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| 1 | A brief history of the discovery of PXR and CAR as xenobiotic receptors显示文摘The nuclear receptors pregnane X receptor(PXR) and constitutive androstane receptor(CAR) were cloned and/or established as xenobiotic receptors in 1998.Due to their activities in the transcriptional regulation of phase I and phase II enzymes as well as drug transporters,PXR and CAR have been defined as the master regulators of xenobiotic responses.The discovery of PXR and CAR provides the essential molecular basis by which drugs and other xenobiotic compounds regulate the expression of xenobiotic enzymes and transporters.This article is intended to provide a historical overview on the discovery of PXR and CAR as xenobiotic receptors. | Jiong Yan Wen Xie | 2016 | Acta Pharmaceutica Sinica B2016，6，5： | 9 |
| 2 | NON-YELLOWING2 (NYE2), a Close Paralog of NYE1, Plays a Positive Role in Chlorophyll Degradation in Arabidopsis显示文摘 | Wu, Shouxin Li, Zhongpeng Yang, Lifeng Xie, Zuokun Chen, Junyi Zhang, Wei Liu, Tianqi Gao, Shan Gao, Jiong Zhu, Yihua Xin, Jiwen Ren, Guodong Kuai, Benke | 2016 | Molecular Plant2016，9，4： | 6 |
| 3 | Marine spatio-temporal process semantics and its applications-taking the El Nio Southern Oscilation process and Chinese rainfall anomaly as an example显示文摘Spatio-temporal semantics based on 'object views' or 'event views' has few abilities to represent and model the continuity and gradual oceanic phenomena or objects,which seriously limits the specific marine applications and knowledge discovery and data mining,so this paper proposes a hierarchical abstraction semantics with 'marine spatio-temporal process → life span phases → evolution sequences → state units' and process objects included by level with 'marine process objects → phase objects → sequence object → state objects' with the oceanic process characteristics into the marine process semantics.In addition,this paper designs the storage and representation of marine process objects using the backus normal forms (BNF) and abstract data type (ADT).Base on El Nin o Southern Oscilation (ENSO) index and Chinese rain gauging station data,this paper also gives a case of study.The spatio-temporal analysis between ENSO process and Chinese rainfall anomalies shows that the marine spatio-temporal semantics not only can illustrate the spatial distribution of Chinese rainfall anomalies in different time scales at ENSO process,life span phases and state units,but also analyze the dynamic changes of Chinese rainfall anomalies in different life span phases or state units within ENSO evolution. | XUE Cunjin DONG Qing XIE Jiong | 2012 | Acta Oceanologica Sinica2012，31，2： | 4 |
| 4 | Prospective, naturalistic study of open-label OROS methylphenidate treatment in Chinese school-aged children with attention-deficit/hyperactivity disorder显示文摘背景注意赤字活动过度混乱( ADHD )在童年期间是最普通的心理混乱之一,由活动过度, impulsivity 和疏忽的核心症状描绘了并且自己把大负担放在孩子上,他们的家庭和 society.Osmotic 释放口头的系统 methylphenidate (OROS哩/时)开发克服一些限制的一次每日的控制版本明确的表达与立即版本的 methylphenidate (红外哩/时)被联系 .It | ZHENG Yi WANG Yu-feng QIN Jiong WANG Li-wen ZOU Li-ping J IN Xing-ming XU Tong WANG Yi OI Yuan-li GONG Mei-en YIN Qing-yun MAI Jian-ning JING Jin LUO Xiang-yang MA Hong-wei LI Hai-bo XIE Ling LIYan Kuang Gui-fang YI Ming-ji WANG Feng ZHU Xiao-hua YAO Yan-bin | 2011 | Chinese Medical Journal2011，，20： | 2 |
