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| 1 | Ideal cardiovascular health and incidence of atherosclerotic cardiovascular disease among Chinese adults:the China-PAR project显示文摘Existing evidence on the relationship between cardiovascular health(CVH) metrics and cardiovascular disease(CVD) was primarily derived from western populations. We aimed to evaluate the benefits of ideal CVH metrics on preventing incident atherosclerotic CVD(ASCVD) in Chinese population. This study was conducted among 93,987 adults from the China-PAR project(Prediction for ASCVD Risk in China) who were followed up until 2015. Cox proportional hazard regression models were used to estimate the hazard ratios(HRs) and their corresponding 95% confidence intervals(CIs) of CVH metrics for the risk of ASCVD, including coronary heart disease(CHD), stroke and ASCVD death. We further estimated the population-attributable risk percentage(PAR%) of these metrics in relation to each outcome. We observed gradient inverse associations between the number of ideal CVH metrics and ASCVD incidence. Compared with participants having ≤2 ideal CVH metrics, the multivariable-adjusted HRs(95% CIs) of ASCVD for those with 3, 4, 5, 6 and 7 ideal CVH metrics were 0.83(0.74–0.93), 0.66(0.59–0.74), 0.55(0.48–0.61), 0.44(0.38–0.50) and 0.24(0.18–0.31), respectively(P for trend <0.0001). Approximately 62.1% of total ASCVD, 38.7% of CHD, 66.4% of stroke, and 60.5% of ASCVD death were attributable to not achieving all the seven ideal CVH metrics. After adjusting effects of ideal health factors, having four ideal health behaviors could independently bring adults health benefits in preventing 17.4% of ASCVD, 18.0% of CHD, 16.7% of stroke, and 10.1% of ASCVD death. Among all the seven CVH metrics, to keep with ideal blood pressure(BP) implied the largest public health gains against various ASCVD events(PAR% between 33.0% and 47.2%), while ideal diet was the metric most difficult to be achieved in the long term. Our study indicates that the more ideal CVH metrics adults have, the less ASCVD burden there is in China. Special efforts of health education and behavior modification should be made on keeping ideal BP and dietary habits in general Chinese population to prevent the epidemic of ASCVD. | Chao Han Fangchao Liu Xueli Yang Jichun Chen Jianxin Li Jie Cao Ying Li Chong Shen Ling Yu Zhendong Liu Xianping Wu Liancheng Zhao Dongshen Hu Xiangfeng Lu Xigui Wu Dongfeng Gu | 2018 | Science China(Life Sciences)2018，61，5： | 60 |
| 2 | Predicting lifetime risk for developing atherosclerotic cardiovascular disease in Chinese population:the China-PAR project显示文摘Evidence on the lifetime risk for atherosclerotic cardiovascular disease(ASCVD) is insufficient;yet,estimating an individual's lifetime risk allows for a comprehensive assessment of ASCVD burden.We developed and validated lifetime risk prediction equations for ASCVD using four large and ongoing prospective cohorts of Chinese,the China-PAR project(Prediction for ASCVD Risk in China).Sexspecific equations were developed using two cohorts(as the derivation cohort) of 21,320 participants.Two other independent cohorts with 14,123 and 70,838 participants were used for their external validation,respectively.We evaluated both calibration and discrimination measures for model performance.Furthermore,we estimated ASCVD-free years lost or excess absolute risk attributable to high 10-year risk(!10.0%) and/or high lifetime risk(!32.8%).After 12.3 years' follow-up of the derivation cohort,1048 ASCVD events and 1304 non-ASCVD deaths were identified.Our sex-specific equations had good internal validation,with discriminant C statistics of 0.776(95% confidence interval [CI]:0.757–0.794) and 0.801(95% CI:0.778–0.825),and calibration χ~2 of 9.2(P = 0.418) and 5.6(P = 0.777) for men and women,respectively.Good external validation was also demonstrated with predicted rates closely matched to the observed ones.Compared with men having both low 10-year and low lifetime risk,men would develop ASCVD 3.0,4.6 and 8.6 