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| 1 | Dendritic cell migration in inflammation and immunity显示文摘Dendritic cells(DCs)are the key link between innate immunity and adaptive immunity and play crucial roles in both the promotion of immune defense and the maintenance of immune tolerance.The trafficking of distinct DC subsets across lymphoid and nonlymphoid tissues is essential for DC-dependent activation and regulation of inflammation and immunity.DC chemotaxis and migration are triggered by interactions between chemokines and their receptors and regulated by multiple intracellular mechanisms,such as protein modification,epigenetic reprogramming,metabolic remodeling,and cytoskeletal rearrangement,in a tissue-specific manner.Dysregulation of DC migration may lead to abnormal positioning or activation of DCs,resulting in an imbalance of immune responses and even immune pathologies,including autoimmune responses,infectious diseases,allergic diseases and tumors.New strategies targeting the migration of distinct DC subsets are being explored for the treatment of inflammatory and infectious diseases and the development of novel DC-based vaccines.In this review,we will discuss the migratory routes and immunological consequences of distinct DC subsets,the molecular basis and regulatory mechanisms of migratory signaling in DCs,and the association of DC migration with the pathogenesis of autoimmune and infectious diseases. | Juan Liu Xiaomin Zhang Yujie Cheng Xuetao Cao | 2021 | Cellular & Molecular Immunology2021，18，11： | 8 |
| 2 | Fabrication of Al_2O_3-NaCl Composite Heat Storage Materials by One-step Synthesis Method显示文摘Thermal energy storage is an attractive option for effectiveness since it gives flexibility and reduces energy consumption and costs. New composite materials for storage and transformation of heat of NaCl-Al_2O_3 composite materials were synthesized by one-step synthesis method. The chemical composition, morphology, structure, and thermal properties were investigated by XRD, EDS, SEM, and DSC. The results show that NaCl can be absorbed by Al_2O_3 particle from 800 to 900 ℃ for Al_2O_3 particle surface is rich active structure. The results also indicate that the leakage of NaCl when the phase change can be prevented by Al_2O_3 particles and the enthalpy of phase change of NaCl-Al_2O_3 material is 362 J/g. The composites have an excellent heat storage capacity. Therefore, this study contributes to one new thought and method to prepare high temperature heat storage material and this material can be applied in future thermal engineering. | 朱教群 李儒光 ZHOU Weibin ZHANG Hongguang CHENG Xiaomin | 2016 | Journal of Wuhan University of Technology(Materials Science)2016，31，5： | 5 |
| 3 | Identification of Chromosomes from Multiple Rice Genomes Using a Universal Molecular Cytogenetic Marker System显示文摘为染色体鉴定开发可靠技术为细胞发生的研究是批评的,特别为有一个大数字和小尺寸的染色体的染色体。当分子的 cytologicalmarkers 为许多有机体被开发了,用细菌的人工的染色体(用绳子拖的平底渡船) 的 Anefficient 途径克隆。此处,我们在场一套 chromosomal arm-specificmolecular cytological 标记源于定序的米饭染色体的充实基因的区域。所有这些标记能在 Oryzasativa L 的 pachytene 染色体上产生很强壮的信号。(AA 染色体) 什么时候用作荧光原位杂交(鱼) ,探查。我们进一步探查了那些标记到 O 的 pachytene 染色体。punctata (BB 染色体) 和 O。依照药方(CCgenome ) 并且相关 pachytene 染色体上的也得到的很强壮的信号。从三个不同米饭染色体的相关染色体上的每个标记的信号位置是漂亮大部分桌子,它使我们能在各种各样的米饭染色体之中识别不同染色体。我们也为两 O 构造了核型。punctata 和 O。依照药方分别地,由 10 个 pachytene 房间的分析与 BB 和 CC 染色体由这些 chromosomal 抛锚了手臂特定的标记…… | Xiaomin Tang Weidong Bao Wenli Zhang Zhukuan Cheng | 2007 | Journal of Integrative Plant Biology2007，49，6： | 4 |
