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| 1 | Anisotropic coding metamaterials and their powerful manipulation of differently polarized terahertz waves显示文摘Metamaterials based on effective media can be used to produce a number of unusual physical properties(for example,negative refraction and invisibility cloaking)because they can be tailored with effective medium parameters that do not occur in nature.Recently,the use of coding metamaterials has been suggested for the control of electromagnetic waves through the design of coding sequences using digital elements‘0’and‘1,'which possess opposite phase responses.Here we propose the concept of an anisotropic coding metamaterial in which the coding behaviors in different directions are dependent on the polarization status of the electromagnetic waves.We experimentally demonstrate an ultrathin and flexible polarization-controlled anisotropic coding metasurface that functions in the terahertz regime using specially designed coding elements.By encoding the elements with elaborately designed coding sequences(both 1-bit and 2-bit sequences),the x-and y-polarized waves can be anomalously reflected or independently diffused in three dimensions.The simulated far-field scattering patterns and near-field distributions are presented to illustrate the dual-functional performance of the encoded metasurface,and the results are consistent with the measured results.We further demonstrate the ability of the anisotropic coding metasurfaces to generate a beam splitter and realize simultaneous anomalous reflections and polarization conversions,thus providing powerful control of differently polarized electromagnetic waves.The proposed method enables versatile beam behaviors under orthogonal polarizations using a single metasurface and has the potential for use in the development of interesting terahertz devices. | Shuo Liu Tie Jun Cui Quan Xu Di Bao Liangliang Du Xiang Wan Wen Xuan Tang Chunmei Ouyang Xiao Yang Zhou Hao Yuan Hui Feng Ma Wei Xiang Jiang Jiaguang Han Weili Zhang Qiang Cheng | 2016 | Light(Science & Applications)2016，5，1： | 36 |
| 2 | Photo-curing 3D printing technique and its challenges显示文摘In recent ten years,3D printing technology has been developed rapidly.As an advanced technology,3D printing has been used to fabricate complex and high-precision objects in many fields.3D printing has several technologies.Among these technologies,photo-curing 3D printing was the earliest and most mature technology.In 1988,the first 3D printing machine which was based on photo-curing and called Stereo lithography Appearance(SLA)technology was produced by 3D system Corp.After 30 years of development,many new technologies based on photocuring mechanism emerged.Based on the different principle of pattern formation and character of printing technology,numerous photocuring 3D printing techniques,such as SLA,DLP,LCD,CLIP,MJP,twophoton 3D printing,holographic 3D printing and so on,have been developed.Photo-curing 3D printing has many advantages,such as high precision,smooth surface of printing objects,rapid printing speed and so on.Here,we would introduce five industrial photocuring 3D printing technologies,which are SLA,DLP,LCD,CLIP and MJP.The characters of the materials and the progress of the application of the technique in the biomedical field is also overviewed.At last,the difficulties and challenges of photo-curing 3D printing are also discussed. | Haoyuan Quan Ting Zhang Hang Xu Shen Luo Jun Nie Xiaoqun Zhu | 2020 | Bioactive Materials2020，5，1： | 33 |
