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| 1 | Carotenoid Pigment Accumulation in Horticultural Plants显示文摘Carotenoids are a group of widely distributed natural pigments.They give many horticultural plants the bright red,orange,and yellow colors,as well as the aroma and flavor.Carotenoids enhance the health value and represent an essential quality trait of horticultural products.Significant efforts have been made to correlate specific carotenoid production with pathway gene expression.Some transcription factors that directly regulate transcription of the pathway genes have been identified.Horticultural crops have evolved with complicated and multifaceted regulatory mechanisms to generate the enormous diversity in carotenoid content and composition.However,the diverse and complex control of carotenoid accumulation is still not well understood.In this review,we depict carotenoid accumulation pathways and highlight the recent progress in the regulatory control of carotenoid accumulation in horticultural plants.Because of the critical roles of chromoplasts for carotenoid hyperproduction,we evaluate chromoplast ultrastructures and carotenoid sequestrations.A perspective on carotenoid research in horticultural crops is provided. | Anna S.Hermanns Xuesong Zhou Qiang Xu Yaakov Tadmor Li Li | 2020 | Horticultural Plant Journal2020，6，6： | 20 |
| 2 | Effect of barium sulfate modification on the SO2 tolerance of V2O5/TiO2 catalyst for NH3-SCR reaction显示文摘Sulfur poisoning of V_2O_5/BaSO_4–TiO_2(VBT),V_2O_5/WO_3–TiO_2(VWT) and V_2O_5/BaSO_4–WO_3–TiO_2(VBWT) catalysts was performed in wet air at 350℃ for 3 hr,and activities for the selective catalytic reduction of NO_x with NH_3 were evaluated for 200–500℃.The VBT catalyst showed higher NO_x conversions after sulfur poisoning than the other two catalysts.The introduction of barium sulfate contributed to strong acid sites for the as-received catalyst,and eliminated the redox cycle of active vanadium oxide to some extent,which resulted in a certain loss of activity.Readily decomposable sulfate species formed on VBT-S instead of inactive sulfates on VWT-S.These decomposable sulfates increased the number of strong acid sites significantly.Some sulfate species escaped during catalyst preparation and barium sulfate was reproduced during sulfur poisoning,which protects vanadia from sulfur oxide attachment to a great extent.Consequently,the VBT catalyst exhibited the best resistance to sulfur poisoning. | Tengfei Xu Xiaodong Wu Xuesong Liu Li Cao Qiwei Lin Duan Weng | 2017 | Journal of Environmental Sciences2017，29，7： | 14 |
| 3 | Loss of 5-hydroxymethylcytosine is linked to gene body hypermethylation in kidney cancer显示文摘5-methylcytosine (5mC ) 和它的氧化形式 5-hydroxymethylcytosine (5hmC ) 被建议了涉及 tumorigenesis。因为印射方法的广泛地使用的 5mC 的读出,定序的重亚硫酸盐(BS-seq ) ,是 5mC 的和, 5hmC 层次, 5mC/5hmC 模式和这二修正的关系仍然保持糟糕理解。由介绍真实 5mC (BS-seq 由帮助 Tet 的 BS-seq 改正了, TAB-seq ) 并且 5hmC (TAB-seq ) 在单个核苷酸的分辨率同时铺平,我们这里证明与匹配的正常纸巾相比没有在肾肿瘤的 5mC 的全球损失。相反地, 5hmC 全球性被失去在几乎所有肾肿瘤纸巾。在肿瘤纸巾的 5hmC 水平是为肾癌症的一个独立预示的标记,与与更短的全面幸存联系的 5hmC 的底层。而且,我们证明 5hmC 的损失与匹配的正常纸巾相比在肿瘤被连接到 hypermethylation,特别地在基因身体区域。惊人地,基因身体 hypermethylation 显著地与肿瘤相关的基因的 silencing 被联系。IDH1 的 Downregulation 作为在肾癌症位于 5hmC 损失下面的机制被识别。恢复 5hmC 层次稀释了肿瘤房间的侵略能力并且在一个异种皮移植模型压制了肿瘤生长。一起,我们的结果证明 5hmC 的损失在由改变 DNA methylation 模式的肾癌症是一个预示的标记和一个 oncogenic 事件。 | Ke Chen Jing Zhang Zhongqiang Guo Qin Ma Zhengzheng Xu Yuanyuan Zhou Ziying Xu Zhongwu Li Xiongjun- Ye Xuesong Li Bifeng Yuan Yuwen Ke Chuan He Liqun Zhou Jiang Liu WeiminCi | 2016 | Cell Research2016，26，1： | 10 |
