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| 1 | Coinfection with influenza A virus enhances SARS-CoV-2 infectivity显示文摘The upcoming flu season in the Northern Hemisphere merging with the current COVID-19 pandemic raises a potentially severe threat to public health.Through experimental coinfection with influenza A virus(IAV)and either pseudotyped or live SARS-CoV-2 virus,we found that IAV preinfection significantly promoted the infectivity of SARS-CoV-2 in a broad range of cell types.Remarkably,in vivo,increased SARS-CoV-2 viral load and more severe lung damage were observed in mice coinfected with IAV.Moreover,such enhancement of SARS-CoV-2 infectivity was not observed with several other respiratory viruses,likely due to a unique feature of IAV to elevate ACE2 expression.This study illustrates that IAV has a unique ability to aggravate SARS-CoV-2 infection,and thus,prevention of IAV infection is of great significance during the COVID-19 pandemic. | Lei Bai Yongliang Zhao Jiazhen Dong Simeng Liang Ming Guo Xinjin Liu Xin Wang Zhixiang Huang Xiaoyi Sun Zhen Zhang Lianghui Dong Qianyun Liu Yucheng Zheng Danping Niu Min Xiang Kun Song Jiajie Ye Wenchao Zheng Zhidong Tang Mingliang Tang Yu Zhou Chao Shen Li Zhou Yu Chen Huan Yan Ke Lan Ke Xu | 2021 | Cell Research2021，31，4： | 16 |
| 2 | Toxicity evaluation in a paper recycling mill effluent by coupling bioindicator of aging with the toxicity identification evaluation method in nematode Caenorhabditis elegans显示文摘Toxicity identification evaluation (TIE) can be used to determine the specific toxicant(s) in industrial effluents.In the current study,the authors have attempted to combine the advantages of the model organism,Caenorhabditis elegans,with the virtues of the TIE technique,to evaluate and identify the toxicity on aging from a paper recycling mill effluent.The results indicate that only the toxicities from mixed cellulose (MC) filtration and EDTA treatment are similar to the baseline aging toxicity,suggesting that the suspect toxicants inducing aging toxicity may largely be the heavy metal substances in this industrial effluent.Examination of the accumulation of intestinal autofluorescence in adult animals further confirms that the short lifespans are actually due to accelerated aging.In addition,exposure to fractions of EDTA manipulations cannot result in severe defects of reproduction and locomotion behaviors in C.elegans.Moreover,high levels of Ca,Al,and Fe in the effluent may account for the severe toxicity on aging of exposed nematodes,by TIE assay.The study here provides a new method for evaluating environmental risk and identifying toxicant(s) from the industrial effluent using C.elegans. | WANG, Xiaoyi SHEN, Lulu YU, Hongxia WANG, Dayong | 2008 | Journal of Environmental Sciences2008，20，11： | 11 |
| 3 | Receptome profiling identifies KREMEN1 and ASGR1 as alternative functional receptors of SARS-CoV-2显示文摘Host cellular receptors play key roles in the determination of virus tropism and pathogenesis.However,little is known about SARS-CoV-2 host receptors with the exception of ACE2.Furthermore,ACE2 alone cannot explain the multi-organ tropism of SARS-CoV-2 nor the clinical differences between SARS-CoV-2 and SARS-CoV,suggesting the involvement of other receptor(s).Here,we performed genomic receptor profiling to screen 5054 human membrane proteins individually for interaction with the SARS-CoV-2 capsid spike(S)protein.Twelve proteins,including ACE2,ASGR1,and KREMEN1,were identified with diverse S-binding affinities and patterns.ASGR1 or KREMEN1 is sufficient for the entry of SARS-CoV-2 but not SARS-CoV in vitro and in vivo.SARS-CoV-2 utilizes distinct ACE2/ASGR1/KREMEN1(ASK)receptor combinations to enter different cell types,and the expression of ASK together displays a markedly stronger correlation