| 4 | A review of internally heat integrated distillation column显示文摘The energy consumption of distillation operation determines the amount of energy consumption throughout the chemical separation process. A heat integrated distillation column(HIDiC) could greatly reduce the irreversibility of the distillation process, so it gradually becomes a research hotspot. There are two major techniques for heat integration in HIDiC: internally and externally. This review paper describes the major research aspects of an internally heat integrated distillation column(IHIDiC), including the heat transfer models, various design structures(including the two-column HIDiC, Concentric HIDiC, Shell and tube HIDiC, Plate-fin HIDiC and the Super HIDiC, etc.), experimental research, simulation and optimization, process control research, as well as industrial plants and potential industrial applications. Among them, the heat transfer performance of various structures was analyzed of the various design structures based on experimental research, the effects of different factors(including relative volatility, reflux ratio, compression ratio, etc.) on HIDiC energy consumption or TAC is summarized in the simulation part. The calculation methods of the overall heat transfer coefficient and heat transfer models are summarized. The various optimization algorithms and optimization results of simplified HIDiC are summarized in the optimization part. The research status and the key technical issues in various aspects of HIDiC are summarized in this paper. In order to meet the requirements of industrial energy efficiency,the selection of multi-component separation distillation configurations needs to be considered more diversified,and internal complex coupling relationship of HIDiC needs to be further studied. | Jing Fang Xiaomin Cheng Zhongyang Li Hao Li Chunli Li | 2019 | Chinese Journal of Chemical Engineering2019，27，6： | 4 |
| 5 | Effect of electroacpuncture of Neiguan(PC 6)and Tianquan(PC 2)on skin temperature,blood perfusion,and adrenoceptor response in rats with acute myocardial ischemia显示文摘OBJECTIVE: To investigate the effect of electroacupuncture(EA) of acupoints Neiguan(PC 6) and Tianquan(PC 2) on the skin temperature, blood perfusion, and alpha1-and beta2-adrenoreceptor(α1-AR and β2-AR) protein and m RNA level in rats with acute myocardial ischemia.METHODS: Thirty male adult Wistar rats [(230 ±20) g] were randomly assigned into five groups(n = 6 each): a control group, sham operation group, model group, model group treated with EA at low frequency(L-EA, 2 Hz, 1 m A) and model group treated with EA at high frequency(H-EA, 100 Hz, 1 m A). The rat model was prepared by ligating the left anterior descending coronary artery. Electroacupuncture was performed at the left Neiguan(PC 6) for 20 min daily for 3 d. After the 3 rd time of the treatment, measurements of skin blood perfusion and temperature in Neiguan(PC 6) and Tianquan(PC 2) in all groups were made by laser speckle contrast imaging and infrared thermal image instrument. Real-time PCR and ELISA were used to measure m RNA level and protein level of α1-AR andβ2-AR in the skin tissues of Neiguan(PC 6) and Tianquan(PC 2), respectively. Serum levels of c Tn T and electrocardiogram were used to identify the state of myocardium.RESULTS: In the group receiving electroacupunture at Neiguan(PC 6), compared with control group,the skin temperature, blood perfusion, and β2-AR m RNA and protein level of model group significantly decreased(P < 0.05), α1-AR m RNA and protein level of model group significantly increased(P < 0.05);compared with model group, the skin temperature,blood perfusion, and β2-AR m RNA and protein level of L-EA significantly increased(P < 0.05), α1-AR m RNA and protein level of L-EA and H-EA significantly decreased(P < 0.05). The same trend has taken place in the former four groups of the Tianquan(PC 2).CONCLUSION: Low-or high-frequency electroacupuncture can improve the skin temperature and blood perfusion which may be induced by decreasingthelevelofα1-ARandincreasingthelevelofβ2-AR of the Neiguan(PC 6) and Tianquan(PC 2) in the rat with acute myocaidial ischemia. | Wang Dan Ji Bo Zhao Guozhen Yan Mingna Bai Hongxin Sun Xiaomin Dai Jian Lu Yawen Liu Yitian You Min Wu Jiaojuan Ge Yunpeng Su Hang Cheng Kai | 2017 | Journal of Traditional Chinese Medicine2017，37，6： | 3 |