| 4 | S100A8 promotes epithelial-mesenchymal transition and metastasis under TGF-β/USF2 axis in colorectal cancer显示文摘Background:The transforming growth factor-β(TGF-β)pathway plays a pivotal role in inducing epithelial-mesenchymal transition(EMT),which is a key step in cancer invasion and metastasis.However,the regulatory mechanism of TGF-βin inducing EMT in colorectal cancer(CRC)has not been fully elucidated.In previous studies,it was found that S100A8 may regulate EMT.This study aimed to clarify the role of S100A8 in TGF-β-induced EMT and explore the underlying mechanism in CRC.Methods:S100A8 and upstream transcription factor 2(USF2)expression was detected by immunohistochemistry in 412 CRC tissues.Kaplan-Meier survival analysis was performed.In vitro,Western blot,and migration and invasion assays were performed to investigate the effects of S100A8 and USF2 on TGF-β-induced EMT.Mouse metastasis models were used to determine in vivo metastasis ability.Luciferase reporter and chromatin immunoprecipitation assay were used to explore the role of USF2 on S100A8 transcription.Results:During TGF-β-induced EMT in CRC cells,S100A8 and the transcription factor USF2 were upregulated.S100A8 promoted cell migration and invasion and EMT.USF2 transcriptionally regulated S100A8 expression by directly binding to its promoter region.Furthermore,TGF-βenhanced the USF2/S100A8 signaling axis of CRC cells whereas extracellular S100A8 inhibited the USF2/S100A8 axis of CRC cells.S100A8 expression in tumor cells was associated with poor overall survival in CRC.USF2 expression was positively related to S100A8 expression in tumor cells but negatively related to S100A8-positive stromal cells.Conclusions:TGF-βwas found to promote EMT and metastasis through the USF2/S100A8 axis in CRC while extracellular S100A8 suppressed the USF2/S100A8 axis.USF2 was identified as an important switch on the intracellular and extracellular S100A8 feedback loop. | Si Li Jun Zhang Senmi Qian Xuesong Wu Liang Sun Tianyi Ling Yao Jin Wenxiao Li Lichao Sun Maode Lai Fangying Xu | 2021 | Cancer Communications2021，41，2： | 5 |
| 5 | Effects of structure and sur-face properties on carbon nanotubes' hydrogen storage characteristics显示文摘Hydrogen adsorption experiments were carried out in special stainless steel vessels at room temperature (298K) and under 10 MPa using self-synthesized multi-walled carbon nanotubes. In the experiments, carbon nanotubessynthesized by the seeded catalyst method were pretreatedby being soaked in chemical reagents or annealed at hightemperature before they were used to adsorb hydrogen, but their capacity for hydrogen storage was still poor. Carbonnanotubes synthesized by the floating catalyst method were found to be able to adsorb more hydrogen. They have ahydrogen storage capacity of over 4% after they wereannealed at high temperatures, which suggested that theycould be used as a promising material for hydrogen storage. | LI Xuesong ZHU Hongwei CI Lijie XU Cailu MAO Zongqiang WEI Bingqing LIANG Ji WU Dehai | 2001 | Chinese Science Bulletin2001，46，16： | 5 |
| 6 | Post-failure behavior of tunnel heading collapse by MPM simulation显示文摘Tunnel collapse presents a serious threat to the safety of urban construction. The traditional approach adopted to assess this risk is to evaluate the factor of safety against failure. However, this analysis only determines on whether the tunnel will collapse or not, and does not provide information on the magnitude of the post-failure behavior(for example, catastrophic or progressive) if the tunnel collapse occurs. In this study, a meshless method based on the material point method(MPM) was used to investigate the post-failure behavior of tunnel heading collapse in two-dimensional plane-strain conditions. The capability and accuracy of MPM were verified by comparing the elicited results to centrifuge test data and to analytical solutions obtained from limit state methods. MPM simulations were conducted at different soil conditions(clay or sand) and profiles(homogenous or linear increasing strength) as well as at different tunnel geometries(i.e. tunnel depth and unlined length). The differences in the post-failure behavior and mechanisms are examined and reported. | CHENG XueSong ZHENG Gang SOGA K. BANDARA S.S. KUMAR K. DIAO Yu XU Jie | 2015 | Science China(Technological Sciences)2015，58，12： | 5 |
