types to current therapies.This finding may reduce or avoid unnecessary biopsies or overtreatment. | Yao-Pan Wu Pei-Qiang Cai Li Tian Jie-Hua Xu Richard Alan Mitteer Jr Yi Fan Zhenfeng Zhang | 2015 | Chinese Journal of Cancer2015，34，3： | 4 |
| 8 | Fluorescent AIE dots encapsulated organically modified silica (ORMOSIL) nanoparticles for two-photon cellular imaging显示文摘2,3-Bis(4-(phenyl(4-(1,2,2-triphenylvinyl)phenyl)amino)phenyl) fumaronitrile (TPE-TPA-FN or TTF), which possesses aggregation-induced emission (AIE) characteristic, is doped in organically modified silica (ORMOSIL) nanoparticles. By increasing the weight ratio of TTF to the precursor of silica nanoparticles (the quantities of the precursors were kept the same), the fluorescence intensity of nanoparticles increased correspondingly, due to the formation of larger AIE dots in the cores of ORMOSIL nanoparticles. The fluorescent and biocompatible nanoprobes were then utilized for in vitro imaging of HeLa cells. Two-photon fluorescence microscopy clearly illustrated that the nanoparticles have the capacity of nucleus permeability, as well as cytoplasm staining towards tumor cells. Our experimental results may offer a promising method for fast and bright fluorescence imaging, as well as bio-molecule/drug delivery to cell nucleus. | ZHU ZhenFeng ZHAO XinYuan QIN Wei CHEN GuangDi QIAN Jun XU ZhengPing | 2013 | Science China Chemistry2013，56，9： | 3 |
| 9 | Interleukin-6 signaling pathway in targeted therapy for cancer显示文摘 | Yuqi Guo Feng Xu TianJian Lu Zhenfeng Duan Zhan Zhang | 2012 | Cancer Treatment Reviews2012，，7： | 2 |
| 10 | Winter soil CO_2 efflux in two contrasting forest ecosystems on the eastern Tibetan Plateau, China显示文摘Significant CO_2 fluxes from snow-covered soils occur in cold biomes. However, little is known about winter soil respiration on the eastern Tibetan Plateau of China. We therefore measured winter soil CO_2 fluxes and estimated annual soil respiration in two contrasting coniferous forest ecosystems(a Picea asperata plantation and a natural forest).Mean winter soil CO_2 effluxes were 1.08 lmol m^-2s^-1in the plantation and 1.16 lmol m^-2s^-1in the natural forest.These values are higher than most reported winter soil CO_2 efflux values for temperate or boreal forest ecosystems.Winter soil respiration rates were similar for our two forest ecosystems but mean soil CO_2 efflux over the growing season was higher in the natural forest than in the plantation. The estimated winter and annual soil effluxes for the natural forest were 176.3 and 1070.3 g m^-2, respectively, based on the relationship between soil respiration and soil temperature,which were 17.2 and 9.7 % greater than their counterparts in the plantation. The contributions of winter soil respiration to annual soil efflux were 15.4 % for the plantation and 16.5 %for the natural forest and were statistically similar. Our results indicate that winter soil CO_2 efflux from frozen soils in the alpine coniferous forest ecosystems of the eastern Tibetan Plateau was considerable and was an important component of annual soil respiration. Moreover, reforestation(natural coniferous forests were deforested and reforested with P. asperata plantation) may reduce soil respiration by reducing soil carbon substrate availability and input. | Zhenfeng Xu Feifei Zhou Huajun Yin Qing Liu | 2015 | Journal of Forestry Research2015，26，3： | 2 |
| 11 | Enhancing Photocatalytic Performance of NH 2-UIO66 by Defective Structural Engineering显示文摘NH_(2)-UIO66(NU)is a promising photocatalyst for the reduction of Cr(VI)to low-toxic Cr(III)driven by visible light under ambient conditions.However,the main limitation in this process is the ineffi cient ligand to metal charge transfer(LMCT)of photo-excited electrons,which is caused by inherent energy gap(ΔE_(LMCT)).This study synthesized the defective NU(NUXH,where X is the molar equivalent of the modulator)with reducedΔE_(LMCT)through linkers removal via acid treatment.The electronic structure of NUX-H was systematically investigated,and the results indicated that the structural defects in NUX-H strongly altered the environment of the Zr atoms.Furthermore,they substantially lowered the energy of the unoccupied d orbitals(LUMO),which was benefi cial to effi cient LMCT,resulting in an improved photocatalytic activity of NUX-H toward high-concentration(100 mg/L)Cr(VI)reduction.Compared to NU with defect-free structure,the reducing rate of Cr(VI)was increased by 47 times.This work introduced an alternative strategy in terms of designing effi cient photocatalysts for reducing Cr(VI)under ambient conditions. | Zhenmin Xu Jiazhen Cao Xiang Chen Liyi Shi Zhenfeng Bian | 2021 | Transactions of Tianjin University2021，27，2： | 2 |
