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| 1 | Current status of diagnosis and treatment of bladder cancer in China-Analyses of Chinese Bladder Cancer Consortium database显示文摘Objective:To investigate current status of diagnosis and treatment of bladder cancer in China.Methods:A database was generated by Chinese Bladder Cancer Consortium(CBCC).From January 2007 to December 2012,14,260 cases from 44 CBCC centers were included.Data of diagnosis,treatment and pathology were collected.Results:The average age was 63.5 year-old and most patients were male(84.3%).The most common histologic types were urothelial carcinoma(91.4%),adenocarcinoma(1.8%),and squamous carcinoma(1.9%).According to 1973 and 2004 WHO grading system,42.0%,41.0%,and 17.0% of patients were grade 1,2,and 3,and 16.0%,48.7%,and 35.3% of patients were papillary urothelial neoplasms of low malignant potential,low,and high grade,respectively.Non-muscle invasive bladder cancer(NMIBC)and muscle invasive bladder cancer(MIBC)were 25.2% and 74.1%,respectively(0.8% not clear).Carcinoma in situ was only 2.4%.Most patients were diagnosed by white-light cystoscopy with biopsy(74.3%).Fluorescence and narrow band imaging cystoscopy had additional detection rate of 1.0% and 4.0%,respectively.Diagnostic transurethral resection(TUR)provided detection rate of 16.9%.Most NMIBCs were treated with TUR(89.2%).After initial TUR,2.6%accepted second TUR,and 45.7%,69.9%,and 58.7% accepted immediate,induced,and maintenance chemotherapy instillation,respectively.Most MIBCs were treated with radical cystectomy(RC,59.7%).Laparoscopic RCs were 35.1%,while open RC 63.4%.Extended and standard pelvic lymph node dissection were 7% and 66%,respectively.Three most common urinary diversions were orthotopic neobladder(44%),ileal conduit(31%),and ureterocutaneostomy(23%).Only 2.3% of patients accepted neo-adjuvant chemotherapy and only 18%of T3 and T4 patients accepted adjuvant chemotherapy.Conclusion:Disease characteristics are similar to international reports,while differences of diagnosis and treatment exist.This study can provide evidences for revisions of the guideline on bladder cancer in China. | Kaiwen Li Tianxin Lin 无 Wei Xue Xin Mu Enci Xu Xu Yang Fubao Chen Guangyong Li Lulin Ma Guoliang Wang Chaozhao Liang Haoqiang Shi Ming Li Mao Tang Xueyi Xue Yisong Lv Yaoliang Deng Chengyang Li Zhiwen Chen Xiaozhou Zhou Fengshuo Jin Xudong Liu Jinxin Wei Lei Shi Xin Gou Weiyang He Liqun Zhou Lin Cai Baiye Jin Guanghou Fu Xiangbo Kong Hongyan Sun Ye Tian Lang Feng Tiejun Pan Yiyi Wu Dongwen Wang Hailong Hao Benkang Shi Yaofeng Zhu Qiang Wei Ping Han Changli Wu Dawei Tian Zhangqun Ye Zheng Liu Zhiping Wang Junqiang Tian Lin Qi Minfeng Chen Wei Li Jinchun Qi Gongxian Wang Longlong Fu Zhaolin Sun Guangheng Luo Zhoujun Shen Zhaowei Zhu Jinchun Xing Zhun Wu Dong Wei Xin Chen Yanqun Na Hongfeng Guo Chunxi Wang Zhihua Lu Chuize Kong Yang Liu Jin Yang Jianyun Hu Xin Gao Jielin Li Changjun Yin Pu Li Shan Chen Zhen Du Jiongming Li Yongji Yan Xu Zhang Shuang Huang Fangjian Zhou Zhiling Zhang Yinghao Sun Shuxiong Zeng Song Cen Jiaquan Zhou Hanzhong Li Jin Wen Jian Huang | 2015 | Asian Journal of Urology2015，2，2： | 21 |
| 2 | Olfactory ecto-mesenchymal stem cell-derived exosomes ameliorate murine Sjögren’s syndrome by modulating the function of myeloid-derived suppressor cells显示文摘Sjögren’s syndrome(SS)is a systemic autoimmune disease characterized by progressive inflammation and tissue damage in salivary glands and lacrimal glands.Our previous studies showed that myeloid-derived suppressor cells(MDSCs)exhibited impaired immunosuppressive function during disease progression in patients with SS and mice with experimental Sjögren’s syndrome(ESS),but it remains unclear whether restoring the function of MDSCs can effectively ameliorate the development of ESS.In this study,we found that murine olfactory ecto-mesenchymal stem cell-derived exosomes(OE-MSC-Exos)significantly enhanced the suppressive function of MDSCs by upregulating arginase expression and increasing ROS and NO levels.Moreover,treatment with OE-MSC-Exos via intravenous injection markedly attenuated disease progression and