| 7 | Efficacy of sunitinib in patients with metastatic renal cell carcinoma: initial experience in two Chinese centers显示文摘 | He Zhisong Guo Gang Zhang Cuijian Li Xuesong Fu Weijun Jin Jie Zhang Xu Zhou Liqun | 2014 | Chinese Medical Journal2014，，8： | 5 |
| 8 | Characteristics of Vibration and Sound Radiation of Metro Resilient Wheel显示文摘Resilient wheels are extensively used in urban rail transit, especially for tramway systems, owing to its advantages in noise reduction. A new type of resilient wheel for a metro is designed, and its characteristics of vibration and sound radiation, including the rolling noise of a resilient single wheel coupled with a track, are studied in this paper. A two-step research is presented. Firstly, laboratory experiments were conducted to obtain the vibration response of the designed resilient wheel under the radial excitation on its tread. Secondly, the rolling noise model of the resilient wheel coupled with a slab track used in a metro line is developed. The wheel model is based on the 3 D finite elementand boundary element methods and verified by using the experimental results obtained from the laboratory. The track vibration model is based on the wavenumber finite element method, and the track sound radiation is calculatedby using an e cient frequency-domain Rayleigh method. The interaction of the resilient wheel and the slab track is analyzed considering the measured wheel/rail roughness of the metro. The contribution of the resilient wheel to the reduction of wheel/rail system noise is analyzed. The results show that the resilient wheel can e ectively reduce the wheel/rail rolling noise by approximately 2 dB(A) to 3 dB(A), mainly because the radiated noise by the rail is reduced. In addition, the elastic modulus of the rubber has an important influence on the noise reduction of resilient wheels. | Xin Zhou Jian Han Yue Zhao Bing Wu Gong Cheng Shenghui Xu Xuesong Jin | 2019 | Chinese Journal of Mechanical Engineering2019，32，4： | 5 |
| 9 | Toxoplasma gondii GRA15II effector-induced M1 cells ameliorate liver fibrosis in mice infected with Schistosomiasis japonica显示文摘Recent studies indicated that type II Toxoplasma gondii(Tg)GRA15II favored the generation of classically activated macrophages(M1),whereas type I/III TgROP16I/III promoted the polarization of alternatively activated macrophages(M2).A number of studies have demonstrated that M2 cells are involved in the pathogenesis of the liver fibrogenesis caused by Schistosoma japonicum.The purpose of the present study was to explore the inhibitory effect of Toxoplasma-derived TgGRA15II on mouse hepatic fibrosis with schistosomiasis.The gra15II and rop16I/III genes were amplified from strains T.gondii PRU and Chinese 1 Wh3,respectively.Lentiviral vectors containing the gra15II or rop16I/III plasmid were constructed and used to infect the RAW264.7 cell line.The polarization of the transfected cells was evaluated,followed by co-culture of the biased macrophages with mouse hepatic stellate JS1 cells.Then,mice were injected with GRA15II-driven macrophages via the tail vein and infected with S.japonicum cercariae.TgGRA15II induced a M1-biased response,whereas TgROP16I/III drove the macrophages to a M2-like phenotype.The in vitro experiments indicated that JS1 cell proliferation and collagen synthesis were decreased following co-culture with TgGRA15II-activated macrophages.Furthermore,mice inoculated with TgGRA15II-biased macrophages displayed a notable alleviation of collagen deposition and granuloma formation in their liver tissues.Our results suggest that TgGRA15II-induced M1 cells may dampen the M2 dominant pathogenesis of hepatic fibrosis and granulomatosis.These results provide insights into the use of parasite-derived immunomodulators as potential anti-fibrosis agents and to re-balance the schistosomiasis-induced immune response. | Yuanyuan Xie Huiqin Wen Ke Yan Shushu Wang Xuesong Wang Jian Chen Yuanling Li Yuanhong Xu Zhengrong Zhong Jilong Shen Deyong Chu | 2018 | Cellular & Molecular Immunology2018，15，2： | 4 |