| 5 | One-stage dorsal lingual mucosal graft urethroplasty for the treatment of failed hypospadias repair显示文摘这研究的目的是回顾地调查经历了一个阶段 onlay 的病人的结果或在没有通过的 hypospadias 修理以后用语言的 mucosal 接枝(LMG ) 镶嵌 urethroplasty。包括标准包括了没有通过的 hypospadias 修理的历史,与皮肤拍动做了操作的本地皮肤的不足困难,并且口头的 mucosal 接枝 urethroplasty 的必要性。如果他们用包皮或多级式的修理 urethroplasty 经历了一个没有通过的 hypospadias 修理,病人们被排除。在 2008 年 1 月和 2012 年 12 月之间,有没有通过的 hypospadias 修理的 110 个病人在我们的中心被对待。这些病人, 56 经历了一个阶段 onlay 或用 LMG 镶嵌 urethroplasty。中部的年龄是 21.8 年(范围:4-45 年) 。56 个病人,一个阶段 onlay LMG urethroplasty 在 42 被执行病人(组 1 ) ,和用一个阶段的一种修改 Snodgrass 技术镶嵌 LMG urethroplasty 在 14 被执行(组 2 ) 。中部的 LMG urethroplasty 长度是 5.6 ±1.6 厘米(变化:4-13 厘米) 。吝啬的后续是 34.7 个月(范围:10-58 月) ,并且复杂并发症在 56 个病人(21.4%) 中的 12 个发展了,包括在 7 的 urethrocutaneous 管(6 在组 1, 1 在组 2 ) 并且在 5 的 neourethral 苛评(4 在组 1, 1 在组 2 ) 。全部的成功率是 78.6% 。我们的调查建议那一个阶段 onlay 或与 LMG 镶嵌 urethroplasty 可以是一种有效选择在没有通过的 hypospadias 修理以后与更少的可得到的皮肤对待病人;收获的 LMG 容易、安全,不管病人年龄。 | Hong-Bin Li Yue-Min Xu Qiang Fu Ying-Long Sa Jiong Zhang Hong Xie | 2016 | Asian Journal of Andrology2016，18，3： | 2 |
| 6 | Kupffer cells contribute to concanavalin A-induced hepatic injury through a Th1 but not Th17 type response-dependent pathway in mice显示文摘BACKGROUND:Increasing evidence suggests that a close interaction of Kupffer cells with T cells plays a central role in concanavalin A-induced hepatic injury in mice,but the underlying mechanisms remain obscure.The present study aimed to determine the relative roles of Th1 and Th17 type responses in concanavalin A-induced hepatic injury in mice, and to investigate whether or not Kupffer cells contribute to hepatic injury via a Th1 or Th17 type response-dependent pathway. METHODS:Immune-mediated hepatic injury was induced in C57BL/6 mice by intravenous injection of concanavalin A. Kupffer cells were inactivated by pretreatment with gadolinium chloride 24 hours before the concanavalin A injection.The interferon-gamma(IFN-γ)and interleukin-17(IL-17)pathways were blocked by specific neutralizing antibodies.Hepatic injury was assessed using serum transferase activity and pathological analysis.Expression of inflammatory cytokines within the liver was detected by real-time polymerase chain reaction and immunohistochemistry. RESULTS:Neutralization of IFN-γsignificantly attenuated concanavalin A-induced hepatic injury.However,neutralization of IL-17 failed to suppress the injury.Inactivation of Kupffer cells by gadolinium chloride pretreatment protected against concanavalin A-induced injury and significantly reduced hepatic cytokine levels including TNF-α,IL-6 and IFN-γbut not IL-17.CONCLUSION:Our findings suggest that Kupffer cells contribute to concanavalin A-induced hepatic injury via a Th1 type response-dependent pathway and production of inflammatory cytokines including TNF-α,IL-6 and IFN-γ. | Lin Chen,Xiao-Jun Xie,Yu-Fu Ye,Lin Zhou,Hai-Yang Xie,Qin-Fen Xie, Jiong Tian and Shu-Sen ZhengZhejiang University School of Medicine,Hangzhou 310003,ChinaKey Laboratory of Combined Multi-organ Transplantation,Ministry of Public Health Department of Hepatobiliary and Pancreatic Surgery Department of Nephrology,First Affiliated Hospital,Zhejiang University School of Medicine,Hangzhou 310003,China | 2011 | Hepatobiliary & Pancreatic Diseases International2011，10，2： | 2 |
