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| 1 | Antibody-drug conjugates:Recent advances in linker chemistry显示文摘Antibody-drug conjugates(ADCs)are gradually revolutionizing clinical cancer therapy.The antibody-drug conjugate linker molecule determines both the efficacy and the adverse effects,and so has a major influence on the fate of ADCs.An ideal linker should be stable in the circulatory system and release the cytotoxic payload specifically in the tumor.However,existing linkers often release payloads nonspecifically and inevitably lead to off-target toxicity.This defect is becoming an increasingly important factor that restricts the development of ADCs.The pursuit of ADCs with optimal therapeutic windows has resulted in remarkable progress in the discovery and development of novel linkers.The present review summarizes the advance of the chemical trigger,linker-antibody attachment and linker-payload attachment over the last 5 years,and describes the ADMET properties of ADCs.This work also helps clarify future developmental directions for the linkers. | Zheng Su Dian Xiao Fei Xie Lianqi Liu Yanming Wang Shiyong Fan Xinbo Zhou Song Li | 2021 | Acta Pharmaceutica Sinica B2021，11，12： | 5 |
| 2 | Using big data to track marine oil transportation along the 21st-century Maritime Silk Road显示文摘China's designation of the '21 st-century Maritime Silk Road'(MSR) region is of extraordinary significance to its maritime rights, transportation security, and socio-economic development. We developed a technical framework allowing the use of 'big data' derived from the Automatic Identification System(AIS, an automatic ship-tracking network) for two purposes: the accurate mapping of oil tanker trajectories and the creation of heat maps showing the relative use of oil tanker routes and marine shipping chokepoints. We then applied these methods to 1.5 billion AIS records collected within the MSR in 2014 to statistically identify and analyze busy routes, areas, and chokepoints in this strategic region. Our results demonstrate that the proposed framework can provide an effective analysis of oil movements based on large-scale AIS datasets, helping researchers and policy makers better understand the footprint and strategic implications of maritime oil transportation in the MSR region. | CHENG Liang YAN ZhaoJin XIAO YiJia CHEN YanMing ZHANG FangLi LI ManChun | 2019 | Science China(Technological Sciences)2019，62，4： | 3 |
| 3 | Analysis of the factors influencing the airflow behavior in an impinging jet ventilation room显示文摘A validated CFD model is employed to predict the airflow behavior in an impinging jet ventilation(IJV)room with cool,isothermal or warm jets.By using the numerical results,the influences of jet discharge height,supply grille shape and room height on the jet flow behavior as well as the draught discomfort are analyzed for IJV operating in heating scenarios.The results indicate that the warm supply jet of IJV rises upward to the ceiling after spreading along the floor for a certain distance due to thermal buoyancy,resulting in a limited dispersion area,while the cool and isothermal jets of IJV always spread along the whole floor.When IJV is used for space heating,the lower the jet discharge height,the farther the supply air spreads along the floor,and the supply grille shape and room height almost have no effect on the air dispersion area.The results also show that the energy-efficient advantage of IJV in its heating mode compared to the mixing ventilation(MV)system is more remarkable in higher rooms.Moreover,there is a risk of draught discomfort in IJV heating rooms and it is recommended to wear socks to avoid this discomfort. | Xiufeng Yang Xiao Ye Bin Zuo Ke Zhong Yanming Kang | 2021 | Building Simulation2021，14，3： | 2 |
| 4 | AtPP2CG1, a protein phosphatase 2C , positively regulates salt tolerance of Arabidopsis in abscisic acid-dependent manner显示文摘 | Xin Liu Yanming Zhu Hong Zhai Hua Cai Wei Ji Xiao Luo Jing Li Xi Bai | 2012 | Biochemical and Biophysical Research Communications2012，，4： | 1 |
| 5 | A portable noncun- tact heartb,at and respiration monitoring sys|em using 5-GHz radar 显示文摘 | Xiao Yanming I i Changzhi l in Jenshan et (d | 2007 | IEEE S ns Journal2007，7，7： | 1 |
| 6 | Experiment and Spectral Analysis of a Low-Power Ka-band Heartbeat De- tector Measuring from Four Sides of a Human Body显示文摘 | Li Changzhi Xiao Yanming Lin Jenshan | 2006 | IEEE Transactions on Microwave Theory and Techniques2006，54，12： | 1 |
