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| 1 | Spider Web‑Inspired Graphene Skeleton‑Based High Thermal Conductivity Phase Change Nanocomposites for Battery Thermal Management显示文摘Phase change materials(PCMs)can be used for efficient thermal energy harvesting,which has great potential for cost-effective thermal management and energy storage.However,the low intrinsic thermal conductivity of polymeric PCMs is a bottleneck for fast and efficient heat harvesting.Simultaneously,it is also a challenge to achieve a high thermal conductivity for phase change nanocomposites at low filler loading.Although constructing a three-dimensional(3D)thermally conductive network within PCMs can address these problems,the anisotropy of the 3D framework usually leads to poor thermal conductivity in the direction perpendicular to the alignment of fillers.Inspired by the interlaced structure of spider webs in nature,this study reports a new strategy for fabricating highly thermally conductive phase change composites(sw-GS/PW)with a 3D spider web(sw)-like structured graphene skeleton(GS)by hydrothermal reaction,radial freeze-casting and vacuum impregnation in paraffin wax(PW).The results show that the sw-GS hardly affected the phase transformation behavior of PW at low loading.Especially,sw-GS/PW exhibits both high cross-plane and in-plane thermal conductivity enhancements of~1260%and~840%,respectively,at an ultra-low filler loading of 2.25 vol.%.The thermal infrared results also demonstrate that sw-GS/PW possessed promising applications in battery thermal management. | Ying Lin Qi Kang Han Wei Hua Bao Pingkai Jiang Yiu‑Wing Mai Xingyi Huang | 2021 | Nano-Micro Letters2021，13，11： | 5 |
| 2 | Soil Nutrient Variance by Slope Position in a Mollisol Farmland Area of Northeast China显示文摘In order to generate scientifically-based comparative information to improve fertilization efficiency and reduce nutrient loss, 610 samples of 122 soil profiles were collected at the 0–60 cm depth to compare soil nutrient contents including soil organic matter(SOM), total nitrogen(TN), total phosphorus(TP), available phosphorus(AP), and available potassium(AK) among different slope positions in a Mollisol farmland area of Northeast China. The contents of SOM and TN typically decreased with increased soil depth at back and bottom slope. Soil loss and deposition tended to decrease SOM and TN at the 0–20 cm soil depth on both the back slope and the slope bottom. The TP firstly decreased from 0–20 cm to 30–40 cm, and then not constantly increased at the back slope and the bottom slope. Due to the characteristics of soil nutrients and crop absorption, the contents of both AP and AK were typically the highest at the summit, followed by the slope bottom and the back slope in the 0–20 cm layer. Generally, in order to sustain the high soil productivity and protect the environment, attention should be paid to soil conservation on back slope; in addition, additional N and P fertilizer is necessary on the back slope. | ZHANG Shaoliang JIANG Lili LIU Xiaobing ZHANG Xingyi FU Shicong DAI Lin | 2016 | Chinese Geographical Science2016，26，4： | 5 |
| 3 | Tumor immune checkpoints and their associated inhibitors显示文摘Immunological evasion is one of the defining characteristics of cancers,as the immune modification of an immune checkpoint(IC)confers immune evasion capabilities to tumor cells.Multiple ICs,such as programmed cell death protein-1(PD-1)and cytotoxic T-lymphocyte-associated antigen-4(CTLA-4),can bind to their respective receptors and reduce tumor immunity in a variety of ways,including blocking immune cell activation signals.IC blockade(ICB)therapies targeting these checkpoint molecules have demonstrated significant clinical benefits.This is because antibody-based IC inhibitors and a variety of specific small molecule inhibitors can inhibit key oncogenic signaling pathways and induce durable tumor remission in patients with a variety of cancers.Deciphering the roles and regulatory mechanisms of these IC molecules will provide crucial theoretical guidance for clinical treatment.In this review,we summarize the current knowledge on the functional and regulatory mechanisms of these IC molecules at multiple levels,including epigenetic regulation,transcriptional regulation,and post-translational modifications.In addition,we provide a summary of the medications targeting various nodes in the regulatory pathway,and highlight the potential of newly identified IC molecules,focusing on their potential implications for cancer diagnostics and immunotherapy. | Zerui GAO Xingyi LING Chengyu SHI Ying WANG Aifu LIN | 2022 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2022，23，10： | 4 |
