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| 1 | SHRIMP zircon U-Pb dating for volcanic rocks of the Dasi Formation in southeast Hubei Province,middle-lower reaches of the Yangtze River and its implications显示文摘The Jinniu Basin in southeast Hubei,located at the westernmost part of middle-lower val-ley of the Yangtze River,is one of the important vol-canic basins in East China. Volcanic rocks in the Jin-niu Basin are distributed mainly in the Majiashan Formation,the Lingxiang Formation and the Dasi Formation,consisting of rhyolite,basalt and basaltic andesite,(trachy)-basalt and basaltic trachy-andesite and (trachy)-andesite and (trachy)-dacite and rhyolite respectively,in which the Dasi volcanism is volumet-rically dominant and widespread. The Dasi volcanic rocks were selected for SHRIMP zircon U-Pb dating to confirm the timing of volcanism. The results indi-cate that there exist a large amount of magmatic zir-cons characterized by high U and Th contents in the volcanic rocks. The concordia ages for 13 points are 128 ± 1Ma (MSWD = 3.0). On account of the shape of zircons and Th/U ratios,this age is considered to represent the crystallization time of the Dasi volcan-ism. The volcanic rocks in the Dasi,Majiashan and Lingxiang Formations share similar trace elementand REE partition patterns as well as Sr-Nd isotopic compositions. In combination with the regional geol-ogy,it is proposed that the southeast Hubei volcanic rocks were formed mainly during the Early Creta-ceous,just like other volcanic basins in middle-lower Yangtze valley. A lithospheric extension is also sug-gested for tectonic regime in this region in the Cre-taceous Period. | XIE Guiqing MAO Jingwen LI Ruiling ZHOU Shaodong YE Huishou YAN Quanren ZHANG Zusong | 2006 | Chinese Science Bulletin2006，51，24： | 38 |
| 2 | Highly Efficient A. T to G. C Base Editing by Cas9n- 3uided tRNA Adenosine Deaminase in Rice显示文摘 | Fang Yan Yongjie Kuang Bin Ren Jingwen Wang Dawei Zhang Honghui Lin Bing Yang Xueping Zhou Huanbin Zhou | 2018 | Molecular Plant2018，11，4： | 26 |
| 3 | Structural basis for the impact of phosphorylation on the activation of plant receptor-like kinase BAK1显示文摘 | Liming Yan Yuanyuan Ma Dan Liu Xiaochao Wei Yuna Sun Xiaoyue Chen Huadong Zhao Jingwen Zhou Zhiyong Wang Wenqing Shui Zhiyong Lou | 2012 | Cell Research2012，22，8： | 10 |
| 4 | Integrated transcriptomic and metabolomic analyses of a wax deficient citrus mutant exhibiting jasmonic acid-mediated defense against fungal pathogens显示文摘Naturally,resistant crop germplasms are important resources for managing the issues of agricultural product safety and environment deterioration.We found a spontaneous mutant of‘Newhall’navel orange(Citrus sinensis Osbeck)(MT)with broad-spectrum protections against fungal pathogens in the orchard,postharvest-storage,and artificial inoculation conditions.To understand the defense mechanism of MT fruit,we constructed a genome-scale metabolic network that integrated metabolome and transcriptome datasets.The coordinated transcriptomic and metabolic data were enriched in two sub-networks,showing the decrease in very long chain fatty acid(by 41.53%)and cuticular wax synthesis(by 81.34%),and increase in the synthesis of jasmonic acid(JA)(by 95.23%)and JA-induced metabolites such as 5-dimethylnobietin(by 28.37%)in MT.Furthermore,cytological and biochemical analyses confirmed that the response to fungal infection in MT was independent of wax deficiency and was correlated with the levels of jasmonates,and the expression of plant defensin gene PDF1.2.Results of exogenous application of MeJA and JA inhibitors such as propyl gallate proved that JA-mediated defense contributes to the strong tolerance against pathogens in MT.Our results indicated that jasmonate biosynthesis and signaling are stimulated by the fatty acid redirection of MT,and participate in the tolerance of pathogenic fungi. | Yizhong He Jingwen Han Runsheng Liu Yuduan Ding Jinqiu Wang Li Sun Xiaoming Yang Yunliu Zeng Weiwei Wen Juan Xu Hongming Zhang Xiang Yan Zhaoxing Chen Zuliang Gu Hong Chen Huanqing Tang Xiuxin Deng Yunjiang Cheng | 2018 | Horticulture Research2018，5，1： | 8 |