with virus susceptibility than that of any individual receptor at both the cell and tissue levels.The cocktail of ASK-related neutralizing antibodies provides the most substantial blockage of SARS-CoV-2 infection in human lung organoids when compared to individual antibodies.Our study revealed an interacting host receptome of SARS-CoV-2,and identified ASGR1 and KREMEN1 as alternative functional receptors that play essential roles in ACE2-independent virus entry,providing insight into SARS-CoV-2 tropism and pathogenesis,as well as a community resource and potential therapeutic strategies for further COVID-19 investigations. | Yunqing Gu Jun Cao Xinyu Zhang Hai Gao Yuyan Wang Jia Wang Juan He Xiaoyi Jiang Jinlan Zhang Guanghui Shen Jie Yang Xichen Zheng Gaowei Hu Yuanfei Zhu Shujuan Du Yunkai Zhu Rong Zhang Jianqing Xu Fei Lan Di Qu Guoliang Xu Yun Zhao Dong Gao Youhua Xie Min Luo Zhigang Lu | 2022 | Cell Research2022，32，1： | 8 |
| 4 | Centrosomal protein FOR20 is essential for S-phase progression by recruiting Plkl to centrosomes显示文摘中心体主要被安排微导管动力学并且便于 G1/S 和 G2/M 转变为有效房间周期前进要求。然而,在 S 阶段前进的中心体的角色大部分是未知的。这里,我们报导 FOR20 (20 kDa 的蠢人相关的蛋白质) 的那弄空,保存 centrosomal 蛋白质,禁止 S 阶段前进并且阻止 Plk1 指向(像马球的 kinase 1 ) 到中心体,在 FOR20 与 Plk1 交往的地方。Plk1 的脱离显著地也导致 S 阶段缺点,它被没能本地化到中心体的 Plk1,甚至 kinase 死了的异种,然而并非异种的宫外的表示颠倒。拴住中心体的 Plk1 的外长的表示,然而并非野类型的 Plk1,撤销 FOR20 导致弄空的 S 阶段独立于它的 kinase 活动背叛。因此,这些数据显示到由 FOR20 的中心体的 Plk1 的招募可以充当一个信号准许 S 阶段的有效前进。这代表一迄今在房间周期规定的中心体的 uncharacterized 角色。 | Minhong Shen Yuqi Cai YuehongYang Xiaoyi Yan Xiaoqi Liu Tianhua Zhou | 2013 | Cell Research2013，23，11： | 6 |
| 5 | Preparation of Monodisperse Spherical SiO_2 by Microwave Hydrothermal Method and Kinetics of Dehydrated Hydroxyl显示文摘Monodisperse spherical SiO2 particles were successfully synthesized in 2-propanol-H2O-NH3 system by the microwave hydrothermal method using ammonia as catalyst. To investigate the influences on the size of spherical SiO2 particles, factors such as ammonia concentration, reaction temperature, stirring intensity and reactants mol ratio have been studied. The orthogonal experiments were carried out. The as-prepared SiO2 particles were characterized by X-ray diffraction (XRD), transmission electron microscopy (TEM), Fourier transform infrared spectroscopy (FTIR) and differential thermal analysis (DTA). The results indicated that the size of SiO2 particles increased greatly with the increase in ammonia concentration, temperature and reactants mol ratio, but increased slightly with the increase in stirring intensity. Monodisperse spherical SiO2 particles were amorphous with perfect sphere and uniform size. Hydroxyl was detected in SiO2. Kinetic parameters were calculated, and finally the reaction rate equation of dehydrated hydroxyl was obtained. | Xiaoyi Shen Yuchun Zhai Yang Sun Huimin Gu | 2010 | Journal of Materials Science & Technology2010，26，8： | 5 |
| 6 | Synthesis and photocatalytic performance of ZnO with flower-like structure from zinc oxide ore显示文摘Employing zinc sulfate solution obtained from zinc oxide ore as raw material,sodium hydroxide as precipitant and PEG20000 as dispersant,ultrafine ZnO powders with different morphologies were successfully synthesized through hydrothermal method.The influences of the dosage of PEG20000 solution,molar ratio of OH-/Zn2+,reaction temperature,reaction time and Zn2+concentration on the structures and morphologies of the ZnO powders were discussed in detail.The reaction conditions of synthesizing ZnO powders with flower-like structure were obtained as below:dosage of PEG20000 with 10%mass fraction 5 mL,molar ratio of OH-to Zn2+5,reaction temperature 150℃,reaction time 8 h at Zn2+concentration1 mol L-1.The growth mechanism of ZnO particles with different morphologies was proposed.The ZnO powder with flower-like structure are composed of multiple micro-rods with hexagon morphology and has good photocatalytic degradation ability to degrade Rh B.20 mL Rh B solution with 15 mgL-1 could be completely degraded over flower-like ZnO powder 300 mg within 3 h. | Xiaoyi Shen Hongmei Shao Yan Liu Yuchun Zhai | 2020 | Journal of Materials Science & Technology2020，47，16： | 5 |
