|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Ticagrelor inhibits the NLRP3 inflammasome to protect against inflammatory disease independent of the P2Y_(12 ) signaling pathway显示文摘Ticagrelor is the first reversibly binding oralP2Y_(12) receptor antagonist to inhibit platelet activation and has been approved by the Food and Drug Administration for the treatment of coronary artery disease. At present, the other pharmacological functions of ticagrelor remain poorly understood. The NOD-, LRR-, and pyrin domain-containing protein 3 (NLRP3) inflammasome plays a critical role in the innate immune system, but its excessive activation also contributes to the pathogenesis of complex diseases. In this study, we systematically examined the effects of ticagrelor on the NLRP3 inflammasome and found that ticagrelor inhibits NLRP3 inflammasome activation in macrophages independent of its classic inhibitory effect on theP2Y_(12) signaling pathway. Further mechanistic studies demonstrate that ticagrelor attenuates the oligomerization of apoptosis-associated speck-like protein containing a CARD (ASC) by blocking chloride efflux, an effect achieved through the degradation of chloride intracellular channel proteins (CLICs) and blockade of the translocation of CLICs to the plasma membrane. Moreover, experiments on lipopolysaccharide-induced sepsis and alum-induced peritonitis in mice confirmed that ticagrelor mitigates the severity of systemic inflammation independent ofP2Y_(12) receptor antagonism. Importantly, oral administration of ticagrelor rapidly and strongly inhibited NLRP3 inflammasome activation in peripheral blood mononuclear cells from patients with acute coronary syndrome. Overall, our study reveals a novel pharmacological function of ticagrelor in addition to its classic antiplatelet properties, which suggests that ticagrelor may serve as a potential therapeutic agent for use in NLRP3-associated diseases. | Bo Huang Yufeng Qian Shujun Xie Xianhua Ye Hanwen Chen Zhifeng Chen Lihuan Zhang Jinming Xu Hu Hu Shenglin Ma Paul Héroux Di Wang Han-Ming Shen Yihua Wu Dajing Xia | 2021 | Cellular & Molecular Immunology2021，18，5： | 3 |
| 2 | Roles of various Ni species on TiO2 in enhancing photocatalytic H2 evolution显示文摘Low-cost nickels can be used as cocatalyst to improve the performance of photocatalysts,which may be promising materials applied in the field of photocatalytic water splitting.In this study,different nickel species Ni,Ni(OH)2,NiO,NiOx,and NiS are used to modified titanium dioxide(P25)to investigate their roles on the photocatalytic hydrogen evolution activities.UV-visible,X-ray diffraction(XRD),Brunner-Emmet-Teller(BET)measurements,transmission electron microscopy(TEM),X-ray photoelectron spectroscopy(XPS)analysis etc.are employed to characterize the physical and chemical properties of catalysts.The results indicate that all the nickel species can improve the photocatalytic hydrogen production activity of P25.The P25 modified with NiOx and NiS has more superior photocatalytic hydrogen evolution activities than those modified with other nickel species.The reason for this is that NiOx and NiS can form p-n junctions with P25 respectively.In addition,NiOx can be selectively deposited on the active sites of P25 via in situ the photodeposition method and NiS is beneficial for H+reacting with photo-excited electrons. | Xiaoping CHEN Jihai XIONG Jinming SHI Song XIA Shuanglin GUI Wenfeng SHANGGUAN | 2019 | Frontiers in Energy2019，13，4： | 2 |
| 3 | Processing and valorization of cellulose,lignin and lignocellulose using ionic liquids显示文摘Cellulose,lignin and lignocellulose are important bioresources in the nature.Their effective and environmentally friendly utilization not only reduces dependence on fossil resources but also protects the environment.Recently,a class of novel eco-friendly solvents,ionic liquids,is employed to dissolve and process these bioresources.In this mini-review,we summarized the recent advances of processing and valorization of cellulose,lignin and lignocellulose in ionic liquids.It is expected that this up-to-date survey provides a comprehensive information of this field,and accelerates the development and utilization of the renewable plant biomass resources. | Zhenghao Xia Jinyang Li Jinming Zhang Xiaocheng Zhang Xuejing Zheng Jun Zhang | 2020 | Journal of Bioresources and Bioproducts2020，5，2： | 2 |