restored MDSC function in ESS mice.Mechanistically,OE-MSC-Exo-secreted IL-6 activated the Jak2/Stat3 pathway in MDSCs.In addition,the abundant S100A4 in OE-MSC-Exos acted as a key factor in mediating the endogenous production of IL-6 by MDSCs via TLR4 signaling,indicating an autocrine pathway of MDSC functional modulation by IL-6.Taken together,our results demonstrated that OE-MSC-Exos possess therapeutic potential to attenuate ESS progression by enhancing the immunosuppressive function of MDSCs,possibly constituting a new strategy for the treatment of Sjögren’s syndrome and other autoimmune diseases. | Ke Rui Yue Hong Qiugang Zhu Xiaofei Shi Fan Xiao Hailong Fu Qing Yin Yida Xing Xinfeng Wu Xiaodan Kong Huaxi Xu Jie Tian Shengjun Wang Liwei Lu | 2021 | Cellular & Molecular Immunology2021，18，2： | 12 |
| 3 | The genome of Medicago polymorpha provides insights into its edibility and nutritional value as a vegetable and forage legume显示文摘Medicago polymorpha is a nutritious and palatable forage and vegetable plant that also fixes nitrogen.Here,we reveal the chromosome-scale genome sequence of M.polymorpha using an integrated approach including Illumina,PacBio and Hi-C technologies.We combined PacBio full-length RNA-seq,metabolomic analysis,structural anatomy analysis and related physiological indexes to elucidate the important agronomic traits of M.polymorpha for forage and vegetable usage.The assembled M.polymorpha genome consisted of 457.53Mb with a long scaffold N50 of 57.72Mb,and 92.92%(441.83Mb)of the assembly was assigned to seven pseudochromosomes.Comparative genomic analysis revealed that expansion and contraction of the photosynthesis and lignin biosynthetic gene families,respectively,led to enhancement of nutritious compounds and reduced lignin biosynthesis in M.polymorpha.In addition,we found that several positively selected nitrogen metabolism-related genes were responsible for crude protein biosynthesis.Notably,the metabolomic results revealed that a large number of flavonoids,vitamins,alkaloids,and terpenoids were enriched in M.polymorpha.These results imply that the decreased lignin content but relatively high nutrient content of M.polymorpha enhance its edibility and nutritional value as a forage and vegetable.Our genomic data provide a genetic basis that will accelerate functional genomic and breeding research on M.polymorpha as well as other Medicago and legume plants. | Jiawen Cui Zhaogeng Lu Tianyi Wang Gang Chen Salma Mostafa Hailong Ren Sian Liu Chunxiang Fu Li Wang Yingfang Zhu Jinkai Lu Xiang Chen Zhenwu Wei Biao Jin | 2021 | Horticulture Research2021，8，1： | 6 |
| 4 | eGPS 1.0: comprehensive software for multi-omic and evolutionary analyses显示文摘It has become increasingly challenging for researchers to analyze the exponentially expanding amount of multi-omic data.Here,we describe multi-functional software named evolutionary GenotypePhenotype Systems(eGPS)that enables users to perform comprehensive multiomic and evolutionary analyses.The eGPS combines the power of cloud computing and the advantage of desktop application,has a user-friendly graphic interface and is highly interactive. | Dalang Yu Lili Dong Fangqi Yan Hailong Mu Bixia Tang Xiao Yang Tao Zeng Qing Zhou Feng Gao Zhonghuang Wang Ziqian Hao Hongen Kang Yi Zheng Hongwei Huang Yuzhang Wei Wei Pan Yaochen Xu Junwei Zhu Shilei Zhao Ciran Wang Pengyu Wang Long Dai Mushan Li Li Lan Yiwei Wang Hua Chen Yi-Xue Li Yun-Xin Fu Zhen Shao Yiming Bao Fangqing Zhao Luo-Nan Chen Guo-Qing Zhang Wenming Zhao Haipeng Li | 2019 | National Science Review2019，6，5： | 4 |