| 10 | Cloning and analysis of a cDNA encoding acetohydroxy acid isomeroreductase from G2 pea显示文摘Using cDNA representational difference analysis (cDNA RDA) method, we have successfully isolated a gene fragment whose expression was specifically induced by external GAa application. Screening a G2 pea cDNA library using this fragment as a probe, we obtained a 2036 bp full-length cDNA. It contains a 1746 bp open reading frame and encodes a protein of 581 amino acids with a theoretical molecular weight of 64 ku. It shares high-level sequenceidentity with AAIR genes from other plant species. This cDNA was cloned into expression vector and recombinant E. coli DH5α cells with remarkable AAIR enzyme activity were obtained. | XU Huasong XU Yunjian GU Xuesong HU Tingzhang SU Yanhui ZHU Yuxian | 2001 | Chinese Science Bulletin2001，46，21： | 4 |
| 11 | Probucol attenuates ethanol‐induced liver fibrosis in rats by inhibiting oxidative stress, extracellular matrix protein accumulation and cytokine production显示文摘 | Xuesong Su Yanqiu Wang Guangyu Zhou Xu Yang Rui Yu Yan Lin Changqing Zheng | 2014 | Clin Exp Pharmacol Physiol2014，，1： | 3 |
| 12 | Comparison of clinical outcomes of Chinese men and women after coronary stenting for coronary artery disease:a multi-center retrospective analysis of 4,334 patients显示文摘The outcome differences between Chinese male and female patients within one-year follow-up after percutaneous coronary intervention(PCI) with stent remain unclear.The present study was aimed to compare clinical outcomes in such two populations.From May 1999 to December 2009,4,334 patients with acute myocardial infarction(MI),unstable angina,stable angina,or silent ischemia,who underwent PCI,were registered at our centers.Among these,3,089 were men and 1,245 were women.We compared these groups with respect to the primary outcomes of MI and secondary outcomes including a composite of major adverse cardiac events(MACE) including cardiac death,MI,target lesion revascularization,target vessel revascularization(TVR),stent thrombosis(ST),definite ST and probable ST at one-year follow-up.Chinese male patients had a higher MACE rate(13%vs.10.7%,P =0.039),mainly led by TVR(9.09%vs.6.98%,P=0.024) at one year,which was significantly different than female patients.Chinese male and female patients showed a significant difference on MACEs.However,there was no significant difference with respect to MI between these groups. | Rajiv Shrestha Jing Xu Dujiang Xie Zhizhong Liu Tian Xu Fei Ye Shiqing Din Xuesong Qian Song Yang Yueqiang Liu Feng Li Aiping Zhang Shaoliang Chen | 2014 | The Journal of Biomedical Research2014，28，5： | 3 |
| 13 | Blockchain-Based Reliable Fog-Cloud Service Solution for IIoT显示文摘Industrial Internet of things(IIoT)deploys a large number of smart devices to obtain industrial data,which will be transmitted to cloud for analysis to improve industrial productivity.The management of large-scale devices is complicated,and it’s also a challenge to choose a high-quality cloud service for data analysis as the number of service with similar functions increases.To address these issues,we propose a reliable fog-cloud service solution with blockchain-based fog-cloud architecture.In fog layer,we build a management blockchain between fog servers and design a management method for industrial devices;In cloud layer,we construct a service blockchain between cloud service providers to form an open'service market'.Quality of service and reputation based matching algorithm and reputation-based consensus algorithm are designed.The simulation results show correctness and efficiency of algorithms,and validate effectiveness of our proposed solution. | DAI Meiling XU Siya SHAO Sujie GUO Shaoyong QIU Xuesong XIONG Ao | 2021 | Chinese Journal of Electronics2021，30，2： | 3 |