| 3 | An Investigation of Oxidative DNA Damage in Pharmacy Technicians Exposed to Antineoplastic Drugs in Two Chinese Hospitals Using The Urinary 8-OHdG Assay显示文摘Objective To investigate oxidative DNA damage in pharmacy technicians preparing antineoplastic drugs at the PIVAS (Pharmacy Intravenous Admixture Service) in two Chinese hospitals.Methods Urinary 8-OHdG served as a biomarker.5-Fluorouracil (5-FU) concentrations in air,masks and gloves were determined.The spill exposure of each PIVAS technician to antineoplastic drugs was investigated.Eighty subjects were divided into exposed group I,II,and control group I,II.Results 5-FU concentration ratios for gloves and masks in exposed group I were significantly higher than those in exposed group II (P<0.05 or P<0.01).The average urinary 8-OHdG concentrations in exposed group I,control group I,exposed group II,and control group II were 14.69±0.93,10.68±1.07,10.57±0.55,and 11.96±0.73 ng/mg Cr,respectively.Urinary 8-OHdG concentration in exposed group I was significantly higher than that in control group I or that in exposed group II (P<0.01).There was a significant correlation between urinary 8-OHdG concentrations and spill frequencies per technician (P<0.01).Conclusion There was detectable oxidative DNA damage in PIVAS technicians exposed to antineoplastic drugs.This oxidative DNA damage may be associated with their spill exposure experience and contamination of their personal protective equipment. | HUANG Yu Wen JIAN Le ZHANG Mei Bian ZHOU Quan YAN Xiao Feng HUA Xu Dong ZHOU Ying HE Ji Liang | 2012 | Biomedical and Environmental Sciences2012，25，1： | 30 |
| 4 | 5-Hydroxymethylcytosine signatures in circulating cell-free DNA as diagnostic biomarkers for human cancers显示文摘象 5-methylcytosine (5mC ) 和 5-hydroxymethylcytosine (5hmC ) 那样的 DNA 修正是知道在哺乳动物影响全球基因表示的 epigenetic 标记。在人的染色体,与基因表示的靠近的关联和高化学的稳定性给他们的流行,这些 DNA epigenetic 标记能为癌症用作理想的 biomarkers 诊断。利用一种高度敏感、选择的化学标记技术,我们这里报导在传播没有房间的 DNA ( cfDNA )并且在从最近与 colorectal 诊断的 260 个病人的一个队收集的配对的肿瘤和邻近的纸巾的 genomic DNA ( gDNA )的 5hmC 的染色体宽的介绍,胃,胰腺,从 90 个健康个人的肝或甲状腺癌症和正常纸巾。5hmC 主要在与开的染色质和容许的 histone 修正重合的 transcriptionally 活跃的区域被散布。柔韧的联系癌症的 5hmC 签名在 cfDNA 被识别为特定的癌症类型是特征的。传播 cfDNA 的 5hmC 底 biomarkers colorectal 和胃的癌症是高度预兆的并且比常规 biomarkers 优异并且比得上从织物活体检视的 5hmC biomarkers。因此,这新策略能从血样品的分析为癌症的诊断和预后导致有效、最低限度地侵略的方法的发展。 | Wenshuai Li Xu Zhang Xingyu Lu Lei You Yanqun Song Zhongguang Luo Jun Zhang Ji Nie Wanwei Zheng Diannan Xu Yaping Wang Yuanqiang Dong Shulin Yu Jun Hong Jianping Shi Hankun Hao Fen Luo Luchun Hua Peng Wang Xiaoping Qian Fang Yuan Lianhuan Wei Ming Cui Taiping Zhang Quan Liao Menghua Dai Ziwen Liu Ge Chen Katherine Meckel Sarbani Adhikari Guifang Jia Marc B Bissonnette Xinxiang Zhang Yupei Zhao Wei Zhang Chuan He Jie Liu | 2017 | Cell Research2017，27，10： | 30 |
| 5 | Experimental and clinical study of influence of high-frequency electric surgical knives on healing of abdominal incision显示文摘瞄准:在腹壁切口愈合上学习高周波的电的外科的刀的影响。方法:240 只白鼠被划分成 10 (0 ) , 10 (2 ) , 10 (5 ) ,并且 10 (8 ) 组和腹部手术的老鼠模型被分别地使用电的外科的刀和普通口针劝诱。然后,他们分别地被给生理盐水和 0.2 mL 的皮下注射在 10 的集中(2 ) 的埃希氏杆菌属关口 i,葡萄球菌 aureus 和绿脓假单胞菌的量的混合, 10 (5 ) 并且 10 (8 ) 。根据动物实验,经历腹部手术(上面的类型 II ) 的 220 个病人随机被分配进跟随三个组之一:电热刀(EK, 93 个盒子) ,电凝法(EC, 55 个盒子) 并且控制(72 个盒子) 。高周波的电的外科的刀习惯于为在 EK 的血壅滞的腹的纸巾和电凝法组织的 dissect。普通口针和电凝法在 EC 组被使用。普通口针和系住的丝缝线在控制被使用。结果:在除了组 10 的所有组(0 ) ,电的外科的刀做的 incisional 创伤的感染率与普通口针比那显著地高。而且,在组有有效差量 10 (2 ) , 10 (5 ) ,并且 10 (8 )(P<0.05 ) ,然而并非(0 )(P>0.05 ) 在组, 10 在 EK 和 EC 之间组织。临床的研究显示出在控制组在 EK,在 EC 的 11 个盒子(16.36%) 和 2 个盒子(2.86%) 在 16 种情况(17.20%) 中愈合的一处推迟的创伤。在 EK 和控制之间的有效差量组织(chi2 = 8.57, P<0.01 ) ,并且在 EC 和控制组之间(chi2 = 5.66, P<0.05 ) 被观察,然而并非在 EK 和 EC 之间(chi2 = 0.017, P>0.05 ) 。结论:高周波的电的刀可以显著地推迟腹壁切口愈合。它的申请应该被最小化以便减少手术后的复杂并发症的可能性。 | Guang-Wei Ji Yuan-Zhi Wu Xu Wang Hua-Xiong Pan Ping Li Wan-Ying Du Zhi Qi An Huang Li-Wei Zhang Li Zhang Wen Chen Guang-Hua Liu Hui Xu Quan Li Ai-Hua Yuan Xiao-Ping He Guo-Hua Mei | 2006 | World Journal of Gastroenterology2006，12，25： | 23 |