| 7 | Characteristics of β-oxidative and reductive metabolism on the acyl side chain of cinnamic acid and its analogues in rats显示文摘Cinnamic acid and its analogues (pyragrel and ozagrel) undergo chain-shortened (β-oxidative) and reductive metabolism on acyl side chain. In this study, we characterized the β-oxidative and reductive metabolism on acyl side chain of cinnamic acid and its analogues using primary rat hepatocytes, hepatic mitochondrial, and microsomal systems. A compartmental model including parent compounds and metabolites was developed to characterize in vivo β-oxidative and reductive metabolism following an intravenous dose of parent compounds to rats. The ?tted total in vivo clearance values were further compared with the in vitro values predicted by the well-stirred model. We showed that hepatic microsomal CYP450s did not catalyze β-oxidative or reductive metabolism of the three compounds. Similar to β-oxidation of fatty acids,β-oxidative metabolism on their acyl side chain occurred mainly in mitochondria, which was highly dependent on ATP, CoA and NAD+. Fatty acids and NADH inhibited the β-oxidative metabolism. Reductive metabolism occurred in both mitochondria and microsomes. Reduction in mitochondria was ATP-, CoA-, and NAD(P)H-dependent and reversible, which was suppressed by enoyl reductase inhibitor triclosan. Reduction in microsomes was ATP-, CoA-, and NADPH-dependent but little affected by triclosan. Both plasma concentrations of β-oxidative metabolites and reductive metabolites were successfully ?tted using the compartmental model. The estimated total in vivo clearance values were consistent with those predicted from hepatocytes and organelles, implicating signi?cance of in vitro kinetics. These ?ndings demonstrate the roles of hepatic mitochondria and microsomes in β-oxidative and reductive metabolism on acyl side chain of cinnamic acid and its analogues along with their metabolic characteristics. | Kai-jing Zhao Yang Chen Shi-jin Hong Yi-ting Yang Jiong Xu Han-yu Yang Liang Zhu Ming Liu Qiu-shi Xie Xian-ge Tang Ting-ting Yang Ya-qian Zhou Li Liu Xiao-dong Liu | 2019 | Acta Pharmacologica Sinica2019，40，8： | 2 |
| 8 | Adaptive Preshuffling in Hadoop Clusters显示文摘 | Xie Jiong Tian Yun Yin Shu | 2013 | Procedia Computer Science2013，18，1： | 1 |
| 9 | Overexpression of YKL-40 is an independent prognostic marker in gastric cancer显示文摘 | Jiong Bi Sze-Hang Lau Zi-Li Lv Dan Xie Wen Li Ying-Rong Lai Jue-Min Zhong Hui-qun Wu Qiao Su Yu-long He Wen-Hua Zhan Jian-Ming Wen Xin-Yuan Guan | 2009 | Human Pathology2009，，： | 1 |
| 10 | Assessment of biological functions for C3A cells interacting with adverse environments of liver failure plasma显示文摘Background:For its better differentiated hepatocyte phenotype,C3A cell line has been utilized in bioar-tificial liver system.However,up to now,there are only a few of studies working at the metabolic alter-nations of C3A cells under the culture conditions with liver failure plasma,which mainly focus on car-bohydrate metabolism,total protein synthesis and ureagenesis.In this study,we investigated the effects of acute liver failure plasma on the growth and biological functions of C3A cells,especially on CYP450 enzymes.Methods:C3A cells were treated with fresh DMEM medium containing 10%FBS,fresh DMEM medium containing 10%normal plasma and acute liver failure plasma,respectively.After incubation,the C3A cells were assessed for cell viabilities,lactate dehydrogenase leakage,gene transcription,protein levels,albu-min secretion,ammonia metabolism and CYP450 enzyme activities.Results:Cell viabilities decreased 15%,and lactate dehydrogenase leakage had 1.3-fold elevation in acute liver failure plasma group.Gene transcription exhibited up-regulation,down-regulation or stability for different hepatic