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| 1 | An in vivo study with an MRI tracer method reveals the biophysical properties of interstitial fluid in the rat brain显示文摘The nature of brain interstitial fluid (ISF) has long been a subject of controversy. Most of the previous studies on brain ISF were carried out in vitro. In the present study, a novel method was developed to characterize ISF in the living rat brain by magnetic resonance (MR) imaging using gadolinium-diethylenetriaminepentaacetic acid (Gd-DTPA) as a tracer. Sprague Dawley rats (n=8) were subjected to MR scanning before and after the introduction of Gd-DTPA into the caudate nucleus. A one-way drainage of brain ISF was demonstrated on the dynamic MR images. According to the traditional diffusion model, the diffusion and clearance rate constants of the tracer within brain extracellular space (ECS) were derived as (3.38±1.07)×10-4 mm 2 s-1 and (7.60±4.18)×10-5 s-1 . Both diffusion and bulk flow contributed to the drainage of ISF from the caudate nucleus, which demonstrated an ISF-cerebrospinal fluid confluence in the subarachnoid space at the lateral and ventral surface of the brain cortex at 3 h after the injection. By using this newly developed method, the brain ECS and ISF can be quantitatively measured simultaneously in the living brain, which will enhance the understanding of ISF and improve the efficiency of drug therapy via the brain interstitium. | HAN HongBin LI Kai YAN JunHao ZHU Kai FU Yu | 2012 | Science China(Life Sciences)2012，55，9： | 25 |
| 2 | Reproductive management through integration of PGD and MPS-based noninvasive prenatal screening/diagnosis for a family with GJB2-associated hearing impairment显示文摘A couple with a proband child of GJB2(encoding the gap junction protein connexin 26)-associated hearing impairment and a previous pregnancy miscarriage sought for a reproductive solution to bear a healthy child. Our study aimed to develop a customized preconception-to-neonate care trajectory to fulfill this clinical demand by integrating preimplantation genetic diagnosis(PGD), noninvasive prenatal testing(NIPT), and noninvasive prenatal diagnosis(NIPD) into the strategy. Auditory and genetic diagnosis of the proband child was carried out to identify the disease causative mutations. The couple then received in-vitro-fertilization treatment, and eight embryos were obtained for day 5 biopsy. PGD was performed by short-tandem-repeat linkage analysis and Sanger sequencing of GJB2 gene. Transfer of a GJB2 c.235del C heterozygous embryo resulted in a singleton pregnancy. At the 13 th week of gestation, genomic DNA(g DNA) from the trio family and cell-free DNA(cf DNA) from maternal plasma were obtained for assessment of fetal chromosomal aneuploidy and GJB2 mutations. NIPT and NIPD showed the absence of chromosomal aneuploidy and GJB2-associated disease in the fetus, which was later confirmed by invasive procedures and postnatal genetic/auditory diagnosis. This strategy successfully prevented the transmission of hearing impairment in the newborn, thus providing a valuable experience in reproductive management of similar cases and potentially other monogenic disorders. | XIONG WenPing WANG DaYong GAO Yuan GAO Ya WANG HongYang GUAN Jing LAN Lan YAN JunHao ZONG Liang YUAN Yuan DONG Wei HUANG SeXin WU KeLiang WANG YaoShen WANG ZhiLi PENG HongMei LU YanPing XIE LinYi ZHAO Cui WANG Li ZHANG QiuJing GAO Yun LI Na YANG Ju YIN ZiFang HAN Bing WANG Wei CHEN Zi-Jiang WANG QiuJu | 2015 | Science China(Life Sciences)2015，58，9： | 12 |
| 3 | Mitochondrial replacement by pre-pronuclear transfer in human embryos显示文摘 | Wu, Keliang Chen, Tailai Huang, Sexin Zhong, Cuiqing Yan, Junhao Zhang, Xiaoyu Li, Jinsong Gao, Yuan Zhao, Han Chen, Zi-Jiang | 2017 | Cell Research2017，27，6： | 7 |
| 4 | Numerical simulation on the seismic absorption effect of the cushion in rigid-pile composite foundation显示文摘In order to quantitatively study the seismic absorption effect of the cushion on a superstructure, a numerical simulation and parametric study are carried out on the overall FEA model of a rigid-pile composite foundation in ABAQUS. A simulation of a shaking table test on a rigid mass block is first completed with ABAQUS and EERA, and the effectiveness of the Drucker-Prager constitutive model and the finite-infinite element coupling method is proved. Dynamic time-history analysis of the overall model under frequent and rare earthquakes is carried out using seismic waves from the El Centro, Kobe, and Bonds earthquakes. The different responses of rigid-pile composite foundations and pile-raft foundations are discussed. Furthermore, the influence of thickness and modulus of cushion, and ground acceleration on the seismic absorption effect of the cushion are analyzed. The results show that: 1) the seismic absorption effect of a cushion is good under rare earthquakes, with an absorption ratio of about 0.85; and 2) the seismic absorption effect is strongly affected by cushion thickness and ground acceleration. | Han Xiaolei Li Yaokun Ji Jing Ying Junhao Li Weichen Dai Baicheng | 2016 | Earthquake Engineering and Engineering Vibration2016，15，2： | 5 |
