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| 1 | nterferon alpha (IFNα)-induced TRIM22 interrupts HCV 'eplication by ubiquitinating NS5A显示文摘 | Chen Yang Xinhao Zhao Dakang Sun Leilei Yang Chang Chong Yu Pan Xiumei Chi Yanhang Gao Moli Wang Xiaodong Shi Haibo Sun Juan Lv Yuanda Gao Jin Zhong Junqi Niu Bing Sun | 2016 | Cellular & Molecular Immunology2016，13，1： | 13 |
| 2 | A neurotrophic peptide-functionalized self-assembling peptide nanofiber hydrogel enhances rat sciatic nerve regeneration显示文摘神经指导水管(NGC ) 是为外部神经新生的自体同源的神经的一种潜在的选择。有希望的治疗学的策略是用物理或化学的指导暗示修改神经指导水管 intraluminal 微型环境。在这研究,神经营养的 peptide-functionalized 能在 vitro 支持 PC12 细胞粘附,增长,和 neuronal 区别的自我装配的肽 nanofiber hydrogel 是在一个空 chitosan 试管(hCST ) 的腔的 prefilled 在一只老鼠加速 axonal 新生臀部的神经缺点模型。functionalized 自我装配的肽被介绍神经营养的肽开发(RGI, RGIDKRHWNSQ ) 源于导出大脑的神经营养的因素(BDNF ) 到自我装配的肽 RADA16 的 C 终点 -- 我(交流 --(RADA )4-CONH2) 。词法,组织学, electrophysiological,和功能的分析证明 RGI-functionalized,自我装配,肽 nanofiber hydrogel RAD/RGI 能生产显著地与提高的 re-myelination 和马达改进了 axonal 新生的神经营养的微型环境功能的恢复。 | Jiaju Lu Xun Sun Heyong Yin Xuezhen Shen Shuhui Yang Yu Wang Wenli Jiang Yue Sun Lingyun Zhao Xiaodan Sun Shibi Lu Antonios G. Mikos Jiang Peng Xiumei Wang | 2018 | Nano Research2018，11，9： | 6 |
| 3 | A 3D-Bioprinted dual growth factor-releasing intervertebral disc scaffold induces nucleus pulposus and annulus fibrosus reconstruction显示文摘Regeneration of Intervertebral disc(IVD)is a scientific challenge because of the complex structure and composition of tissue,as well as the difficulty in achieving bionic function.Here,an anatomically correct IVD scaffold composed of biomaterials,cells,and growth factors were fabricated via three-dimensional(3D)bioprinting technology.Connective tissue growth factor(CTGF)and transforming growth factor-β3(TGF-β3)were loaded onto polydopamine nanoparticles,which were mixed with bone marrow mesenchymal stem cells(BMSCs)for regenerating and simulating the structure and function of the nucleus pulposus and annular fibrosus.In vitro experiments confirmed that CTGF and TGF-β3 could be released from the IVD scaffold in a spatially controlled manner,and induced the corresponding BMSCs to differentiate into nucleus pulposus like cells and annulus fibrosus like cells.Next,the fabricated IVD scaffold was implanted into the dorsum subcutaneous of nude mice.The reconstructed IVD exhibited a zone-specific matrix that displayed the corresponding histological and immunological phenotypes:primarily type II collagen and glycosaminoglycan in the core zone,and type I collagen in the surrounding zone.The testing results demonstrated that it exhibited good biomechanical function of the reconstructed IVD.The results presented herein reveal the clinical application potential of the dual growth factors-releasing IVD scaffold fabricated via 3D bioprinting.However,the evaluation in large mammal animal models needs to be further studied. | Binbin Sun Meifei Lian Yu Han Xiumei Mo Wenbo Jiang Zhiguang Qiao Kerong Dai | 2021 | Bioactive Materials2021，6，1： | 5 |
| 4 | Enhanced angiogenesis by the hyaluronic acid hydrogels immobilized with a VEGF mimetic peptide in a traumatic brain injury model in rats显示文摘Angiogenesis plays an important role in brain injury repair,which contributes to the reconstruction of regenerative neurovascular niche for promoting axonal regeneration in the lesion area.As a major component of developing brain extracellular matrix,hyaluronic acid(HA)has attracted more attention as a supporting matrix for brain repair.In the present study,HA-KLT hydrogel was developed via modifying HA with a VEGF mimetic peptide of KLT(KLTWQELYQLKYKGI).The characterization of the hydrogel shows that it could provide a porous,three-dimensional scaffold structure,which has a large specific surface area available for cell adhesion and interaction.Compared with the unmodified HA hydrogel,the HA-KLT hydrogel could effectively promote the attachment,spreading and proliferation of endothelial cells in vitro.Furthermore,the pro-angiogenic ability of hydrogels in vivo was evaluated