| 7 | Alcohol use and HIV risk taking among Chinese MSM in Beijing显示文摘 | Hongyan Lu Yang Han Xiong He Yanming Sun Guiying Li Xuefeng Li Willi McFarland Yan Xiao Yiming Shao Yuhua Ruan H. Fisher Raymond | 2013 | Drug and Alcohol Dependence2013，，： | 1 |
| 8 | Intercalation of 2,4-dihydroxybenzophenone-5-sulfonate anion into Zn/AI layered double hydroxides for UV absorption properties显示文摘 | Li Shifeng Shen Yanming Xiao Min | 2014 | Journal of Industrial and Engineering Chemistry2014，20，4： | 1 |
| 9 | Overexpression of GsZFP1 enhances salt and drought tolerance in transgenic alfalfa ( Medicago sativa L.)显示文摘 | Lili Tang Hua Cai Wei Ji Xiao Luo Zhenyu Wang Jing Wu Xuedong Wang Lin Cui Yang Wang Yanming Zhu Xi Bai | 2013 | Plant Physiology and Biochemistry2013，，： | 1 |
| 10 | On the Use of Wavelet MoM to Solve the EFIE显示文摘OntheUseofWaveletMoMtoSolvetheEFIEZhouQun,PengYuhua,WangWenbing&XiaoYanmingTheMicrowaveEngineringandOpticalCommunicationInsti... | Zhou Qun, Peng Yuhua, Wang Wenbing & Xiao Yanming The Microwave Engineering and Optical Communication Institute,Xi’an Jiaotong University,710049, P. R. China | 1997 | Journal of Systems Engineering and Electronics1997，8，4： | 0 |
| 11 | Status of transjugular intrahepatic portosystemic shunt for portal hypertension in China:A national survey analysis显示文摘Aim:The transjugular intrahepatic portosystemic shunt(TIPS)procedure has been performed in China for 30 years,but our understanding of the status and difficulties associated with the use of TIPS for portal hypertension is incomplete.This study aims to investigate the current situation of the use of TIPS for portal hypertension,which should aid the development of TIPS in China.Methods:This study involved a questionnaire survey,initiated by the China Portal Hypertension Alliance(CHESS)to investigate the use of TIPS for portal hypertension in China.Questionnaires were released on the Internet between August 16,2022 and September 16,2022.Detailed information was collected from 545 hospitals contracted by the CHESS in China,which performed TIPS surgery in 2021.Results:The 545 hospitals covers the majority of hospitals in China that conduct TIPS intervention.In the survey,a total of 13,527 TIPS interventions were carried out with 94.1%(498/545)of them had a system of routine follow‐up after TIPS.The majority(42.6%[232/545])believed that the main indication of TIPS was the control of acute bleeding.Overall,48.1%(262/545)carried out early or pre‐emptive TIPS,53.0%(289/545)carried out TIPS for cavernous transformation of the portal vein,and 81.0%(441/545)chose routine embolization of collateral circulation during operation.Most used coils(97.0%[475/490])and biological glue(72.0%[353/490])as embolic materials,and 78.5%(428/545)routinely performed intraoperative portal pressure gradient measurements.When selecting TIPS stents,57.1%(311/545)chose viator‐specific stents,and 57.2%(312/545)chose conventional anticoagulation after TIPS.Conventional anticoagulation after TIPS is over a time interval of 3–6 months(55.4%[173/312]).The limitation of TIPS surgery is mainly its cost(72.3%[394/545])and insufficient understanding of the procedure by doctors in other related departments(77.4%[422/545]).Most of the hospital teams accept the use of domestic instruments in TIPS surgery(92.7%[505/545]).Conclusions:This survey shows that TIPS is an essential part of the treatment of portal hypertension in China.TIPS is widely used in Chinese patients with portal hypertension,and this survey presents a more comprehensive picture of the options and difficulties encountered in the implementation of TIPS.In the future,it is necessary to promote TIPS technology and further standardize surgical indications,routine operations,and instrument application. | Haibo Shao Xinwei Han Jianbo Zhao Junhui Sun Zhuting Fang Bin Xiong Xiaoli Zhu Weixin Ren Min Yuan Shiping Yu Meng Niu Weifu Lv Xueqiang Zhang Chunqing Zhang Lei Li Xuefeng Luo Yusheng Song Yilong Ma Tong Dang Hua Xiang Yun Jin Hui Xue Guiyun Jin Xiao Li Jiarui Li Shi Zhou Changlu Yu Song He Lei Yu Hongmei Zu Jun Ma Yanming Lei Ke Xu Xiaolong Qi | 2023 | Portal Hypertension & Cirrhosis2023，2，1： | 0 |