| 5 | Effect of disconnector and high-voltage conductor on propagation characteristics of PD-induced UHF signals显示文摘UHF(ultra high frequency)method has been widely used in PD(partial discharge)detection for its high sensitivity.The resonance,distortion,and attenuation appearing in the propagation process of UHF signals in GIS(gas insulated switchgear)will influence the real situation of PD detection.Therefore,it is necessary to investigate the effect of GIS components such as disconnectors or high voltage conductors on the propagation characteristics of PD-induced UHF signals in various voltage classes GIS.The factors of PD signals propagation characteristics in axial and radial directions are both analysed to avoid the effect caused by placement of sensor in this paper.First,the simulation models of GIS are built based on FDTD(finite difference time domain)method.Then the propagation characteristics of PD-induced UHF signals are studied in the GIS with different disconnector gap lengths and different high voltage conductor radii.Finally,the reliability of the simulation results is verified by compared with laboratory tests.The disconnector gap and the change of conductor radii can both result in the signals attenuation which rises highest in the direction of 180°.The lower the GIS class voltage is,the larger the attenuation of signals after passing through disconnector gap is. | Minxia Shi Xutao Han Xuanrui Zhang Zheming Zhang Junhao Li | 2018 | High Voltage2018，3，3： | 2 |
| 6 | Influence of freeze tube deviation on the development of frozen wall during long cross-passage construction显示文摘This paper investigates the influence of the deviation in freeze pipe installation on the development of the frozen wall in long cross passages by numerical simulation with ANSYS software.The study case is from the artificial ground freezing project along the Fuzhou Metro Line 2 between Ziyang Station and Wuliting Station.Two freezepipe configurations,i.e.,one with perfectly aligned pipes without any deviation from design and another with randomly distributed deviation,are included for comparison.The effect of the random deviation in the freeze pipes on frozen wall interconnection time,the thickness of the frozen wall and the development of the temperature field is explored.For the characteristic section of the numerical model at a depth of 25 m,it is found that the frozen wall interconnection time under the random deviation case and no deviation case is 24 days and 18 days,respectively.The difference in the thickness of the thinnest frozen wall segment between the random deviation and no deviation cases is the largest in the early freezing stage(up to 0.75 m),which decreases with time to 0.31 m in the late freezing stage.The effects of random deviation are more significant in the early freezing stage and diminish as the freezing time increases. | JunHao Chen JianLin Wang LeXiao Wang Han Li MeiLin Chen | 2022 | Research in Cold and Arid Regions2022，14，4： | 2 |
| 7 | Early changes to the extracellular space in the hippocampus under simulated microgravity conditions显示文摘The smooth transportation of substances through the brain extracellular space(ECS)is crucial to maintaining brain function;however,the way this occurs under simulated microgravity remains unclear.In this study,tracer-based magnetic resonance imaging(MRI)and DECS-mapping techniques were used to image the drainage of brain interstitial fluid(ISF)from the ECS of the hippocampus in a tail-suspended hindlimb-unloading rat model at day 3(HU-3)and 7(HU-7).The results indicated that drainage of the ISF was accelerated in the HU-3 group but slowed markedly in the HU-7 group.The tortuosity of the ECS decreased in the HU-3 group but increased in the HU-7 group,while the volume fraction of the ECS increased in both groups.The diffusion rate within the ECS increased in the HU-3 group and decreased in the HU-7 group.The alterations to ISF drainage and diffusion in the ECS were recoverable in the HU-3 group,but neither parameter was restored in the HU-7 group.Our findings suggest that early changes to the hippocampal ECS and ISF drainage under simulated microgravity can be detected by tracer-based MRI,providing a new perspective for studying microgravity-induced nano-scale structure abnormities and developing neuroprotective approaches involving the brain ECS. | Yajuan Gao Hongbin Han Jichen Du Qingyuan He Yanxing Jia Junhao Yan Hui Dai Bin Cui Jing Yang Xunbin Wei Liu Yang Rui Wang Ren Long Qiushi Ren Xing Yang Jiabin Lu | 2022 | Science China(Life Sciences)2022，65，3： | 2 |