years earlier if they had high 10-year risk alone,high lifetime risk alone,or both high 10-year and high lifetime risk at the index age of 35 years,respectively.We developed wellperformed lifetime risk prediction equations that will help to identify those with the greatest potential to avert ASCVD burden after implementation of innovative clinical and public health interventions in China. | Fangchao Liu Jianxin Li Jichun Chen Dongsheng Hu Ying Li Jianfeng Huang Xiaoqing Liu Xueli Yang Jie Cao Chong Shen Ling Yu Zhendong Liu Xianping Wu Liancheng Zhao Xigui Wu Dongfeng Gu Xiangfeng Lu | 2018 | Science Bulletin2018，63，12： | 30 |
| 3 | Fruit and vegetable consumption,cardiovascular disease,and all-cause mortality in China显示文摘Evidence about the response patterns of fruit and vegetable consumption with the risk of cardiovascular disease(CVD)and allcause mortality was inconsistent.These associations were examined using a large-scale,population-based Chinese cohort comprising 100,728 participants.A food-frequency questionnaire was used to assess fruit and vegetable consumption.Outcomes were ascertained by interviewing individuals or their proxies and checking hospital records or death certificates.Cox proportional hazards regression was used to calculate hazard ratios(HRs)with 95% confidence intervals(CIs).At the 736,668 person-years of follow-up,3,677 CVD cases and 5,466 deaths were identified.The multivariable-adjusted HRs for CVD across increasing quartiles of total fruit and vegetable consumption were 1(reference),0.94(95%CI=0.85-1.04),0.89(95%CI=0.80-0.98),and 0.85(95%CI=0.77-0.95).Moreover,participants in the highest quartile displayed a 13% lower risk of all-cause mortality(HR=0.87;95%CI=0.80-0.95).A nonlinear dose-response relation was found for CVD,without additional benefits beyond a consumption of600 g d-1,whereas the all-cause mortality risk decreased along with higher consumption,with a linear trend.These associations remained significant for fruit consumption but not for vegetable consumption.Our findings indicated that greater fruit and vegetable consumption was significantly associated with a lower risk of CVD and all-cause mortality.Increasing fruit and vegetable consumption,especially fruit,in the general population would prevent CVD and premature mortality. | Jun Wang Fangchao Liu Jianxin Li Keyong Huang Xueli Yang Jichun Chen Xiaoqing Liu Jie Cao Shufeng Chen Chong Shen Ling Yu Fanghong Lu Xianping Wu Liancheng Zhao Ying Li Dongsheng Hu Jianfeng Huang Dongfeng Gu Xiangfeng Lu | 2022 | Science China(Life Sciences)2022，65，1： | 8 |
| 4 | Associations of egg consumption with incident cardiovascular disease and all-cause mortality显示文摘Eggs are nutrient-dense while also loaded with abundant cholesterol, thus making the public hesitant about their consumption.We conducted the study to investigate if egg consumption is associated with incident cardiovascular disease(CVD) and all-cause mortality. Using the project of Prediction for Atherosclerotic Cardiovascular Disease Risk in China, we included 102,136 adults free of CVD and assessed their egg consumption with food-frequency questionnaires. CVD endpoints and all-cause mortality were confirmed during follow-ups by interviewing participants or their proxies and checking hospital records/death certificates.The HRs(95% CIs) were calculated using the cohort-stratified Cox regression models. During 777,163 person-years of followup, we identified 4,848 incident CVD and 5,511 deaths. U-shaped associations of egg consumption with incident CVD and allcause mortality were observed. Compared with consumption of 3–<6/week, the multivariable-adjusted HRs(95% CIs) of <1/week and ≥10/week for incident CVD were 1.22(1.11 to 1.35) and 1.39(1.28 to 1.52), respectively. The corresponding HRs(95% CIs) for all-cause mortality were 1.29(1.18 to 1.41) and 1.13(1.04 to 1.24). Our findings identified that both low and high consumption were associated with increased risk of incident CVD and all-cause mortality, highlighting that moderate egg consumption of 3–<6/week should be recommended for CVD prevention in China. | Xue Xia Fangchao Liu Xueli Yang Jianxin Li Jichun Chen Xiaoqing Liu Jie Cao Chong Shen Ling Yu Yingxin Zhao Xianping Wu Liancheng Zhao Ying Li Jianfeng Huang Xiangfeng Lu Dongfeng Gu | 2020 | Science China(Life Sciences)2020，63，9： | 7 |