| 7 | Microelectronics-embedded channel bridging and signal regeneration of injured spinal cords显示文摘Due to the dificulty in spinal cord regeneration with biological methods,the microelectronic neural bridge,a new concept based on microelectronic technology,is presented.The microelectronic system has been realized in the forms of hybrid and integrated circuits.The integrated circuits forneural signal detection,stimulation,and regeneration are realized in a CMOS process.In animal experiments with 100 toads,48 rats,and 3 rabbits,nerve signals have been successfully detected from spinal cords and sciatic nerves,and functional electrical stimulation has been carried out for spinal cords and sciatic nerves.When the microelectronic system is bridged between the controlling and stimulated nerve,the relevant motion of legs and nerve signal waveforms,which are stimulated by the evoked or spontaneous nerve signal through such a system,have been observed.Therefore,the feasibility of the presented method was demonstrated. | Zhigong Wang Xiaosong Gu Xiaoying Lǔ Zhenglin Jiang Wenyuan Li Guangming Lǔ Yufeng Wang Xiaoyan Shen Xintai Zhao Huiling Wang Zhenyu Zhang Hongmei Shen Yang Wu Weixing Shen Jingyang Zhang Dong Chen Xiaoyi Mao Huaxiang Shen | 2009 | Progress in Natural Science:Materials International2009，19，10： | 5 |
| 8 | Structural,Functional,and Molecular Imaging of Autism Spectrum Disorder显示文摘Autism spectrum disorder(ASD)is a heterogeneous neurodevelopmental disorder associated with both genetic and environmental risks.Neuroimaging approaches have been widely employed to parse the neurophysiological mechanisms underlying ASD,and provide critical insights into the anatomical,functional,and neurochemical changes.We reviewed recent advances in neuroimaging studies that focused on ASD by using magnetic resonance imaging(MRI),positron emission tomography(PET),or single-positron emission tomography(SPECT).Longitudinal structural MRI has delineated an abnormal developmental trajectory of ASD that is associated with cascading neurobiological processes,and functional MRI has pointed to disrupted functional neural networks.Meanwhile,PET and SPECT imaging have revealed that metabolic and neurotransmitter abnormalities may contribute to shaping the aberrant neural circuits of ASD.Future large-scale,multi-center,multimodal investigations are essential to elucidate the neurophysiological underpinnings of ASD,and facilitate the development of novel diagnostic biomarkers and better-targeted therapy. | Xiaoyi Li Kai Zhang Xiao He Jinyun Zhou Chentao Jin Lesang Shen Yuanxue Gao Mei Tian Hong Zhang | 2021 | Neuroscience Bulletin2021，37，7： | 4 |
| 9 | Dental plaque-inspired versatile nanosystem for caries prevention and tooth restoration显示文摘Dental caries is one of the most prevalent human diseases resulting from tooth demineralization caused by acid production of bacteria plaque.It remains challenges for current practice to specifically identify,intervene and interrupt the development of caries while restoring defects.In this study,inspired by natural dental plaque,a stimuli-responsive multidrug delivery system(PMs@NaF-SAP)has been developed to prevent tooth decay and promote enamel restoration.Classic spherical core-shell structures of micelles dual-loaded with antibacterial and restorative agents are self-assembled into bacteria-responsive multidrug delivery system based on the pH-cleavable boronate ester bond,followed by conjugation with salivary-acquired