| 4 | Flexible,Highly Thermally Conductive and Electrically Insulating Phase Change Materials for Advanced Thermal Management of 5G Base Stations and Thermoelectric Generators显示文摘Thermal management has become a crucial problem for high-power-density equipment and devices.Phase change materials(PCMs)have great prospects in thermal management applications because of their large capacity of heat storage and isothermal behavior during phase transition.However,low intrinsic thermal conductivity,ease of leakage,and lack of flexibility severely limit their applications.Solving one of these problems often comes at the expense of other performance of the PCMs.In this work,we report core–sheath structured phase change nanocomposites(PCNs)with an aligned and interconnected boron nitride nanosheet network by combining coaxial electrospinning,electrostatic spraying,and hot-pressing.The advanced PCN films exhibit an ultrahigh thermal conductivity of 28.3 W m^(-1)K^(-1)at a low BNNS loading(i.e.,32 wt%),which thereby endows the PCNs with high enthalpy(>101 J g^(-1)),outstanding ductility(>40%)and improved fire retardancy.Therefore,our core–sheath strategies successfully balance the trade-off between thermal conductivity,flexibility,and phase change enthalpy of PCMs.Further,the PCNs provide powerful cooling solutions on 5G base station chips and thermoelectric generators,displaying promising thermal management applications on high-power-density equipment and thermoelectric conversion devices. | Ying Lin Qi Kang Yijie Liu Yingke Zhu Pingkai Jiang Yiu‑Wing Mai Xingyi Huang | 2023 | Nano-Micro Letters2023，15，3： | 2 |
| 5 | Crucial control measures to contain China's first Delta variant outbreak显示文摘The SARS-C oV-2 B.1.617.2(Delta) variant flared up in late May in Guangzhou,China.Transmission characteristics of Delta variant were analysed for 153 confirmed cases and two complete transmission chains with seven generations were fully presented.A rapid transmission occurred in five generations within10 days.The basic reproduction number(R_0) was 3.60(95% confidence interval:2.50-5.30).After redefining the concept of close contact,the proportion of confirmed cases discovered from close contacts increased from 43% to 100%.With the usage of a yellow health code,the potential exposed individuals were self-motivated to take a nucleic acid test and regained public access with a negative testing result.Facing the massive requirement of screening,novel facilities like makeshift inflatable laboratories were promptly set up as a vital supplement and 17 cases were found,with 1 pre-symptomatic.The dynamic adjustment of these three interventions resulted in the decline of Rt from 5.00 to 1.00 within 9 days.By breaking the transmission chain and eliminating the transmission source through extending the scope of the close-contact tracing,health-code usage and mass testing,the Guangzhou D elta epidemic was effectively contained. | Lei Luo Zifeng Yang Jingyi Liang Yu Ma Hui Wang Chitin Hon Mei Jiang Zhengshi Lin Wenda Guan Zhitong Mai Yongming Li Kailin Mai Zhiqi Zeng Chuanmeizi Tu Jian Song Bin Liu Yong Liu Jianfeng He Huiyuan Li Bosheng Li Hang Dong Yutian Miao Shujun Fan Lirui Fan Xingyi Liang Ke Li Chun Chen Huihong Deng Zhicong Yang Nanshan Zhong | 2022 | National Science Review2022，9，4： | 2 |