| 6 | A New Kind of Pilot Controlled Proportional Direction Valve with Internal Flow Feedback显示文摘Proportional direction valve is one of the most fundamental elements in electronic-hydraulic control technique. Its function is to control the operating speed, direction, position, and strength of output force of the hydraulic actuator continuously. Considering the different application and the cost, the existing technique mainly includes the internal feedback valve used in open loop system, and the electronic closed loop controlled valve used in closed loop system. Because of their different mechanical structure and the great different in performance, it brings inconvenience for customer to select, also inconvenience for enterprise to produce. Aiming at this problem, the idea of combining the above two kinds of valves into one body is proposed first, and then the new valve’s structure to realize this target is designed. The idea intends to apply the displacement pilot flow feedback control principle in present 2-position 2-way valve system to the proportional direction valve of 3-position 4-way system. Newly designed feed forward controller can decouple the interference between the internal feedback and the electronic closed loop. Redundant conversion is designed to electronic switch mode. Experiment on dynamic and static characteristic of new proportional direction valve in internal feedback control mode and electronic closed loop control mode is discussed to prove the new theory is correct. Although the new valve is of excellent dynamic response characteristic, its steady control characteristic in open loop control mode needs to be improved further. The research results prepare one new fundamental element for electronic-hydraulic control technology. | QUAN Long XU Xiaoqing YAN Zheng ZHANG Xiaojun | 2010 | Chinese Journal of Mechanical Engineering2010，23，1： | 22 |
| 7 | Lithium, an anti-psychotic drug, greatly enhances the generation of induced pluripotent stem cells显示文摘体的房间能由定义因素是进导致的 pluripotent 干细胞(iPSCs ) 的 reprogrammed。reprogramming 的低效率和 oncogenes 和病毒的向量的 genomic 集成限制了 iPSCs 的潜在的申请。这里,我们报导那锂(李) ,药过去常对待心情混乱,极大地从老鼠提高 iPSC 产生胚胎的成纤维细胞和人的脐的静脉 endothelial 房间。李与(Oct4 ) 或二个因素(OS 或好) 便于 iPSC 产生。支持 reprogramming 上的李的效果仅仅部分取决于它的主要目标 GSK3β。不同于另外的 GSK3β禁止者,李不仅增加 Nanog 的表示,而且提高 Nanog 的 transcriptional 活动。我们也发现李由经由 LSD1 的 downregulation 支持 epigenetic 修正施加它的效果, H3K4 特定的 histone demethylase。将 LSD1 击倒部分在提高 reprogramming 模仿李的效果。我们的结果不仅提供一个直接方法改进 iPSC 产生效率,而且为体的房间 reprogramming 作为一个批评调节的人识别了 histone demethylase。 | Quan Wang Xinxiu Xu Jun Li Jing Liu Haifeng Gu Ru Zhang Jiekai Chen Yin Kuang Jian Fei Cong Jiang Ping Wang Duanqing Pei Sheng Ding Xin Xie | 2011 | Cell Research2011，21，10： | 23 |
| 8 | Transforming growth factor-β in stem cells and tissue homeostasis显示文摘TGF-β 1–3 are unique multi-functional growth factors that are only expressed in mammals, and mainly secreted and stored as a latent complex in the extracellular matrix(ECM). The biological functions of TGF-β in adults can only be delivered after ligand activation, mostly in response to environmental perturbations. Although involved in multiple biological and pathological processes of the human body, the exact roles of TGF-β in maintaining stem cells and tissue homeostasis have not been well-documented until recent advances, which delineate their functions in a given context. Our recent findings, along with data reported by others, have clearly shown that temporal and spatial activation of TGF-β is involved in the recruitment of stem/progenitor cell participation