| 4 | Mutations in hepatitisC virus E2 located outside the CD81 binding sites lead to es-cape from broadly neutralizing antibodies but compromise virusinfectivity显示文摘 | Keck Z Y Li S H Xia Jinming | 2009 | J Virol2009，83，12： | 1 |
| 5 | Developmental recording of the ghost-moth larvae after ex situ infection by Ophiocordyceps sinensis显示文摘Dear Editor,Chinese cordyceps, a valuable Chinese traditional medicine, is a complex of mummified ghost moth caterpillars and fungal stroma of Ophiocordyceps sinensis (Winkler, 2010). O. sinensis has been nominated as the national fungus of China and flagship species of the Tibetan Plateau (Cannon, 2010;Zhang et al., 2012). | Wenjia Li Jinming Xia Quanping Li Zongyao Zhang Weiwei Zhang Caihong Dong Jiangchun Wei Xingzhong Liu | 2020 | Science China(Life Sciences)2020，63，7： | 1 |
| 6 | Definition of a con-served immunodominant domain on hepatitis C virus E2 glyco-protein by neutralizing human monoclonal antibodies显示文摘 | Keck Z Y Li T K Xia Jinming | 2008 | J Virol2008，82，6： | 1 |
| 7 | Effects of Health Qigong Exercise on Depression and Anxiety in Patients with Parkinson’s Disease显示文摘Objective: This study explored the effects of Health Qigong exercise on depression and anxiety in patients withParkinson’s disease (PD). Methods: A total of 42 volunteers who met the inclusion criteria were recruited andrandomly allocated into the experimental group and the control group. The experimental group carried out60-minute sessions of Health Qigong exercise five times a week for 12 weeks while the control group did not performany regular physical exercise. Data on cognitive impairment, psychomotor retardation, somatic anxiety,weight loss and sleep disorders, the sum score of the 17-item Hamilton Depression Rating Scale (HDRS-17), stateanxiety, trait anxiety as well as the sum score of the State-Trait Anxiety Inventory (STAI) were collected for threerepeated measurements (baseline, 6, and 12 weeks). Results: Significant differences were observed in depression,state anxiety, trait anxiety, cognitive impairment and psychomotor retardation in the experimental group but nodifference in somatic anxiety, weight loss and sleep disorders. Conclusion: Health Qigong exercise can pose positivepsychological effects and alleviate the depression and anxiety in patients with Parkinson’s disease. It can beapplied as an accessible supplement to the existent drug treatment for PD. | Xiying Li Alyx Taylor Jinming Li Ting Wang Jing Kuang Zhihao Zhang Xiaolei Liu Tingting Liu Xia Qin Shenghua Lu Liye Zou | 2022 | International Journal of Mental Health Promotion2022，24，6： | 0 |
| 8 | Lipidome Atlas of the Developing Heart Uncovers Dynamic Membrane Lipid Attributes Underlying Cardiac Structural and Metabolic Maturation显示文摘Precise metabolic rewiring during heart organogenesis underlies normal cardiac development.Herein,we utilized high-coverage,quantitative lipidomic approaches to construct lipidomic atlases of whole hearts(861 lipids;31 classes)and mitochondria(587 lipids;27 classes)across prenatal and postnatal developmental stages in mice.We uncovered the progressive formation of docosahexaenoyl-phospholipids and enhanced remodeling of C18:2,C20:3,and C20:4 fatty acyl moieties into cardiolipins as cardiac development progresses.A preferential flow of ceramides toward sphingomyelin biosynthesis over complex glycosphingolipid formation was also noted.Using maSigPro and GPclust algorithms,we identified a repertoire of 448 developmentally dynamic lipids and mapped their expression patterns to a library of 550 biologically relevant developmentally dynamic genes.Our combinatorial transcriptomics and lipidomics approaches identified Hadha,Lclat1,and Lpcat3 as candidate molecular drivers governing the dynamic remodeling of cardiolipins and phospholipids,respectively,in heart development.Our analyses revealed