| 5 | The effect of proppant embedment upon the long-term conductivity of fractures显示文摘 | Qingzhi Wen Shicheng Zhang Lei Wang Yongshan Liu Xianping Li | 2006 | Journal of Petroleum Science and Engineering2006，，3： | 2 |
| 6 | Lanthanide doped fluorosilicate glass-ceramics:A review on experimental and theoretical progresses显示文摘Significant developments have been made in the past few decades for lanthanide(Ln)ions doped fluorosilicate glass-ceramics(Flusi-GCs).As novel generation of luminescence materials with a wide range of applications,Flusi-GCs as a single host combine the advantages of glass and ceramics/crystals as well as fluorides and silicates.In this review,the chemical design principles and experimental procedures of Flusi-GCs are summarized in detail.Flusi-GCs are categorized as those containing PbxCd_(1-x)F_(2),RF_(3)(R=Y,La,Gd),MF_(2)(M=Ca,Sr,Ba),xMF_(2)-yRF_(3)(R=Y,La-Lu),mAF-nRF_(3)(A=Li,Na,K),KTF_(3)(T=Zn,Mn)and K2 SiF6 nanocrystals(NCs).Theoretical breakthroughs mainly by molecular dynamic(MD)simulation have been recapitulated as efficient routes for composition-design,nano-crystallization-prediction,and performance-optimization of Flusi-GCs containing target fluoride NCs.Essential research progresses pertaining photonic applications have been made in random lasers,communication amplifiers,optical fibers,spectral converters,white light-emitting-diodes(WLEDs),and thermal sensors.In the end,we propose three future research directions for Flusi-GCs. | Pengcheng Li Xiuxia Xu Junjie Zhao Pragati Awasthi Xusheng Qiao Jincheng Du Xianping Fan Guodong Qian | 2022 | Journal of Rare Earths2022，40，2： | 2 |
| 7 | Adverse associations of sedentary behavior with cancer incidence and all-cause mortality:A prospective cohort study显示文摘Background:Inconsistent results have been reported in developed countries for relationships between sedentary behavior and cancer incidence and mortality,and evidence from the Chinese population is scarce.This study aimed to investigate such relationships in large Chinese population-based prospective cohorts and to explore the joint effect and interaction of sedentary behavior and moderate-to-vigorous physical activity(MVPA)on these relationships.Methods:We included 95,319 Chinese adults without cancer from 3 large cohorts and assessed their sedentary behavior and physical activity with a unified questionnaire.Cancer incidence and mortality were confirmed by interviewing participants or their proxies and checking hospital records and death certificates.Hazard ratios(HRs)and 95%confidence intervals(95%CIs)for cancer and mortality were estimated using Cox proportional hazards regression models.Results:During 559,002 person-years of follow-up,2388 cancer events,1571 cancer deaths,and 4562 all-cause deaths were recorded.Sedentary behavior was associated with increased risk of developing cancer and deaths in a doseresponse manner.The multivariable-adjusted HRs(95%CIs)were the following:HR=1.16,95%CI:1.01-1.33;HR=1.24,95%CI:1.04-1.48;and HR=1.15,95%CI:1.04-1.28 for cancer incidence,cancer mortality,and all-cause mortality,respectively,for those having≥10 h/day of sedentary time compared with those having<6 h/day of sedentary time.Sedentary populations(≥10 h/day)developed cancer or died 4.09 years and 2.79 years earlier,respectively,at the index age of 50 years.Failure to achieve the recommended level of MVPA may further aggravate the adverse associations,with the highest cancer and mortality risks being observed among participants with both≥10 h/day of sedentary time and<150 min/week of MVPA.Limitations of this study include the fact that physical activity information was obtained via questionnaire instead of objective measurement and that there were insufficient