in tissue regeneration/remodeling process, whereas sustained abnormalities in TGF-β ligand activation, regardless of genetic or environmental origin, will inevitably disrupt the normal physiology and lead to pathobiology of major diseases. Modulation of TGF-β signaling with different approaches has proven effective pre-clinically in the treatment of multiple pathologies such as sclerosis/fibrosis, tumor metastasis, osteoarthritis, and immune disorders. Thus, further elucidation of the mechanisms by which TGF-β is activated in different tissues/organs and how targeted cells respond in a context-dependent way can likely be translated with clinical benefits in the management of a broad range of diseases with the involvement of TGF-β. | Xin Xu Liwei Zheng Quan Yuan Gehua Zhen Janet L.Crane Xuedong Zhou Xu Cao | 2018 | Bone Research2018，6，1： | 22 |
| 9 | Quantitative evaluation of diffusion-weighted magnetic resonance imaging of focal hepatic lesions显示文摘AIM: To explore the quantitative analysis of diffusionweighted magnetic resonance imaging (DWMRI) in differential diagnosis of focal hepatic lesions.METHODS: DWMRI was performed in 149 hepatic lesions, including hepatocellular carcinoma (34 cases),hepatic metastases (37 cases), cavernous hemangioma (42 cases), hepatic cyst (36 cases). Apparent diffusion coefficient (ADC) values were evaluated using four different b values in different sequences. The ratio of ADC values of lesion/liver in hepatocellular carcinoma and hepatic metastases was also calculated.RESULTS: The mean ADC values of hepatic lesions were as follows: hepatocellular carcinoma (0.95 ± 0.11) × 10-3 mm2/s, hepatic metastasis (1.13 ± 0.21)× 10-3 mm2/s, cavernous hemangioma (1.86±0.36)×10-3 mm2/s,hepatic cyst(3.14±0.31)×10-3 mm2/s. The ratio of ADC values in lesion/liver in hepatocellular carcinoma was 0.91 ±0.11, being significantly different from that in hepatic metastasis (1.21 ± 0.18, P< 0.05).CONCLUSION: ADC values and quantitative analysis of focal hepatic lesions are of significant values in differential diagnosis of focal hepatic lesions. | Xi-Jie Sun Xian-Yue Quan Fan-Heng Huang Yi-Kai Xu | 2005 | World Journal of Gastroenterology2005，11，41： | 21 |
| 10 | Dynamics and adaptive control of a dual-arm space robot with closed-loop constraints and uncertain inertial parameters显示文摘A dynamics-based adaptive control approach is proposed for a planar dual-arm space robot in the presence of closed-loop constraints and uncertain inertial parameters of the payload.The controller is capable of controlling the position and attitude of both the satellite base and the payload grasped by the manipulator end efectors.The equations of motion in reduced-order form for the constrained system are derived by incorporating the constraint equations in terms of accelerations into Kane’s equations of the unconstrained system.Model analysis shows that the resulting equations perfectly meet the requirement of adaptive controller design.Consequently,by using an indirect approach,an adaptive control scheme is proposed to accomplish position/attitude trajectory tracking control with the uncertain parameters being estimated on-line.The actuator redundancy due to the closed-loop constraints is utilized to minimize a weighted norm of the joint torques.Global asymptotic stability is proven by using Lyapunov’s method,and simulation results are also presented to demonstrate the efectiveness of the proposed approach. | Ying-Hong Jia Quan Hu Shi-Jie Xu | 2014 | Acta Mechanica Sinica2014，30，1： | 20 |