| 8 | Original Sedimentary Pattern of an Inverted Basin:A Case Study from the Bozhong Depression,Offshore Bohai Bay Basin显示文摘The third member of Shahejie Formation(Sha-3 member; 42–38Ma of Eocene) in the Bozhong Depression,offshore Bohai Bay Basin was subject to multiple post-depositional modifications. The present structural framework of the Bozhong Depression,which is characterized by sags alternating with uplifts,does not reflect its original sedimentary pattern. Previous studies have not discussed the post-depositional modification of this succession,including the sedimentary pattern variations and the depositional geodynamic setting. This work determined the characteristics of the post-depositional modification and original sedimentary pattern of the Bozhong Depression through analysis of seismic data,well-log data and fission-track ages. The results demonstrate that the Shijiutuo rise,a major structural feature of the current basin,did not exist during the major depositional stage of the Sha-3 member,when the Qinnan sag was largely connected to the Bozhong sag to form a single contiguous deposition area within the basin. By contrast,the Shaleitian and Chengbei rises,located in the western part of the Bozhong Depression,have existed before the depositional period of the Eocene Sha-3 member; these features were manifested as syn-depositional tilted fault blocks,the uplifted footwall blocks of which provided sediments for the neighboring Shanan and Chengbei sags. The western part of the Bonan low rise,located in the southern part of the Bozhong Depression,did not experience uplifting during the depositional phase of the Eocene Sha-3 member. The Huanghekou sag was connected with the Bozhong sag in the western part of the Bozhong Depression. The original sedimentary boundary of the southern Miaoxi sag possibly extended eastward about 10 km and connected with the Bozhong sag at its northern part. The present-day Bodong low rise,which is bounded by the Tan–Lu fault zone,also formed after the depositional period of Eocene Sha-3 member. It is thus concluded that the Bozhong Depression formed a connected large-scale sub-basin during the depositional stage of the Eocene Sha-3 member. Several neighboring sags that are now separated by rises,including the Qinnan,Shanan,Chengbei,Huanghekou,Miaoxi and Bodong sags,formed a single contiguous depositional area during the Eocene. The significant differences between the present and original basin patter and framework provide valuable information for better understanding the history of basin inversion and its impact on related hydrocarbon-system evolution. | ZHAO Junfeng LIU Chiyang HUANG Lei MOUNTNEY Nigel HAN Shaojia LIU Peng HU Junhao | 2016 | Acta Geologica Sinica(English Edition)2016，90，6： | 2 |
| 9 | The effect of SARS-CoV-2 infection on human embryo early development:a multicenter prospective cohort study显示文摘Dear Editor,Severe acute respiratory syndrome coronavirus 2(SARSCo V-2)infection has swept the globe for 3 years(Zhou et al.,2020).With the nationwide relaxation of controls on the coronavirus disease 2019(COVID-19)epidemic since December 2022 in China,fertility and in vitro fertilization(IVF)centers are receiving increasing numbers of infected patients. | Xiaolei Chen Huangcong Shi Cheng Li Wanxia Zhong Linlin Cui Wenjun Zhang Ling Geng Kuona Hu Mei Fang Daimin Wei Junhao Yan Yun Sun Keliang Wu Han Zhao Zi-Jiang Chen | 2023 | Science China(Life Sciences)2023，66，7： | 1 |
| 10 | DYZ1 copy number variation, Y chromosome polymorphism and early recurrent spontaneous abortion/early embryo growth arrest显示文摘 | Junhao Yan Lingling Fan Yueran Zhao Li You Laicheng Wang Han Zhao Yuan Li Zi-Jiang Chen | 2011 | European Journal of Obstetrics and Gynecology2011，，2： | 1 |