| 6 | Research progress in cation-π interactions显示文摘Cation-π interaction is a potent intermolecular interaction between a cation and an aromatic system,which has been viewed as a new kind of binding force,as being compared with the classical interactions(e.g. hydrogen bonding,electrostatic and hydrophobic interactions). Cation-π interactions have been observed in a wide range of biological contexts. In this paper,we present an overview of the typical cation-π interactions in biological systems,the experimental and theoretical investigations on cation-π interactions,as well as the research results on cation-π interactions in our group. | CHENG JiaGao LUO XiaoMin YAN XiuHua LI Zhong TANG Yun JIANG HuaLiang ZHU WeiLiang | 2008 | Science China Chemistry2008，51，8： | 3 |
| 7 | A Quasi-Optimal Probabilistic Fault Localization Algorithm in Communication Networks显示文摘 | LIAO Jianxin ZHANG Cheng LI Tonghong ZHU Xiaomin | 2011 | Chinese Journal of Electronics2011，20，1： | 2 |
| 8 | Four COVID-19 Cases of New Variant B.1.351 First Emerging in South Africa in Chinese Passengers on Same Flight-Shenzhen,China,January 2021显示文摘At 04∶50 on January 1,2021,a 36-year-old Chinese project manager(Case A),a 29-year-old Chinese worker(Case B),and a 53-year-old Chinese businessman(Case C)returned from Africa(Case A and B from South Africa and Case C from Lesotho)on the same flight and tested coronavirus disease 2019(COVID-19)RNA positive by real-time polymerase chain reaction(PCR)by Baoan District People’s Hospital.Shenzhen CDC received their oral nasopharyngeal swabs packages from the hospital and retested COVID-19 RNA positive at 09∶50.Meanwhile,Case D. | Cong Cheng Lei Wang Ziquan Lyu Bo Peng Yinghui Li Dongfeng Kong Le Zuo Xiaomin Zhang Chao Yang Weiwen Liu Jia Wan Yijun Tang Junjia He Ying Wen Shule Xu Weihua Wu Ying Chen Guangnan Liu Junjie Xia Xuan Zou Renli Zhang Qinghua Hu Shujiang Mei Tiejian Feng | 2021 | China CDC weekly2021，3，8： | 2 |
| 9 | Preparation and electrical conductivity of(Zr,Hf,Pr,Y,La)O high entropy fluorite oxides显示文摘A series of compositionally complex fluorite oxides(CCFOs)were prepared by ball milling the mixture of ZrO_(2),HfO_(2),Y_(2)O_(3),La_(2)O_(3),and Pr_(6)O_(11)followed by conventional solid-state sintering.Both XRD and TG-DSC results demonstrated that single-phase(Zr_(0.2)Hf_(0.2)Pr_(0.2)Y_(0.2)La_(0.2))O_(2-)δwas formed at 1400°C.Elements in bulk ceramic were uniformly distributed without evident accumulation according to SEM-EDS pictures.TEM results revealed that polycrystalline ceramic powder was assignable to cubic Fm-3m fluorite structure.The electrical conductivity(σ)was measured via EIS technology and activation energy(E_(a))of CCFOs was calculated in Arrhenius plots.In the temperature range of 300-750°C,CCFOs preserved the same conduction mechanism and(Zr_(0.1667)Hf_(0.1667)Pr_(0.1667)Y_(0.25)La_(0.25))O_(2-)δpossessed higherσand lower E_(a) than other high entropy fluorite oxides which is related to the incorporation of Pr element or the connection of cation-V_(o) complex. | Fengnian Zhang Fuhao Cheng Chufei Cheng Meng Guo Yufeng Liu Yang Miao Feng Gao Xiaomin Wang | 2022 | Journal of Materials Science & Technology2022，，10： | 2 |
