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| 1 | Mesenchymal stem cell treatment improves outcome of COVID-19 patients via multiple immunomodulatory mechanisms显示文摘The infusion of coronavirus disease 2019(COVID-19)patients with mesenchymal stem cells(MSCs)potentially improves clinical symptoms,but the underlying mechanism remains unclear.We conducted a randomized,single-blind,placebo-controlled(29 patients/group)phase II clinical trial to validate previous findings and explore the potential mechanisms.Patients treated with umbilical cord-derived MSCs exhibited a shorter hospital stay(P=0.0198)and less time required for symptoms remission(P=0.0194)than those who received placebo.Based on chest images,both severe and critical patients treated with MSCs showed improvement by day 7(P=0.0099)and day 21(P=0.0084).MSC-treated patients had fewer adverse events.MSC infusion reduced the levels of C-reactive protein,proinflammatory cytokines,and neutrophil extracellular traps(NETs)and promoted the maintenance of SARS-CoV-2-specific antibodies.To explore how MSCs modulate the immune system,we employed single-cell RNA sequencing analysis on peripheral blood.Our analysis identified a novel subpopulation of VNN2+hematopoietic stem/progenitorlike(HSPC-like)cells expressing CSF3R and PTPRE that were mobilized following MSC infusion.Genes encoding chemotaxis factors—CX3CR1 and L-selectin—were upregulated in various immune cells.MSC treatment also regulated B cell subsets and increased the expression of costimulatory CD28 in T cells in vivo and in vitro.In addition,an in vivo mouse study confirmed that MSCs suppressed NET release and reduced venous thrombosis by upregulating kindlin-3 signaling.Together,our results underscore the role of MSCs in improving COVID-19 patient outcomes via maintenance of immune homeostasis. | Rongjia Zhu Tingdong Yan Yingmei Feng Yan Liu Hongcui Cao Gongxin Peng Yanlei Yang Zhen Xu Jingqi Liu Wei Hou Xiaoyue Wang Zhe Li Luchan Deng Shihua Wang Jing Li Qin Han Hongling Li Guangliang Shan Yinghao Cao Xingyan An Jianshe Yan Zhonghui Zhang Huafei Li Xuebin Qu Jiaqi Zhu Shumin Zhou Jiao Wang Fengchun Zhang Jinming Gao Ronghua Jin Dayong Xu Yan-Qing Ma Tao Huang Shuang Peng Zhi Zheng Ilia Stambler Eric Gilson Lee Wei Lim Alexey Moskalev Antonio Cano Sasanka Chakrabarti Brun Ulfhake Huanxing Su Haoying Xu Sihuan Xu Feng Wei Holly MBrown-Borg Kyung-Jin Min Georgina Ellison-Hughes Calogero Caruso Kunlin Jin Robert Chunhua Zhao | 2021 | Cell Research2021，31，12： | 5 |
| 2 | Prevalence, risk factors, and survival associated with pulmonary hypertension and heart failure among patients with underlying coronary artery disease: a national prospective, multicenter registry study in China显示文摘Background: Coronary artery disease (CAD) is the commonest cause of heart failure (HF), whereas pulmonary hypertension (PH) has not been established or reported in this patient population. Therefore, we assessed the prevalence, risk factors, and survival in CAD-associated HF (CAD-HF) complicated with PH.Methods: Symptomatic CAD-HF patients were continuously enrolled in this prospective, multicenter registry study. Echocardiography, coronary arteriography, left and right heart catheterization (RHC), and other baseline clinical data were recorded. Patients were followed up and their survival was recorded.Results: One hundred and eighty-two CAD-HF patients were enrolled, including 142 with HF with a preserved ejection fraction (heart failure with preserved ejection fraction [HFpEF];left ventricular ejection fraction [LVEF] ≥50%) and 40 with a reduced ejection fraction (heart failure with reduced ejection fraction [HFrEF];LVEF < 50%). PH was diagnosed with RHC in 77.5% of patients. Patients with PH showed worse hemodynamic parameters and higher mortality. HFrEF-PH patients had worse survival than HFpEF-PH patients. CAD-HF patients with an enlarged left ventricular end-diastolic diameter and reduced hemoglobin were at higher risk of PH. Nitrate treatment reduced the risk of PH. Elevated creatinine and mean pulmonary arterial pressure (mPAP), diastolic pressure gradient (DPG) ≥7 mmHg, and previous myocardial