| 5 | Chemical characteristics and source apportionment of PM_(2.5) in a petrochemical city: Implications for primary and secondary carbonaceous component显示文摘To study the pollution features and underlying mechanism of PM_(2.5) in Luoyang, a typical developing urban site in the central plain of China, 303 PM_(2.5) samples were collected from April 16 to December 29, 2015 to analyze the elements, water soluble inorganic ions, organic carbon and elemental carbon. The annual mean concentration of PM_(2.5) was 142.3 μg/m^(3), and 75% of the daily PM_(2.5) concentrations exceeded the 75 μg/m^(3). The secondary inorganic ions, organic matter and mineral dust were the most abundant species, accounting for 39.6%, 19.2% and 9.3% of the total mass concentration, respectively. But the major chemical components showed clear seasonal dependence. SO_(4)^(2-) was most abundant specie in spring and summer, which related to intensive photochemical reaction under high O_3 concentration. In contrast, the secondary organic carbon and ammonium while primary organic carbon and ammonium significantly contributed to haze formation in autumn and winter, respectively. This indicated that the collaboration effect of secondary inorganic aerosols and carbonaceous matters result in heavy haze in autumn and winter. Six main sources were identified by positive matrix factorization model: industrial emission, combustion sources, traffic emission, mineral dust, oil combustion and secondary sulfate, with the annual contribution of 24%, 20%, 24%, 4%, 5% and 23%, respectively. The potential source contribution function analysis pointed that the contribution of the local and short-range regional transportation had significant impact. This result highlighted that local primary carbonaceous and precursor of secondary carbonaceous mitigation would be key to reduce PM_(2.5) and O_3 during heavy haze episodes in winter and autumn. | Guangxuan Yan Puzhen Zhang Jie Yang Jingwen Zhang Guifen Zhu Zhiguo Cao Jing Fan Zirui Liu Yuesi Wang | 2021 | Journal of Environmental Sciences2021，33，5： | 6 |
| 6 | SHRIMP Zircon U-Pb and Molybdenite Re-Os Datings of the Superlarge Donggou Porphyry Molybdenum Deposit in the East Qinling,China,and Its Geological Implications显示文摘摘要:在东方 Qinling 铝带的东方部分定位了, Donggou 存款是在最近的年里发现的 superlarge 斑岩铝存款。作者执行了在 Donggou 铝存款的使矿物化的斑岩和矿石的高度精确的标明日期。Donggou 铝土的 A 类型花岗石斑岩标明日期的虾 U-Pb 锆石给了 112 楬瑡摥 ? 的形成岩石的年龄 ??????? | YE Huishou MAO Jingwen LI Yongfeng GUO Baojian ZHANG Changqing LIU Jun YAN Quanren LIU Guoyin | 2008 | Acta Geologica Sinica(English Edition)2008，82，1： | 6 |
| 7 | Lx2-32c,a novel semi-synthetic taxane,exerts antitumor activity against prostate cancer cells in vitro and in vivo显示文摘Tubulin has been shown to be an effective target for the development of cytotoxic agents against prostate cancer. Previously, we reported that Lx2-32 c is an anti-tubulin agent with high binding affinity to tubulin. In this study, we investigated the potential of Lx2-32 c to act as an effective cytotoxic agent in the treatment of prostate cancer. MTT assays showed that Lx2-32 c was cytotoxic to all tested prostate cancer cell lines. The Lx2-32c-treated cells typically exhibited a rounded morphology associated with the onset of apoptosis, as evidenced by immunocytochemical staining. Human prostate cancer cell lines treated with Lx2-32 c arrest in the G2/M phase of the cell cycle and the treatment is associated with an increased ratio of cells in the sub-G0/G1 phase as determined by flow cytometry. Furthermore, expression of the cleaved form of poly(ADP-ribose) polymerase in prostate cancer cell lines treated with Lx2-32 c was shown by Western blotting assay. Xenograft implants of LNCa P and PC3-derived tumors in nude mice showed that Lx2-32 c treatment significant inhibited tumor growth with effects equivalent to those of docetaxel. These findings demonstrate the potential of Lx2-32 c as a candidate antitumor agent for the treatment of prostate cancer. | Guangyao Lv Dengjun Sun Jingwen Zhang Xiaoxia Xie Xiaoqiong Wu Weishuo Fang Jingwei Tian Chunhong Yan Hongbo Wang Fenghua Fu | 2017 | Acta Pharmaceutica Sinica B2017，7，1： | 6 |