| 11 | Intestinal microbiota: a potential target for the treatment of postmenopausal osteoporosis显示文摘Postmenopausal osteoporosis(PMO) is a prevalent metabolic bone disease characterized by bone loss and structural destruction, which increases the risk of fracture in postmenopausal women. Owing to the high morbidity and serious complications of PMO, many efforts have been devoted to its prophylaxis and treatment. The intestinal microbiota is the complex community of microorganisms colonizing the gastrointestinal tract. Probiotics, which are dietary or medical supplements consisting of beneficial intestinal bacteria, work in concert with endogenous intestinal microorganisms to maintain host health. Recent studies have revealed that bone loss in PMO is closely related to host immunity, which is influenced by the intestinal microbiota. The curative effects of probiotics on metabolic bone diseases have also been demonstrated. The effects of the intestinal microbiota on bone metabolism suggest a promising target for PMO management.This review seeks to summarize the critical effects of the intestinal microbiota and probiotics on PMO, with a focus on the molecular mechanisms underlying the pathogenic relationship between bacteria and host, and to define the possible treatment options. | Xin Xu Xiaoyue Jia Longyi Mo Chengcheng Liu Liwei Zheng Quan Yuan Xuedong Zhou | 2017 | Bone Research2017，5，3： | 20 |
| 12 | The rice OsV4 encoding a novel pentatricopeptide repeat protein is required for chloroplast development during the early leaf stage under cold stress显示文摘Pentatricopeptide repeat(PPR)proteins,characterized by tandem arrays of a 35 amino acid motif,have been suggested to play central and broad roles in modulating the expression of organelle genes in plants.However,the molecular mechanisms of most rice PPR genes remains unclear.In this paper,we isolated and characterized a temperature-conditional virescent mutant,OsV4,in rice(Oryza sativa cultivar Jiahua1(WT,japonica rice variety)).The mutant displays albino phenotype and abnormal chloroplasts at the three leaf stage,which gradually turns green after the four leaf stage at a low temperature(20°C).But the mutant always develops green leaves and well-developed chloroplasts at a high temperature(32°C).Genetic and molecular analyses uncovered that OsV4 encodes a novel chloroplast-targeted PPR protein including four PPR motifs.Further investigations show that the mutant phenotype is associated with changes in chlorophyll content and chloroplast development.The OsV4transcripts only accumulate to high levels in young leaves,indicating that its expression is tissue-specific.In addition,transcript levels of some ribosomal components and plastid-encoded polymerase-dependent genes are dramatically reduced in the albino mutants grown at 20°C.These findings suggest that OsV4 plays an important role during early chloroplast development under cold stress in rice. | Xiaodi Gong Qianqian Su Dongzhi Lin Quan Jiang Jianlong Xu Jianhui Zhang Sheng Teng Yanjun Dong | 2014 | Journal of Integrative Plant Biology2014，56，4： | 19 |
| 13 | Metal Flowing of Involute Spline Cold Roll-beating Forming显示文摘The present research on involute spline cold roll-beating forming is mainly about the principles and motion relations of cold roll-beating,the theory of roller design,and the stress and strain field analysis of cold roll-beating,etc.However,the research on law of metal flow in the forming process of involute spline cold roll-beating is rare.According to the principle of involute spline cold roll-beating,the contact model between the rollers and the spline shaft blank in the process of cold roll-beating forming is established,and the theoretical analysis of metal flow in the cold roll-beating deforming region is proceeded.A finite element model of the spline cold