infarction (MI) entailed a higher risk of mortality in CAD-HF patients with PH.Conclusions: PH is common in CAD-HF and worsens the hemodynamics and survival in these patients. Left ventricle enlargement and anemia increase the risk of PH in CAD-HF. Patients may benefit from nitrate medications. Renal impairment, elevated mPAP, DPG ≥7 mmHg, and previous MI are strong predictors of mortality in CAD-HF-PH patients.Trial Registration: ClinicalTrials.gov, NCT02164526. | Li Huang Lingpin Pang Qing Gu Tao Yang Wen Li Ruilin Quan Weiqing Su Weifeng Wu Fangming Tang Xiulong Zhu Jieyan Shen Jingzhi Sun Guangliang Shan Changming Xiong Shian Huang Jianguo He | 2022 | Chinese Medical Journal2022，，15： | 4 |
| 3 | Accurate and precise determination of lead isotope composition in selected geochemical reference materials显示文摘Lead(Pb)isotopes have been extensively employed in tracing sources of Pb and its transport pathways through the environment.However,Pb isotopic ratios in related geochemical reference materials are scarce.Here,we report high-precision Pb isotopic ratios measured by Nu Plasma II MC-ICP-MS using calibrated ^(205)Tl/^(203)Tl=2.38865(NIST SRM 997)for mass discrimination correction.The long-term external precision(2SD)for NISTSRM 981 of Pb,BCR-2,and BHVO-2 are 0.31‰(n=105),0.42‰(n=11),and 0.25‰(n=5)for ^(208)Pb/ ^(206)Pb and 0.16‰,0.53‰,and 0.07‰for ^(206)Pb/ ^(207)Pb,both respectively,and their Pb isotopic ratios are in excellent agreement with the recommended values.Using this method,we report for the first time Pb isotopic compositions in shale SGR-1b(USGS);coal CLB-1(USGS);stream sediments GSD-17,-21,and-23(IGGE);soils GSS-12,-13,-14,-15,and-16(IGGE);plants GSV-1,-2,and-3(IGGE);and human hair GSH-1(IGGE). | Guangliang Wu Jian-Ming Zhu Decan Tan Guilin Han Lixing Zhang Kun Ren | 2017 | Acta Geochimica2017，36，3： | 3 |
| 4 | Hydroxyl radical formation upon dark oxidation of reduced iron minerals: Effects of iron species and environmental factors显示文摘Dark formation of hydroxyl radical upon oxidation of reduced iron minerals plays an important role in the degradation and transformation of organic and inorganic pollutants.Herein,we compared the hydroxyl radical formation from various reduced iron minerals at different redox conditions.·OH production was generally observed from the oxidation of reduced iron minerals,following the order:mackinawite(FeS)>reduced nontronite(iron-bearing smectite clay)> pyrite(FeS2)> side rite(FeCO3).Structural Fe^2+ and dissolved O2 play critical roles in ·OH production from reduced iron minerals.·OH production increases with decreasing pH,and Cl^-has little effect on this process.More importantly,dissolved organic matter significantly enhances ·OH production,especially under O2 purging,highlighting the importance of this process in ambient environments.This sunlight-independent pathway in which ’OH forms during oxidation of reduced iron minerals is helpful for understanding the degradation and transformation of various inorganic and organic pollutants in the redox-fluctuation environments. | Ailing Zhu Yingying Guo Guangliang Liu Maoyong Song Yong Liang Yong Cai Yongguang Yin | 2019 | Chinese Chemical Letters2019，30，12： | 2 |
| 5 | Modeling of ultrasonic enhancement on membrane distillation显示文摘 | Zhu Chao Liu Guangliang | 2000 | J Membr Sci2000，176，： | 1 |
| 6 | Danhong Injection Inhibits the Development of Atherosclerosis in Both Apoe?/? and Ldlr?/? Mice显示文摘 | Yuanli Chen Mengyang Liu Tao Zhao Buchang Zhao Lifu Jia Yan Zhu Boli Zhang Xiumei Gao Guangliang Li Xiaoju Li Rong Xiang Jihong Han Yajun Duan | 2014 | Journal of Cardiovascular Pharmacology2014，，5： | 1 |