| 10 | SLC1A1-mediated cellular and mitochondrial influx of R-2-hydroxyglutarate in vascular endothelial cells promotes tumor angiogenesis in IDH1-mutant solid tumors显示文摘Muta nt isocitrate dehydrog en ase 1(mlDH1)drives tumorigenesis via produci ng on cometabolite R-2-hydroxyglutarate(R-2-HG)across various tumor types.However,mlDHl in hibitors appear only effective in hematological tumors.The therapeutic ben efit in solid tumors remains elusive,likely due to the complex tumor microenvironment.In this study,we discover that R-2-HG produced by IDH1-mutant tumor cells is preferentially imported into vascular endothelial cells and remodels mitochondrial respiration to promote tumor angiogenesis,conferring a therapeutic vulnerability in IDH1-mutant solid tumors.Mechanistically,SLC1 Alz a Na'-depe ndent glutamate tran sporter that is prefere ntially expressed in en dothelial cells,facilitates the in flux of R-2-HG from the tumor microenvironment into the endothelial cells as well as the intracellular trafficking of R-2-HG from cytoplasm to mitochondria.R-2-HG hijacks SLC1A1 to promote mitochondrial Na^(+)/Ca^(2+)exchange,which activates the mitochondrial respiratory chain and fuels vascular en dothelial cell migratio n in tumor an giogenesis.SLC1A1 deficiency in mice abolishes mlDHl-promoted tumor an giogenesis as well as the therapeutic benefit of mlDHl in hibitor in solid tumors.Moreover,we report that HH2301,a newly discovered mlDHl inhibitor,shows promising efficacy in treating IDH1-mutant cholangiocarcinoma in preclinical models.Together,we identify a new role of SLC1A1 as a gatekeeper of R-2-HG-mediated crosstalk between IDH1-mutant tumor cells and vascular en dothelial cells,and dem on strate the therapeutic potential of mlDHl in hibitors in treating IDH1-muta nt solid tumors via disrupting R-2-HG-promoted tumor angiogenesis. | Xiaomin Wang Ziqi Chen Jun Xu Shuai Tang Nan An Lei Jiang Yixiang Zhang Shaoying Zhang Qingli Zhang Yanyan Shen Shijie Chen Xiaojing Lan Ting Wang Linhui Zhai Siyuwei Cao Siqi Guo Yingluo Liu Aiwei Bi Yuehong Chen Xiameng Gai Yichen Duan Ying Zheng Yixian Fu Yize Li Liang Yuan Linjiang Tong Kun Mo Mingcheng Wang Shu-Hai Lin Minjia Tan Cheng Luo Yi Chen Jia Liu Qiansen Zhang Leping Li Min Huang | 2022 | Cell Research2022，32，7： | 2 |
| 11 | The effect of multilayer structure on magnetic properties of FePt thin films显示文摘The Fe/Pt multilayer films with different structures were deposited by RF magnetron sputtering on glass substrates, and the L10-FePt films were obtained after the as- deposited samples were subjected to vacuum annealing at various temperatures. Re- sults show that the Fe/Pt multilayer structure can effectively reduce the ordering temperature of FePt film, and the in-plane coercivity of [Fe (5.2 nm)/Pt (5.2 nm)]7 multilayers can reach 161.2 kA/m after annealed at 350 ffC for 30 min. When Fe and Pt layer thickness is equal, the coercivity of the film is the largest. On the other hand, the different Fe-Pt crystalline phases such as Fe3Pt and FePt3 phases are formed after annealing when the thickness ratio of Fe/Pt deviates from 1 after annealing. When Fe and Pt have the same thickness, the thinner single layer gets the lower ordering temperature and the larger coercivity. | Kaifeng DONG Xiaofei YANG Junbing YAN Weiming CHENG Xiaomin CHENG | 2009 | Acta Metallurgica Sinica(English Letters)2009，22，1： | 1 |
| 12 | Effect of Ni doping on the microstructure and magnetic properties of FePt films显示文摘FePtNi films with different Ni contents were deposited on glass substrates by RF magnetron sputtering, and the L10-FePtNi films were obtained after the asdeposited samples were subjected to vacuum annealing. The magnetic properties, structures, and orientations of the L10-FePt films with Ni doping were studied. The results show that with increasing Ni content, the (001) peak position of the FePtNi films shifts to a higher angle in comparison with FePt, which suggests that there is partial Ni substitution in the L10 lattice. The perpendicular coercivity decreases from 661 to 142 kA/m and magnetization decreases from 512 to 433 kA/m with increasing Ni content. In comparison with FePt films, the FePtNi films can effectively reduce the Curie temperature, which makes FePtNi films promising media candidates in thermally assisted recording (TAR). | DONG Kaifeng CHENG Xiaomin YAN Junbing CHENG Weiming LI Peng YANG Xiaofei | 2009 | Rare Metals2009，28，3： | 1 |
