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| 1 | Programmed Death Ligand-1 on Microglia Regulates Th1 Differentiation via Nitric Oxide in Experimental Autoimmune Encephalomyelitis显示文摘Microglia are considered to be potential antigen-presenting cells and have the ability to present antigen under pathological conditions. Nevertheless, whether and how microglia are involved in immune regulation are largely unknown. Here, we investigated the suppressive activity of microglia during experimental autoimmune encephalomyelitis(EAE) induced by myelin oligodendrocyte glycoprotein, with the goal of understanding their role in regulating the T cell reaction. Using flow cytometric analysis, we found that microglia were characterized by increased cell number and up-regulated programmed death ligand-1(PD-L1) at the peak phase of EAE. Meanwhile,both the CD^(4+)T cells and microglia that infiltrated the central nervous system expressed higher levels of PD1, the receptor for PD-L1, accompanied by a decline of Th1 cells.In an ex vivo co-culture system, microglia from EAE mice inhibited the proliferation of antigen-specific CD^(4+)T cells and the differentiation of Th1 cells, and this was significantly inhibited by PD-L1 blockade. Further,microglia suppressed Th1 cells via nitric oxide(NO), the production of which was dependent on PD-L1. Thus, these data suggest a scenario in which microglia are involved in the regulation of EAE by suppressing Th1-cell differentiation via the PD-L1-NO pathway. | Jingxia Hu Hao He Zhengang Yang Guangming Zhu Li Kang Xiuli Jing Hai Lu Wengang Song Bo Bai Hua Tang | 2016 | Neuroscience Bulletin2016，32，1： | 9 |
| 2 | Effect of rapid quenching on the microstructure and electrochemical characteristics of La_(0.6)Ce_(0.4)Ni_(3.6)Co_(0.65)Mn_(0.4)Al_(0.2)Ti_(0.05_(FeB)_(0.1) hydrogen storage alloy显示文摘In order to improve the cycling stability of AB5 type alloy electrodes,rapid quenching technology and new alloy composition design were employed.A hydrogen storage alloy with nominal composition La0.6Ce0.4Ni3.6Co0.65Mn0.4Al0.2Ti0.05(FeB)0.1 was prepared by vacuum magnetic levitation melting under high purity argon atmosphere,followed by rapid quenching at different cooling rates.XRD results show that all alloys exhibit the single-phase CaCu5-type structure.Electrochemical tests indicate that rapid quenching can slightly improve the cycling life of the alloy.Nevertheless,the high-rate dischargeability of the quenched alloys is lower than that of the as-cast alloy. | ZHANG Peilong SONG Xiping WANG Xiuli PEI Pei LUO Guiping TU Jiangping CHEN Guoliang | 2010 | Rare Metals2010，29，6： | 4 |
| 3 | Change in Sediment Provenance Near the Current Estuary of Yellow River Since the Holocene Transgression显示文摘Sedimentary sequence and sediment provenance are important factors when it comes to the studies on marine sedimentation. This paper studies grain size distribution, lithological characteristics, major and rare earth elemental compositions, micropaleontological features and ^(14)C ages in order to examine sedimentary sequence and sediment provenance of the core BH6 drilled at the mouth of the Yellow River in Bohai Sea. According to the grain size and the micropaleontological compositions, 4 sedimentary units have been identified. Unit 1(0–8.08 mbsf) is of the delta sedimentary facies, Unit 2(8.08–12.08 mbsf) is of the neritic shelf facies, Unit 3(12.08–23.85 mbsf) is of near-estuary beach-tidal facies, and Unit 4(23.85 mbsf–) is of the continental lake facies. The deposits from Unit 1 to Unit 3 have been found to be marine strata formed after the Holocene transgression at about 10 ka BP, while Unit 4 is continental lacustrine deposit formed before 10 ka BP. The provenances of core BH6 sediments show properties of the continental crust and vary in different sedimentary periods. For Unit 4 sediments, the source regions are dispersed while the main provenance is not clear, although the parent rock characteristics of a few samples are similar to the Luanhe River sediments. For Unit 3, sediments at 21.1–23.85 mbsf have been mainly transported from the Liaohe River, while sediments above 21.1 mbsf are mainly from the Yellow River and partially from the Liaohe River. For Unit 2, the sediments have been mainly transported from the Yellow River, with a small amount from other rivers. For Unit 1, the provenance is mainly the Yellow River catchment. These results help in better understanding the evolution of the Yellow River Delta. | SONG Sheng FENG Xiuli LI Guogang LIU Xiao XIAO Xiao FENG Li | 2018 | Journal of Ocean University of China2018，17，3： | 3 |