| 6 | Expression Profile and Function Analysis of Long Non-coding RNAs in the Infection of Coxsackievirus B3显示文摘The roles of IncRNAs in the infection of enteroviruses have been barely demonstrated.In this study,we used coxsackievirus B3(CVB3),a typical enterovirus,as a model to investigate the expression profiles and functional roles of IncRNAs in enterovirus infection.We profiled IncRNAs and mRNA expression in CVB3-infected HeLa cells by IncRNA-mRNA integrated microarrays.As a result,700 differentially expressed IncRNAs(431 up-regulated and 269 down-regulated)and 665 differentially expressed mRNAs(299 up-regulated and 366 down-regulated)were identified in CVB3 infection.Then we performed IncRNA-mRNA integrated pathway analysis to identify potential functional impacts of the differentially expressed mRNAs,in which IncRNA-mRNA correlation network was built.According to IncRNA-mRNA correlation,we found that XLOC-001188,an IncRNA down-regulated in CVB3 infection,was negatively correlated with NFAT5 mRNA,an anti-CVB3 gene reported previously.This interaction was supported by qPCR detection following siRNA-mediated knockdown of XLOC-001188,which showed an increase of NFAT5 mRNA and a reduction of CVB3 genomic RNA.In addition,we observed that four most significantly altered IncRNAs,SNHG11,RP11-145F16.2,RP11-1023L17.1 and RP11-1021N1.2 share several common correlated genes critical for CVB3 infection,such as BRE and IRF2BP1.In all,our studies reveal the alteration of IncRNA expression in CVB3 infection and its potential influence on CVB3 replication,providing useful information for future studies of enterovirus infection. | Lei Tong Ye Qiu Hui Wang Yunyue Qu Yuanbo Zhao Lexun Lin Yan Wang Weizhen Xu Wenran Zhao Hongyan He Guangze Zhao Mary HZhang Decheng Yang Xingyi Ge Zhaohua Zhong | 2019 | Virologica Sinica2019，34，6： | 2 |
| 7 | Wet-resilient graphene aerogel for thermal conductivity enhancement in polymer nanocomposites显示文摘Three-dimensional(3 D)graphene-based aerogels have significant potential for adsorption,sensors,and thermal management applications.However,their practical applications are limited by their disorganized structure and ultra-low resilience after compression.Some methods can realize a well-aligned structure,however,they involve high costs and complex technology.Herein,a 3 D graphene hybrid aerogel with an anisotropic open-cell and well-oriented structure is realized by unidirectional freeze casting,which combines the‘soft’(e.g.graphene oxide,Tween-80)and‘hard’(e.g.graphene assembly)components to realize full recovery after flattening.A graphene aerogel annealed at a moderate temperature(200℃)can possess superhydrophilicity and outstanding wet-resilience properties,including after being pressed under40 MPa.Furthermore,the graphene aerogel annealed at a high temperature of 1500℃exhibits excellent thermal conductivity enhancement efficiency in polydimethylsiloxane(PDMS).The resultant nanocomposites clearly demonstrate anisotropic thermal conductivity and promising applications as thermal interface materials.This strategy offers new insights into the design and fabrication of 3 D multifunctional graphene aerogels. | Ying Lin Jin chen Shian Dong Guangning Wu Pingkai Jiang Xingyi Huang | 2021 | Journal of Materials Science & Technology2021，，24： | 1 |
| 8 | Epoxy thermoset resins with high pristine thermal conductivity显示文摘Heat dissipation becomes a critical problem because of the miniaturisation and the increase of power density in electronic devices and electric equipment,which calls for electrical insulating materials with high thermal management capability.Epoxy thermosets have been widely used as electrical insulating materials,but suffer from their low thermal conductivity.This study reviewed the research progress on the development of epoxy thermosets with high pristine thermal conductivity.First,the thermal conduction mechanism of polymers was briefly introduced.Second,the approaches used to enhance the thermal conductivity of epoxy thermosets were summarised,which mainly dealt with the formation of microscopically anisotropic but macroscopically isotropic structure in the epoxy thermosets.Third,the applications of high thermal conductivity epoxy thermoset resins were reviewed.Finally,the review provided the existing challenges and the future directions for the development of epoxy thermosets with high pristine thermal conductivity. | Ying Lin Xingyi Huang Jin Chen Pingkai Jiang | 2017 | High Voltage2017，2，3： | 1 |