| 12 | Under-ice ambient noise in the Arctic Ocean: observations at the long-term ice station显示文摘Under-ice ambient noise in the Arctic Ocean is studied using the data recorded by autonomous hydrophones at the long-term ice station during the 9th Chinese National Arctic Research Expedition.Time-frequency analysis of two 7-s-long ice-induced noise samples shows that both ice collision and ice breaking noise have many outliers in the time-domain(impulsive characteristic)and abundant frequency components in the frequency-domain.Ice collision noise lasts for several seconds while the duration of ice breaking noise is much shorter(i.e.,less than tens of milliseconds).Gaussian distribution and symmetric alpha stable(sαs)distribution are used in this paper to fit the impulsive under-ice noise.The sαs distribution can achieve better performance as it can track the heavy tails of impulsive noise while Gaussian distribution fails.This paper also analyzes the meteorological variables during the under-ice noise observation experiment and deduces that the impulsive ambient noise was caused by the combined force of high wind speed and increasing atmosphere temperature on the ice canopy.The Pearson correlation coefficients between long-term power spectral density variations of under-ice ambient noise and meteorological variables are also studied in this paper. | Xiao Han Jingwei Yin Yanming Yang Hongtao Wen Longxiang Guo | 2020 | Acta Oceanologica Sinica2020，39，9： | 0 |
| 13 | Space/Air Covert Communications:Potentials,Scenarios,and Key Technologies显示文摘Space/air communications have been envisioned as an essential part of the next-generation mobile communication networks for providing highquality global connectivity. However, the inherent broadcasting nature of wireless propagation environment and the broad coverage pose severe threats to the protection of private data. Emerging covert communications provides a promising solution to achieve robust communication security. Aiming at facilitating the practical implementation of covert communications in space/air networks, we present a tutorial overview of its potentials, scenarios, and key technologies. Specifically, first, the commonly used covertness constraint model, covert performance metrics, and potential application scenarios are briefly introduced. Then, several efficient methods that introduce uncertainty into the covert system are thoroughly summarized, followed by several critical enabling technologies, including joint resource allocation and deployment/trajectory design, multi-antenna and beamforming techniques, reconfigurable intelligent surface(RIS), and artificial intelligence algorithms. Finally, we highlight some open issues for future investigation. | Mao Haobin Liu Yanming Zhu Lipeng Mao Tianqi Xiao Zhenyu Zhang Rui Han Zhu Xia Xianggen | 2024 | China Communications2024，21，3： | 0 |
| 14 | From prodrug to pro-prodrug:hypoxia-sensitive antibody–drug conjugates显示文摘Dear Editor,Antibody‒drug conjugates(ADCs),famous as biological targeting prodrugs,are gradually revolutionizing clinical cancer therapy.However,less than 1%of the dosed ADCs accumulate in the tumors.1 Therefore,the nonspecific release of the highly toxic payload(MMAE et al.,10−12–10−10 M)is a real threat,which could induce severe off-target toxicity.2 This danger necessitates strict requirements for the design of the linker.To date,the mainstream enzyme cleavable linkers,includingβ-glucuronidase cleavable linkers,sulfatase-cleavable linkers,and the most popular cathepsin cleavable linkers(valine-citrulline linker),all face this nonspecific release problem,3 because their cleaving enzymes are widely distributed with no significant difference in their quantities between tumor tissues and normal tissues. | Yanming Wang Dian Xiao Jiaguo Li Shiyong Fan Fei Xie Wu Zhong Xinbo Zhou Song Li | 2022 | Signal Transduction and Targeted Therapy2022，7，2： | 0 |
| 15 | Neighborhood diversity structure and neighborhood species richness effects differ across life stages in a subtropical natural secondary forest显示文摘Natural secondary forest has a strong capacity to regrow naturally and recover biodiversity rapidly on abandoned lands.However,at the neighborhood scale,which can truly reflect the facilitative or competitive interactions among individual plants,the local diversity spatial structure in secondary forest and the feedback effects of neighborhood diversity on natural regeneration remain unclear,and this may be the key to properly understand the mechanisms of natural secondary forest species diversity recovery.To this end,this study established a dynamic plot in a rehabilitated secondary forest after disturbance and conducted a comprehensive survey of 68,336 individual plants with repeated measurements at 5-year interval to assess the characteristics of neighborhood diversity structure across life history stages and link the neighborhood species richness(NSR)effect translated by species interactions at species diversity structure with individual trees recruitment/mortality in secondary forest regeneration.The results showed that,compared with tropical and temperate natural forests,a higher proportion of