| 14 | High-purity helical carbon nanotubes by trace-water- assisted chemical vapor deposition: Large-scale synthesis and growth mechanism显示文摘 | Fanbin Meng Ying Wang Qiang Wang Xiaoling Xu Man Jiang Xuesong Zhou Ping He Zuowan Zhou | 2018 | Nano Research2018，11，6： | 3 |
| 15 | Generation and characterization of monoclonal antibodies against the NS1 protein of H17N10 bat influenza virus显示文摘 | Junna Gao Kaidi Xu Haiwei Sun Qinfang Liu Jianmei Yang Qiaoyang Teng Xuesong Li Zhaoguo Chen Zejun Li Hongjun Chen | 2017 | Acta Biochimica et Biophysica Sinica2017，49，7： | 2 |
| 16 | Effects of bile salts and divalent cations on the adsorption of norfloxacin by agricultural soils显示文摘The effects of bile salts(sodium cholate and sodium deoxycholate, 0–20 mmol/L), divalent cations(Ca2+, Mg2+, Cu2+and Zn2+, 0–20 mmol/L) or pH(3.0–10.0) on the adsorption of norfloxacin by three selected soils(Paddy H, Paddy G and Red J) were systematically studied. Soil adsorption of norfloxacin follows a pseudo second-order kinetics model, and the maximum adsorption capacity has been determined from the nonlinear fit of the Langmuir isotherm model to be 88.8, 88.1 and 63.0 μmol/g for the adsorption onto Paddy H, Paddy G and Red J, respectively. The results indicate that norfloxacin has a high adsorption affinity for the agricultural soils tested and that the organic content of these soils have at least a slight influence on this adsorption. The adsorption of norfloxacin to soils was strongly dependent on pH and exhibited a maximum at approximately pH 6. The presence of divalent cations prominently suppressed the adsorption of norfloxacin by paddy soils, which followed an order of Cu2+> Mg2+> Ca2+> Zn2+, and by red soil, which followed an order of Cu2+> Zn2+> Ca2+ > Mg2+. The adsorption of norfloxacin(by the soils studied) sharply decreased as the amount of bile salts was increased. For uncharged norfloxacin at environmentally relevant pH values, such factors as soil type, exogenous divalent cations and macromolecules significantly altered the environmental fate and transport of norfloxacin between aquatic and soil interfaces. | Xuesong Kong Shixiang Feng Xu Zhang Yan Li | 2014 | Journal of Environmental Sciences2014，26，4： | 2 |
| 17 | Self-sacrificial templating synthesis of flower-like nickel phyllosilicates and its application as high-performance reinforcements in epoxy nanocomposites显示文摘The nanocomposites of flower-like nickel phyllosilicate particles incorporated into epoxy resin were fabricated via an in-situ mixing process.The flower-like nickel phyllosilicate particles were firstly synthesized using a mild self-sacrificial templating method,and the morphology and lamellar structure were examined carefully.Several properties of mechanical,thermal and tribological responses of epoxy nanocomposites were performed.It was demonstrated that adequate flower-like nickel phyllosilicate particles dispersed well in the matrix,and the nanocomposites displayed enhanced tensile strength and elastic modulus but decreased elongation at break as expected.In addition,friction coefficient and wear rate were increased first and then decreased along with the particle content,and showed the lowest values at a mass fraction of 5%.Nevertheless,the incorporated flower-like nickel phyllosilicate particles resulted in the continuously increasing thermal stability of epoxy resin(EP)nanocomposites.This study revealed the giant potential of flower-like particles in preparing high-quality EP nanocomposites. | Jinian Yang Xuesong Feng Shibin Nie Yuxuan Xu Zhenyu Li | 2022 | Frontiers of Chemical Science and Engineering2022，16，4： | 2 |