incident cases for the analysis of associations between sedentary behavior and site-specific cancers.Conclusion:Sedentary behavior was associated with an increased risk of cancer and all-cause mortality among Chinese adults,especially for those with≥10 h/day of sedentary time.It is necessary to reduce sedentary time,in addition to increasing MVPA levels,for the prevention of cancer and premature death. | Yuan Lin Qiong Liu Fangchao Liu Keyong Huang Jianxin Li Xueli Yang Xinyan Wang Jichun Chen Xiaoqing Liu Jie Cao Chong Shen Ling Yu Fanghong Lu Xianping Wu Liancheng Zhao Ying Li Dongsheng Hu Xiangfeng Lu Jianfeng Huang Dongfeng Gu | 2021 | Journal of Sport and Health Science2021，10，5： | 2 |
| 8 | An Efficient and Scalable Room Temperature Aerobic Alcohol Oxidation Catalyzed by Iron Chloride Hexahydrate/Mesoporous Silica Supported TEMPO显示文摘 | Wang Lianyue Li Jun Zhao Xianping | 2013 | Tetrahedron2013，69，30： | 1 |
| 9 | Development of Triticum aestivume——Leymus mollis Translocation Lines and Identification of Resistance to Stripe Rust显示文摘Wheat stripe rust,caused by Puccinia striiformis f.sp.tritici,is one of the most widely distributed and destructive fungal diseases worldwide.Since 1995,most Chinese wheat cultivars have lost their stripe rust resistance due to the subsequent emergence of the new races CYR30,CYR31,CYR32,and CYR33(Han et al.,2010).Therefore,it is necessary to seek effective resistance genes and develop new resistance germplasm for wheat resistance breeding. | Haoxun Li Renchun Fan Shulan Fu Bo Wei Shichang Xu Jing Feng Qi Zheng Xianping Wang Fangpu Han Xiangqi Zhang | 2015 | Journal of Genetics and Genomics2015，42，3： | 1 |
| 10 | Optimal stopping investment in a logarithmic utility-based portfolio selection problem显示文摘Background:In this paper,we study the right time for an investor to stop the investment over a given investment horizon so as to obtain as close to the highest possible wealth as possible,according to a Logarithmic utility-maximization objective involving the portfolio in the drift and volatility terms.The problem is formulated as an optimal stopping problem,although it is non-standard in the sense that the maximum wealth involved is not adapted to the information generated over time.Methods:By delicate stochastic analysis,the problem is converted to a standard optimal stopping one involving adapted processes.Results:Numerical examples shed light on the efficiency of the theoretical results.Conclusion:Our investment problem,which includes the portfolio in the drift and volatility terms of the dynamic systems,makes the problem including multi-dimensional financial assets more realistic and meaningful. | Xun Li Xianping Wu Wenxin Zhou | 2017 | Financial Innovation2017，3，1： | 1 |
| 11 | Seasonal variation in blood pressure and its relationship with outdoor temperature in 10 diverse regions of China: the China Kadoorie Biobank显示文摘 | Sarah Lewington Liming Li Paul Sherliker Yu Guo Iona Millwood Zheng Bian Gary Whitlock Ling Yang Rory Collins Junshi Chen Xianping Wu Shaojie Wang Yihe Hu Li Jiang Liqiu Yang Ben Lacey Richard Peto Zhengming Chen | 2012 | Journal of Hypertension2012，，7： | 1 |
| 12 | A hierarchical framework for parallel seismic applications 显示文摘 | Lu Jian Li Yingjun Ma Xiaoxing Cai Min Tao Xianping | 2000 | Communications of ACM2000，43，10： | 1 |
| 13 | Biosensor based on hollow-core metal-cladding waveguide显示文摘 | Pingping Xiao Xianping Wang Jingjing Sun Honggen Li Meizhen Huang Xianfeng Chen Zhuangqi Cao | 2012 | Sensors & Actuators: A. Physical2012，，： | 1 |
| 14 | Diastereoselective construction of structurally diverse 2,3-dihydroquinolin-4-one scaffolds via redox neutral cascade[1,7]-hydride transfer/cyclization显示文摘The pharmaceutically significant 2,3-dihydroquinolin-4-one scaffolds were constructed diastereoselectively and facilely via redox-neutral cascade Knoevengel condensation/[1,7]-hydride transfer/cyclization/transesterification in DCE from readily available methyl 2-aminobenzoacetate and diverse aldehydes,which features novel and highly valuable product structures. | Ronghao Xie Shixiao Chen Xianping Xiang Xiangcong Yin Lubin Xu Shuai-Shuai Li Liang WangFengying Dong | 2022 | Organic Chemistry Frontiers2022，9，3： | 0 |