| 8 | Geochemistry of Apatite from the Apatite-rich Iron Deposits in the Ningwu Region,East Central China显示文摘磷灰石的四种类型在 Ningwu 区域被识别了。磷灰石的第一种类型广泛地在中间的黑暗有颜色的地区被散布(即铁矿) 单个存款。集合包括磁铁矿,磷灰石和阳起石(或透辉石) 。Thesecond 类型在铁矿发生在磁铁矿磷灰石静脉以内。第三种类型是看见的 inmagnetite 磷灰石静脉并且(或) 在主人岩石中的小瘤(即斑粝岩闪长岩斑岩 orgabbro 闪长岩或辉石闪长岩) 。第四种类型在在 Xiangshan 组充满破裂的 apatite-pyrite-quartz 静脉以内发生。在斑岩铁矿床的四出现的磷灰石的稀土元素元素(REE ) 地球化学被介绍。磷灰石的 REE 分发模式通常类似于在 Kiruna 类型铁矿的磷灰石的那些, nelsonites。他们在轻 REE 被充实,与显著否定 Eu 异例。在从在在世界上的不同地点的各种各样的存款的磷灰石的 REE 分发模式的类似为各种各样的矿石类型显示形成的一个普通过程,例如 immiscibility。早 magmatic 磷灰石 contain3031.48-12080 x 10 ^(-6) REE。后来热水的磷灰石包含 1958 x10^(-6) REE,显示以后热水的形成矿石的答案包含降低 REE。尽管斑粝岩闪长岩斑岩和磷灰石显示出类似的 REE 模式,斑粝岩闪长岩斑岩没有铕异例或微弱的积极或微弱的否定的铕异例,在一个高氧易逃逸条件下面由披风源地的减小环境并且由分别和结晶化(immiscibility ) 引起了。磷灰石的否定 Eu 异例被更早的 diopsite 在矿石岩浆冷却期间由于 Eu^(2+) 的获得可能形成。在 Aoshan 和泰山铁矿床的磷灰石产出Sr/^( 86 ) Sr 从 0.7071~0.7073 珍视的^( 87 )的一个狭窄的变化范围,类似于那些暴烈并且潜水艇火山岩,显示磷灰石被液体 immiscibility 和中间、基本的岩浆的区别形成。 | YU Jinjie ZHANG Qi MAO Jingwen YAN Shenghao | 2007 | Acta Geologica Sinica(English Edition)2007，81，4： | 5 |
| 9 | Redox regulation in tumor cell epithelial-mesenchymal transition:molecular basis and therapeutic strategy显示文摘Epithelial–mesenchymal transition(EMT)is recognized as a driving force of cancer cell metastasis and drug resistance,two leading causes of cancer recurrence and cancer-related death.It is,therefore,logical in cancer therapy to target the EMT switch to prevent such cancer metastasis and recurrence.Previous reports have indicated that growth factors(such as epidermal growth factor and fibroblast growth factor)and cytokines(such as the transforming growth factor beta(TGF-β)family)are major stimulators of EMT.However,the mechanisms underlying EMT initiation and progression remain unclear.Recently,emerging evidence has suggested that reactive oxygen species(ROS),important cellular secondary messengers involved in diverse biological events in cancer cells,play essential roles in the EMT process in cancer cells by regulating extracellular matrix(ECM)remodeling,cytoskeleton remodeling,cell–cell junctions,and cell mobility.Thus,targeting EMT by manipulating the intracellular redox status may hold promise for cancer therapy.Herein,we will address recent advances in redox biology involved in the EMT process in cancer cells,which will contribute to the development of novel therapeutic strategies by targeting redox-regulated EMT for cancer treatment. | Jingwen Jiang Kui Wang Yan Chen Haining Chen Edouard C Nice Canhua Huang | 2017 | Signal Transduction and Targeted Therapy2017，2，1： | 5 |
| 10 | Anti-rutting performance evaluation of modified asphalt binders: A review显示文摘Asphalt pavement inevitably suffers rutting distress induced by repeated loads under high temperatures, which can be effectively alleviated by the modification of asphalt binders.This paper summarized the asphalt modifiers for enhancing the performance of asphalt pavement at high temperatures in terms of the modifier type, additive amount and improving effect. Then, the anti-rutting performance evaluation methods of asphalt binder were introduced with details, including the ring and ball(R&B) test, the dynamic viscosity test, the zero/low shear viscosity(ZSV/LSV) test, the dynamic shear rheometer(DSR) test,the repeated creep and recovery(RCR) test, and the multiple stress creep and recovery(MSCR) test. Furthermore, the sensitivity of the evaluation method to asphalt modifier was analyzed using the normalization method. It was found that the indicators from the MSCR test could clearly reveal the influence of asphalt modifiers on high temperature performance of asphalt binder. But it still had some limitations affecting the accuracy of evaluation results, such as the number of creep-recovery cycles, the stress level and the recovery time. In addition, according to the rutting resistance improvement ratio(RRIR),the styrene-butadiene-styrene(SBS) modifier performed better in improving the rutting resistance of asphalt binder, compared with other modifiers when added within the usual dosage range. | Yan Li Peiwen Hao Chaozhi Zhao Jwnqiang Ling Tao Wu Dewen Li Jingwen Liu Bowei Sun | 2021 | Journal of Traffic and Transportation Engineering(English Edition)2021，8，3： | 4 |