| 7 | Identification of Suitable Hydrologic Response Unit Thresholds for Soil and Water Assessment Tool Streamflow Modelling显示文摘Use of a non-zero hydrologic response unit(HRU) threshold is an effective way of reducing unmanageable HRU numbers and simplifying computational cost in the Soil and Water Assessment Tool(SWAT) hydrologic modelling. However, being less representative of watershed heterogeneity and increasing the level of model output uncertainty are inevitable when minor HRU combinations are disproportionately eliminated. This study examined 20 scenarios by running the model with various HRU threshold settings to understand the mechanism of HRU threshold effects on watershed representation as well as streamflow predictions and identify the appropriate HRU thresholds. Findings show that HRU numbers decrease sharply with increasing HRU thresholds. Among different HRU threshold scenarios, the composition of land-use, soil, and slope all contribute to notable variations which are directly related to the model input parameters and consequently affect the streamflow predictions. Results indicate that saturated hydraulic conductivity, average slope of the HRU, and curve number are the three key factors affecting stream discharge when changing the HRU thresholds. It is also found that HRU thresholds have little effect on monthly model performance, while evaluation statistics for daily discharges are more sensitive than monthly results. For daily streamflow predictions, thresholds of 5%/5%/5%(land-use/soil/slope) are the optimum HRU threshold level for the watershed to allow full consideration of model accuracy and efficiency in the present work. Besides, the results provide strategies for selecting appropriate HRU thresholds based on the modelling goal. | JIANG Liupeng ZHU Jinghai CHEN Wei HU Yuanman YAO Jing YU Shuai JIA Guangliang HE Xingyuan WANG Anzhi | 2021 | Chinese Geographical Science2021，31，4： | 1 |
| 8 | Prevalence of diabetes among menand women in China显示文摘 | Yang Wenying Lu Juming Weng Jianping Jia Weiping Ji Linong Xiao Jianzhong Shan Zhongyan Liu Jie Tian Ha- oming Ji Qiuhe Zhu Dalong Ge Jiapu Lin Lixiang Chen Li Guo Xiaohui Zhao Zhigang Li Qiang Zhou Zhiguang Shan Guangliang He Jiang | 2010 | N Engl J Med2010，362，： | 1 |
| 9 | A spatial-temporal system for dynamic cadastral management显示文摘 | Liu Nan Liu Renyi Zhu Guangliang Xie Jiong | 2006 | Journal of Environmental Management2006，，78： | 1 |
| 10 | 2,5-Dibenzoylterephthalic acid ethanol disolvate显示文摘 | Zhu Hongjun Wang Dandan Song Guangliang | 2005 | Acta Cryst2005，61，： | 1 |
| 11 | Serum Lipids and Lipoproteins in Chinese Men and Women显示文摘 | Wenying Yang Jianzhong Xiao Zhaojun Yang Linong Ji Weiping Jia Jianping Weng Juming Lu Zhongyan Shan Jie Liu Haoming Tian Qiuhe Ji Dalong Zhu Jiapu Ge Lixiang Lin Li Chen Xiaohui Guo Zhigang Zhao Qiang Li Zhiguang Zhou Guangliang Shan Jiang He | 2012 | Circulation2012，，18： | 1 |
| 12 | Modeling of ultrasonic enhancement on membrane distillation 显示文摘 | ZHU chao LIU Guangliang | 2000 | Journal of Membrane Science2000，176，： | 1 |
| 13 | A Spatial-temporal system for dynamic cadastral management 显示文摘 | Liu Nan Liu Renyi Zhu guangliang Xie Jiong | 2006 | Journal of Environmental Management2006，78，4： | 1 |
| 14 | A Spatial-temporal system for dynamic cadastral management 显示文摘 | Liu Nan Liu Renyi Zhu guangliang Xie Jiong | 2006 | Journal of Environmental Management2006，78，4： | 1 |
| 15 | Sound assisted fluidization of nanoparticle agglomerates显示文摘 | Chao Zhu Guangliang Liu Qun Yu | 2004 | Powder Technology2004，141，： | 1 |
| 16 | Modding of ulsonic enhancement on membrane distillation 显示文摘 | Zhu chao Liu Guangliang | 2000 | J Membr Sci2000，176，： | 1 |
| 17 | Evaluation of ICUs and weight of quality control indicators:an exploratory study based on Chinese ICU quality data from 2015 to 2020显示文摘This study aimed to explore key quality control factors that affected the prognosis of intensive care unit(ICU)patients in Chinese mainland over six years(2015–2020).The data for this study were from 31 provincial and municipal hospitals(3425 hospital ICUs)and included 2110685 ICU patients,for a total of 27607376 ICU hospitalization days.We found that 15 initially established quality control indicators were good predictors of patient prognosis,including percentage of ICU patients out of all inpatients(%),percentage of ICU bed occupancy of total inpatient bed occupancy(%),percentage of all ICU inpatients with an APACHE II score≥15(%),three-hour(surviving sepsis campaign)SSC bundle compliance(%),six-hour SSC bundle compliance(%),rate of microbe detection before antibiotics(%),percentage of drug deep venous thrombosis(DVT)prophylaxis(%),percentage