| 12 | Universally composable anonymous password authenticated key exchange显示文摘Anonymous password authenticated key exchange(APAKE) is an important cryptographic primitive, through which a client holding a password can establish a session key with a server both authentically and anonymously. Although the server is guaranteed that the client in communication is from a pre-determined group, but the client's actual identity is protected. Because of their convenience, APAKE protocols have been widely studied and applied to the privacy protection research. However, all existing APAKE protocols are handled in stand-alone models and do not adequately settle the problem of protocol composition, which is a practical issue for protocol implementation. In this paper, we overcome this issue by formulating and realizing an ideal functionality for APAKE within the well-known universal composability(UC) framework, which thus guarantees security under the protocol composition operations. Our formulation captures the essential security requirements of APAKE such as off-line dictionary attack resistance, client anonymity and explicit mutual authentication. Moreover, it addresses the arbitrary probabilistic distribution of passwords. The construction of our protocol, which utilizes SPHF-friendly commitments and CCA2-secure encryption schemes, can be instantiated and proven secure in the standard model, i.e., without random oracle heuristics. | Xuexian HU Jiang ZHANG Zhenfeng ZHANG Jing XU | 2017 | Science China(Information Sciences)2017，60，5： | 2 |
| 13 | Simulation-based optimization of control policy on multi-echelon inventory system for fresh agricultural products显示文摘As fresh agricultural products are perishable and vulnerable,reducing inventory cost is a strategic target for supply chain enterprises.How to design a reliable multi-echelon inventory control policy is still a great challenge.Therefore,the inventory cost of a three-level fresh agricultural products inventory system was firstly mathematically analyzed.Then,the simulation-based optimization model of the multi-echelon inventory system for fresh agricultural products was proposed by using the Flexsim simulation software and the improved particle swarm optimization algorithm.Finally,the multi-echelon inventory system is simulated based on a large number of survey data.Simulation results demonstrate that the proposed simulation-based optimization model of multi-echelon inventory system for fresh agricultural products can provide decision-making and technical support for the formulation of inventory control policy,and also it shows that the modeling of system simulation is an effective method to solve the problem of complex system. | Guangyin Xu Jihao Feng Fenglei Chen Heng Wang Zhenfeng Wang | 2019 | International Journal of Agricultural and Biological Engineering2019，12，2： | 2 |
| 14 | Systematic Investigation of the Molecular Behaviors of Heterofullerenes C48X2 (X=B,N)显示文摘 | Xing Yumei Shang Zhenfeng | 2003 | Chemical Physics2003，287，3： | 1 |
| 15 | Pyrolysis behavior of pectin under the conditions that simulate cigarette smoking显示文摘 | Shun Zhou Yingbo Xu Chenghui Wang Zhenfeng Tian | 2011 | Journal of Analytical and Applied Pyrolysis2011，，1： | 1 |
| 16 | Theoretical Studies of the Substitution Patterns of Boron-Nitrogen (BN) Fullerenes:From C50 up to C20B15N15 CBN Ball显示文摘 | Shang Zhenfeng Wang Guichang | 2005 | Journal of Physical Chemistry A2005，109，： | 1 |
| 17 | Chinese Journal of Construction Machinery显示文摘 | Hu Zhenfeng Xu Binshi Dong Shiyun | 2004 | 2(1): 462004，2，1： | 1 |
| 18 | Effector cells derived from naive T cells used in tumor immunotherapy of mice bearing B16 melanoma显示文摘 | Wen Ming Xu Weili Ren Lili Gao Fei Cui Naipeng Wen Junye Li Xinjiang Lin Lin Ma Zhenfeng Chen Baoping Cai Jianhui | 2014 | Chinese Medical Journal2014，，7： | 1 |
| 19 | Research Advances in Detection Methods of Herbicide Paraquat显示文摘This paper summarized the main detection methods of paraquat,including the instrumental analysis like HPLC,GC,LC-MS / MS,and so on. The research prospects of paraquat detection were also put forward. | Xu Zhen Zhao Fang Xie Benhua Chen Mingshan Zhu Hai Yue Zhenfeng Bi Siyuan | 2014 | Plant Diseases and Pests2014，5，6： | 1 |
| 20 | An activated form of NB-ARC protein RLS1 functions with cysteine-rich receptor-like protein RMC to trigger cell death in rice显示文摘A key event that follows pathogen recognition by a resistance(R)protein containing an NB-ARC(nucleotide-binding adaptor shared by Apaf-1,R proteins,and Ced-4)domain is hypersensitive response(HR)-type cell death accompanied by accumulation of reactive oxygen species and nitric oxide.However,the integral mechanisms that underlie this process remain relatively opaque.Here,we show that a gain-offunction mutation in the NB-ARC protein RLS1(Rapid Leaf Senescence 1)triggers high-light-dependent HR-like cell death in rice.The RLS1-mediated defense response is largely independent of salicylic acid accumulation,NPR1(Nonexpressor of Pathogenesis-Related Gene 1)activity,and RAR1(Required for Mla12 Resistance 1)function.A screen for suppressors of RLS1 activation identified RMC(Root Meander Curling)as essential for the RLS1-activated defense response.RMC encodes a cysteine-rich receptor-like secreted protein(CRRSP)and functions as an RLS1-binding partner.Intriguingly,their co-expression resulted in a change in the pattern of subcellular localization and was sufficient to trigger cell death accompanied by a decrease in the activity of the antioxidant enzyme APX1.Collectively,our findings reveal an NBARC-CRRSP signaling module that modulates oxidative state,the cell death process,and associated immunity responses in rice. | Yiqin Wang Zhenfeng Teng Hua Li Wei Wang Fan Xu Kai Sun Jinfang Chu Yangwen Qian Gary JLoake Chengcai Chu Jiuyou Tang | 2023 | Plant Communications2023，4，2： | 1 |
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