| 11 | Control measures during the COVID-19 outbreak reduced the transmission of hand,foot,and mouth disease显示文摘Control measures during the coronavirus disease 2019(COVID-19)outbreak may have limited the spread of infectious diseases.This study aimed to analyze the impact of COVID-19 on the spread of hand,foot,and mouth disease(HFMD)in China.A mathematical model was established to fit the reported data of HFMD in six selected cities in China's Mainland from 2015 to 2020.The absolute difference(AD)and relative difference(RD)between the reported incidence in 2020,and simulated maximum,minimum,or median incidence of HFMD in 2015-2019 were calculated.The incidence and R effof HFMD have decreased in six selected cities since the outbreak of COVID-19,and in the second half of 2020,the incidence and R effof HFMD have rebounded.The results show that the total attack rate(TAR)in 2020 was lower than the maximum,minimum,and median TAR fitted in previous years in six selected cities(except Changsha City).For the maximum,median,minimum fitted TAR,the range of RD(%)is 42·20-99·20%,36·35-98·41%48·35-96·23%(except Changsha City)respectively.The preventive and control measures of COVID-19 have significantly contributed to the containment of HFMD transmission. | Yan Niu Li Luo Jia Rui Shiting Yang Bin Deng Zeyu Zhao Shengnan Lin Jingwen Xu Yuanzhao Zhu Yao Wang Meng Yang Xingchun Liu Tianlong Yang Weikang Liu Peihua Li Zhuoyang Li Chan Liu Jiefeng Huang Tianmu Chen | 2021 | Journal of Safety Science and Resilience2021，2，2： | 3 |
| 12 | Innovations and challenges of polyphenol-based smart drug delivery systems显示文摘Polyphenols,as widely existing natural bioactive products,provide a vast array of advanced biomedical applications attributing to their potential health benefits that linked to antioxidant,anti-inflammatory,immunoregulatory,neuroprotective,cardioprotective function,etc.The polyphenol compounds could dynamically interact and bind with diverse species(such as polymers,metal ions,biomacromolecules,etc.)via multiple interactions,including hydrogen bond,hydrophobic,π–π,and cation–πinteractions due to their unique chemical polyphenolic structures,providing far-ranging strategies for designing of polyphenol-based vehicles.Natural polyphenols emerged as multifaceted players,acting either as inherent therapeutics delivered to combat diverse diseases or as pivotal assemblies of drug delivery vehicles.In this review,we focused on the rational design and application of metal-phenolic network(MPN)based delivery systems,polyphenol-based coating films,polyphenol hollow capsules,polyphenolincorporated hydrogels,and polymer-polyphenol-based nanoparticles(NPs)in various diseases therapeutic,including cancer,infection,cardiovascular disease,neurodegenerative disease,etc.Additionally.the versatility and mechanisms of polyphenols in the field of biomacromolecules(e.g.,protein,peptide,nucleic acid,etc.)delivery and cell therapy have been comprehensively summarized.Going through the literature review,the remaining challenges of polyphenol-containing nanosystems need to be addressed are involved,including long-term stability,biosafety in vivo,feasibility of scale-up,etc.,which may enlighten the further developments of this field.This review provides perspectives in utilizing natural polyphenol-based biomaterials to rationally design next generation versatile drug delivery system in the field of biomedicine,which eventually benefits public health. | Yanan Wang Jingwen Zhang Yi Zhao Minju Pu Xinyu Song Liangmin Yu Xuefeng Yan Jun Wu Zhiyu He | 2022 | Nano Research2022，15，9： | 2 |
| 13 | MicroRNA-449 and MicroRNA-34b/c Function Redundantly in Murine Testes by Targeting E2F Transcription Factor-Retinoblastoma Protein (E2F-pRb) Pathway显示文摘 | Jianqiang Bao Ding Li Li Wang Jingwen Wu Yanqin Hu Zhugang Wang Yan Chen Xinkai Cao Cizhong Jiang Wei Yan Chen Xu | 2012 | Journal of Biological Chemistry2012，，26： | 2 |