| 11 | First-principles study on the alkali chalcogenide secondary compounds in Cu(In,Ga)Se_2 and Cu_2ZnSn(S,Se)_4 thin film solar cells显示文摘The beneficial effect of the alkali metals such as Na and K on the Cu(In,Ga)Se_2(CIGS) and Cu_2ZnSn(S,Se)_4(CZTSSe) solar cells has been extensively investigated in the past two decades, however, in most of the studies the alkali metals were treated as dopants. Several recent studies have showed that the alkali metals may not only act as dopants but also form secondary phases in the absorber layer or on the surfaces of the films. Using the first-principles calculations, we screened out the most probable secondary phases of Na and K in CIGS and CZTSSe, and studied their electronic structures and optical properties. We found that all these alkali chalcogenide compounds have larger band gaps and lower VBM levels than CIGS and CZTSSe, because the existence of strong p-d coupling in CIS and CZTS pushes the valence band maximum(VBM) level up and reduces the band-gaps, while there is no such p-d coupling in these alkali chalcogenides. This band alignment repels the photo-generated holes from the secondary phases and prevents the electron-hole recombination. Moreover, the study on the optical properties of the secondary phases showed that the absorption coefficients of these alkali chalcogenides are much lower than those of CIGS and CZTSSe in the energy range of 0-3.4 e V, which means that the alkali chalcogenides may not influence the absorption of solar light. Since the alkali metal dopants can passivate the grain boundaries and increase the hole carrier concentration, and meanwhile their related secondary phases have innocuous effect on the optical absorption and band alignment, we can understand why the alkali metal dopants can improve the CIGS and CZTSSe solar cell performance. | Xian Zhang Dan Han Shiyou Chen Chungang Duan Junhao Chu | 2018 | Journal of Energy Chemistry2018，27，4： | 1 |
| 12 | Blood–brain barrier disruption following subarchnoid hemorrhage may be faciliated through PUMA induction of endothelial cell apoptosis from the endoplasmic reticulum显示文摘 | Junhao Yan Li Li Nikan H. Khatibi Lei Yang Ke Wang Weiguang Zhang Robert D. Martin Jingyan Han John Zhang Changman Zhou | 2011 | Experimental Neurology2011，，2： | 1 |
| 13 | Effects of ARHI on breast cancer cell biological behavior regulated by microRNA-221显示文摘 | Ying Li Mei Liu Yanjun Zhang Chun Han Junhao You Junlan Yang Cheng Cao Shunchang Jiao | 2013 | Tumor Biology2013，，6： | 1 |
| 14 | Hydrothermal Synthesis and Phase-, Morphology-Evolution Mechanism of Lead Titanate Nanostructures Assisted with Tetramethylammonium Hydroxide显示文摘 | Liang Bao Junhao He Gang Xu Yangang Zhao Xin Yang Ge Shen Gaorong Han | 2017 | Chinese Journal of Chemistry2017，35，7： | 0 |
| 15 | Innovation and Practice of Training Mode for Professional Postgraduates of Acupuncture and Tuina Based on Artificial Intelligence显示文摘In view of the common problems of integrating artificial intelligence into the training of postgraduates in Acupuncture and Tuina major,this paper reviews the related research progress both at home and abroad.It puts forward the innovative reform paths for integrating artificial intelligence into postgraduate training mode of Acupuncture and Tuina major:construct the teaching staff of artificial intelligence graduate students;innovating artificial intelligence to promote the integration of classics and scientific research;constructing the ideological and political case base of artificial intelligence courses;implementing artificial intelligence platform blended teaching;building a domestic and foreign exchange platform for artificial intelligence.Through practical research in teaching,it has achieved good teaching results and played a good demonstration,leading and radiation role in similar majors in China. | Mingjun LIU Xiaochao GANG Zhengri CONG Junhao HU Jianfeng LIANG Chongwen ZHONG Xinyi YUAN Bing DAI Yuzhe ZHANG Lijie LI Tianyi MU Yiran HAN Chaochao HUA | 2024 | Asian Agricultural Research2024，16，3： | 0 |
| 16 | Time-resolved visualization of coherent structures during supersonic boundary layer transition显示文摘The coherent structures arising during flat-plate boundary layer transition at Mach num-ber 3.4 are investigated using a custom-built hyper-rate imaging system.The evolution of transi-tional structures is investigated in the Eulerian and Lagrangian reference frames.The upstream evolution of transition is dominated by the generation of new hairpin structures,while the interac-tion among multiple structural types dominates the evolution downstream.The breakdown of the existing structure,which may be caused by interactions among multiple types of structures with sim-ilar scales,is also visualized. | Lin HE Xiaoge LU Junhao HAN Zhengbang WU Shihe YI | 2023 | Chinese Journal of Aeronautics2023，36，4： | 0 |