| 4 | Exome sequencing reveals genetic architecture in patients with isolated or syndromic short stature显示文摘Short stature is among the most common endocrinological disease phenotypes of childhood and may occur as an isolated finding or in conjunction with other clinical manifestations.Although the diagnostic utility of clinical genetic testing in short stature has been implicated,the genetic architecture and the utility of genomic studies such as exome sequencing(ES)in a sizable cohort of patients with short stature have not been investigated systematically.In this study,we recruited 561 individuals with short stature from two centers in China during a 4-year period.We performed ES for all patients and available parents.All patients were retrospectively divided into two groups:an isolated short stature group(group I,n=257)and an apparently syndromic short stature group(group II,n=304).Causal variants were identified in 135 of 561(24.1%)patients.In group I,29 of 257(11.3%)of the patients were solved by variants in 24 genes.In group II,106 of 304(34.9%)patients were solved by variants in 57 genes.Genes involved in fundamental cellularprocess played an important role in the genetic architecture of syndromic short stature.Distinct genetic architectures and pathophysiological processes underlie isolated and syndromic short stature. | Xin Fan Sen Zhao Chenxi Yu Di Wu Zihui Yan Lijun Fan Yanning Song Yi Wang Chuan Li Yue Ming Baoheng Gui Yuchen Niu Xiaoxin Li Xinzhuang Yang Shiyu Luo Qiang Zhang Xiuli Zhao Hui Pan Mei Li Weibo Xia Guixing Qiu Pengfei Liu Shuyang Zhang Jianguo Zhang Zhihong Wu James R.Lupski Jennifer E.Posey Shaoke Chen Chunxiu Gong Nan Wu | 2021 | Journal of Genetics and Genomics2021，48，5： | 2 |
| 5 | Molecular characterization of the genome of duck enteritis virus显示文摘 | Yufeng Li Bing Huang Xiuli Ma Jing Wu Feng Li Wu Ai Minxun Song Hanchun Yang | 2009 | Virology2009，，2： | 2 |
| 6 | Substituent groups from aromatic dicarboxylates modulated structural diversification in the assembly of Co(Ⅱ)complexes based on the bis-pyridyl-bis-amide ligands显示文摘Four coordination polymers based on two bis-pyridyl-bis-amide ligands and three aromatic dicarboxylates with different substituent groups, namely, [Co(3-bpcb) 1.5 (NPH)(H2O)]·4H2O (1), [Co(3-bpcb)(NIPH)] (2), [Co(3-bpcb)0.5 (5-H2 AIP)]·2H2O (3), [Co(3-bpcd) 0.5 (5-H2 AIP)(H2O)]·2H2O (4) [3-bpcb = N,N′-bis(3-pyridinecarboxamide)-1,4-benzene, 3-bpcd = N,N′-bis(3- pyridine)cyclohexane-1,4-dicarboxamide, H2 NPH = 3-nitrophthalic acid, H2 NIPH = 5-nitroisophthalic acid, 5-H4 AIP = 5-aminoisophthalic acid] have been synthetized under hydrothermal conditions. Complex 1 displays a one dimensional (1D) chain based on the binuclear [Co2 (NPH)2 ] units and 3-bpcb ligands, which is extended into a three dimensional (3D) supramolecular framework through hydrogen bonding and - stacking interactions. In complex 2, the (3,5)-connected two dimensional (2D) layers are constructed from 1D Co-NIPH chains and bidentate-bridging 3-bpcb ligands. Complex 3 is a 2D double layer based on Co-5-H2 AIP 2D layers and 3-bpcb pillars. Complex 4 also displays a 2D network, which is constructed from the Co-5-H2AIP 1D double chains and 3-bpcd ligands. Finally, complexes 2-4 are extended into 3D supramolecular frameworks by hydrogen bonding or - stacking interactions. The substituent groups of dicarboxylates play an important role in the assembly and structures of the title complexes. In addition, the fluorescent properties of complexes 1-4 and the electrochemical behaviors of 3 and 4 at room temperature have been investigated. | WANG XiuLi MU Bao LIN HongYan YANG Song LIU GuoCheng TIAN AiXiang ZHANG JuWen | 2013 | Science China Chemistry2013，56，5： | 2 |
| 7 | Enantioselective sensing of chiral aminoacids by potentiometricsensors based on optical active polyaniline films显示文摘 | Yin Xiuli Ding Jingjing Zhang Song Kong Jilie | | 0，，： | 1 |