that postnatal cardiolipin remodeling in the heart constitutes a biphasic process,which first accumulates polyunsaturated C78-cardiolipins prior to tetralinoleoyl cardiolipin forming the predominant species.Multiomics analyses supplemented with transmission electron microscopy imaging uncovered enhanced mitochondria–lipid droplet contacts mediated by perilipin-5.Our combinatorial analyses of multiomics data uncovered an association between mitochondrial-resident,docosahexaenoic acid-phospholipids and messenger RNA levels of proton-transporting adenosine triphosphate synthases on inner mitochondrial membranes,which adds credence to the membrane pacemaker theory of metabolism.The current findings offer lipid-centric biological insights potentially important to understanding the molecular basis of cardiac metabolic flexibility and disease pathology. | Huan Miao Bowen Li Zehua Wang Jinming Mu Yanlin Tian Binhua Jiang Shaohua Zhang Xia Gong Guanghou Shui Sin Man Lam | 2023 | Research2023，，3： | 0 |
| 9 | Erratum to:Developmental recording of the ghost-moth larvae after ex situ infection by Ophiocordyceps sinensis显示文摘This paper contains errors in the authors’affiliations.Wenjia Li,is a Ph.D.candidate in the University of Chinese Academy of Sciences,Jiangchun Wei and Xingzhong Liu are professors in the University of Chinese Academy of Sciences,which is missing in the original version. | Wenjia Li Jinming Xia Quanping Li Zongyao Zhang Weiwei Zhang Caihong Dong Jiangchun Wei Xingzhong Liu | 2023 | Science China(Life Sciences)2023，66，4： | 0 |
| 10 | An Embedded Internet interface system显示文摘This article has introduced a method to connect theembedded system with Internet, and given a circuit of embeddedsystem connect. | Peng XuanGe Xia Jiewu Liao Jinming | 2005 | 微计算机信息2005，21，10Z： | 0 |
| 11 | USH2A mutation and specific driver mutation subtypes are associated with clinical efficacy of immune checkpoint inhibitors in lung cancer显示文摘This study aimed to identify subtypes of genomic variants associated with the efficacy of immune checkpoint inhibitors(ICIs)by conducting systematic literature search in electronic databases up to May 31,2021.The main outcomes including overall survival(OS),progression-free survival(PFS),objective response rate(ORR),and durable clinical benefit(DCB)were correlated with tumor genomic features.A total of 1546 lung cancer patients with available genomic variation data were included from 14 studies.The Kirsten rat sarcoma viral oncogene homolog G12C(KRAS^(G12C))mutation combined with tumor protein P53(TP53)mutation revealed the promising efficacy of ICI therapy in these patients.Furthermore,patients with epidermal growth factor receptor(EGFR)classical activating mutations(including EGFRL858Rand EGFRΔ19)exhibited worse outcomes to ICIs in OS(adjusted hazard ratio(HR),1.40;95%confidence interval(CI),1.01-1.95;P=0.0411)and PFS(adjusted HR,1.98;95%CI,1.49-2.63;P<0.0001),while classical activating mutations with EGFR^(T790)Mshowed no difference compared to classical activating mutations without EGFR^(T790)Min OS(adjusted HR,0.96;95%CI,0.48-1.94;P=0.9157)or PFS(adjusted HR,0.72;95%CI,0.39-1.35;P=0.3050).Of note,for patients harboring the Usher syndrome type-2A(USH2A)missense mutation,correspondingly better outcomes were observed in OS(adjusted HR,0.52;95%CI,0.32-0.82;P=0.0077),PFS(adjusted HR,0.51;95%CI,0.38-0.69;P<0.0001),DCB(adjusted odds ratio(OR),4.74;95%CI,2.75-8.17;P<0.0001),and ORR(adjusted OR,3.45;95%CI,1.88-6.33;P<0.0001).Our findings indicated that,USH2A missense mutations and the KRAS^(G12C)mutation combined with TP53 mutation were associated with better efficacy and survival outcomes,but EGFR classical mutations irrespective of combination with EGFR^(T790)Mshowed the opposite role in the ICI therapy among lung cancer patients.Our findings might guide the selection of precise targets for effective immunotherapy in the clinic. | DEXIN YANG YUQIN FENG HAOHUA LU KELIE CHEN JINMING XU PEIWEI LI TIANRU WANG DAJING XIA YIHUA WU | 2023 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2023，24，2： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员