roll-beating process is established,the formation mechanism of the involute spline tooth profile in cold roll-beating forming process is studied,and the node flow tracks of the deformation area are analyzed.The experimental research on the metal flow of cold roll-beating spline is conducted,and the metallographic structure variation,grain characteristics and metal flow line of the different tooth profile area are analyzed.The experimental results show that the particle flow directions of the deformable bodies in cold roll-beating deformation area are determined by the minimum moving resistance.There are five types of metal flow rules of the deforming region in the process of cold roll-beating forming.The characteristics of involute spline cold roll-beating forming are given,and the forming mechanism of involute spline cold roll-beating is revealed.This paper researches the law of metal flow in the forming process of involute spline cold roll-beating,which provides theoretical supports for solving the tooth profile forming quality problem. | CUI Fengkui WANG Xiaoqiang ZHANG Fengshou XU Hongyu QUAN Jianhui LI Yan | 2013 | Chinese Journal of Mechanical Engineering2013，26，5： | 19 |
| 14 | Joint Radar and Communication: A Survey显示文摘Joint radar and communication(JRC)technology has become important for civil and military applications for decades.This paper introduces the concepts,characteristics and advantages of JRC technology,presenting the typical applications that have benefited from JRC technology currently and in the future.This paper explores the state-of-the-art of JRC in the levels of coexistence,cooperation,co-design and collaboration.Compared to previous surveys,this paper reviews the entire trends that drive the development of radar sensing and wireless communication using JRC.Specifically,we explore an open research issue on radar and communication operating with mutual benefits based on collaboration,which represents the fourth stage of JRC evolution.This paper provides useful perspectives for future researches of JRC technology. | Zhiyong Feng Zixi Fang Zhiqing Wei Xu Chen Zhi Quan Danna Ji | 2020 | China Communications2020，17，1： | 19 |
| 15 | Natural Variation in CCD4 Promoter Underpins Species-Specific Evolution of Red Coloration in Citrus Peel显示文摘Carotenoids and apocarotenoids act as phytohormones and volatile precursors that influence plant development and confer aesthetic and nutritional value critical to consumer preference.Citrus fruits display considerable natural variation in carotenoid and apocarotenoid pigments.In this study,using an integrated genetic approach we revealed that a 5;c/s-regulatory change at CCD4b encoding CAROTENOID CLEAVAGE DIOXYGENASE 4b is a major genetic determinant of natural variation in C3 0 apocarotenoids responsible for red coloration of citrus peel.Functional analyses demonstrated that in addition the known role in synthesizing 3-citraurin,CCD4b is also responsible for the production of another important C3 0 apocarotenoid pigment,p-citraurinene.Furthermore,analyses of the CCD4b promoter and transcripts from various citrus germplasm accessions established a tight correlation between the presence of a putative 5'c/s-regulatory enhancer within an MITE transposon and the enhanced allelic expression of CCD4b in C3 0 apocarotenoid-rich red-peeled accessions.Phylogenetic analysis provided further evidence that functional diversification of CCD4b and naturally occurring variation of the CCD4b promoter resulted in the stepwise evolution of red peels in mandarins and their hybrids.Taken together,our findings provide new insights into the genetic and evolutionary basis of apocarotenoid diversity in plants,and would facilitate breeding efforts that aim to improve the nutritional and aesthetic value of citrus and perhaps other fruit crops. | Xiongjie Zheng Kaijie Zhu Quan Sun Weiyi Zhang Xia Wang Hongbo Cao Meilian Tan Zongzhou Xie Yunliu Zeng Junli Ye Lijun Chai Qiang Xu Zhiyong Pan Shunyuan Xiao Paul D.Fraser Xiuxin Deng | 2019 | Molecular Plant2019，12，9： | 18 |