diversity accumulators and a lower proportion of repellers in subtropical secondary forests resulted in neighborhood diversity structures characterized by heterospecific or high-diversity patches,which are beneficial to the maintenance or restoration of biodiversity.As an important supplement to the research on the relationship between diversity and productivity,our findings show a positive diversity-survival relationship in subtropical secondary forests.Importantly,we observed that the neighborhood diversity structure exhibited a trend of accumulator-dominated to neutral-dominant changes with life stage from sapling to adult,which,in turn,determined the direction and strength of NSR effects on recruitment/mortality.Specifically,diverse local neighborhoods at a later successional stage characterized with‘neutral’species-species interactions can act as a‘welfare net’by offering favorable microhabitats for the most vulnerable recruitments or saplings,i.e.,the NSR effects that promoted individual recruitment/survival in our study.These results not only enrich our understanding of the biodiversity-productivity-survival relationship but also highlight the importance of retaining latesuccessional species of native trees in intensive forest production or in situ conservation policies. | Haonan Zhang Shuifei Chen Xiao Zheng Xiaomin Ge Yao Li Yanming Fang Peng Cui Hui Ding | 2022 | Forest Ecosystems2022，9，6： | 0 |
| 16 | Identification of the receptor of oncolytic virus M1 as a therapeutic predictor for multiple solid tumors显示文摘Over the last decade,oncolytic virus(OV)therapy has shown its promising potential in tumor treatment.The fact that not every patient can benefit from it highlights the importance for defining biomarkers that help predict patients’responses.As particular self-amplifying biotherapeutics,the anti-tumor effects of OVs are highly dependent on the host factors for viral infection and replication.By using weighted gene co-expression network analysis(WGCNA),we found matrix remodeling associated 8(MXRA8)is positively correlated with the oncolysis induced by oncolytic virus M1(OVM). | Deli Song Xudong Jia Xincheng Liu Linyi Hu Kaiying Lin Tong Xiao Yangyang Qiao Jiayu Zhang Jia Dan Chunwa Wong Cheng Hu Ke Sai Shoufang Gong Max Sander Runling Shen Xiaoyu Chen Xiaoting Xiao Jiehong Chen Yanming Zhang Cailv Wei Xiao Xiao Jiankai Liang Qinfen Zhang Jun Hu Wenbo Zhu Guangmei Yan Yuan Lin Jing Cai | 2022 | Signal Transduction and Targeted Therapy2022，7，5： | 0 |
| 17 | SBC(Sanhuang Xiexin Tang combined with Baihu Tang plus Cangzhu)alleviates NAFLD by enhancing mitochondrial biogenesis and ameliorating inflammation in obese patients and mice显示文摘In the context of non-alcoholic fatty liver disease (NAFLD), characterized by dysregulated lipid metabolism in hepatocytes, the quest for safe and effective therapeutics targeting lipid metabolism has gained paramount importance. Sanhuang Xiexin Tang (SXT) and Baihu Tang (BHT) have emerged as prominent candidates for treating metabolic disorders. SXT combined with BHT plus Cangzhu (SBC) has been used clinically for Weihuochisheng obese patients. This retrospective analysis focused on assessing the anti-obesity effects of SBC in Weihuochisheng obese patients. We observed significant reductions in body weight and hepatic lipid content among obese patients following SBC treatment. To gain further insights, we investigated the effects and underlying mechanisms of SBC in HFD-fed mice. The results demonstrated that SBC treatment mitigated body weight gain and hepatic lipid accumulation in HFD-fed mice. Pharmacological network analysis suggested that SBC may affect lipid metabolism, mitochondria, inflammation, and apoptosis—a hypothesis supported by the hepatic transcriptomic analysis in HFD-fed mice treated with SBC. Notably, SBC treatment was associated with enhanced hepatic mitochondrial biogenesis and the inhibition of the c-Jun N-terminal kinase (JNK)/nuclear factor-kappa B (NF-κB) and extracellular signal-regulated kinase (ERK)/NF-κB pathways. In conclusion, SBC treatment alleviates NAFLD in both obese patients and mouse models by improving lipid metabolism, potentially through enhancing mitochondrial biogenesis. These effects, in turn, ameliorate inflammation in hepatocytes. | REN Zhitao XIAO Gemin CHEN Yixin WANG Linli XIANG Xiaoxin YANG Yi WEN Siying XIE Zhiyong LUO Wenhui LI Guowei ZHENG Wenhua QIAN Xiaoxian HAI Rihan YANG Liansheng ZHU Yanhua CAI Mengyin YE Yinong SHI Guojun CHEN Yanming | 2023 | Chinese Journal of Natural Medicines2023，21，11： | 0 |
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