| 17 | Ore-controlling Regularitiesof Structureinthe Lehong Lead-zinc Deposit, Northeastern Yunnan显示文摘1 Introduction The Lehonglead-zincdeposit is a large-sized Pb-Zn depositnewly found in recent years in the Sichuan-Yunnan-Guizhou Lead-zinc Poly-metallic Mineralization Area,which occurrenceis | CUI Junhao HAN Runsheng ZHAO Dong ZHANG Xiaopei | 2017 | Acta Geologica Sinica(English Edition)2017，91，S1： | 0 |
| 18 | Peanut drying:Effects of various drying methods on drying kinetic models,physicochemical properties,germination characteristics,and microstructure显示文摘The current work aims to explore the suitable drying technique for peanut pods which can be used for seeds or edible peanuts.Four drying methods,namely naturally-open sun drying as the control check(CK),hot air drying(HAD),pulsed vacuum drying(PVD),and radio frequency combined hot air drying(RF-HAD),were employed to dry peanut pods,and their effects on the nutritional quality attributes in terms of protein,fat,fatty acid contents,etc.,germination characteristics,microstructure,color,texture,acid value and peroxide value of peanuts were explored.Mathematical models of peanuts drying with four drying methods were also established.According to the statistical parameters including the determination coefficient(R^(2))、root mean square error(RMSE)and chi-square value(v^(2)),theWeibull model was best for predicting the moisture ratio change kinetics of peanuts during its four drying processes.There were significant differences in physicochemical indexes of peanut by different drying methods(p<0.05).Fat and oleic acid contents under RF-HAD were significantly higher than those by the other three drying methods.Compared with the naturally-open sun drying,RF-HAD reduced drying time by 76.70%and the microstructure of RF-HAD peanuts produced larger and more cavities.The RF-HAD kept better comprehensive nutritional quality,but the germination rate was reduced by 27.80%.PVD could maintain good nutritional quality and germination rate among these mechanical drying technologies.However,PVD had a longer drying time of 9.5 h than RF-HAD and HAD,and the microstructure of pulsed vacuum dried peanuts showed dense structure and less cavity.Hot air-dried peanut kernel held the highest protein(28.75%),fatty acids contents(26.11%)and germination rate(88.00%).However,peanut kernel dried by HAD showed poor qualities,such as high acid value,peroxide value and large color changes.These findings indicated RF-HAD was a promising drying technique for edible peanuts regarding the higher drying rate and better-quality preservation,while HAD was suitable for peanut seeds drying as it could well protect the germination rate. | Yongkang Xie Yawen Lin Xingyi Li Hui Yang Junhao Han Chaojie Shang Aiqing Li Hongwei Xiao Fengyin Lu | 2023 | Information Processing in Agriculture2023，10，4： | 0 |
| 19 | Tectonic Geochemical Characteristics and Ore Prediction in Hongdoushan Copper Deposit, Yunxian, Yunnan显示文摘South Lancangjiang metallogenic condition is superior,the volcanic arc metallogenic belt has been praised by geologists,the north district of Guanfang,Wenyu copper prospecting research has made important progress in recent years,the paper study in the Hongdoushan mountain copper deposit(the newly discovered deposits) | GUO Zehua WANG Lei HAN Runsheng WANG Jiasheng BAI Longan QIU Wenlong LIU Fei CUI Junhao TAN Wei | 2017 | Acta Geologica Sinica(English Edition)2017，91，S1： | 0 |
| 20 | Influence of Beta-Cyclodextrin Functionalized Tin Phenylphosphonate on the Thermal Stability and Flame Retardancy of Epoxy Composites显示文摘To enhance the thermal stability and flame retardancy of epoxy resin(EP),beta-cyclodextrin(β-CD)is successfully introduced into the layered tin phenylphosphonate(SnPP),which is incorporated into EP matrix for preparing EP/β-CD@SnPP composites.The results indicate that the addition ofβ-CD@SnPP obviously improve the thermal stability and residual yield of EP composites at higher temperature.When the amount ofβ-CD@SnPP is only 4 wt%,EP/4β-CD@SnPP composites pass V-1 rating,and LOI value is up to 30.8%.Meanwhile,β-CD@SnPP effectively suppress the heat release and reduce the smoke production of EP/β-CD@SnPP composites in combustion,and the peak heat release rate(PHRR),total heat release(THR),smoke production rate(SPR)of EP/6β-CD@SnPP composites reduce by 28.4%,33.0%and 44.8%by comparison with those of pure EP.The good flame retardancy and smoke suppression are ascribed to the synergistic effect of excellent carbon-forming capability and fire retardancy ofβ-CD@SnPP. | Yongming Chen Shuai Huang Han Zhao Ru Yang Yining He Tianyu Zhao Yunlong Zhang Qinghong Kong Shasha Sun Junhao Zhang | 2022 | Journal of Renewable Materials2022，10，12： | 0 |
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