| 13 | Highyield synthesis of nickel flowers from nickel hydroxide precursor显示文摘 | Xiaomin Ni Qingbiao Zhao Jing Cheng | | 0，，10： | 1 |
| 14 | TaASR1 , a transcription factor gene in wheat, confers drought stress tolerance in transgenic tobacco显示文摘 | WEI HU CHAO HUANG XIAOMIN DENG SHIYI ZHOU LIHONG CHEN YIN LI CHENG WANG ZHANBING MA QIANQIAN YUAN YAN WANG RUI CAI XIAOYU LIANG GUANGXIAO YANG GUANGYUAN HE | 2013 | Plant Cell Environ2013，，8： | 1 |
| 15 | Controlled WS_(2) crystallinity effectively dominating sodium storage performance显示文摘WS2 exhibits tremendous potentials for Na-ions storage owing to high capacity(433 mAh g^(-1)). Nevertheless, WS2 layered structure is often exfoliated with rapid capacity decay and sluggish reaction kinetics.In this work, WS2 nanosheets with different crystallinities are controlled by different synthesis methods.The high crystallinity WS2 exhibits high degree of interlayer order and strong interlayer force. It exhibits superior electrochemical properties, at the current density of 200 mA g^(-1) after 300 cycles with reversible capacity of 471 mAh g^(-1). Even at 5.0 A g^(-1), the capacities can still arrive at 240 mAh g^(-1) after 250 cycles, exhibiting stable cycling performance. Further electrochemical research finds that the high degree of interlayer order of layered WS2 structure can perform highly conducive Na+insertion/extraction with greatly improved contribution of intercalation capacity. Moreover, the strong interlayer force can effectively restrain the exfoliating of the WS2 nanosheets, guaranteeing the stability of the structure. Combining the above result reveals that controlling the order and force of the interlayer is an effective way to enhance the electrochemical properties of WS2 as SIBs anode materials. This work can provide new insight for inhibiting the exfoliation of layered compounds to pursue excellent electrochemical performance in Na-ion storage systems. | Xiaomin Luo Jianfeng Huang Jiayin Li Liyun Cao Yong Wang Zhanwei Xu Ling Guo Yayi Cheng Koji Kajiyoshi Shaoyi Chen | 2020 | Journal of Energy Chemistry2020，29，12： | 1 |
| 16 | Study on seismic behavior of lime sand brick walls with con- structional column显示文摘 | Cheng Caiyuan Zhou Bolong Wang Xiaomin | 1989 | Sichuan Building Scientific Re- search1989，，4： | 1 |
| 17 | High-yieldSynthesis of Nickel Flowers From Nickel Hydroxide Precursor显示文摘 | Ni Xiaomin Zhao Qingbiao Cheng Jing | 2005 | Chemistry Letters2005，34，10： | 1 |
| 18 | Sustainability of SARS-CoV-2 Induced Humoral Immune Responses in COVID-19 Patients from Hospitalization to Convalescence Over Six Months显示文摘Understanding the persistence of antibody in convalescent COVID-19 patients may help to answer the current major concerns such as the risk of reinfection,the protection period of vaccination and the possibility of building an active herd immunity.This retrospective cohort study included 172 COVID-19 patients who were hospitalized in Wuhan.A total of404 serum samples were obtained over six months from hospitalization to convalescence.Antibodies in the specimens were quantitatively analyzed by the capture chemiluminescence immunoassays(CLIA).All patients were positive for the anti-SARS-Co V-2 Ig M/Ig G at the onset of COVID-19 symptoms,and the Ig G antibody persisted in all the patients during the convalescence.However,only approximately 25%of patients can detect the Ig M antibodies,Ig M against N protein(NIg M)and receptor binding domain of S protein(RBD-Ig M)at the 27 th week.The titers of Ig M,N-Ig M and RBD-Ig M reduced to 16.7%,17.6%and 15.2%of their peak values respectively.In contrast,the titers of Ig G,N-Ig G and RBD-Ig G peaked at 4–5 th week and reduced to 85.9%,62.6%and 87.2%of their peak values respectively