by implanting them into the lesion cavities in the injured rat brain.Our results showed that the hydrogels could form a permissive interface with the host tissues at 4 weeks after implantation.Moreover,they could efficiently inhibit the formation of glial scars at the injured sites.The HA-KLT hydrogel could significantly increase the expression of endoglin/CD105 and promote the formation of blood vessels,suggesting that HA-KLT hydrogel promoted angiogenesis in vivo.Collectively,the HA-KLT hydrogel has the potential to repair brain defects by promoting angiogenesis and inhibiting the formation of glial-derived scar tissue. | Jiaju Lu Fengyi Guan Fuzhai Cui Xiaodan Sun Lingyun Zhao Ying Wang Xiumei Wang | 2019 | Regenerative Biomaterials2019，6，6： | 5 |
| 5 | Fargeted elimination of mutant mitochondria DNA in MELAS-iPSCs by mitoTALENs显示文摘 | Yi Yang Han Wu Xiangjin Kang Yanhui Liang Ting Lan Tianjie Li Tao Tan Jiangyun Peng Quanjun Zhang Geng An Yali Liu Qian Yu Zhenglai Ma Ying Lian Boon Seng Soh Qingfeng Chen Ping Liu Yaoyong Chen Xiaofang Sun Rong Li Xiumei Zhen Yang Yu Xiaoping Li Yong Fan | 2018 | Protein & Cell2018，9，3： | 4 |
| 6 | “Polymer-in-ceramic” based poly(ε-caprolactone)/ceramic composite electrolyte for all-solid-state batteries显示文摘Inspired by the concept of 'polymer-in-ceramic',a composite poly(ε-caprolactone)(PCL)/ceramic containing LiTFSI is prepared and investigated as a solid electrolyte for all-solid-state batteries.The composite with the optimum concentration of 45 wt% LiTFSI and 75 wt% Li1.5Al0.5Ge1.5(PO4)3(LAGP,NASICON-type structure) exhibits a high ionic conductivity(σi=0.17 mS cm-1) at 30℃,a transference number of 0.30,and is stable up to 5.0 V.The composite electrolyte is a flexible and self-standing membrane.Solid-state LiFePO4//Li batteries with this composite electrolyte demonstrate excellent cycling stability with high discharge capacity of 157 mA h g-1,high capacity retention of 96% and coulombic efficiency of 98.5% after 130 cycles at 30℃ and 0.1 C rate.These electrochemical properties are better than other PCL-based allsolid-lithium batteries,and validate the concept of 'polymer-in-ceramic' by avoiding the drawback of lower conductivity in prior 'polymer-in-ceramic' electrolyte at high concentration of the ceramic. | Bohao Zhang Yulong Liu Jia Liu Liqun Sun Lina Cong Fang Fu Alain Mauger Christian M.Julien Haiming Xie Xiumei Pan | 2021 | Journal of Energy Chemistry2021，30，1： | 4 |
| 7 | Electrical and Raman properties of p-type and n-type modified graphene by inorganic quantum dot and organic molecule modification显示文摘We obtained n-type and p-type modified graphene by mixing quantum dots and depositing electron-acceptor molecules on the surface of graphene, respectively. The electrical and optical properties of these two types of samples were measured. For n-type modified graphene, the electrons were transferred from quantum dots to graphene. The resistance of these quantum dots in modified n-type graphene is significantly smaller than that of pristine graphene. For p-type graphene, modified by electron-acceptor organic molecules of tetracyanoethylene (TCNE), electrons were transferred from graphene to TCNE molecules. The resistance of this molecular modified p-type graphene is about 10% larger than that of pristine graphene. The charge transfer effect on the optical properties of graphene was investigated with Raman spectra. | HOU YanXue GENG XiuMei LI YuanZuo DONG Bin LIU LiWei SUN MengTao | 2011 | Science China(Physics,Mechanics & Astronomy)2011，54，3： | 4 |
| 8 | Doxorubicin-Ioaded Fe3O4@MoS2-PEG-2DG nanocubes as a theranostic platform for magnetic resonance imaging- guided chemo-photothermal therapy of breast cancer显示文摘 | Wensheng Xie Qin Gao Dan Wang Zhenhu Guo Fei Gao Xiumei Wang Qiang Cai Si-shen Feng Haiming Fan Xiaodan Sun Lingyun Zhao | 2018 | Nano Research2018，11，5： | 4 |