| 8 | Biodegradable soy protein isolate-based materials: a review 显示文摘 | SONG Fei TANG Daolu WANG Xiuli | 2011 | Biomacromolecules2011，12，10： | 1 |
| 9 | Dl-3-n butylphthalide attenuates brain injury caused by cortical infarction accompanied by cranial venous drainage disturbance显示文摘Background Cerebral venous disorder may have a harmful effect on ischaemic stroke;however,the underlying mechanism remains to be elucidated.Although Dl-3-n butylphthalide is a multitarget agent for antiischaemic stroke,its neuroprotective role in brain ischaemia accompanied by brain venous disturbance remains unclear.In this study,we induced cerebral venous disturbance by the occlusion of bilateral external jugular veins(EJVs)to explore the potential mechanism of the adverse effects of cerebrovenous disorders in cerebral infarction and explore the protective effect of Dl-3-n butylphthalide on cerebral infarction accompanied through cerebral venous disturbance.Methods Cerebral venous disturbance was induced in Sprague-Dawley rats through the permanent occlusion of bilateral EJVs,and cerebral ischaemic stroke was induced through the permanent occlusion of the right cortical branches of the middle cerebral artery.2,3,5-triphenyltetrazolium chloride staining,MRI,Evans blue extravasation and behavioural test were performed to evaluate infarction volume,cerebral blood flow(CBF),blood-brain barrier(BBB)integrity and neurological function.Immunofluorescence staining and western blot analysis were performed to detect loss of neuron,endothelial cells,pericytes and tight junctions.Results Bilateral EJVs occlusion did not cause cerebral infarction;however,it increased the infarction volume compared with the simple middle cerebral artery occlusion(MCAO)group,accompanied by severe neuron loss,worse neurological function,lower CBF,increased EJVs pressure,exacerbated Evans blue extravasation and brain oedema,as well as attenuated angiogenesis.Dl-3-n butylphthalide displayed a neuroprotective effect in rats with MCAO accompanied by EJVs occlusion by reducing neuron loss,accelerating CBF restoration,promoting angiogenesis and relieving BBB damage.Conclusion Bilateral EJVs occlusion did not significantly affect normal rats but aggravated brain damage in the case of ischaemic stroke.Dl-3-n butylphthalide treatment plays a neuroprotective role in rats with MCAO accompanied by EJVs occlusion,mainly due to the promotion of CBF restoration and BBB protection. | Kangping Song Xiuli Zeng Xiaomei Xie Rongxuan Zhu Jianye Liang Guobing Chen Li’an Huang | 2022 | Stroke & Vascular Neurology2022，7，3： | 1 |
| 10 | 显示文摘 | YIN Xiuli DING Jingjing ZHANG Song | 2006 | Biosensors and Bioelectronics2006，21，： | 1 |
| 11 | Enantioselective sensing of chiral amino acids by potentiometric sensors based on optical active polyaniline films 显示文摘 | Yin Xiuli Ding Jingjing Zhang Song | 2006 | Biosensors and Bioelectronics2006，21，： | 1 |
| 12 | Effect of acetylation on the properties of corn starch显示文摘 | Hui Chi Kun Xu Xiuli Wu Qiang Chen Donghua Xue Chunlei Song Wende Zhang Pixin Wang | 2007 | Food Chemistry2007，，3： | 1 |
| 13 | Dynamic adsorption of diarrhetic shellfish poisoning (DSP) toxins in passive sampling relates to pore size distri- bution of aromatic adsorbent显示文摘 | LI Aifeng MA Feifei SONG Xiuli | 2011 | Journal of Chroma- tography A2011，1218，11： | 1 |
| 14 | Seismic response comparison and sensitivity analysis of pile foundation in liquefiable and non-liquefiable soils显示文摘Case history investigations have shown that pile foundations are more critically damaged in liquefiable soils than non-liquefiable soils.This study examines the differences in seismic response of pile foundations in liquefiable and non-liquefiable soils and their sensitivity to numerical model parameters.A two-dimensional finite element(FE)model is developed to simulate the experiment of a single pile foundation centrifuge in liquefiable soil subjected to earthquake motions and is validated against real-world test results.The differences in soil-pile seismic response of liquefiable and non-liquefiable soils are explored.Specifically,the first-order second-moment