| 16 | Chemokine SR-PSOX/CXCL16 expression in peripheral blood of patients with acute coronary syndrome显示文摘背景:绑 phosphatidylserine 和氧化 lipoprotein/CXC chemokine ligand 的清道工人受体(SR-PSOX/CXCL16 ) 16 通过肿瘤坏死因素(TNF ) 支持泡沫房间形成 -alpha 调停了机制。因为 chemokine CXCL16 能在动脉粥样硬化患者损害和 induce 平滑肌房间(SMC ) 增长被表示,我们想在病人的外部血的单核白血球 SR-PSOX/CXCL16 察觉将为动脉粥样硬化的早诊断和预后是重要的(作为) 。方法:在这注册了学习是有急性冠的症候群(交流) 的 40 个病人,包括有尖锐心肌的梗塞(AMI ) 的 20 个病人和有不稳定的心绞痛(UAP ) 的 20 个病人,并且 20 正常控制。在外部血的单核白血球被孤立,并且 CXCL16/SR-PSOX mRNA 的表示的变化用反向的抄写聚合酶链反应(RT-PCR ) 被比较,与象内部控制的贝它肌动朊。我们在 ACS 亚群比较了 CXCL16/SR-PSOX 的表示,用对分析蛋白质表示层次西方污点。组织节由象正常控制一样与易传染的心内膜炎,肝肝硬化,和肺癌症从病人拿的活体检视标本制造了。并且 CXCL16/SR-PSOX 的表示与一台共焦的显微镜被分析。结果:在外部血的单核白血球的 CXCL16/SR-PSOX mRNA 和蛋白质的表示比在正常控制在交流病人是显著地更高的(P <
0.05 ) ;然而,在在 UAP 组和 AMI 组之间的 CXCL16/SR-PSOX 表示没有有效差量(P >
0.05 ) 。Immunofluorescence 证明有在正常脉管的 endothelial 的 SR-PSOX 的低表示并且在感染的容器的每层提高了表示,当从 endothelial 传播到包围感染变得更坏的纸巾时。共焦的显微镜学证明 SR-PSOX 的表示在肝肝硬化在渗入的淋巴细胞被提高,并且表示铺平,这对在门 hepatis 和叶的发炎的度相称。结论:在外部血的单核白血球的 CXCL16/SR-PSOX 的表达式比在控制在交流病人是显著地更高的。CXCL16/SR-PSOX-mediated 发炎可以贡献交流的致病,并且 CXCL16 可以在致病和发展起一个重要作用是在人。 | YANG Hui-ling XU Yang-yan DU Li-fen LIU Chang-hui ZHAO Qiang WEI Wu-jie YOU Yong QUAN Zhi-hua | 2008 | Chinese Medical Journal2008，，2： | 17 |
| 17 | Beclin 1 cleavage by caspase-3 inactivates autophagy and promotes apoptosis显示文摘Autophagy and apoptosis are both highly regulated biological processes that play essential roles in tissue homeostasis,development and diseases.Autophagy is also described as a mechanism of death pathways,however,the precise mechanism of how autophagy links to cell death remains to be fully understood.Beclin 1 is a dual regulator for both autophagy and apoptosis.In this study we found that Beclin 1 was a substrate of caspase-3 with two cleavage sites at positions 124 and 149,respectively.Furthermore,the autophagosome formation occurred,followed by the appearance of morphological hallmarks of apoptosis after staurosporine treatment.The cleavage products of Beclin 1 reduced autophagy and promoted apoptosis in HeLa cells and the cells in which Beclin 1 was stably knocked down by specific shRNA.In addition,the cleavage of Beclin 1 resulted in abrogating the interaction between Bcl-2 with Beclin 1,which could be blocked by z-VAD-fmk.Thus,our results suggest that the cleavage of Beclin 1 by caspase-3 may contribute to inactivate autophagy leading towards augmented apoptosis. | Yushan Zhu Lixia Zhao Lei Liu Ping Gao Weili Tian Xiaohui Wang Haijing Jin Haidong Xu Quan Chen | 2010 | Protein & Cell2010，1，5： | 17 |
| 18 | Construction and Functional Analysis of a Lentiviral Expression Vector Containing a Scavenger Receptor (SR-PSOX) that Binds Uniquely Phosphatidylserine and Oxidized Lipoprotein显示文摘这研究的目的是构造包含特别地绑与的 scavenger 受体(SR-PSOX ) 的 lentiviral 表达式向量有六个 histidine 标签并且到的 phosphatidylserine 和氧化脂蛋白在动脉粥样硬化调查 SR-PSOX 的函数。我们利用有效在 vitro 或 invivo 交付目标基因进用提高的 biosafetyreplication 无能的 lentivirus 划分和非划分的哺乳动物的房间的 ViraPower lentiviral 表达式系统。钝结束的顺序用克隆反应的 reversetranscription 聚合酶链反应和方向性的 TOPO 被放大。通过一双 thecytomegalovirus 提交教材和 SR-PSOX 的反向的教材,正确克隆被聚合酶链反应识别并且定序。包装混合 andSR-PSOX-pLenti6/V5 TOPO 表示原生质标志的 ViraPower 是进 293FT 房间线 usingLipofectamine 的 co-transfected 2000。内长、外长的 SR-PSOX 以及在在不同时间的各种各样的泡沫房间模型的 - α蛋白质削尖的肿瘤坏死因素(TNF ) 的表示被 sodiumdodecyl sulfate-polyacrylamide 凝胶电泳,蛋白质印迹和间接 immunofluorescenceassay 检测。蛋白质印迹和免疫荧光分析证实α蛋白质是起来的 SR-PSOX andTNF- 的表情在泡沫房间模型调整了。我们的数据建议过去表示 ofrecom-binant 人 SR-PSOX 蛋白质能支持泡沫房间形成并且起来调整煽动性的因素 TNF- α的表示。 | Zhihua QUAN Huiling YANG Yongzong YANG Bin YAN Renxian CAO Gebo WEN Changhui LIU Yangyan XU | 2007 | Acta Biochimica et Biophysica Sinica2007，39，3： | 16 |