| 9 | Moisture sorption and thermodynamic properties of Camellia oleifera seeds as influenced by oil content显示文摘Moisture sorption isotherms and thermodynamic properties of Camellia oleifera seeds as influenced by oil content were investigated.Moisture desorption and adsorption isotherms of Camellia oleifera seeds,kernels and shells from three varieties were determined using constant temperature and humidity chamber method at different temperatures(10°C,25°C,and 40°C)with water activity ranging from 0.20 to 0.90.Six selected mathematic models were employed to fit the experimental data.The Peleg model gave the best results for both seeds and kernels and Langmuir model was the best for shells.The difference of equilibrium moisture contents at the same water activities during desorption and adsorption indicated the occurrence of hysteresis of adsorption processes and the equilibrium moisture contents tended to decrease with the increasing oil content and temperature.The binding energy and average capacity per unit mass decreased with increasing temperature and oil content.The relationships between water activity and the logarithm of sorption activity showed the capillary porous body characteristics of the seeds. | Guangfei Zhu Qi Jin Yanhong Liu Yawen Lin Jun Wang Xingyi Li | 2021 | International Journal of Agricultural and Biological Engineering2021，14，1： | 1 |
| 10 | Identification of egg’s freshness using NIR and support vector data description显示文摘 | Jiewen Zhao Hao Lin Quansheng Chen Xingyi Huang Zongbao Sun Fang Zhou | 2010 | Journal of Food Engineering2010，，4： | 1 |
| 11 | Mechano- chemical- assisted extraction and antioxidant activities of kaempferol glycosides from camellia oleifera Abel显示文摘 | Zhu Xingyi Lin Haimin Chen Xiu | 2011 | J Agric Food Chem2011，59，8： | 1 |
| 12 | Scalable synthesis of A_2S_3 (A=Sb, Bi) submicro/nanowires using their powders via solvothermal proceeding显示文摘Single-crystal A2S3 (A=Sb, Bi) nanowires were successfully prepared via using their powders as precursors by solvothermal proceeding. The reac-tion temperature and time as well as solvent strongly influence final A2S3 crystalline morphology and size. Experimental results show that Sb2S3 rods prepared in ethylene glycol are thicker than its wires with av-erage diameter of 400 nm prepared in the mixture solvent of ethylene glycol and ethylenediamine at 200 oC for 24 h. However, under the same reaction con-dition, uniform submicrowires of Bi2S3 with average diameter of 150 nm can be obtained. When reaction temperature is decreased to 150 oC and reaction time is 40 h, pure Sb2S3 wires cannot be prepared. The possible mechanism is briefly discussed for the transformation of the Sb2S3 powders to their wire-like crystals. | JI Tianhao LIU Guanrao QI Xingyi YANG Qinglin DENG Yuan GUO Lin | 2006 | Chinese Science Bulletin2006，51，6： | 1 |
| 13 | Reduction of Nanostructured CuO Bundles: Correlation between Mi- crostructure and Reduction Properties显示文摘 | Chongqi Chen Yuanhui Zheng Yingying Zhan Xingyi Lin Qi Zheng and Kemei Wei | 2008 | Crystal Growth & Design2008，8，10： | 1 |
| 14 | Identification of egg’s freshness using NIR and support vector data description显示文摘 | Jiewen Zhao Hao Lin Quansheng Chen Xingyi Huang Zongbao Sun Fang Zhou | 2010 | Journal of Food Engineering2010，，4： | 1 |
| 15 | Improved Performance of Au/Fe2O3 Catalysts Promoted with ZrO2 and Nb2O5 in the WGS Reaction under Hydrogen-rich Conditions显示文摘 | Fengli Zhang Qi Zheng Kemei Wei Xingyi Lin Hanhui Zhang Jinwei Li Yanning Cao | 2006 | Catalysis Letters (-)2006，，3： | 1 |