| 18 | Twin and twin intersection phenomena in a creep deformed microalloyed directionally solidified high Nb containing TiAl alloy显示文摘The creep behavior of a directionally solidified TiAl alloy with a high Nb content after microalloying by the addition of small amounts of W,Cr,and B elements was investigated by scanning electron microscopy and transmission electron microscopy.By means of directional solidification and microalloying,a TiAl alloy with a fine and uniform microstructure and continuous columnar crystals was obtained.High-density dislocations,deformation nanotwins,and twin intersections were observed inγlamellae.The results show that,in comparison with the ternary TiAl alloy,the microalloyed high Nb containing TiAl alloy exhibited better creep properties at 760℃and 275 MPa.The decrease in stacking fault energy can promote dislocation dissociation and the formation of deformation twins,and the twin intersections can hinder the movement of dislocation to enhance the creep performance of the TiAl alloy. | Xuesong Xu Hongsheng Ding Haitao Huang He Liang Hao Guo Ruirun Chen Jingjie Guo Hengzhi Fu | 2022 | Journal of Materials Science & Technology2022，，32： | 2 |
| 19 | Application of fluorescence in situ hybridization in the detection of bladder transitional-cell carcinoma: A multi-center clinical study based on Chinese population显示文摘Objective:To evaluate the diagnostic value of fluorescence in situ hybridization(FISH)in bladder cancer.Methods:We enrolled healthy volunteers and patients who were clinically suspected to have bladder cancer and conducted FISH tests and cytology examinations from August 2007 to December 2008.Receiver operating characteristic(ROC)curve analysis was performed and the area under curve(AUC)values were calculated for both the FISH and urine cytology tests.Results:A cohort of 988 healthy volunteers was enrolled to establish a reference range for the normal population.A total of 4807 patients with hematuria were prospectively,randomly enrolled for the simultaneous analysis of urine cytology,FISH testing,and a final diagnosis as determined by the pathologic findings of a biopsy or a surgically-excised specimen.Overall,the sensitivity of FISH in detecting transitional-cell carcinoma was 82.7%,while that of cytology was 33.4%(p<0.001).The sensitivity values of FISH for non-muscle invasive and muscle invasive bladder transitional-cell carcinoma were 81.7%and 89.6%,respectively(p=0.004).The sensitivity values of FISH for low and high grade bladder cancer were 82.6%and 90.1%,respectively(p=0.002).Conclusion:FISH is significantly more sensitive than voided urine cytology for detecting bladder cancer in patients evaluated for gross hematuria at all cancer grades and stages.Higher sensitivity using FISH was obtained in high grade and muscle invasive tumors. | Liqun Zhou Kaiwei Yang Xuesong Li Yi Ding Dawei Mu Hanzhong Li Yong Yan Jinyi Li Dongwen Wang Wei Li Yulong Cong Jiangping Gao Kewei Ma Yajun Xiao Sheng Zhang Hongyi Jiang Weilie Hu Qiang Wei Xunbo Jin Zhichen Guan Qingyong Liu Danfeng Xu Xin Gao Yongguang Jiang Weimin Gan Guang Sun Qing Wang Yanhui Liu Jianquan Hou Liping Xie Xishuang Song Fengshuo Jin Jiafu Feng Ming Cai Zhaozhao Liang Jie Zhang Dingwei Ye Lin Qi Lulin Ma Jianzhong Shou Yuping Dai Jianyong Shao Ye Tian Shizhe Hong Tao Xu Chuize Kong Zefeng Kang Yuexin Liu Xun Qu Benkang Shi Shaobin Zheng Yi Lin Shujie Xia Dong Wei Jianbo Wu Weiling Fu Zhiping Wang Jianbo Liang | 2019 | Asian Journal of Urology2019，6，1： | 2 |
| 20 | Multi-responsive wholly aromatic sulfonated polyamide ultra-sensitive to pH value显示文摘We demonstrated here a new family of multi-responsive polymer:wholly aromatic sulfonated polyamide(SPA).SPA exhibited the unusual response to temperature and pH with the tunable low critical solution temperature(LCST).LCST of the obtained SPA decreased sharply with the increasing pH,and the difference of LCST between pH 6.0-6.8 is about 60 ℃. | ZHAO Jing XU HongJie JIANG XueSong YIN Jie | 2012 | Science China Chemistry2012，55，12： | 1 |
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