of unplanned endotracheal extubations(%),percentage of patients reintubated within 48 hours(%),unplanned transfers to the ICU(%),48-h ICU readmission rate(%),ventilator associated pneumonia(VAP)(per 1000 ventilator days),catheter related blood stream infection(CRBSI)(per 1000 catheter days),catheter-associated urinary tract infections(CAUTI)(per 1000 catheter days),in-hospital mortality(%).When exploratory factor analysis was applied,the 15 indicators were divided into 6 core elements that varied in weight regarding quality evaluation:nosocomial infection management(21.35%),compliance with the Surviving Sepsis Campaign guidelines(17.97%),ICU resources(17.46%),airway management(15.53%),prevention of deep-vein thrombosis(14.07%),and severity of patient condition(13.61%).Based on the different weights of the core elements associated with the 15 indicators,we developed an integrated quality scoring system defined as F score=21.35%xnosocomial infection management+17.97%xcompliance with SSC guidelines+17.46%×ICU resources+15.53%×airway management+14.07%×DVT prevention+13.61%×severity of patient condition.This evidence-based quality scoring system will help in assessing the key elements of quality management and establish a foundation for further optimization of the quality control indicator system. | Longxiang Su Xudong Ma Sifa Gao Zhi Yin Yujie Chen Wenhu Wang Huaiwu He Wei Du Yaoda Hu Dandan Ma Feng Zhang Wen Zhu Xiaoyang Meng Guoqiang Sun Lian Ma Huizhen Jiang Guangliang Shan Dawei Liu Xiang Zhou China-NCCQC | 2023 | Frontiers of Medicine2023，17，4： | 0 |
| 18 | Optimizing the ratio of the spike to sample for isotope dilution analysis:a case study with selenium isotopes显示文摘Isotope dilution(ID)method has been widely applied to studies of elemental speciation and certification of the concentrations of geological reference materials.One of the key factors restricting the application of the ID method is the difficulty in identifying the optimal ratios of the isotope tracer(spike)to sample(S/N)and in estimating the error propagation.Here,using Se isotope as an example and employing a Monte Carlo method,we found that the optimal choice of spike and S/N are^(77)Se(spike)and 0.7,respectively.The S/N in the range from 0.1 to 4 can produce sufficiently low errors(<0.4%).Extending this method to other elements such as Cr,Fe,Ni,Sr,Cd and etc.,their optimal spike and S/N were also presented.According to the optimized parameters of Se,we determined the Se concentrations of geological reference materials(GRMs)by thiol cotton fiber(TCF)-hydride generation ID-MC-ICP-MS.The relative standard deviation is<5%,and the detection limit is reduced to0.1 ng/g.Most of the measured concentrations are consistent with those recommended by IGGE or reported previously.For some GRMs,discrepancies(e.g.6.90%for GSS-5)exist between our measurements and previous ones,which can be explained by the inhomogeneity of GRMs and/or the different digestion,purification and measurement methods among laboratories. | Decan Tan Wenpo Xu Zuochen Zhu Shehong Li Guangliang Wu Haibo Qin | 2020 | Acta Geochimica2020，39，2： | 0 |
| 19 | Characteristics and reference values of the atherogenic index of plasma in an adult population in China显示文摘To the Editor:The atherogenic index of plasma(AIP)is derived from the logarithmic conversion of the ratio of triglyceride(TG)to high-density lipoprotein cholesterol(HDL-C).It comprehensively reflects plasma lipid homeostasis.AIP has been reported to be related to cardiovascular disease(CVD)in population-based studies,^([1])and is regarded as a potential independent predictor for CVD risk in clinical practice.Currently,there are limited data on the characteristics of AIP values in China.We examined the differences in AIP values among ethnic groups based on multiethnic Chinese population data.The reference values of AIP in Chinese adults were established,and their variation tendencies according to age were identified. | Yuelun Zhang Yunying Feng Shi Chen Hanze Du Huijuan Zhu Hui Pan Guangliang Shan | 2022 | Chinese Medical Journal2022，135，24： | 0 |
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