| 16 | Drug-peptide supramolecular hydrogel boosting transcorneal permeability and pharmacological activity via ligand-receptor interaction显示文摘Boosting transcorneal permeability and pharmacological activity of drug poses a great challenge in the field of ocular drug delivery.In the present study,we propose a drug-peptide supramolecular hydrogel based on anti-inflammatory drug,dexamethasone(Dex),and Arg-Gly-Asp(RGD)motif for boosting transcorneal permeability and pharmacological activity via the ligand-receptor interaction.The drug-peptide(Dex-SA-RGD/RGE)supramolecular hydrogel comprised of uniform nanotube architecture formed spontaneously in phosphate buffered saline(PBS,pH=7.4)without external stimuli.Upon storage at 4℃,25℃,and 37℃ for 70 days,Dex-SA-RGD in hydrogel did not undergo significant hydrolysis,suggesting great long-term stability.In comparison to Dex-SA-RGE,Dex-SA-RGD exhibited a more potent in vitro anti-inflammatory efficacy in lipopolysaccharide(LPS)-activated RAW 264.7 macrophages via the inhibition of nuclear factorкB(NF-κB)signal pathway.More importantly,using drug-peptide supramolecular hydrogel labeled with 7-nitro-2,1,3-benzoxadiazole(NBD),the Dex-SA-K(NBD)RGD showed increased performance in terms of integrin targeting and cellular uptake compared to Dex-SA-K(NBD)RGE,as revealed by cellular uptake assay.On topical instillation in rabbit’s eye,the proposed Dex-SA-K(NBD)RGD could effectively enhance the transcorneal distribution and permeability with respect to the Dex-SA-K(NBD)RGE.Overall,our findings demonstrate the performance of the ligand-receptor interaction for boosting transcorneal permeability and pharmacological activity of drug. | Lin Chen Jie Deng Ailing Yu Yuhan Hu Bo Jin Pengyuan Du Jianhong Zhou Lei Lei Yuan Wang Serhii Vakal Xingyi Li | 2022 | Bioactive Materials2022，7，4： | 0 |
| 17 | Bioinspired self-assembly supramolecular hydrogel for ocular drug delivery显示文摘Based on a recent report concerning endogenous agents(i.e., pyridoxal phosphate, adenosine triphosphate, adenosine monophosphate, folinic acid) that modulate the oligomerization of apoptosis-associated speck-like protein(ASC) via the peptide epitope of KKFKLKL, we rationally designed and synthesized a nonapeptide(Nap FFKKFKLKL), which can co-assemble with dexamethasone sodium phosphate(Dexp) to generate a Nap FFKKFKLKL/Dexp supramolecular hydrogel for ocular drug delivery.The Nap FFKKFKLKL/Dexp hydrogel formed instantly after the complexation of Nap FFKKFKLKL with Dexp in aqueous solution. The formed supramolecular hydrogels were thoroughly characterized by transmission electron microscopy(TEM), fluorescent spectrum, circular dichroism(CD) spectra and rheology. The peptide concentration significantly affected the in vitro release behavior of Dexp from the supramolecular hydrogel, and the higher peptide concentration resulted in the slower drug release.Following a single intravitreal injection, the proposed Nap FFKKFKLKL/Dexp hydrogel displayed good intraocular biocompatibility without having an adverse impact on the retinal architecture and eyesight functions during one month of follow-up. Using an experimental autoimmune uveitis(EAU) rat model,we demonstrated that the resulting Nap FFKKFKLKL/Dexp hydrogel had potent capacity to alleviate the intraocular inflammation and retain the morphology of retinal architecture. Overall, the resulting Nap FFKKFKLKL/Dexp hydrogel may be a promising drug carrier system to treat various posterior disorders(i.e., uveitis). | Xianglian Li Hui Liu Ailing Yu Dan Lin Zhishu Bao Yuqin Wang Xingyi Li | 2021 | Chinese Chemical Letters2021，32，12： | 0 |
| 18 | Peanut drying:Effects of various drying methods on drying kinetic models,physicochemical properties,germination characteristics,and microstructure显示文摘The current work aims to explore the suitable drying technique for peanut pods which can be used for seeds or edible peanuts.Four drying methods,namely naturally-open sun drying as the control check(CK),hot air drying(HAD),pulsed vacuum drying(PVD),and radio frequency combined hot air drying(RF-HAD),were employed to dry peanut pods,and their effects on the nutritional quality attributes in terms of protein,fat,fatty acid contents,etc.,germination characteristics,microstructure,color,texture,acid value and peroxide value of peanuts were explored.Mathematical models of peanuts drying with four drying methods were also established.According to the statistical parameters including the determination coefficient(R^(2))、root mean square error(RMSE)and chi-square value(v^(2)),theWeibull model was best for predicting the moisture ratio change kinetics of peanuts during its four drying processes.There were significant differences in physicochemical indexes of peanut by different drying