at the end of observation.Dynamic behavior of antibodies and their correlation in age,gender and severity groups were investigated.In general,the COVID-19 antibody was sustained at high levels for over six months in most of the convalescent patients.Only a few patients with antibody reducing to an undetectable level which needs further attention.The humoral immune response against SARS-Co V-2 infection in COVID-19 patients exhibits a typical dynamic of acquired immunity. | Yang Zheng Qing Zhang Ashaq Ali Ke Li Nan Shao Xiaoli Zhou Zhiqin Ye Xiaomin Chen Shanshan Cao Jing Cui Juan Zhou Dianbing Wang Baidong Hou Min Li Mengmeng Cui Lihua Deng Xinyi Sun Qian Zhang Qinfang Yang Yong li Hui Wang Yake Lei Bo Yu Yegang Cheng Xiaolin Tong Dong Men Xian-En Zhang | 2021 | Virologica Sinica2021，36，5： | 1 |
| 19 | Facing small and biased data dilemma in drug discovery with enhanced federated learning approaches显示文摘Artificial intelligence(AI)models usually require large amounts of high-quality training data,which is in striking contrast to the situation of small and biased data faced by current drug discovery pipelines.The concept of federated learning has been proposed to utilize distributed data from different sources without leaking sensitive information of the data.This emerging decentralized machine learning paradigm is expected to dramatically improve the success rate of AI-powered drug discovery.Here,we simulated the federated learning process with different property and activity datasets from different sources,among which overlapping molecules with high or low biases exist in the recorded values.Beyond the benefit of gaining more data,we also demonstrated that federated training has a regularization effect superior to centralized training on the pooled datasets with high biases.Moreover,different network architectures for clients and aggregation algorithms for coordinators have been compared on the performance of federated learning,where personalized federated learning shows promising results.Our work demonstrates the applicability of federated learning in predicting drug-related properties and highlights its promising role in addressing the small and biased data dilemma in drug discovery. | Zhaoping Xiong Ziqiang Cheng Xinyuan Lin Chi Xu Xiaohong Liu Dingyan Wang Xiaomin Luo Yong Zhang Hualiang Jiang Nan Qiao Mingyue Zheng | 2022 | Science China(Life Sciences)2022，65，3： | 1 |
| 20 | Advances in post-operative prognostic models for hepatocellular carcinoma显示文摘Hepatocellular carcinoma(HCC)is one of the most common malignancies and a leading cause of cancer-related death worldwide.Surgery remains the primary and most successful therapy option for the treatment of early-and mid-stage HCCs,but the high heterogeneity of HCC renders prognostic prediction challenging.The construction of relevant prognostic models helps to stratify the prognosis of surgically treated patients and guide personalized clinical decision-making,thereby improving patient survival rates.Currently,the prognostic assessment of HCC is based on several commonly used staging systems,such as Tumor-Node-Metastasis(TNM),Cancer of the Liver Italian Program(CLIP),and Barcelona Clinic Liver Cancer(BCLC).Given the insufficiency of these staging systems and the aim to improve the accuracy of prognostic prediction,researchers have incorporated further prognostic factors,such as microvascular infiltration,and proposed some new prognostic models for HCC.To provide insights into the prospects of clinical oncology research,this review describes the commonly used HCC staging systems and new models proposed in recent years. | Ziqin HE Xiaomin SHE Ziyu LIU Xing GAO Lu LU Julu HUANG Cheng LU Yan LIN Rong LIANG Jiazhou YE | 2023 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2023，24，3： | 1 |
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