method(FOSM)is used for sensitivity analysis of the seismic response.The results show significant differences in seismic response for a soil-pile system between liquefiable and non-liquefiable soil.The seismic responses are found to be significantly larger in liquefiable soil than in non-liquefiable soil.Moreover,the pile bending moment was mainly affected by the kinematic effect in liquefiable soil,while the inertial effect was more significant in non-liquefiable soil.The controlling parameters of seismic response were PGA,soil density,and friction angle in liquefiable soil,while the pile bending moment was mainly controlled by PGA,the friction angle of soil,and shear modulus of loose sand in non-liquefiable soil. | Jia Kemin Xu Chengshun Du Xiuli Cui Chunyi Dou Pengfei Song Jia | 2023 | Earthquake Engineering and Engineering Vibration2023，22，1： | 1 |
| 15 | The soil seed banks of typical communities in wetlands converted from farmlands by different restoration methods in Nansi Lake,China显示文摘 | Ge Xiuli Wang Renqing Zhang Yiran Song Baimin Liu Jian* | 2013 | Ecological Engineering2013，60，： | 1 |
| 16 | Redefining the Age of the Cenozoic Shanwang Formation in Shanwang Basin显示文摘Objective The Shanwang Basin is a small Cenozoic sedimentary basin located in Linqu county,Shandong province.The Shanwang Formation,especially the diatomaceous shale member,contains diverse and finely preserved flora and fauna fossils(Fig.1).Previous paleontological study and radiometric dating show that it was formed in the Miocene.However,on the precise age of the formation,there are such different opinions as Late Miocene。 | YU Jifeng ZHAO Xiangguang PANG Xinlong JASON Hilton FU Wenzhao ZHAO Xiuli SONG Zhaojun HU Jialiang LU Lei ZHANG Hongjun YANG Ziqun QIAO Wenyan SHI Suo | 2017 | Acta Geologica Sinica(English Edition)2017，91，4： | 1 |
| 17 | A sequence variant in the phospholipase C epsilon C2 domain is associated with esophageal carcinoma and esophagitis显示文摘 | Li‐Dong Wang Xiuli Bi Xin Song Nicole M. Pohl Yulan Cheng Yixing Zhou Stephen Shears Emmanuel Ansong Mengtao Xing Shaomeng Wang Xiao‐Chun Xu Peng Huang Liyan Xu Liang Wang Zongmin Fan Xueke Zhao Huali Dong Stephen J. Meltzer Ivan Ding Wancai Yang | 2013 | Mol Carcinog2013，，1： | 1 |
| 18 | Adsorption Mechanism of Acetylene Hydrogenation on the Pd (111) Surface显示文摘First-principles calculations are carried out to examine the adsorption of acetylene over the Pd(111)surface.A hydrogen adsorption system is initially investigated to confirm the reliability of the selected calculation method.Adsorption energies,Mulliken-populations,overlap populations,charge density,and projected density of states(PDOS)are then calculated in the optimised acetylene adsorption system.Results show that C_(2)H_(2) molecule tends to adsorb through the threefold parallel-bridge configuration that is computed to be the most stable.In this structure,the distance of the C-H bond is calculated to be 1.09 Å,and the C-C-H bond angle is 128°.The distance of the C-C bond in acetylene is 1.36 Å,increasing from 1.21 Å in the gas phase.Moreover,the C-C bond overlap population decreases from 1.98 to 1.38,revealing that the carbon configuration in C2H2 rehybridises from sp to sp^(2) and beyond.The obtained results are compared with available experimental studies on acetylene hydrogenation on single-metal surfaces.The PDOS study indicates that a carbonaceous layer may generate on the metal surface during acetylene adsorption.The carbonaceous layer can affect the adsorption and reaction of acetylene,thereby inactivating the metal surface.Our experiments also show that Pd exhibits high catalytic activity. | Xuejia Xie Xiuli Song Wenyan Dong Zhenhai Liang Caimei Fan Peide Han | 2014 | Chinese Journal of Chemistry2014，32，7： | 1 |
| 19 | Synthesis of three-dimensionally ordered macroporous manganese dioxide–carbon nanocomposites for supercapacitors显示文摘 | Zhi Liu Xiuli Tan Xin Gao Lihong Song | 2014 | Journal of Power Sources2014，，： | 1 |
| 20 | Effect of acetylation on the properties of corn starch显示文摘 | Hui Chi Kun Xu Xiuli Wu Qiang Chen Donghua Xue Chunlei Song Wende Zhang Pixin Wang | 2007 | Food Chemistry2007，，3： | 1 |
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