genes.In contrast,protein expression levels for several CYP450 enzymes kept constant,while the CYP450 enzyme activities decreased or remained stable.Albumin secretion reduced about 48%,and ammonia accumulation increased approximately 41%.Conclusions:C3A cells cultured with acute liver failure plasma showed mild inhibition of cell viabilities,reduction of albumin secretion,and increase of ammonia accumulation.Furthermore,CYP450 enzymes demonstrated various alterations on gene transcription,protein expression and enzyme activities. | Zu-Hong Li Zhong-Yang Xie Xiao-Xi Ouyang Kai-Zhou Huang Xiao-Peng Yu Ya-Lei Zhao Yan-Hong Zhang Dan-Hua Zhu Jiong Yu Lan-Juan Li | 2020 | Hepatobiliary & Pancreatic Diseases International2020，19，2： | 1 |
| 11 | A spatial-temporal system for dynamic cadastral management显示文摘 | Liu Nan Liu Renyi Zhu Guangliang Xie Jiong | 2006 | Journal of Environmental Management2006，，78： | 1 |
| 12 | Correlation of AIB1 overexpression with advanced clinical stage of human colorectal carcinoma显示文摘 | Dan Xie Jonathan S.T. Sham Wei-Fen Zeng Han-Liang Lin Jiong Bi Li-Hong Che Liang Hu Yi-Xin Zeng Xin-Yuan Guan | 2005 | Human Pathology2005，，7： | 1 |
| 13 | Lymphangiogenesis and Prognostic Significance of Vascular Endothelial Growth Factor C in Gastro‐oesophageal Junction Adenocarcinoma显示文摘 | Liang‐Xi Xie Tian‐Tian Zhai Li‐Ping Yang Eleanor Yang Xiao‐Hui Zhang Jiong‐Yu Chen Hao Zhang | 2013 | Int J Exp Path2013，，1： | 1 |
| 14 | Lymphangiogenesis and Prognostic Significance of Vascular Endothelial Growth Factor C in Gastro‐oesophageal Junction Adenocarcinoma显示文摘 | Liang‐Xi Xie Tian‐Tian Zhai Li‐Ping Yang Eleanor Yang Xiao‐Hui Zhang Jiong‐Yu Chen Hao Zhang | 2013 | Int J Exp Path2013，，1： | 1 |
| 15 | Deciphering the roles of the constitutive androstane 'eceptor in energy metabolism显示文摘The constitutive androstane receptor (CAR) is initially defined as a xenobiotic nuclear receptor that protects the liver from injury. Detoxification of damaging chemicals iS achieved by CAR-mediated induction of drug-metabolizing enzymes and transporters. More recent research has implicated CAR in energy metabolism, suggesting a therapeutic potential for CAR in metabolic diseases, such as type 2 diabetes and obesity. A better understanding of the mechanisms by which CAR regulates energy metabolism will allow us to take advantage of its effectiveness while avoiding its side effects. This review summarizes the cúrrent progress on the regulation of CAR nuclear translocation, upstream modulators of CAR activity, and the crosstalk between CAR and other transcriptional factors, with the aim of elucidating how CAR regulates glucose and lipid metabolism. | Jiong YAN Baian CHEN Jing LU Wen XIE | 2015 | Acta Pharmacologica Sinica2015，36，1： | 1 |
| 16 | A Spatial-temporal system for dynamic cadastral management 显示文摘 | Liu Nan Liu Renyi Zhu guangliang Xie Jiong | 2006 | Journal of Environmental Management2006，78，4： | 1 |
| 17 | A Spatial-temporal system for dynamic cadastral management 显示文摘 | Liu Nan Liu Renyi Zhu guangliang Xie Jiong | 2006 | Journal of Environmental Management2006，78，4： | 1 |
| 18 | SOLUTION OF MULTIPLE CRACKS IN A FINITE PLATE OF AN ELASTIC ISOTROPIC MATERIAL WITH THE DISTRIBUTED DISLOCATION METHOD显示文摘This paper presents a numerical solution to model multiple cracks in a finite plate of an elastic isotropic material. Both the boundaries and the cracks are modeled by distributed dislocations. This method results in a system of singular integral equations with Cauchy kernels which can be solved by Gauss-Chebyshev quadrature method. Four examples are provided to assess the capability of this method. | Jiong Zhang Zhan Qu Qiqing Huang Lechun Xie Cenbo Xiong | 2014 | Acta Mechanica Solida Sinica2014，27，3： | 1 |