| 15 | Climate extremes,variability,and trade shape biogeographical patterns of alien species显示文摘Understanding how alien species assemble is crucial for predicting changes to community structure caused by biological invasions and for directing management strategies for alien species,but patterns and drivers of alien species assemblages remain poorly understood relative to native species.Climate has been suggested as a crucial filter of invasion-driven homogenization of biodiversity.However,it remains unclear which climatic factors drive the assemblage of alien species.Here,we compiled global data at both grid scale(2,653 native and 2,806 current grids with a resolution of 2°x 2°)and administrative scale(271 native and 297 current nations and sub-nations)on the distributions of 361 alien amphibians and reptiles(herpetofauna),the most threatened vertebrate group on the planet.We found that geographical distance,proxy for natural dispersal barriers,was the dominant variable contributing to alien herpetofaunal assemblage in native ranges.In contrast,climatic factors explained more unique variation in alien herpetofaunal assemblage after than before invasions.This pattern was driven by extremely high temperatures and precipitation seasonality,2 hallmarks of global climate change,and bilateral trade which can account for the alien assemblage after invasions.Our results indicated that human-assisted species introductions combined with climate change may accelerate the reorganization of global species distributions. | Xuan Liu Jason R.Roh Xianping Li Teng Deng Wenhao Li Yiming Li | 2021 | Current Zoology2021，67，4： | 0 |
| 16 | Towards a programming framework for activity-oriented context-aware applications显示文摘 | Xuansong LI Xianping TAO Jian LU | 2017 | Frontiers of Computer Science2017，11，6： | 0 |
| 17 | IMPA2 blocks cervical cancer cell apoptosis and induces paclitaxel resistance through p53-mediated AIFM2 regulation显示文摘Cervical cancer continues to be a concern,and the prognosis of locally advanced cervical cancer remains poor.IMPA2 was previously identified as a potential oncogene and regulator of tumor apoptosis.In this study,we aim to further elucidate the underlying mechanisms of IMPA2 gene in the regulation of cervical cancer apoptosis.First,we identify AIFM2 as an upregulated gene in IMPA2-silenced cervical cancer cells,and inhibition of AIFM2 reverses IMPA2 knockdown-induced apoptosis.Further study reveals that AIFM2 regulates cell apoptosis in a mitochondrial-dependent manner with a redistribution of mitochondrial membrane potential and intracellular Ca^(2+) levels.However,the analysis of the STRING database and our experimental results show that AIFM2 has little effect on cervical cancer progression and survival.Further mechanistic study demonstrates that IMPA2 and AIFM2 silencing inhibits apoptosis by activating p53.Meanwhile,the knockdown of IMPA2 enhances the chemosensitivity of cervical cancer cells by strengthening paclitaxel-induced apoptosis.Based on the above results,the IMPA2/AIFM2/p53 pathway may be a new molecular mechanism for paclitaxel treatment of cervical cancer and an effective strategy to enhance the sensitivity of cervical cancer cells to paclitaxel.Our findings display a novel function of IMPA2 in regulating cell apoptosis and paclitaxel resistance mediated by a disturbance of AIFM2 and p53 expression,potentially making it a novel therapeutic target for cervical cancer treatment. | Kexin Xie Lei Liu Min Wang Xianping Li Bingqi Wang Sheng Yin Wanxin Chen Yingrui Lin Xiaolin Zhu | 2023 | Acta Biochimica et Biophysica Sinica2023，55，4： | 0 |