| 5 | Effects of Dietary Concentrate to Forage Ratios on Production Performance and Serum Biochemical Indicators in Post-fattening Hainan Yellow Cattle显示文摘[Objective]The paper was to investigate the effects of dietary concentrate to forage ratios on production performance and serum bio-chemical indicators of post-fattening Hainan Yellow Cattle.[Method]Sixteen Hainan Yellow Cattles with the same genetic backgrounds and similar initial weight of(242.22 ±0.71 kg) were randomly divided into four treatments.Cattles were fed with diets of different concentrate to forage ratios(20:80, group Ⅰ;30:70, Group Ⅱ;40:60, group Ⅲ;50:50, group Ⅳ).The trial lasted 62 d.[Result]The daily gain in experimental group Ⅳ was significantly higher than that in experimental group Ⅱ(P<0.05), but the feed gain ratio in experimental group Ⅳ was lower than those in other ex-perimental groups(P>0.05).The feed intake in experimental group Ⅳ was also markedly higher than those in experimental groups Ⅰ and Ⅱ(P<0.05).Compared with the experimental group Ⅱ, the gross profit of experimental group Ⅳ was significantly promoted(P<0.05).The alanine aminotransferase and aspartate aminotransferase activities in experimental group Ⅱ were markedly higher than those in experimental groups Ⅰ, Ⅲ and Ⅳ.[Conclusion]When the dietary concentrate to forage ratios was 50∶50, the production performance of post-fattening Hainan Yellow Cattle was better. | Wang Feng Wei Limin Zheng Xinli Liu Hailong Sun Ruiping Chao Zhe Huang Lili Fu Liang Liu Quanwei | 2020 | Animal Husbandry and Feed Science2020，12，1： | 3 |
| 6 | Determination of paraquat in water samples using a sensitive fluorescent probe titration method显示文摘Paraquat(PQ),a nonselective herbicide,is non-fluorescent in aqueous solutions.Thus,its determination through direct fluorescent methods is not feasible.The supramolecular inclusion interaction of PQ with cucurbit[7]uril was studied by a fluorescent probe titration method.Significant quenching of the fluorescence intensity of the cucurbit[7]uril-coptisine fluorescent probe was observed with the addition of PQ.A new fluorescent probe titration method with high selectivity and sensitivity at the ng/mL level was developed to determine PQ in aqueous solutions with good precision and accuracy based on the significant quenching of the supramolecular complex fluorescence intensity.The proposed method was successfully used in the determination of PQ in lake water,tap water,well water,and ditch water in an agricultural area,with recoveries of 96.73% to 105.77%.The fluorescence quenching values(F) showed a good linear relationship with PQ concentrations from 1.0 × 108 to 1.2× 105 mol/L with a detection limit of 3.35 × 109 mol/L.In addition,the interaction models of the supramolecular complexes formed between the host and the guest were established using theoretical calculations.The interaction mechanism between the cucurbit[7]uril and PQ was confirmed by 1 H NMR spectroscopy. | Feihu Yao Hailong Liu Guangquan Wang Liming Du Xiaofen Yin Yunlong Fu | 2013 | Journal of Environmental Sciences2013，25，6： | 2 |
| 7 | Rapid determination of methanol in black liquors by full evaporation headspace gas chromatography 显示文摘 | Li Hailong Zhan Huaiyu Fu Shiyu | 2007 | Journal of Chromatography A2007，1175，1： | 1 |
| 8 | Model of chloride penetration into cracked concrete subject to drying–wetting cycles显示文摘 | Hailong Ye Nanguo Jin Xianyu Jin Chuanqing Fu | 2012 | Construction and Building Materials2012，，： | 1 |
| 9 | Feasibility design of derrick anchor pile piling position based on ANSYS optimization 显示文摘 | Zhu Juan Zou Longqing Fu Hailong | 2013 | Advanced Mate- rial Research2013，，： | 1 |
| 10 | Simultaneous determination of Repaglinide and Irbesartan in biological plasmas using micellar enhanced excitation-emission matrix fluorescence coupled with ATLD method显示文摘A highly sensitive and selective 3D excitation-emission fluorescence method has been proposed to rapidly quantify the combined antidiabetics Repaglinide(Re) and Irbesartan(Ir) in rat and human plasmas with the aid of second-order calibration method based on alternating trilinear decomposition(ATLD) method. Re and Ir with weak fluorescence can be endowed with strong fluorescent property by changing the microenvironment in samples and improving the fluorescence quantum yield by using an appropriate micellar enhanced surfactant. The enhanced excitation-emission matrix fluorescence of Re and Ir can be accurately resolved and can simultaneously attain the optimal concentration even in the presence of a potentially strong intrinsic fluorescence from complex biological matrices, such as rat and human plasmas, by using the ATLD method, which completely exploits the 'second-order advantage'. The average