| 19 | Detecting benign uterine tumors by autofuorescence lifetime imaging microscopy through adjacent healthy cervical tissues显示文摘The endogenous fluorophores such as reduced nicotinarmide adenine dinucleotide(phosphate)(NAD(P)H)and favin adenine dinucleotide(FAD)in cells and tissues can be imaged by fuo-rescence lifetime imaging microscopy(FLIM)to show the tisute morphology features,as well as the biomolecular changes in microenvironment.The two important coenzymes in cellular metabolism,NAD(P)H and FAD,can be used to monitor the cellular metabolic status.This work proposed a novel method to study the uterine metabolism at the adjacent site of healthy cervix.It was found that the benign uterine tumors such as leiomyomas and adenomyosis with abnormal cell growth can be detected by measuring the fluorescence lifetime of NAD(P)H and FAD in adjacent healthy cervical tisues.This method opened a novel strategy for alicted women to undergo the cervical biopsies instead of hysterectomies for detecting tumors,which can preserve the fertility of patients.The FLIM studying on NAD(P)H and FAD indicated the correlation between metabolism and some diseases,including diabetes,hyperthyroidism and obesity.It was also suggested that the metabolic level might be quite different for a patient with a malignant tumnor history. | Maojia Huang Zixiao Zhang Xinyi Wang Yonghui Xie Yiyan Fei Jiong Ma Jing Wang Li Chen Lan Mi Yulan Wang | 2019 | Journal of Innovative Optical Health Sciences2019，，5： | 0 |
| 20 | Specific pupylation as IDEntity reporter(SPIDER)for the identification of protein-biomolecule interactions显示文摘Protein-biomolecule interactions play pivotal roles in almost all biological processes.For a biomolecule of interest,the identification of the interacting protein(s)is essential.For this need,although many assays are available,highly robust and reliable methods are always desired.By combining a substrate-based proximity labeling activity from the pupylation pathway of Mycobacterium tuberculosis and the streptavidin(SA)-biotin system,we developed the Specific Pupylation as IDEntity Reporter(SPIDER)method for identifying protein-biomolecule interactions.Using SPIDER,we validated the interactions between the known binding proteins of protein,DNA,RNA,and small molecule.We successfully applied SPIDER to construct the global protein interactome for m^(6)A and m RNA,identified a variety of uncharacterized m^(6)A binding proteins,and validated SRSF7 as a potential m^(6)A reader.We globally identified the binding proteins for lenalidomide and Cob B.Moreover,we identified SARS-CoV-2-specific receptors on the cell membrane.Overall,SPIDER is powerful and highly accessible for the study of proteinbiomolecule interactions. | He-Wei Jiang Hong Chen Yun-Xiao Zheng Xue-Ning Wang Qingfeng Meng Jin Xie Jiong Zhang ChangSheng Zhang Zhao-Wei Xu Zi-Qing Chen Lei Wang Wei-Sha Kong Kuan Zhou Ming-Liang Ma Hai-Nan Zhang Shu-Juan Guo Jun-Biao Xue Jing-Li Hou Zhe-Yi Liu Wen-Xue Niu Fang-Jun Wang Tao Wang Wei Li Rui-Na Wang Yong-Jun Dang Daniel MCzajkowsky JianFeng Pei Jia-Jia Dong Sheng-Ce Tao | 2023 | Science China(Life Sciences)2023，66，8： | 0 |
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