| 18 | Synthesis and Characterization of Fine Grained High Density La_2Mo_2O_9-based Oxide-ion Conductors显示文摘A cost-effective technique,including nanocrystalline powder preparation using a modified Pechini method and a two-step low-temperature sintering route,was developed for the synthesis of high performance La_2Mo_2O_9- based oxide-ion conductors.The optimum parameters of the compaction pressure,the first step and the second step sintering temperatures for the synthesis of fine grained,high density and uniform La_2Mo_2O_9- based oxide-ion conductors were determined by a series of sintering experiments.High density and uniform sintered La_2Mo_2O_9 samples with average grain size from 0.8 to 5μm and La_(1.96)K_(0.04)Mo_2O_(8.96) sample with average grain size as small as 500 nm were synthesized by using this cost-effective method.The impedance measurement results show that the as-fabricated La_2Mo_2O_9-based ceramics possess much higher ionic con- ductivity than that obtained by solid state reaction method.It is found that in the range of 0.8-5μm the grain size of dense La_2Mo_2O_9 samples prepared from the nanocrystalline powders has little influence on their conductivities. | Jianxin WANG Qin WANG Xianping WANG Chun LI Qianfeng FANG | 2008 | Journal of Materials Science & Technology2008，24，5： | 0 |
| 19 | Breeding of T.aestivum-Ag.intermedium translocation lines with T.timopheevii cytoplasm and characterization by GISH显示文摘A male-sterile T. aestivum-Ag. intermedium partial amphiploid with cytoplasm of T. timopheevii as a female parent was crossed to common wheat. The hybrid was backcrossed to the male parent several times continually and self-crossed at last. Two stable lines with common wheat phenotype, H96269-2 and H96278, have been obtained. The chromosome numbers of the two lines are all 2n = 42 in somatic cells. By inoculation test, the two lines show a high level of resistance to yellow rust. Through genomic in situ hybridization (GISH) with Ag. intermedium total genomic DNA as a probe, it is demonstrated that the two stable lines are all small segmental translocation lines, and the translocated chromosome segments from Ag. intermedium are located on the short arm terminals of wheat chromosomes. Genetics analysis suggests that the yellow rust resistance gene(s) are probably located on the translocated chromosome segments of Ag. intermedium. | MU Jinye LI Jilin WANG Xianping JING Jiankang ZHANG Xiangqi | 2000 | Chinese Science Bulletin2000，45，15： | 0 |
| 20 | Calcium-fortified fresh milk ameliorates postmenopausal osteoporosis via regulation of bone metabolism and gut microbiota in ovariectomized rats显示文摘The aging of the global population has made postmenopausal osteoporosis prevention essential;however,pharmacological treatments are limited.Herein,we evaluate the effect of calcium-fortified fresh milk(FM)in ameliorating postmenopausal osteoporosis in a rat model established using bilateral ovariectomy.After 3 months of FM(containing vitamin D,and casein phosphopeptides,1000 mg Ca/100 g)or control milk(110 mg Ca/100 g milk)supplementation,bone changes were assessed using dual-energy X-ray absorptiometry,microcomputed tomography,and bone biomechanical testing.The results revealed that FM can regulate bone metabolism and gut microbiota composition,which act on bone metabolism through pathways associated with steroid hormone biosynthesis,relaxin signaling,serotonergic synapse,and unsaturated fatty acid biosynthesis.Furthermore,FM administration significantly increased bone mineral content and density in the lumbar spine and femur,as well as femoral compressive strength,while improving femoral trabecular bone parameters and microarchitecture.Mechanistically,we found that the effects may be due to increased levels of estrogen,bone formation marker osteocalcin,and procollagen typeⅠN-propeptide,and decreased expression of the bone resorption marker C-telopiptide and tartrate-resistant acid phosphatase 5b.Overall,the findings suggest that FM is a potential alternative therapeutic option for ameliorating postmenopausal osteoporosis. | Qishan Wang Bin Liu Xianping Li Junying Zhao Zongshen Zhang Weicang Qiao Xinyue Wei Lijun Chen | 2024 | Food Science and Human Wellness2024，13，3： | 0 |
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