| 9 | A novel mitochondrial tRNA gene mutation in a chinese family with dilated cardiomyopathy and sensorineural deafness显示文摘Objective: To determine whether a mutation of mitochondrial DNA induces familial dilated cardiomyopathy in Chinese families with cardiomyopathy,and analyzed the correlation between the genotype and phenotype. Methods: Affected members in three Chinese families of the familial dilated cardiomyopathy underwent clinical evaluation and DNA analysis. Polymerase chain reaction and direct DNA sequencing were used to screen for mitochondrial DNA mutation. The type of mtDNA variations and clinical situation were analysed on the patients with mitochondrial DNA mutation. Results: The mitochondrial A3434G mutation was identified in one of the three families,the 3434 th nucleotide A was replaced by G, which led to change of amino acid. No mutations were identified in the clinically unaffected members of the family and all members of the other two families. Conclusion: This study indicates that the mitochondrial A3434G mutation maybe related with familial dilated cardiomyopathy and deafness. | Xianghong Wu Xiumei Xie Guotian Ma Guoju Sun Xiaobin Chen | 2006 | Journal of Nanjing Medical University2006，20，5： | 3 |
| 10 | Synthesis and crystal structure of hydroquinone-β-cyclo-dextrin complex显示文摘The title inclusion complex with the formula [(C42H70O35)2 · (C6O2H6)3 · (H2O)21.2(CH3OH)2] has been crystallized and characterized by single crystal X-ray analysis. The complex crystallizes in the triclinic system, space group P1, with a =1.5500 (1), b =1.5536(1), c = 1.8246(1) nm, α = 113.17(2), β = 99.12(2), γ=103.37(3)? V = 3.7739(4) nm3, Z = 1; Dc =1.343 g/cm3, μ = 0.124 mm-1, F(000) = 1594, R = 0.0795 and S = 0.9639. Two independent molecules of β-cyclodextrin (β-CD) form a 'head-to-head' dimer. The fairly important factor of the position and stability of the guest in the host cavity is the solvation of the polar group of the guest. | Shikun Ma Jinling Wang Aixiu Li Ming Yu Ming Sun Xiumei Su Fangming Miao | 2001 | Chinese Science Bulletin2001，46，5： | 3 |
| 11 | Determination of Steroid Hormone Residues in Fish Tissues Using Gel Permeation Chromatography and Ultra Performance Liquid Chromatography-Tandem Mass Spectrometry显示文摘A highly sensitive method was developed for the simultaneous determination of 8 steroid hormones in high-fat fish tissues using ultra high performance liquid chromatography-tandem mass spectrometry(UPLC-MS/MS).The 8 steroid hormones were extracted from the tissues with diethyl ether.Differing from other common purification methods,the extract solutions were cleaned by gel permeation chromatography(GPC) using ethyl acetate-cyclohexane solution(1:1,v/v) as the mobile phase.The separation of target compounds was carried out by a BEH C18 column and a gradient elution consisting of acetonitrile and 0.2% aqueous formic acid(v/v).The compounds were detected under the multiple reaction monitoring(MRM) mode and quantified with external standard method.This method was validated with respect to linearity,specificity,accuracy and precision.A linearity with correlation coefficient larger than 0.995 was achieved in the range of 0.5 to 50 ng m L^(-1).The average recoveries at the spiked levels of 1.0,5.0,and 10.0 μg kg^(–1) varied between 81.7% and 90.8%,with the relative standard deviations(n=5) ranged from 3.50% to 10.0%.The limit of quantification(LOQ) for 8 steroid hormones ranged from 0.2 to 1.5 μg kg^(-1).It was concluded that this method can be successfully applied for the determination of 8 steroid hormones in complicated matrices including high-fat fish tissues. | LI Peipei YAN Zhongyong SUN Xiumei CHEN Si CHEN Yin ZHANG Xiaojun | 2018 | Journal of Ocean University of China2018，17，5： | 3 |
| 12 | Antioxidant and antihyperlipidemic activities of polysaccharides from sea cucumber Apostichopus japonicus显示文摘 | Xin Liu Zhenliang Sun Miansong Zhang Xiumei Meng Xuekui Xia Wenpeng Yuan Feng Xue Changheng Liu | 2012 | Carbohydrate Polymers2012，，4： | 3 |
| 13 | The hepatitis B virus X protein downregulates NF-κB signaling pathwaysthrough decreasing the Notch signaling pathway in HBx-transformed L02 cells显示文摘 | Jing Luo Haiyan Zhou Fan Wang Xiumei Xia Qian Sun Ronghua Wang Bin Cheng | 2013 | International Journal of Oncology2013，，5： | 2 |