methods(p<0.05).Fat and oleic acid contents under RF-HAD were significantly higher than those by the other three drying methods.Compared with the naturally-open sun drying,RF-HAD reduced drying time by 76.70%and the microstructure of RF-HAD peanuts produced larger and more cavities.The RF-HAD kept better comprehensive nutritional quality,but the germination rate was reduced by 27.80%.PVD could maintain good nutritional quality and germination rate among these mechanical drying technologies.However,PVD had a longer drying time of 9.5 h than RF-HAD and HAD,and the microstructure of pulsed vacuum dried peanuts showed dense structure and less cavity.Hot air-dried peanut kernel held the highest protein(28.75%),fatty acids contents(26.11%)and germination rate(88.00%).However,peanut kernel dried by HAD showed poor qualities,such as high acid value,peroxide value and large color changes.These findings indicated RF-HAD was a promising drying technique for edible peanuts regarding the higher drying rate and better-quality preservation,while HAD was suitable for peanut seeds drying as it could well protect the germination rate. | Yongkang Xie Yawen Lin Xingyi Li Hui Yang Junhao Han Chaojie Shang Aiqing Li Hongwei Xiao Fengyin Lu | 2023 | Information Processing in Agriculture2023，10，4： | 0 |
| 19 | Recommendation on data collection and annotation of ocular appearance images in ptosis显示文摘Ptosis is a common ophthalmologic condition,and the diagnosis is primarily based on ocular appearance.Thediagnosis of such conditions can be improved using emerging technology such as artificial intelligence-basedmethods.However,unified data collection and labeling standards have not yet been established.This directlyimpacts the accuracy of ptosis diagnosis based on appearance alone.Therefore,in the present study,we aimedto establish a procedure to obtain and label images to devise a recommendation system for optimal recognitionof ptosis based on ocular appearances.This would help to standardize and facilitate data sharing and serve as aguideline for the development and improvisation of algorithms in artificial intelligence for ptosis. | Jie Meng Binying Lin Dongmei Li Shiqi Hui Xuanwei Liang Xianchai Lin Zhen Mao Xingyi Li Zuohong Li Rongxin Chen Yahan Yang Ruiyang Li Anqi Yan Haotian Lin Danping Huang Chinese Association of Artificial Intelligence,Medical Artificial IntelligenceBranch of Guangdong Medical Association | 2023 | Intelligent Medicine2023，3，4： | 0 |
| 20 | Self-powered electrochemical water treatment system for pollutant degradation and bacterial inactivation based on high-efficient Co(OH)_(2)/Pt electrocatalyst显示文摘Electrochemical system with electro-Fenton reaction is an effective pathway for oxidative degradation of refractory organic pollutants for water treatment.However,the method is limited by the low catalytic efficiency and high electrical cost in practical applications.This work presents a self-powered and high-efficient electrochemical system for water treatment including pollutant degradation and bacterial inactivation,which is composed of a self-powered triboelectric nanogenerator(TENG)converting mechanical energy into electrical energy,a power management circuit integrated with a supercapacitor to store the harvesting electrical energy temporarily,and an electrochemical setup integrated with two-dimentional Co(OH)_(2)/Pt nanosheet as electrocatalyst.The nanocatalyst,ultrafine Pt nanoparticles(Pt NPs)loaded on Co(OH)_(2) nanosheet(Co(OH)_(2)/Pt),is synthesized by a facile one step hydrothermal reaction without any surfactant,which can improve H_(2)O_(2)and hydroxyl radical production via redox reaction.This self-powered electrocatalytic system is able to degrade nearly 100%of organic pollutant within 100 min,and efficiently kill bacteria.This work shows great potential to develop high-efficient and self-powered electrochemical water treatment system through integrating TENG and nanocatalyst. | Zhuo Wang Xi Liang Zhirong Liu Tian Huang Shaobo Wang Shuncheng Yao Yiming Ding Jiaming Zhang Xingyi Wan Zhong Lin Wang Linlin Li | 2023 | Nano Research2023，16，2： | 0 |
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