| 14 | Feasibility of Booster Vaccination in High-Risk Populations for Controlling Coronavirus Variants—China,2021显示文摘Introduction:Vaccination booster shots are completely necessary for controlling breakthrough infections of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)in China.The study aims to estimate effectiveness of booster vaccines for high-risk populations(HRPs).Methods:A vaccinated Susceptible-Exposed-Symptomatic-Asymptomatic-Recovered/Removed(SEIAR)model was developed to simulate scenarios of effective reproduction number(Reff)from 4 to 6.Total number of infectious and asymptomatic cases were used to evaluated vaccination effectiveness.Results:Our model showed that we could not prevent outbreaks when covering 80%of HRPs with booster unless Reff=4.0 or the booster vaccine had efficacy against infectivity and susceptibility of more than 90%.The results were consistent when the outcome index was confirmed cases or asymptomatic cases.Conclusions:An ideal coronavirus disease 2019(COVID-19)booster vaccination strategy for HRPs would be expected to reach the initial goal to control the transmission of the Delta variant in China.Accordingly,the recommendation for the COVID-19 booster vaccine should be implemented in HRPs who are already vaccinated and could prevent transmission to other groups. | Kangguo Li Zeyu Zhao Hongjie Wei Jia Rui Jiefeng Huang Xiaohao Guo Yichao Guo Shiting Yang Guzainuer Abudurusuli Li Luo Xingchun Liu Yao Wang Jingwen Xu Yuanzhao Zhu Meng Yang TianlongYang Weikang Liu Bin Deng Chan Liu Zhuoyang Li Peihua Li Shanshan Yu Zimei Yang Yanhua Su Benhua Zhao Yan Niu Tianmu Chen | 2021 | China CDC weekly2021，3，50： | 2 |
| 15 | A parameter adjusting polar format algorithm for extremely high squint SAR imaging显示文摘 | WANG Yan LI Jingwen CHEN Jie | 2014 | IEEE Transactions on Geoscience and Remote Sensing2014，52，1： | 1 |
| 16 | Dilute sulfuric acid cycle spray, ow-through pretreatment of corn stover for enhancement of sugar recovery显示文摘 | Yan Lishi Zhang Hongman Chen Jingwen | | Bioresouree Technology0，，1130： | 1 |
| 17 | An iteratire learning approach for density control of freeway traffic flow via ramp metering显示文摘 | Zhongsheng Hou Jian-Xin Xu Jingwen Yan | 2008 | Transportation Research Part C: Emerging Technologies2008，6，1： | 1 |
| 18 | An Improved 3D SPIHT Coding for Hyper Spectral Imagery Data Compression 显示文摘 | Yan Jingwen Shen Guiming Hu Xiaoyi | 2002 | Chinese Journal of Lasers2002，11，4： | 1 |
| 19 | A Design Method of the Rotor Auxiliary Slot for the Water-filled Submersible Induction Motors显示文摘Aiming at the problem of electromagnetic vibration of the water-filled submersible induction motor(WSIM),a method of opening auxiliary slots on the rotor side is proposed to weaken the air-gap field harmonics caused by the rotor slot permeance harmonics.By analyzing the research status of electromagnetic vibration of the WSIM and the composition of the air-gap magnetic field of the motor,the idea that the auxiliary slots mainly affect the air-gap field harmonics by changing the air-gap permeance of the motor is put forward.The mathematical model of air-gap permeance of WSIM is established to simulate the influence of auxiliary slots on the air-gap permeance.Through the parametric analysis of the mathematical model,the change of auxiliary slot size is simulated.The air-gap permeance waveform is decomposed by the two-dimensional Fourier transform,and then the variation of the air-gap permeance harmonics with the size of the auxiliary slot is analyzed.Finally,the finite element simulation model of the WSIM with the auxiliary slots is established,and the waveform of the air-gap flux density of the motor is analyzed to verify the effectiveness of the mathematical model.Meanwhile,the results show that after opening the auxiliary slot,the radial electromagnetic force of the motor was reduced by 28.4%. | Jiaxin Li Jingwen Yan Chong Di Xiaohua Bao Qinglong Zhu | 2022 | CES Transactions on Electrical Machines and Systems2022，6，1： | 1 |
| 20 | Major types, characteristics and geodynamic mechanism of Upper Paleozoic copper deposits in northern Xinjiang, northwestern China显示文摘 | Chunming Han Wenjiao Xiao Guochun Zhao Jingwen Mao Sanzhong Li Zhen Yan Qigui Mao | 2005 | Ore Geology Reviews2005，，3： | 1 |
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