recoveries of Re and Ir obtained from ATLD with the factor number of 3(N=3) were 101.0%±4.3% and 99.1%±4.1% for rat plasma and 100.5%±5.4% and 97.1%±3.6% for human plasma. Several statistical methods, including Student's t-test, figures of merit, and elliptical joint confidence region, have been utilized to evaluate the accuracy of the proposed method. Results show that the developed method can maintain second-order advantage in simultaneous determinations of the weak fluorescent analytes of interest in different biological plasma matrices. | Haiyan Fu Hedong Li Mei Shao Tianming Yang Xu Zhang Rujing Xu Yujuan Wei Shuhua Chen Chuang Ni Hailong Wu | 2016 | Science China Chemistry2016，59，7： | 1 |
| 11 | Rapid determination of methanol in black liquors by full evaporation headspace gas chromatography显示文摘 | Li Hailong Zhan Huaiyu Fu Shiyu | 2007 | Journal of Chromatography A2007，1175，： | 1 |
| 12 | Rapid determination of ethanol in fermentation liquor by full evaporation headspace gas chromatography显示文摘 | Li Hailong Chai Xin-Sheng Deng Yulin Zhan Huaiyu Fu Shiyu | 2008 | Journal of Chromatography A2008，，： | 1 |
| 13 | Genetic polymorphism of MMP family and coronary disease susceptibility: A meta-analysis显示文摘 | Min Li Jingpu Shi Lingyu Fu Hailong Wang Bo Zhou Xiaomei Wu | 2011 | Gene2011，，1： | 1 |
| 14 | Theoretical and experimental investigation of loading effects on chloride diffusion insaturated concrete显示文摘 | FU Chuanqing JIN Xianyu YE Hailong | 2015 | J Adv Concr Technol2015，13，： | 1 |
| 15 | Effect of Curing Temperature on the Morphology and Hydration of MgO Expansive Material in Paste显示文摘The morphologies and hydration properties of MgO expansive material at different curing temperatures were investigated.When the curing temperature varies from 25℃to 50℃,the conductivity of MgO rises from 40 to 80μs/cm,the hydration product of MgO expansive material curing in water for 28 days is from 1.5—2 mm to 2—2.5μm in length through SEM observation,and the expansion of pastes with 5%of the magnesium oxide is from 0.36%up to 1.01%,it is increased by 2.78 times.When the content of cement paste increases to 95%and cured in water for 90 days,the brucite forms as hexaflaggy?shaped crystal,which is less than 0.1μm and tends to aggregates.The effect of curing temperature on the hydration of MgO expansive material is obvious. | ENG Tian Zi WANG Fu PENG Hailong YANG Weibo GAO Peiwei | 2019 | Transactions of Nanjing University of Aeronautics and Astronautics2019，36，4： | 1 |
| 16 | Variable-weighted least-squares support vector machine for multivariate spectral analysis显示文摘 | Zou Hongyan Wu Hailong Fu Haiyan | 2010 | Talanta2010，80，： | 1 |
| 17 | Influence of cracking on chloride diffusivity and moisture influential depth in concrete subjected to simulated environmental conditions显示文摘 | Hailong Ye Ye Tian Nanguo Jin Xianyu Jin Chuanqing Fu | 2013 | Construction and Building Materials2013，，： | 1 |
| 18 | Model of chloride penetration into cracked concrete subject to drying–wetting cycles显示文摘 | Hailong Ye Nanguo Jin Xianyu Jin Chuanqing Fu | 2012 | Construction and Building Materials2012，，： | 1 |
| 19 | Picture archiv- ing and communication system in China: the development, prob- lem, strategy with IHE显示文摘 | Hailong Fu Zhengyun Jin Jianping Dai | 2003 | Elsevier Science2003，，： | 1 |
| 20 | Crude Polysaccharide and Triterpene Content of Ganoderma Fruit Bodies at Different Stages of Development显示文摘Crude polysaccharide and triterpene levels were determined in the fruit bodies of eleven Lingzhi samples,designated as Ganoderma lucidum,G.capense and G.tsugae,harvested at four different stages of development: budding,elongation,maturation and senescence.In most cases,crude polysaccharide levels were highest at the budding stage,decreased during the elongation stage,increased again at maturation and were lowest at senescence.Triterpene levels generally remained relatively high during the first three developmental stages but were markedly lower at senescence. | FU Lizhong WU Xueqian LI Mingyan LI Haibo WEI Hailong WU Qingqi CHENG Junwen HE Liang | 2008 | 食用菌学报2008，15，3： | 1 |
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