peptide(SAP)to endow the nanoparticle with strong adhesion to tooth enamel.The constructed PMs@NaF-SAP specifically adheres to tooth,identifies cariogenic conditions and intelligently releases drugs at acidic pH,thereby providing antibacterial adhesion and cariogenic biofilm resistance,and restoring the microarchitecture and mechanical properties of demineralized teeth.Topical treatment with PMs@NaF-SAP effectively diminishes the onset and severity of caries without impacting oral microbiota diversity or surrounding mucosal tissues.These findings demonstrate this novel nanotherapy has potential as a promising biomedical application for caries prevention and tooth defect restoration while resisting biofilm-associated diseases in a controlled manner activated by pathological bacteria. | Yue Xu Yuan You Luyao Yi Xiaoyi Wu Yaning Zhao Jian Yu He Liu Ya Shen Jingmei Guo Cui Huang | 2023 | Bioactive Materials2023，，2： | 3 |
| 10 | Choroidal thickness and choriocapillaris vascular density in myopic anisometropia显示文摘Background:This study aims to examine interocular differences in the choroidal thickness and vascular density of the choriocapillaris in anisometropic myopes and to further explore the relationship between choroidal blood flow and myopia.Methods:The sample comprised 44 participants with anisometropic myopia,aged 9 to 18 years,with normal bestcorrected visual acuity.All participants underwent a series of examinations,including spherical equivalent refraction(SER)and axial length(AL),measured by a Lenstar optical biometer and optical coherence tomography angiography(OCTA)scanner.OCT measured the choroidal thickness,vascular density,and flow voids of the choriocapillaris,and a customized algorithm was implemented in MATLAB R2017a with the post-correction of AL.The choroidal thickness was measured at the fovea and 0.5,1.0,1.5,2.0,2.5,and 3.0 mm nasally,temporally,inferiorly,and superiorly to the fovea.The vascular density and the flow voids of the choriocapillaris were measured at a 0.6-mm-diameter central circle,and the 0.6-2.5 mm diameter circle in the nasal,temporal,inferior,and superior regions.Repeated-measured ANOVAs were used to analyze the interocular differences.Partial correlations with the K value and age adjustments were used to study the relationships between the choroidal thickness,the choriocapillaris vascular density and flow voids,the SER and AL.Results:The choroidal thickness of the more myopic eyes was significantly thinner than less myopic eyes(P≤0.001),and the flow voids in the more myopic eyes were more than less myopic eyes(P=0.002).There was no significant difference in the vascular density of the choriocapillaris between the more and less myopic eyes(P=0.525).However,when anisometropia was more than 1.50 D,the vascular density of choriocapillaris in the more myopic eyes was significantly less than the less myopic eyes(P=0.026).The interocular difference of the choroidal thickness was significantly correlated with the interocular difference in SER and AL in the center,superior,and inferior regions but not in the nasal or temporal regions.The interocular differences of the vascular density and the flow voids of the choriocapillaris were not correlated with the interocular difference of SER and AL.Conclusions:The choroidal thickness is thinner in the more myopic eyes.The flow void is increased,and the vascular density of the choriocapillaris is reduced in the more myopic eyes of children with anisometropia exceeding 1.50 D. | Xinting Liu Zhiyi Lin Feifu Wang Xiaoyi Peng Wenwen He Dan Chen Meixiao Shen Fan Lu Jun Jiang | 2021 | Eye and Vision2021，8，1： | 3 |