| 14 | Stem cell homing-based tissue engineering using bioactive materials显示文摘 | Yinxian YU Binbin SUN Chengqing YI Xiumei MO | 2017 | Frontiers of Materials Science2017，11，2： | 2 |
| 15 | DEAP1 encodes a fasciclin-like arabinogalactan protein required for male fertility in rice显示文摘Arabinogalactan proteins(AGPs)are widely distributed in plant cells.Fasciclin-like AGPs(FLAs)belong to a subclass of AGPs that play important roles in plant growth and development.However,little is known about the biological functions of rice FLA.Herein,we report the identification of a male-sterile mutant of DEFECTIVE EXINE AND APERTURE PATTERNING1(DEAP1)in rice.The deap1 mutant anthers produced aberrant pollen grains with defective exine formation and a flattened aperture annulus and exhibited slightly delayed tapetum degradation.DEAP1 encodes a plasma membrane-associated member of groupⅢplant FLAs and is specifically and temporally expressed in reproductive cells and the tapetum layer during male development.Gene expression studies revealed reduced transcript accumulation of genes related to exine formation,aperture patterning,and tapetum development in deap1 mutants.Moreover,DEAP1 may interact with two rice D6 PROTEIN KINASE-LIKE3 s(OsD6PKL3s),homologs of a known Arabidopsis aperture protein,to affect rice pollen aperture development.Our findings suggested that DEAP1 is involved in male reproductive development and may affect exine formation and aperture patterning,thereby providing new insights into the molecular functions of plant FLAs in male fertility. | Dan Zhou Ting Zou Kaixuan Zhang Pingping Xiong Fuxing Zhou Hao Chen Gongwen Li Kaiyou Zheng Yuhao Han Kun Peng Xu Zhang Shangyu Yang Qiming Deng Shiquan Wang Jun Zhu Yueyang Liang Changhui Sun Xiumei Yu Huainian Liu Lingxia Wang Ping Li Shuangcheng Li | 2022 | Journal of Integrative Plant Biology2022，64，7： | 2 |
| 16 | 显示文摘 | Zhang Yao Sun Xiumei Jia Nengqin | 2011 | Sensors and Actua- tors B-Chemical2011，157，2： | 1 |
| 17 | Direct electrochemistry and electrocatalysis of horseradish peroxidase based on halloysite nanotubes/chitosan nanocomposite film显示文摘 | SUN Xiumei ZHANG Yao SHEN Heba | | 0，，02： | 1 |
| 18 | Determination of vitexin-2'-O-rhamnoside in rat plasma by ultra-performance liquid chromatography clectrospray ionization tandem mass spectrometry and its application to pharmacokinetic study显示文摘 | Ying Xixiang Lu Xiumei Sun Xiaohong | 2007 | Talanta2007，72，4： | 1 |
| 19 | Influence of ammonium sulfate on YAG nanopowders and Yb:YAG ceramics synthesized by a novel homogeneous co-precipitation method显示文摘Homogeneous and dispersed Y_3 Al_5 O_(12)(yttrium aluminum garnet,YAG) nanopowders were synthesized via a homogeneous co-precipitation method from the mixed solutions of yttrium nitrate,aluminum nitrate and a small amount of ammonium sulfate using hot urea as the precipitant.The method has the superiorities that co-precipitation of cations is ensured and continuous decomposition of the hot urea is achieved to obtain the narrow size distribution particles.The addition of small amount of ammonium sulfate surfactant,although has no influence on YAG garnet phase formation,has significant effect on dispersion,particles distribution and sinterability of the resultant YAG and Yb:YAG powders.Compared with the undoped sample,the green body of Yb:YAG doped with ammonium sulfate has higher total shrinkage,linear shrinkage rate and relative density through sintering at 1600 ℃.The resultant Yb:YAG powders can be sintered into transparent ceramics at 1700 ℃ through vacuum sintering.The influence of the sulfate ions on characteristics of the resultant powders was thoroughly studied. | Jinsheng Li Zhifa Liu Lei Wu Xiumei Han Xiwei Qi Xudong Sun | 2018 | Journal of Rare Earths2018，36，9： | 1 |
| 20 | Oral Preparations of Chinese materiamedicabysemi - bionicextraetion 显示文摘 | Zhang Zhaowang Sun Xiumei | 1996 | ChemicalAbstraetsVol1996，，： | 1 |
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