| 19 | Dissection of No.13 lymph node in radical gastrectomy for gastric carcinoma显示文摘AIM: To evaluate the feasibility and safety of No. 13 lymphadenectomy in radical gastrectomy for gastric carcinoma. METHODS: Medical records of the patients undergone No. 13 lymph node dissection during D2 gastrectomy for gastric carcinoma, were reviewed from March 2003 to May 2007. RESULTS: One hundred and fifty-eight patients underwent No. 13 lymph node dissection for D2 gastric carcinoma, of them, 4 (2.53%) were found to have metastasis in No. 13 lymph node. Metastasis to No. 12 lymph node was detected in 6 patients and 4 of them had positive No. 13 lymph node. The operative morbidity except for wound infection was 15.19% (24/158), and hospital death rate was 1.27% (2/158). No obstructive jaundice caused by No. 13 lymph node metastasis after No. 13 lymph node dissection in radical gastrectomy for gastric carcinoma was detected during the follow-up study to end of January 2007. CONCLUSION: Dissection of No. 13 lymph node in D2 gastrectomy for gastric carcinoma is safe with a low morbidity and mortality rate. Further study is needed to explore its long-term effect. | Ding-Feng Shen Da-Wei Chen Zhi-Wei Quan Ping Dong Xue-Feng Wang Hai-Zhou Xu Ming-Lin Zhao Lei Chen | 2008 | World Journal of Gastroenterology2008，14，6： | 16 |
| 20 | Surgical approaches for stage Ⅰ and Ⅱ thymoma-associated myasthenia gravis:feasibility of complete video-assisted thoracoscopic surgery (VATS) thymectomy in comparison with trans-sternal resection显示文摘Complete resection could be achieved in virtually all myasthenic patients with Masaoka stage Ⅰ and Ⅱ thymoma using the trans-sternal technique.Whether this is appropriate for minimally invasive approach is not yet clear.We evaluated the feasibility of complete video-assisted thoracoscopic surgery (VATS) thymectomy for the treatment of Masaoka stage Ⅰ and Ⅱ thymoma-associated myasthenia gravis,compared to conventional trans-sternal thymectomy.We summarized 33 patients with Masaoka stage Ⅰ and Ⅱ thymoma-associated myasthenia gravis between April 2006 and September 2011.Of these,15 patients underwent right-sided complete VATS (the VATS group) by using adjuvant pneuomomediastinum,comparing with 18 patients using the trans-sternal approach (the T3b group).No intraoperative death was found and no VATS case required conversion to median sternotomy.Significant differences between the two groups regarding duration of surgery and volume of intraoperative blood loss (P=0.001 and P < 0.001,respectively) were observed.Postoperative morbidities were 26.7% and 33.3% for the VATS and T3b groups,respectively.All 33 patients were followed up for 12 to 61 months in the study.The cumulative probabilities of reaching complete stable remission and effective rate were 26.7% (4/15) and 93.3% (14/15) in the VATS group,which had a significantly higher complete stable remission and effective rate than those in the T3b group (P=0.026 and P=0.000,respectively).We conclude that VATS thymectomy utilizing adjuvant pneuomomediastinum for the treatment of stage Ⅰ and Ⅱ thymoma-associated myasthenia gravis is technically feasible but deserves further investigation in a large series with long-term follow-up. | Zhicheng He Quan Zhu Wei Wen Liang Chen Hai Xu Hai Li | 2013 | The Journal of Biomedical Research2013，27，1： | 15 |
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