| 11 | Shape-controllable Synthesis of Ultrafine ZnO Powders of Different Morphologies显示文摘By employing zinc acetate and sodium hydroxide as raw materials, ultrafine ZnO powders with different morphologies were successfully synthesized through hydrothermal method. The influences of the reaction temperature, the OH-/Zn2+ mol ratio and the reaction time on the morphologies of the ZnO powders were discussed. The reaction conditions were obtained, under which the ZnO of flower-like particles, micro-rods and flake particles was synthesized, respectively. The crystal structures and morphologies of those ZnO particles were characterized by X-ray diffraction (XRD) and scanning electron microscopy (SEM). The ZnO with flower-like structures was composed of lots of micro-rods with hexagon morphology. The XRD patterns indicated that the ZnO powders were hexagonal wurtzite structures with high purity. Finally, the growth mechanism of the ZnO particles was discussed. | Xiaoyi Shen Yuan Liang Yuchun Zhai Zhiqiang Ning | 2013 | Journal of Materials Science & Technology2013，29，1： | 2 |
| 12 | Pd films on soft substrates:a visual,high-contrast and low-cost optical hydrogen sensor显示文摘For the rapid development of the hydrogen economy,a reliable and low-cost hydrogen sensor appears to be extremely important.Here,we first show that a palladium film deposited on polydimethylsiloxane(PDMS)can obtain an exceedingly high-reflectance contrast of 25.78 over the entire visible band upon exposure to 4 vol% hydrogen gas(H2)mixed with nitrogen gas.This high-reflectance contrast results from the surface deformation induced by the volume inflation after exposure to H2,leading to the transition of the near-specular surface to a diffusing surface.In addition,a change in brightness is readable by naked eye upon exposure to H2 with various concentrations from 0.6 to 1 vol% under the illumination of a fluorescent tube.Furthermore,this sensor possesses an excellent recyclability and quick response time of a few seconds.Compared with Pd nanostructure-based hydrogen sensors,this visual,high-contrast and low-cost sensor is of great potential for practical hydrogen sensing. | Xiaoyi She Yang Shen Jianfang Wang Chongjun Jin | 2019 | Light(Science & Applications)2019，8，1： | 2 |
| 13 | Real-time whole-brain imaging of hemodynamics and oxygenation at micro-vessel resolution with ultrafast wide-field photoacoustic microscopy显示文摘High-speed high-resolution imaging of the whole-brain hemodynamics is critically important to facilitating neurovascular research.High imaging speed and image quality are crucial to visualizing real-time hemodynamics in complex brain vascular networks,and tracking fast pathophysiological activities at the microvessel level,which will enable advances in current queries in neurovascular and brain metabolism research,including stroke,dementia,and acute brain injury.Further,real-time imaging of oxygen saturation of hemoglobin(sO_(2))can capture fast-paced oxygen delivery dynamics,which is needed to solve pertinent questions in these fields and beyond.Here,we present a novel ultrafast functional photoacoustic microscopy(UFF-PAM)to image the whole-brain hemodynamics and oxygenation.UFF-PAM takes advantage of several key engineering innovations,including stimulated Raman scattering(SRS)based dual-wavelength laser excitation,water-immersible 12-facet-polygon scanner,high-sensitivity ultrasound transducer,and deep-learning-based image upsampling.A volumetric imaging rate of 2 Hz has been achieved over a field of view(FOV)of 11×7.5×1.5 mm^(3) with a high spatial resolution of~10 μm.Using the UFF-PAM system,we have demonstrated proof-of-concept studies on the mouse brains in response to systemic hypoxia,sodium nitroprusside,and stroke.We observed the mouse brain's fast morphological and functional changes over the entire cortex,including vasoconstriction,vasodilation,and deoxygenation.More interestingly,for the first time,with the whole-brain FOV and micro-vessel resolution,we captured the vasoconstriction and hypoxia simultaneously in the spreading depolarization(SD)wave.We expect the new imaging technology will provide a great potential for fundamental brain research under various pathological and physiological conditions. | Xiaoyi Zhu Qiang Huangl Anthony Dispirito Tri Vu Qiangzhou Rong Xiaorui Peng Huaxin Sheng Xiling Shen Qifa Zhou Laiming Jiang Ulrike Hoffmann Junjie Yao | 2022 | Light(Science & Applications)2022，11，6： | 2 |
| 14 | Genetic variants of miRNA sequences and non-small cell lung cancer survival显示文摘 | Hu Zhibin Chen Jiaping Tian Tian Zhou Xiaoyi Gu Haiyong Xu Lin Zeng Yi Miao Ruifen Jin Guangfu Ma Hongxia Chen Yijiang Shen Hongbing | 2008 | Journal of Clinical Investigation2008，，7： | 1 |
| 15 | Western Literary Theories in China:Reception,Influence and Resistance显示文摘 | Shen Dan Zhou Xiaoyi | 2006 | Comparative Critical Studies2006，3，12： | 1 |
| 16 | Preparation and properties of silicon carbide ceramics enhanced by TiN nanoparticles and SiC whiskers显示文摘 | Lingjie Zhang Hui Yang Xingzhong Guo Jianchao Shen Xiaoyi Zhu | 2011 | Scripta Materialia2011，，： | 1 |
| 17 | An Improved 3D SPIHT Coding for Hyper Spectral Imagery Data Compression 显示文摘 | Yan Jingwen Shen Guiming Hu Xiaoyi | 2002 | Chinese Journal of Lasers2002，11，4： | 1 |
| 18 | Polymorphisms involved in the miR-218 - LAMB3 pathway and susceptibility of cervical cancer, a case–control study in Chinese women显示文摘 | Xiaoyi Zhou Xiaojun Chen Lingmin Hu Suping Han Fulin Qiang Yuling Wu Li Pan Hongbing Shen Ying Li Zhibin Hu | 2010 | Gynecologic Oncology2010，，2： | 1 |
| 19 | Treatment for HIV prevention study in southwestern areas of China显示文摘Background:China has ambitious to achieve significant reductions in HIV transmission and HIV-related mortality by adopting the World Health Organization's“Treat All”approach.Such a prevention strategy is needed future study on regional scale.Methods:An observational cohort study of HIV epidemiology and treatment databases was used to study the effectiveness of antiretroviral therapy on the transmission of HIV in serodiscordant couples in Guangxi of China.Results:A total of 7713 couples were entered into the cohort study analysis which included 1885 couples in the treatment-naive cohort and 5828 couples in the treated cohort.During the follow-up of 18985.29 person-years from 2003 to 2014,the average incidence of HIV was 2.4 per 100 person-years(95%CI 2.1e2.6).HIV seroincidence rate was significantly higher among the treatment naive group(4.2 per 100 person-years,3.7e4.8)compared with the on treatment group(1.6 per 100 person-years,1.3e1.8).An overall 45%reduction in risk of HIV transmission among serodiscordant couple was associated with ART treatment(adjusted Hazard Ratio[HR]0.55,95%Confidence Interval[CI]0.44e0.69).Treatment prevention had significantly effectiveness for most baseline characteristics of index partners,such as for male,female,age above 25 years,education below high school,farmer,infected by heterosexual intercourse.Conclusion:Treatment-as-prevention can be implemented in the real-world on a national or regional scale,but ART adherence and comprehensive harm reduction while implementing this strategy require further study. | Huanhuan Chen Xiaoyi Yang Qiuying Zhu Xinghua Wu Li Chen Huaxiang Lu Liuhong Luo Guanghua Lan Xianming Ge Zhenzhu Tang Zhiyong Shen Stephen WPan Hui Xing Yuhua Ruan Yiming Shao Wenmin Yang | 2018 | Infectious Disease Modelling2018，3，1： | 1 |
| 20 | Polymorphisms involved in the miR-218 - LAMB3 pathway and susceptibility of cervical cancer, a case–control study in Chinese women显示文摘 | Xiaoyi Zhou Xiaojun Chen Lingmin Hu Suping Han Fulin Qiang Yuling Wu Li Pan Hongbing Shen Ying Li Zhibin Hu | 2010 | Gynecologic Oncology2010，，2： | 1 |
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